D:Cholecystitis

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Empyema Gall Bladder, EMPYEMA GALLBLADDER, Gall Bladder Empyema, Gallbladder Empyema, Gallbladder Inflammation, INFLAMMATION GALLBLADDER, Inflammation Of The Gall Bladder, Inflammations Of The Gall Bladder
Documents 752
Hot Single Events 53
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cholecystitis. They are ordered first by their relevance to Cholecystitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215955 Binding of alp and Cys1 1 0.00 0.95 0.22 90.28
2 INT153154 OPN1MW Regulation of PTPRF 1 0.03 0.51 0.14 82.32
3 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05 57.48
4 INT252646 Binding of C6orf25 and SYT16 1 0.00 0.51 0.17 5.08
5 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38 5.00
6 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91 5.00
7 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24 5.00
8 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17 5.00
9 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17 5.00
10 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 5.00
11 INT332637 Negative_regulation of Dpp4 Negative_regulation of Localization of Ins1 1 0.06 1.66 0.1 5.00
12 INT332639 Glp1r Negative_regulation of Localization of Gcg 1 0.03 0.87 0.07 5.00
13 INT332641 Binding of PPARG and Ins1 1 0.12 1.05 0.05 5.00
14 INT332631 Negative_regulation of Dpp4 Negative_regulation of Gcg 1 0.05 1 0.05 5.00
15 INT332628 Negative_regulation of Dpp4 Negative_regulation of Positive_regulation of Gcg 1 0.05 1 0.05 5.00
16 INT332638 Gip Regulation of Glp1r 1 0.02 0.47 0.05 5.00
17 INT332633 Glp1r Negative_regulation of Gcg 1 0.04 1.13 0.05 5.00
18 INT332632 Gip Negative_regulation of Localization of Gcg 1 0.05 0.47 0.04 5.00
19 INT332635 Glp1r Regulation of Localization of Gcg 1 0.03 0.94 0.04 5.00
20 INT332640 Glp1r Regulation of Localization of Ins1 1 0.04 0.52 0.04 5.00
21 INT341847 ERBB2 Positive_regulation of Gene_expression of ESYT1 1 0.02 1.42 0.03 5.00
22 INT314771 Glp1r Positive_regulation of Gene_expression of Ins1 2 0.04 1.23 0.03 5.00
23 INT332629 Binding of Glp1r and Positive_regulation of Localization of Gcg 1 0.03 0.47 0 5.00
24 INT332636 Binding of Glp1r and Positive_regulation of Localization of Ins1 1 0.03 0.47 0 5.00
25 INT332634 Dpp4 Positive_regulation of Localization of Ins1 1 0.06 0.76 0 5.00
26 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
27 INT331909 Binding of ALB and SPARC 1 0.06 2.01 0 5.00
28 INT341856 Binding of EGFR and IgG1 1 0.27 1.12 0 5.00
29 INT211067 Pth Regulation of DMD 1 0.01 0.12 0 5.00
30 INT332627 Positive_regulation of Ins1 Positive_regulation of Phosphorylation of Hk2 1 0.01 0.83 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cholecystitis. They are ordered first by their pain relevance and then by number of times they were reported in Cholecystitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28402 Negative_regulation of Negative_regulation of MME 3 0.43 1.51 0.57 100.00
2 INT27964 Negative_regulation of CBR1 12 0.58 5.48 3.74 99.92
3 INT39049 Negative_regulation of Negative_regulation of CBR1 1 0.05 1.07 0.49 99.92
4 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1 99.40
5 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 98.64
6 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 98.28
7 INT39047 Gene_expression of PGF 34 0.78 17.48 6 98.28
8 INT143300 Positive_regulation of Positive_regulation of 4930519F16Rik 1 0.01 0.49 0.23 97.32
9 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 97.24
10 INT135383 Positive_regulation of 4930519F16Rik 3 0.01 1.75 0.78 96.84
11 INT36480 Localization of NR0B2 1 0.73 0.78 0.12 96.24
12 INT39048 Regulation of Gene_expression of PTGER1 3 0.45 2.55 1.31 95.84
13 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 95.44
14 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 95.28
15 INT4553 Binding of G6PD 7 0.37 3 0.44 94.96
16 INT96071 Localization of PIAS1 6 0.71 4.44 3.79 94.48
17 INT97118 Localization of ALPI 2 0.61 1.37 0.3 94.48
18 INT29421 Positive_regulation of CDS1 7 0.46 3.16 1.47 94.40
19 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 94.40
20 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39 94.40
21 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 93.84
22 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 92.76
23 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 92.40
24 INT892 Regulation of TRH 23 0.60 8.46 8.54 92.40
25 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 91.84
26 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 91.48
27 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 91.44
28 INT52749 Gene_expression of alp 24 0.44 12.84 5.97 91.44
29 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 91.36
30 INT24439 Gene_expression of Spink1 19 0.63 10.05 4.35 90.88
31 INT115392 Transcription of Spink1 4 0.69 2.31 1.13 90.88
32 INT215952 Localization of alp 2 0.65 1.9 0.22 90.28
33 INT143299 Transcription of Pars2 2 0.21 0.79 0.4 90.28
34 INT209083 Positive_regulation of GPBAR1 1 0.01 0.84 0.41 90.04
35 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 89.32
36 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 89.32
37 INT138691 Negative_regulation of OPN1MW 2 0.38 1.61 0.29 88.88
38 INT1939 Localization of Cys1 6 0.73 5.9 0.64 88.32
39 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 88.28
40 INT812 Localization of INS 1026 0.81 515.6 145.31 87.96
41 INT22906 Positive_regulation of Ggt1 3 0.45 5.42 0.92 87.00
42 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28 87.00
43 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24 86.96
44 INT12563 Localization of Mpo 33 0.81 20.99 9.58 85.40
45 INT57431 Binding of PIAS1 4 0.30 4.35 1.94 84.44
46 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 83.80
47 INT39045 Negative_regulation of Gene_expression of PTGER1 3 0.27 3.15 1.86 82.08
48 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 81.24
49 INT112126 Positive_regulation of Gast 7 0.55 4.06 0.38 81.08
50 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 80.92
51 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 80.72
52 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 80.44
53 INT70696 Positive_regulation of Localization of Mpo 2 0.44 2.17 0.82 80.20
54 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 79.84
55 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 79.84
56 INT14513 Localization of Ghrl 52 0.78 29.26 11.63 79.36
57 INT141285 Positive_regulation of Localization of Ghrl 11 0.63 9.38 3.86 79.36
58 INT75908 Regulation of LEP 77 0.60 60.16 15.19 79.28
59 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 79.04
60 INT313395 Gene_expression of OPN1MW 2 0.18 1.46 0.81 78.84
61 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 78.56
62 INT176202 Gene_expression of Abcb4 6 0.68 5.25 0.52 77.40
63 INT90350 Gene_expression of Gast 27 0.78 14.07 4.74 77.20
64 INT41893 Negative_regulation of HBS1L 16 0.23 8.98 1.19 76.92
65 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 76.84
66 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 75.60
67 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54 75.00
68 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32 75.00
69 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 75.00
70 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 75.00
71 INT18545 Positive_regulation of GGT6 1 0.15 1.33 0.19 75.00
72 INT180739 Binding of ACE2 5 0.37 7.88 0.45 74.00
73 INT39050 Positive_regulation of PGF 14 0.49 8.05 1.43 73.84
74 INT115654 Localization of Glp1r 11 0.75 3.79 2.34 73.84
75 INT39046 Positive_regulation of PTGER1 28 0.69 18.18 13.21 73.52
76 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 73.48
77 INT142695 Gene_expression of HMGCR 17 0.65 3.75 0.32 73.36
78 INT3214 Localization of Ins1 527 0.80 196.9 79.26 73.12
79 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 72.44
80 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 72.44
81 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 72.08
82 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 72.00
83 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12 70.08
84 INT280030 Localization of Dpp4 2 0.28 2.03 0.27 70.08
85 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 68.40
86 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 68.40
87 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 68.40
88 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03 68.40
89 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 67.40
90 INT120062 Binding of AIP 4 0.42 28.86 3.91 66.84
91 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 65.92
92 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 65.28
93 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 64.96
94 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 62.40
95 INT38056 Localization of Crp 71 0.78 53.14 17.03 60.52
96 INT158440 Negative_regulation of Nsdhl 4 0.21 3.22 0.51 59.44
97 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94 57.48
98 INT206798 Binding of VAMP7 1 0.30 2.23 0.26 56.56
99 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 55.96
100 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 55.84
101 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 55.84
102 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 55.84
103 INT44817 Negative_regulation of Gene_expression of Shbg 9 0.34 9.84 1.11 55.84
104 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2 52.04
105 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 51.72
106 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 50.16
107 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 50.00
108 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 50.00
109 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 50.00
110 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 50.00
111 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 50.00
112 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 50.00
113 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 50.00
114 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 50.00
115 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 50.00
116 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 50.00
117 INT39374 Gene_expression of Sct 5 0.68 1.42 3.89 50.00
118 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 50.00
119 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 50.00
120 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 50.00
121 INT86889 Gene_expression of Cdx2 8 0.60 4.23 1.02 50.00
122 INT234494 Positive_regulation of Syp 12 0.65 2.47 0.69 50.00
123 INT288302 Positive_regulation of Phosphorylation of SLC17A5 1 0.49 2 0.24 50.00
124 INT288301 Phosphorylation of SLC17A5 1 0.79 1.8 0.23 50.00
125 INT288300 Positive_regulation of Phosphorylation of GGT1 1 0.49 1.94 0.21 50.00
126 INT87573 Phosphorylation of Crp 2 0.05 1.99 0.21 50.00
127 INT288297 Positive_regulation of Phosphorylation of Crp 1 0.03 1.93 0.21 50.00
128 INT288303 Phosphorylation of GGT1 1 0.79 1.74 0.2 50.00
129 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 45.72
130 INT210021 Binding of Abcb4 1 0.37 2.47 0 44.36
131 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 43.36
132 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 42.00
133 INT2723 Gene_expression of Salpa1 16 0.64 11.78 3.5 42.00
134 INT31340 Positive_regulation of Gene_expression of Got1 20 0.46 10.5 3.17 42.00
135 INT4027 Positive_regulation of Gene_expression of Salpa1 3 0.48 1.51 0.53 42.00
136 INT323759 Regulation of Binding of ACE2 1 0.45 0.22 0.04 39.16
137 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 38.56
138 INT280033 Binding of Dpp4 2 0.14 1.94 0.17 38.16
139 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 36.56
140 INT135386 Localization of 4930519F16Rik 4 0.01 1.16 1.06 36.16
141 INT323762 Regulation of ACE2 1 0.39 1.63 0.12 35.40
142 INT332614 Positive_regulation of Dpp8 1 0.07 0.84 0.1 34.68
143 INT332625 Positive_regulation of Dpp9 1 0.09 0.84 0.1 34.68
144 INT66258 Negative_regulation of Positive_regulation of Salpa1 2 0.16 0.5 0.6 34.64
145 INT325379 Regulation of Positive_regulation of Ghrl 1 0.26 0.23 0.17 32.56
146 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68 32.24
147 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 31.76
148 INT48993 Positive_regulation of Cftr 17 0.57 6.02 4.12 31.40
149 INT153015 Positive_regulation of Gene_expression of nct 3 0.24 0.9 0.74 30.52
150 INT153016 Gene_expression of nct 4 0.32 0.97 0.89 30.08
151 INT2884 Positive_regulation of CCK 66 0.69 25.25 30.6 28.40
152 INT94827 Gene_expression of HBS1L 24 0.67 26.11 1.61 27.12
153 INT143298 Gene_expression of 4930519F16Rik 1 0.01 0.12 0.15 26.04
154 INT17049 Localization of CD4 57 0.75 35.33 6.89 25.00
155 INT284 Positive_regulation of Ggt6 18 0.67 13.56 4.62 25.00
156 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 24.88
157 INT317188 Protein_catabolism of OPN1MW 1 0.17 0.79 0.09 24.44
158 INT107288 Positive_regulation of ACE2 4 0.66 5.48 0.99 21.72
159 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 18.76
160 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76 16.64
161 INT287798 Localization of AIP 1 0.63 5.96 1.31 14.80
162 INT274238 Positive_regulation of AIP 2 0.42 8.14 0.97 10.88
163 INT287800 Positive_regulation of Positive_regulation of AIP 1 0.42 2.15 0.3 10.88
164 INT184747 Regulation of Skap2 2 0.26 1.34 0.31 9.56
165 INT299469 Regulation of HMGB1 2 0.18 2.27 0.03 9.56
166 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 9.12
167 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 6.92
168 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 6.00
169 INT193437 Negative_regulation of MCO 4 0.48 0.68 0 5.80
170 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
171 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
172 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
173 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
174 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
175 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
176 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
177 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
178 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
179 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
180 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
181 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
182 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
183 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
184 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
185 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
186 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
187 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 5.00
188 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
189 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
190 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
191 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
192 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
193 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
194 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
195 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
196 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
197 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
198 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
199 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
200 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox