D:Cholecystolithiasis

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Disease Term
Synonyms None
Documents 106
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cholecystolithiasis. They are ordered first by their relevance to Cholecystolithiasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT81716 ITGAL Regulation of ITGB2 2 0.30 1.24 0.78 5.00
2 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 5.00
3 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
4 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
5 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28 5.00
6 INT354195 Binding of GH1 and Sstr5 1 0.00 0.1 0.17 5.00
7 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16 5.00
8 INT354194 Mtpn Negative_regulation of MIR524 1 0.00 0.08 0.11 5.00
9 INT354120 Binding of IGF2 and IGFBP5 1 0.01 0.45 0.09 5.00
10 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09 5.00
11 INT354113 Binding of IGFBP3 and MIR524 1 0.01 0.69 0.07 5.00
12 INT354125 Binding of IGFBP3 and MIR15B 1 0.00 0.7 0.07 5.00
13 INT354126 Binding of IGFALS and MIR125A 1 0.23 0.7 0.07 5.00
14 INT354111 Binding of IGFBP3 and MIR125A 1 0.11 0.7 0.07 5.00
15 INT354109 Binding of IGFALS and MIR15B 1 0.00 0.7 0.07 5.00
16 INT354116 Binding of IGFALS and MIR524 1 0.02 0.69 0.07 5.00
17 INT354123 MIR124-1 Negative_regulation of Gene_expression of CTDSP1 1 0.01 0.15 0 5.00
18 INT170121 ITGAL Regulation of CD44 1 0.07 1.07 0 5.00
19 INT255020 TF Positive_regulation of Binding of Gtf3a 1 0.00 0.06 0 5.00
20 INT255012 TF Positive_regulation of F10 1 0.06 0.06 0 5.00
21 INT354122 MIR126 Regulation of PIK3CG 1 0.03 2.01 0 5.00
22 INT170119 PECAM1 Regulation of Positive_regulation of ITGAL 1 0.01 1.07 0 5.00
23 INT170124 ITGAM Regulation of ITGB2 1 0.04 1.07 0 5.00
24 INT170120 PECAM1 Regulation of ITGAM 1 0.00 1.07 0 5.00
25 INT170118 PECAM1 Regulation of CD44 1 0.01 1.07 0 5.00
26 INT354112 MIR126 Regulation of Localization of MIR381 1 0.01 0.7 0 5.00
27 INT170123 ITGAL Regulation of Positive_regulation of PECAM1 1 0.01 1.07 0 5.00
28 INT170125 ITGAM Regulation of Positive_regulation of PECAM1 1 0.01 1.07 0 5.00
29 INT170126 PECAM1 Regulation of ITGB2 1 0.01 1.07 0 5.00
30 INT354115 MIR222 Regulation of Gene_expression of CDKN1B 1 0.07 0.98 0 5.00
31 INT170116 ITGAM Regulation of CD44 1 0.07 1.07 0 5.00
32 INT354127 MIR381 Regulation of GH1 1 0.00 0.69 0 5.00
33 INT354119 MIR381 Regulation of Localization of MIR126 1 0.01 0.7 0 5.00
34 INT354110 MIR126 Regulation of GH1 1 0.01 0.69 0 5.00
35 INT255019 Myo7a Positive_regulation of F10 1 0.00 0.06 0 5.00
36 INT170114 ITGAM Regulation of Positive_regulation of ITGAL 1 0.04 1.07 0 5.00
37 INT170115 PECAM1 Regulation of ITGAL 1 0.00 1.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cholecystolithiasis. They are ordered first by their pain relevance and then by number of times they were reported in Cholecystolithiasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT290301 Regulation of Localization of JMJD6 1 0.03 1.25 0.08 96.88
2 INT290302 Localization of JMJD6 1 0.05 1.25 0.08 96.88
3 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 94.92
4 INT252 Localization of GH1 529 0.80 227.4 122.05 94.40
5 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 91.84
6 INT812 Localization of INS 1026 0.81 515.6 145.31 91.08
7 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 87.32
8 INT15825 Negative_regulation of Klra1 1 0.35 0.37 0.56 86.08
9 INT22080 Regulation of ras 40 0.53 36.24 4.44 84.88
10 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 74.20
11 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 73.28
12 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 51.32
13 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 51.32
14 INT9660 Regulation of TNF 363 0.62 312.94 139.99 49.68
15 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 48.48
16 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 47.32
17 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 46.00
18 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 42.76
19 INT222742 Regulation of S100A12 4 0.53 12.09 3.03 38.12
20 INT222744 Regulation of MEPE 1 0.05 0.5 0.03 38.12
21 INT222743 Regulation of RTL1 1 0.28 0.51 0.03 38.12
22 INT255017 Gene_expression of Got2 3 0.65 0.33 0 35.84
23 INT255018 Positive_regulation of Got2 1 0.45 0.15 0 35.84
24 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 32.52
25 INT110319 Positive_regulation of SRGN 10 0.40 6.2 0.56 25.00
26 INT170138 Positive_regulation of Regulation of IL8 2 0.22 0.89 0.04 18.84
27 INT10835 Regulation of IL8 79 0.49 53.04 24.14 18.56
28 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 13.04
29 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 12.64
30 INT94827 Gene_expression of HBS1L 24 0.67 26.11 1.61 11.44
31 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.96
32 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
33 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
34 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
35 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
36 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
37 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
38 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
39 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
40 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
41 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
42 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
43 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
44 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
45 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
46 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
47 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
48 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 5.00
49 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34 5.00
50 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 5.00
51 INT276358 Gene_expression of MIR150 42 0.74 38.44 7.82 5.00
52 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
53 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 5.00
54 INT30777 Negative_regulation of SELL 20 0.56 18.05 7.32 5.00
55 INT64792 Positive_regulation of Gene_expression of ITGAM 39 0.69 23.21 6.71 5.00
56 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 5.00
57 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
58 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 5.00
59 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
60 INT10919 Positive_regulation of ITGB2 25 0.67 13.75 5.45 5.00
61 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22 5.00
62 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 5.00
63 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 5.00
64 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 5.00
65 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 5.00
66 INT54911 Localization of FOS 20 0.78 3.27 4.56 5.00
67 INT35609 Negative_regulation of F10 37 0.57 17.15 4.41 5.00
68 INT51898 Binding of PECAM1 26 0.36 18.87 4.22 5.00
69 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 5.00
70 INT70326 Positive_regulation of Gene_expression of ITGB2 24 0.67 15.42 3.86 5.00
71 INT62945 Negative_regulation of Gene_expression of SELL 12 0.58 12.86 3.23 5.00
72 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77 5.00
73 INT14447 Localization of F2 20 0.79 12.77 2.67 5.00
74 INT76713 Regulation of Gene_expression of PECAM1 16 0.40 14.52 2.51 5.00
75 INT39560 Positive_regulation of F10 25 0.67 10.67 2.5 5.00
76 INT61418 Positive_regulation of ITGAL 24 0.14 12.86 2.3 5.00
77 INT20991 Regulation of ITGAM 9 0.45 5.46 2.27 5.00
78 INT46088 Localization of F3 15 0.37 13.7 2.23 5.00
79 INT74425 Gene_expression of SPHAR 8 0.08 7.81 2.15 5.00
80 INT268573 Gene_expression of MIR16-2 11 0.11 11.79 2.01 5.00
81 INT70526 Binding of CALR 11 0.35 7.09 1.97 5.00
82 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
83 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76 5.00
84 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
85 INT20992 Regulation of ITGB2 11 0.37 9.04 1.73 5.00
86 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 5.00
87 INT12942 Regulation of ITGAL 8 0.35 3.29 1.57 5.00
88 INT38831 Regulation of SELL 9 0.20 5.82 1.56 5.00
89 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
90 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 5.00
91 INT138343 Positive_regulation of Localization of F2 5 0.41 5.06 1.24 5.00
92 INT41893 Negative_regulation of HBS1L 16 0.23 8.98 1.19 5.00
93 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07 5.00
94 INT63348 Regulation of PECAM1 14 0.40 16.05 0.97 5.00
95 INT10928 Localization of FLII 5 0.66 1.3 0.87 5.00
96 INT19637 Localization of TF 14 0.73 5.74 0.86 5.00
97 INT74421 Positive_regulation of Gene_expression of SPHAR 2 0.06 0.99 0.81 5.00
98 INT82845 Binding of F10 25 0.37 7.07 0.81 5.00
99 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75 5.00
100 INT252975 Positive_regulation of Gene_expression of PTTG1 36 0.28 31.96 0.74 5.00
101 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 5.00
102 INT31576 Transcription of SST 5 0.69 0.89 0.68 5.00
103 INT169000 Gene_expression of MIR15B 13 0.65 9.24 0.67 5.00
104 INT217168 Gene_expression of MIR21 30 0.55 30.86 0.62 5.00
105 INT63356 Regulation of CD44 6 0.23 6.29 0.61 5.00
106 INT354183 Regulation of MIR524 1 0.05 1.26 0.59 5.00
107 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59 5.00
108 INT283263 Negative_regulation of Gene_expression of MIR150 3 0.41 2.6 0.57 5.00
109 INT354186 Negative_regulation of MIR524 1 0.03 1.4 0.57 5.00
110 INT290303 Localization of HPCAL1 1 0.04 1.2 0.52 5.00
111 INT217160 Gene_expression of MIR223 5 0.44 2.41 0.48 5.00
112 INT133283 Negative_regulation of Localization of FOS 2 0.41 0.29 0.46 5.00
113 INT88952 Gene_expression of Sic 4 0.58 0.81 0.42 5.00
114 INT323721 Positive_regulation of Gene_expression of MIR223 2 0.07 1.18 0.3 5.00
115 INT217152 Gene_expression of MIR145 4 0.43 5.15 0.29 5.00
116 INT255014 Negative_regulation of Binding of F10 7 0.34 1.81 0.28 5.00
117 INT78824 Localization of SLURP1 3 0.28 1.11 0.22 5.00
118 INT63067 Localization of MYC 13 0.78 6.93 0.19 5.00
119 INT312242 Binding of IGFBP5 2 0.08 0.69 0.18 5.00
120 INT354166 Gene_expression of MIR524 1 0.06 0.94 0.16 5.00
121 INT195213 Positive_regulation of Gene_expression of HBS1L 4 0.15 3.5 0.16 5.00
122 INT354185 Regulation of Gene_expression of MIR524 1 0.03 0.19 0.16 5.00
123 INT354160 Negative_regulation of Transcription of SST 1 0.09 0.09 0.16 5.00
124 INT255016 Negative_regulation of Tnxa-ps1 1 0.01 0.3 0.16 5.00
125 INT242196 Positive_regulation of Localization of F3 3 0.09 1.71 0.15 5.00
126 INT354155 Binding of MIR524 1 0.03 0.47 0.15 5.00
127 INT217189 Gene_expression of MIR222 5 0.46 4.58 0.12 5.00
128 INT268552 Positive_regulation of Gene_expression of MIR222 4 0.21 4.06 0.12 5.00
129 INT314712 Negative_regulation of Localization of MYC 2 0.22 1.43 0.11 5.00
130 INT354156 Positive_regulation of Regulation of MIR524 1 0.03 0.08 0.11 5.00
131 INT217170 Gene_expression of MIR15A 4 0.75 8.17 0.09 5.00
132 INT217197 Gene_expression of MIR16-1 5 0.45 3.93 0.09 5.00
133 INT217173 Negative_regulation of MIR15B 6 0.42 4.37 0.08 5.00
134 INT217184 Negative_regulation of MIR145 5 0.31 4.04 0.08 5.00
135 INT167448 Localization of CCND2 2 0.57 0.57 0.07 5.00
136 INT354146 Regulation of Gene_expression of CALR 1 0.04 0.73 0.07 5.00
137 INT354165 Binding of MIR516B1 1 0.36 0.12 0.06 5.00
138 INT354162 Binding of MIR96 1 0.06 0.12 0.06 5.00
139 INT354174 Localization of MIR15A 1 0.73 0.85 0.05 5.00
140 INT354153 Localization of MIR16-1 1 0.12 0.85 0.05 5.00
141 INT308789 Gene_expression of MIR184 2 0.22 0.89 0.04 5.00
142 INT308773 Positive_regulation of Gene_expression of MIR184 2 0.20 0.89 0.04 5.00
143 INT290297 Binding of Cq2 1 0.08 1.16 0.03 5.00
144 INT290298 Positive_regulation of Binding of Cq2 1 0.11 1.16 0.03 5.00
145 INT217158 Regulation of MIR145 2 0.32 1.15 0.03 5.00
146 INT354152 Gene_expression of MIR141 1 0.10 2.85 0.03 5.00
147 INT255015 Positive_regulation of Localization of TF 1 0.05 0.14 0.03 5.00
148 INT354176 Localization of MIR145 1 0.35 0.19 0 5.00
149 INT354144 Negative_regulation of Gene_expression of MIR15A 1 0.57 2.41 0 5.00
150 INT354149 Gene_expression of MIR381 1 0.09 0.28 0 5.00
151 INT354161 Gene_expression of MIR516B1 1 0.65 0.47 0 5.00
152 INT354193 Negative_regulation of Negative_regulation of MIR15B 1 0.01 0.71 0 5.00
153 INT354157 Positive_regulation of Gene_expression of MIR124-1 1 0.05 0.28 0 5.00
154 INT354182 Regulation of Gene_expression of MIR15A 1 0.60 1.66 0 5.00
155 INT170139 Negative_regulation of Regulation of PECAM1 1 0.02 0.19 0 5.00
156 INT354179 Regulation of Gene_expression of MIR126 1 0.05 0.72 0 5.00
157 INT354158 Gene_expression of MIR744 1 0.09 0.48 0 5.00
158 INT354171 Regulation of MIR126 1 0.05 0.78 0 5.00
159 INT354177 Negative_regulation of Gene_expression of CTDSP1 1 0.15 0.18 0 5.00
160 INT354151 Positive_regulation of Gene_expression of MIR125A 1 0.49 0.28 0 5.00
161 INT354148 Positive_regulation of Gene_expression of MIR524 1 0.04 0.28 0 5.00
162 INT354192 Positive_regulation of MIR141 1 0.07 0.91 0 5.00
163 INT354189 Negative_regulation of MIR126 1 0.09 0.68 0 5.00
164 INT354163 Regulation of CTDSP1 1 0.16 0.17 0 5.00
165 INT354128 Gene_expression of Hydin 1 0.65 0.39 0 5.00
166 INT354180 Binding of CTDSP1 1 0.13 0.15 0 5.00
167 INT354145 Regulation of Gene_expression of CTDSP1 1 0.16 0.18 0 5.00
168 INT354154 Regulation of Localization of MIR145 1 0.21 0.19 0 5.00
169 INT354181 Positive_regulation of Gene_expression of MIR381 1 0.06 0.28 0 5.00
170 INT354170 Negative_regulation of Localization of FLII 1 0.04 0.29 0 5.00
171 INT354147 Gene_expression of MIR126 1 0.14 1.46 0 5.00
172 INT354190 Negative_regulation of Gene_expression of MIR141 1 0.08 1.98 0 5.00
173 INT354178 Gene_expression of MIR96 1 0.10 0.48 0 5.00
174 INT354150 Negative_regulation of Gene_expression of MIR21 1 0.05 0.98 0 5.00
175 INT354159 Binding of IRS4 1 0.11 0.73 0 5.00
176 INT354173 Gene_expression of CTDSP1 1 0.27 0.32 0 5.00
177 INT354167 Gene_expression of MIR124-1 1 0.07 0.72 0 5.00
178 INT354191 Positive_regulation of Gene_expression of MIR126 1 0.09 0.28 0 5.00
179 INT354175 Gene_expression of MIR151A 1 0.01 0.46 0 5.00
180 INT354187 Localization of MIR126 1 0.13 1.35 0 5.00
181 INT354164 Regulation of MIR381 1 0.03 0.78 0 5.00
182 INT354172 Negative_regulation of Localization of CCND2 1 0.07 0.29 0 5.00
183 INT271572 Gene_expression of MIR125A 2 0.65 0.83 0 5.00
184 INT354169 Localization of MIR381 1 0.09 0.69 0 5.00
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