D:Cholestasis

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Disease Term
Synonyms Bile Duct Obstruction, Bile Duct Obstructions, Biliary Stases, Biliary Stasis, Cholestases, Duct Obstruction Bile, Duct Obstructions Bile, Obstruction Bile Duct, Obstructions Bile Duct, Stases Biliary, Stasis Biliary
Documents 180
Hot Single Events 40
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cholestasis. They are ordered first by their relevance to Cholestasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 85.00
2 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25 82.08
3 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24 78.32
4 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 50.00
5 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 50.00
6 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 50.00
7 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57 5.00
8 INT174917 Negative_regulation of PLG Negative_regulation of Positive_regulation of FUT1 1 0.01 0.68 0.13 5.00
9 INT201490 Gene_expression of SPINK1 Negative_regulation of PRSS1 1 0.44 0.82 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cholestasis. They are ordered first by their pain relevance and then by number of times they were reported in Cholestasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT260738 Gene_expression of Ugt1a2 2 0.02 2.22 0.5 99.92
2 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 99.86
3 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.96
4 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 98.76
5 INT96777 Localization of Pdgfa 12 0.79 5.86 3.52 98.38
6 INT158 Localization of Prl 2431 0.81 378.96 952.2 98.38
7 INT86805 Localization of HGF 49 0.71 28.48 6.35 98.38
8 INT93578 Localization of Hgf 6 0.77 2.97 1.03 98.38
9 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 98.24
10 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 98.00
11 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 97.32
12 INT251 Regulation of INS 398 0.62 232.47 55.04 95.88
13 INT4494 Regulation of GCG 41 0.45 18.38 9.68 95.88
14 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9 95.88
15 INT39212 Binding of Ttr 14 0.48 9.62 2.31 95.76
16 INT156484 Binding of Apoa1 4 0.47 6.78 1.63 95.76
17 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 95.36
18 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 95.24
19 INT260740 Negative_regulation of Localization of Vegfa 1 0.10 0.19 0.12 95.24
20 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 94.84
21 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 94.56
22 INT12442 Localization of Vegfa 11 0.73 4.85 1.68 94.28
23 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 94.00
24 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 93.68
25 INT7979 Binding of Nsdhl 6 0.30 3.71 0.4 92.92
26 INT210613 Binding of TBRG1 1 0.05 4.54 0.54 92.88
27 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 92.84
28 INT12890 Gene_expression of Ttr 15 0.63 7.68 1.6 90.00
29 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 88.92
30 INT1869 Negative_regulation of SLC17A5 12 0.42 5.51 0.75 88.92
31 INT342901 Negative_regulation of Regulation of SLC17A5 1 0.03 1.15 0.04 88.92
32 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21 88.80
33 INT159232 Negative_regulation of SYP 4 0.41 4.45 0.38 87.40
34 INT82374 Binding of SYP 13 0.36 13.69 0.85 86.88
35 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 85.72
36 INT119818 Negative_regulation of CHGA 10 0.57 8.21 2.04 84.84
37 INT48854 Positive_regulation of CALCB 4 0.46 2.4 3.06 82.96
38 INT284123 Binding of DLST 2 0.32 2.3 0.29 82.64
39 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 82.16
40 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24 82.08
41 INT2464 Gene_expression of AMY2A 21 0.75 13.76 2.78 79.80
42 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 76.16
43 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 76.16
44 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 75.84
45 INT59433 Gene_expression of PASK 24 0.68 25.13 3.21 75.44
46 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 75.24
47 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 74.84
48 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 74.84
49 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 74.28
50 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 71.84
51 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15 71.84
52 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97 71.84
53 INT173505 Localization of Hand2 63 0.57 45.32 13.66 71.52
54 INT90792 Localization of Il10 144 0.80 87.88 30.03 70.68
55 INT20379 Localization of Il4 85 0.73 51.22 20.55 70.68
56 INT284117 Protein_catabolism of Epcam 2 0.43 3.01 0.31 69.12
57 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 68.64
58 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 68.00
59 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 67.52
60 INT260741 Gene_expression of Il9 1 0.24 0.67 0.43 67.44
61 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 67.04
62 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 66.64
63 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 66.36
64 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 66.36
65 INT181107 Gene_expression of Epcam 45 0.73 44.33 1.96 66.00
66 INT210614 Positive_regulation of TBRG1 1 0.07 2.59 0.37 65.36
67 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 64.48
68 INT260742 Gene_expression of Lamb3 1 0.65 0.72 0.32 62.96
69 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 62.96
70 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 62.96
71 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 54.48
72 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 53.76
73 INT260735 Protein_catabolism of Acin1 1 0.06 0.35 0.03 53.12
74 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 50.00
75 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 50.00
76 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 50.00
77 INT134651 Binding of TLR4 89 0.48 66.96 23.19 50.00
78 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 50.00
79 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 50.00
80 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 50.00
81 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 50.00
82 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 50.00
83 INT28861 Binding of Gh 61 0.46 25.61 6.38 50.00
84 INT47391 Positive_regulation of Paf 16 0.62 12.31 3.79 50.00
85 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 50.00
86 INT89592 Localization of Ccl5 10 0.61 7.65 3.62 50.00
87 INT171233 Binding of Ecm1 25 0.07 12.41 3.36 50.00
88 INT145760 Binding of Tlr2 5 0.46 3.59 0.89 50.00
89 INT179814 Positive_regulation of Protein_catabolism of Ecm1 5 0.06 3.38 0.85 50.00
90 INT260734 Gene_expression of Acin1 2 0.16 1 0.03 50.00
91 INT284120 Positive_regulation of ZNF845 5 0.05 1.91 0.22 43.96
92 INT284124 Positive_regulation of Gene_expression of ZNF845 1 0.04 0.53 0.09 43.96
93 INT284122 Gene_expression of ZNF845 6 0.07 6.67 0.27 43.80
94 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 43.72
95 INT3529 Regulation of GOT1 6 0.52 2.4 1.01 43.72
96 INT342900 Negative_regulation of Regulation of GOT1 1 0.04 0.42 0.12 43.72
97 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 27.44
98 INT284 Positive_regulation of Ggt6 18 0.67 13.56 4.62 25.00
99 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
100 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
101 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 5.00
102 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
103 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
104 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
105 INT2140 Regulation of REN 104 0.62 28.24 24.49 5.00
106 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48 5.00
107 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
108 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33 5.00
109 INT23654 Binding of SPINK1 27 0.48 30.85 11.53 5.00
110 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77 5.00
111 INT82743 Gene_expression of SPINK1 48 0.78 44.28 8.77 5.00
112 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
113 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 5.00
114 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 5.00
115 INT24946 Binding of PRSS1 23 0.47 16.75 6.41 5.00
116 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 5.00
117 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12 5.00
118 INT89114 Binding of Cftr 13 0.37 11.29 4.99 5.00
119 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 5.00
120 INT169756 Binding of CFTR 9 0.35 9.65 4.55 5.00
121 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 5.00
122 INT3327 Protein_catabolism of PRSS1 22 1.00 6.96 4.29 5.00
123 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 5.00
124 INT156416 Gene_expression of Lipg 38 0.67 18.35 4.07 5.00
125 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
126 INT55093 Negative_regulation of SPINK1 13 0.42 15.11 3.8 5.00
127 INT35864 Regulation of PRSS1 19 0.61 8.14 3.63 5.00
128 INT12241 Negative_regulation of Positive_regulation of PRSS1 6 0.43 5.39 3.22 5.00
129 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77 5.00
130 INT103977 Positive_regulation of Gene_expression of SPINK1 7 0.50 7.38 2.66 5.00
131 INT122656 Gene_expression of MTNR1A 21 0.75 6.37 2.46 5.00
132 INT104980 Transcription of PRSS1 5 0.69 3.54 2.12 5.00
133 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03 5.00
134 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 5.00
135 INT94534 Gene_expression of MT2A 8 0.75 11.28 1.76 5.00
136 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76 5.00
137 INT201496 Binding of hcp 1 0.10 4.02 1.75 5.00
138 INT45692 Positive_regulation of Gene_expression of PRSS1 8 0.49 4.07 1.73 5.00
139 INT143664 Gene_expression of ST2 9 0.77 5.03 1.73 5.00
140 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73 5.00
141 INT70916 Binding of Thim 13 0.02 8.35 1.72 5.00
142 INT111958 Regulation of Thim 4 0.16 3.34 1.67 5.00
143 INT230 Positive_regulation of GGTLC1 14 0.68 11.78 1.55 5.00
144 INT10873 Localization of Twist1 21 0.74 10.43 1.37 5.00
145 INT3333 Positive_regulation of Protein_catabolism of PRSS1 3 0.49 2.23 1.29 5.00
146 INT118131 Negative_regulation of C1s 10 0.07 2.92 1.15 5.00
147 INT153115 Protein_catabolism of SPINK1 2 0.90 2.46 1.11 5.00
148 INT201499 Binding of Prss2 1 0.23 1.81 1.08 5.00
149 INT201497 Negative_regulation of Positive_regulation of Prss2 1 0.27 1.7 1 5.00
150 INT52330 Gene_expression of Synm 4 0.45 0.72 1 5.00
151 INT201504 Positive_regulation of Prss2 1 0.32 1.68 0.99 5.00
152 INT201501 Negative_regulation of Prss2 1 0.27 1.69 0.99 5.00
153 INT72024 Localization of EDNRA 11 0.57 8.22 0.96 5.00
154 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9 5.00
155 INT103944 Negative_regulation of Synm 3 0.41 2.17 0.83 5.00
156 INT91815 Positive_regulation of Positive_regulation of PRSS1 6 0.49 3.79 0.75 5.00
157 INT201503 Gene_expression of Prss2 2 0.42 3.21 0.75 5.00
158 INT201502 Positive_regulation of Gene_expression of Prss2 1 0.32 0.98 0.7 5.00
159 INT118133 Negative_regulation of Gene_expression of PRSS1 2 0.50 3.58 0.69 5.00
160 INT257455 Binding of PDLIM5 2 0.08 1.72 0.64 5.00
161 INT201500 Gene_expression of hcp 1 0.13 1.3 0.61 5.00
162 INT275637 Positive_regulation of Gene_expression of MT2A 2 0.28 2.49 0.6 5.00
163 INT158440 Negative_regulation of Nsdhl 4 0.21 3.22 0.51 5.00
164 INT173023 Gene_expression of MUC6 13 0.69 9.77 0.46 5.00
165 INT226490 Localization of ST2 5 0.31 1.99 0.44 5.00
166 INT172996 Gene_expression of MUC2 14 0.69 11.01 0.42 5.00
167 INT199121 Positive_regulation of Gene_expression of Lipg 4 0.13 2.44 0.32 5.00
168 INT3959 Regulation of Lipg 6 0.27 2.48 0.29 5.00
169 INT156595 Gene_expression of CDX2 10 0.69 7.8 0.25 5.00
170 INT201498 Positive_regulation of hcp 1 0.09 0.39 0.25 5.00
171 INT295943 Negative_regulation of MTNR1A 4 0.21 2.66 0.24 5.00
172 INT174925 Binding of Hspg2 3 0.05 1.11 0.24 5.00
173 INT143422 Negative_regulation of Gene_expression of SPINK1 2 0.39 2.5 0.22 5.00
174 INT201506 Gene_expression of COL14A1 1 0.65 0.96 0.2 5.00
175 INT201511 Negative_regulation of Gene_expression of COL14A1 1 0.41 0.96 0.2 5.00
176 INT118130 Negative_regulation of Spink3 3 0.42 2.08 0.17 5.00
177 INT77540 Gene_expression of Gapdh 4 0.65 0.96 0.15 5.00
178 INT201509 Regulation of Protein_catabolism of PRSS1 1 0.61 1.2 0.14 5.00
179 INT181102 Binding of Epcam 6 0.37 3.85 0.12 5.00
180 INT180883 Positive_regulation of MT1E 7 0.27 4.63 0.11 5.00
181 INT296126 Negative_regulation of Gene_expression of MTNR1A 2 0.21 0.77 0.11 5.00
182 INT171653 Positive_regulation of Negative_regulation of PRSS1 2 0.49 1.27 0.11 5.00
183 INT94535 Negative_regulation of Gene_expression of MT2A 1 0.34 1.7 0.07 5.00
184 INT94531 Transcription of MT2A 2 0.56 1.52 0.07 5.00
185 INT174921 Positive_regulation of Gene_expression of LOC100310874 1 0.01 0.65 0.05 5.00
186 INT174922 Gene_expression of LOC100310874 1 0.01 0.64 0.05 5.00
187 INT181104 Negative_regulation of Epcam 5 0.55 4.53 0.04 5.00
188 INT201510 Negative_regulation of Negative_regulation of PRSS1 1 0.37 0.78 0.04 5.00
189 INT296123 Negative_regulation of Transcription of MT2A 1 0.13 0.44 0 5.00
190 INT296121 Phosphorylation of ST2 1 0.08 0.2 0 5.00
191 INT296119 Negative_regulation of Transcription of MTNR1A 1 0.07 0.44 0 5.00
192 INT296122 Regulation of Binding of SDCBP 1 0.44 0.51 0 5.00
193 INT284116 Positive_regulation of Epcam 1 0.11 0 0 5.00
194 INT296125 Regulation of Gene_expression of MT2A 1 0.14 0.49 0 5.00
195 INT296124 Transcription of MTNR1A 1 0.11 0.44 0 5.00
196 INT153162 Gene_expression of SDCBP 2 0.65 0.8 0 5.00
197 INT296120 Binding of SDCBP 1 0.36 1.16 0 5.00
198 INT296127 Negative_regulation of MT2A 1 0.06 0.43 0 5.00
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