D:Chemotherapy-induced Neutropenia

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Disease Term
Synonyms Chemotherapy Induced Neutropaenia, Chemotherapy Induced Neutropenia, Decrease In Neutrophils, Decreased Neutrophils, Neutropaenic Disorder, Neutropaenic Disorders, NEUTROPENIC DISORDER, Neutrophils Decreased, Neutropsenic Disorders
Documents 19
Hot Single Events 28
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chemotherapy-induced Neutropenia. They are ordered first by their relevance to Chemotherapy-induced Neutropenia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 17.60
2 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7 5.00
3 INT178340 Cxcl1 Positive_regulation of Nfkb1 1 0.11 1.01 0.41 5.00
4 INT178342 Positive_regulation of Tlr4 Positive_regulation of Il6 1 0.13 0.25 0.3 5.00
5 INT347334 Binding of S100a9 and Il1 1 0.09 0.45 0.15 5.00
6 INT347335 Binding of S100a4 and S100a9 1 0.39 0.51 0.15 5.00
7 INT347338 Binding of Fgf1 and S100a9 1 0.26 0.46 0.15 5.00
8 INT347333 Binding of S100a9 and Vegfa 1 0.38 0.46 0.15 5.00
9 INT178341 Tlr4 Positive_regulation of Gene_expression of Cxcl2 1 0.04 0.41 0.15 5.00
10 INT347336 Binding of S100a4 and S100a8 1 0.40 0.51 0.15 5.00
11 INT347332 Binding of S100a8 and Vegfa 1 0.38 0.46 0.15 5.00
12 INT347339 Binding of Il6 and S100a9 1 0.29 0.46 0.15 5.00
13 INT347331 Binding of Fgf1 and S100a8 1 0.26 0.46 0.15 5.00
14 INT347330 Binding of S100a8 and Il1 1 0.09 0.45 0.15 5.00
15 INT347337 Binding of Il6 and S100a8 1 0.29 0.46 0.15 5.00
16 INT342439 PPP2CA Negative_regulation of PRMT1 1 0.12 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chemotherapy-induced Neutropenia. They are ordered first by their pain relevance and then by number of times they were reported in Chemotherapy-induced Neutropenia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266342 Negative_regulation of Gene_expression of S100a9 2 0.58 1.65 0.31 100.00
2 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 100.00
3 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 99.98
4 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 99.76
5 INT26584 Gene_expression of Nes 76 0.75 24.03 4.17 95.48
6 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 94.84
7 INT132246 Negative_regulation of S100a8 19 0.43 22 7.25 92.80
8 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 92.80
9 INT257801 Negative_regulation of S100a9 6 0.35 5.12 0.96 92.80
10 INT221213 Negative_regulation of Hspa9 7 0.34 2.79 1.18 92.20
11 INT152728 Negative_regulation of Positive_regulation of S100a8 4 0.43 3.96 1.29 91.44
12 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 90.92
13 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 90.92
14 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 90.92
15 INT181054 Positive_regulation of S100a9 14 0.56 9.83 4.6 90.92
16 INT161506 Regulation of Gene_expression of S100a8 6 0.45 4.68 2.9 90.92
17 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 89.24
18 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 88.64
19 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 87.40
20 INT57525 Negative_regulation of Ltf 9 0.50 4.2 4.03 86.64
21 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 85.40
22 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 85.36
23 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 85.08
24 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54 83.80
25 INT28731 Negative_regulation of Elane 14 0.14 8.97 3.01 82.96
26 INT97596 Localization of S100a8 94 0.78 90.69 40.41 81.28
27 INT97598 Negative_regulation of Localization of S100a8 8 0.42 6.52 4.31 81.28
28 INT131228 Regulation of Localization of S100a8 4 0.45 1.81 1.65 81.28
29 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 77.76
30 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 77.76
31 INT90372 Negative_regulation of Hrec 12 0.03 11.73 4.74 70.32
32 INT236089 Regulation of Negative_regulation of Hrec 1 0.03 1.56 0.55 70.32
33 INT236090 Regulation of Negative_regulation of S100a8 1 0.02 1.55 0.54 69.52
34 INT165915 Regulation of Negative_regulation of Pde4a 5 0.29 6.72 2.91 67.72
35 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 67.00
36 INT145119 Gene_expression of Cor 11 0.65 3.24 0.93 66.56
37 INT181018 Binding of S100a8 20 0.45 22.14 3.18 64.80
38 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 60.76
39 INT181061 Localization of S100a9 9 0.74 4.98 2.19 55.92
40 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 50.00
41 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 50.00
42 INT14690 Localization of CSF2 124 0.80 85.17 27.26 50.00
43 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 50.00
44 INT14301 Binding of CSF2 82 0.48 67.95 8.98 50.00
45 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 50.00
46 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 49.64
47 INT236093 Negative_regulation of Bdywt 1 0.18 0.58 0 49.28
48 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 44.40
49 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 44.40
50 INT156109 Positive_regulation of TSS 6 0.40 0.92 0.41 43.72
51 INT219595 Positive_regulation of Gene_expression of Pde4a 3 0.39 2.81 1.11 41.68
52 INT105777 Gene_expression of Pde4a 30 0.76 12.67 8.52 40.80
53 INT342438 Positive_regulation of Nr2e3 1 0.04 0.31 0 40.20
54 INT125711 Negative_regulation of TSS 6 0.51 3.64 0.12 39.56
55 INT336735 Regulation of Gene_expression of S100a9 2 0.45 1.17 0.24 39.48
56 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 38.96
57 INT254145 Gene_expression of Ppap2a 9 0.10 2.66 4.33 36.52
58 INT53500 Negative_regulation of Ppap2a 11 0.45 3.31 1.92 31.52
59 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 29.44
60 INT85653 Regulation of Gene_expression of Cpox 24 0.24 20.55 5.22 27.84
61 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 27.52
62 INT53262 Gene_expression of TSS 6 0.52 1.35 0.37 21.80
63 INT254146 Localization of Ppap2a 2 0.11 0.39 1.01 21.12
64 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 15.04
65 INT172870 Negative_regulation of Ptger3 6 0.23 2.96 1.48 8.64
66 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 8.08
67 INT118492 Regulation of Pde4a 7 0.61 6.32 6.04 6.72
68 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.04
69 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
70 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
71 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
72 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
73 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
74 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
75 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 5.00
76 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
77 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
78 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
79 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
80 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
81 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
82 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
83 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
84 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
85 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
86 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
87 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
88 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
89 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
90 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
91 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
92 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
93 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
94 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
95 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
96 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 5.00
97 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
98 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 5.00
99 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59 5.00
100 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
101 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
102 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
103 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 5.00
104 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
105 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
106 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
107 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 5.00
108 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
109 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 5.00
110 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
111 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
112 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
113 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
114 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
115 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
116 INT71879 Negative_regulation of Localization of Nfkb1 30 0.57 21.8 13.48 5.00
117 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
118 INT150851 Positive_regulation of Cxcl1 45 0.57 20.83 11.88 5.00
119 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5 5.00
120 INT71766 Transcription of Il10 31 0.69 24.66 10.78 5.00
121 INT90371 Localization of Hrec 28 0.05 19.11 10.12 5.00
122 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.00
123 INT150867 Regulation of COPD 54 0.48 71.38 8.8 5.00
124 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
125 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76 5.00
126 INT79456 Gene_expression of PDE4A 35 0.77 19.42 7.42 5.00
127 INT89660 Positive_regulation of Gene_expression of Hrec 15 0.17 12.06 7.37 5.00
128 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32 5.00
129 INT147793 Localization of COPD 70 0.64 89.01 7.3 5.00
130 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22 5.00
131 INT15007 Gene_expression of Pbrgcsf1 31 0.49 17.82 6.99 5.00
132 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 5.00
133 INT73479 Positive_regulation of Hrec 21 0.04 16.16 6.87 5.00
134 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
135 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
136 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
137 INT89603 Regulation of Negative_regulation of Cpox 11 0.30 10.59 6.28 5.00
138 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
139 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 5.00
140 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46 5.00
141 INT118124 Binding of USE1 24 0.16 16.64 5.44 5.00
142 INT134966 Localization of Col7a1 23 0.42 16.4 5.24 5.00
143 INT135436 Gene_expression of Hspa9 31 0.62 14.75 5.2 5.00
144 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08 5.00
145 INT59320 Transcription of Il2 32 0.69 6.39 4.95 5.00
146 INT71767 Positive_regulation of Transcription of Il10 10 0.67 5.55 4.66 5.00
147 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
148 INT99905 Negative_regulation of Negative_regulation of Cpox 11 0.35 7.01 4.37 5.00
149 INT170738 Binding of Icam1 23 0.37 25.49 4.09 5.00
150 INT62545 Regulation of Gene_expression of Icam1 17 0.49 14.26 4.06 5.00
151 INT151736 Binding of Hand1 15 0.26 9.77 4.04 5.00
152 INT156131 Binding of Hand2 14 0.25 10.35 3.99 5.00
153 INT17879 Positive_regulation of Ppap2a 17 0.53 9.72 3.8 5.00
154 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 5.00
155 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59 5.00
156 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
157 INT227523 Localization of Hspa9 9 0.60 5.26 3.18 5.00
158 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
159 INT152861 Binding of S100a9 11 0.37 12.19 2.91 5.00
160 INT220858 Positive_regulation of Mmp1a 15 0.38 9.11 2.77 5.00
161 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74 5.00
162 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57 5.00
163 INT139101 Negative_regulation of Gene_expression of Hrec 3 0.03 1.31 2.56 5.00
164 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47 5.00
165 INT181986 Negative_regulation of Positive_regulation of Col7a1 6 0.08 7.4 2.46 5.00
166 INT173511 Localization of Mmp1a 4 0.21 2.73 2.39 5.00
167 INT91276 Positive_regulation of Negative_regulation of Cpox 4 0.27 3.11 2.2 5.00
168 INT122206 Binding of Hrec 5 0.02 4 2.19 5.00
169 INT19823 Negative_regulation of Pbrgcsf1 12 0.36 7.37 2.13 5.00
170 INT178339 Binding of Cxcl1 17 0.36 5.14 2.04 5.00
171 INT38118 Negative_regulation of Positive_regulation of IFNA1 8 0.43 3.95 2.04 5.00
172 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01 5.00
173 INT100940 Regulation of Negative_regulation of Nfkb1 5 0.35 3.59 1.91 5.00
174 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87 5.00
175 INT112684 Positive_regulation of Cor 10 0.45 3.48 1.82 5.00
176 INT183753 Regulation of HBM 24 0.39 13.13 1.79 5.00
177 INT204763 Transcription of S100a8 8 0.69 6.22 1.69 5.00
178 INT52530 Regulation of Gene_expression of Nfkb1 8 0.59 4.41 1.68 5.00
179 INT135930 Regulation of Gene_expression of Pde4a 3 0.61 0.52 1.63 5.00
180 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63 5.00
181 INT155153 Binding of S100a1 15 0.35 6.42 1.63 5.00
182 INT173510 Positive_regulation of Localization of Mmp1a 4 0.13 2.55 1.62 5.00
183 INT236092 Gene_expression of Fut1 2 0.06 8.11 1.47 5.00
184 INT200185 Regulation of Igfals 10 0.26 11.4 1.47 5.00
185 INT134092 Binding of Cxcl2 5 0.21 2.57 1.45 5.00
186 INT121820 Binding of STAT1 9 0.46 2.54 1.4 5.00
187 INT164915 Gene_expression of CXCL2 7 0.55 5.25 1.4 5.00
188 INT177527 Negative_regulation of Binding of Pde4a 4 0.28 3.5 1.23 5.00
189 INT236091 Positive_regulation of Transcription of Il2 2 0.44 2.78 1.19 5.00
190 INT268662 Regulation of Araf 4 0.17 2.5 1.13 5.00
191 INT8482 Positive_regulation of PIAS1 2 0.40 0.73 1.12 5.00
192 INT124623 Binding of GDF15 4 0.35 2.06 1.09 5.00
193 INT51089 Negative_regulation of PRMT1 3 0.24 1.18 0.98 5.00
194 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97 5.00
195 INT56771 Regulation of Cor 7 0.23 1.33 0.93 5.00
196 INT87240 Gene_expression of Aggf1 14 0.11 8.41 0.93 5.00
197 INT177531 Binding of Pde4a 4 0.29 2.46 0.91 5.00
198 INT128424 Transcription of STAT1 5 0.37 3.28 0.9 5.00
199 INT184386 Binding of DNAI1 5 0.36 3.77 0.82 5.00
200 INT73433 Gene_expression of S100a6 10 0.71 2.74 0.76 5.00
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