D:Cholesteatoma

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Disease Term
Synonyms CHOLESTEATOMAS
Documents 127
Hot Single Events 42
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cholesteatoma. They are ordered first by their relevance to Cholesteatoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT307225 CYLD Regulation of TNFRSF11A 1 0.14 0.81 0 99.12
2 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0 91.12
3 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06 68.48
4 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06 61.68
5 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
6 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 5.00
7 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 5.00
8 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 5.00
9 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 5.00
10 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
11 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 5.00
12 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36 5.00
13 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34 5.00
14 INT267628 IL4 Positive_regulation of IgG 1 0.00 1.42 0.27 5.00
15 INT267586 IL4 Positive_regulation of IGHE 1 0.00 1.42 0.27 5.00
16 INT267632 Il1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.86 0.25 5.00
17 INT267624 Klk1 Positive_regulation of KNG1 1 0.05 0.52 0.25 5.00
18 INT267584 TNF Positive_regulation of Gene_expression of PLA2G6 1 0.08 0.87 0.25 5.00
19 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25 5.00
20 INT267596 KNG1 Positive_regulation of Gene_expression of PLA2G6 1 0.01 0.87 0.25 5.00
21 INT267591 CYSLTR1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.87 0.25 5.00
22 INT267623 IL6 Positive_regulation of Crp 1 0.00 1.6 0.24 5.00
23 INT267629 PTAFR Positive_regulation of Localization of Il1 1 0.00 1.32 0.18 5.00
24 INT267627 Il1 Positive_regulation of Gene_expression of TNF 1 0.02 0.45 0.17 5.00
25 INT267587 PTAFR Positive_regulation of Localization of PTPRC 1 0.00 2.04 0.09 5.00
26 INT267626 Il1 Positive_regulation of ICAM1 1 0.00 0.79 0.09 5.00
27 INT267618 Il1 Positive_regulation of Vcam1 1 0.00 0.81 0.09 5.00
28 INT267592 IL6 Positive_regulation of Localization of MUC1 1 0.00 1.24 0.07 5.00
29 INT267593 IL8 Positive_regulation of Localization of MUC1 1 0.00 1.06 0.06 5.00
30 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cholesteatoma. They are ordered first by their pain relevance and then by number of times they were reported in Cholesteatoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT181177 Gene_expression of CYLD 5 0.69 24.96 0.89 100.00
2 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 100.00
3 INT217832 Negative_regulation of Gene_expression of TSC1 5 0.04 5.45 0.21 100.00
4 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 100.00
5 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16 100.00
6 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12 99.96
7 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75 99.96
8 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 99.84
9 INT307244 Regulation of Gene_expression of CYLD 1 0.24 1.84 0 99.84
10 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 99.84
11 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 99.72
12 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 99.68
13 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 99.52
14 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 99.52
15 INT185437 Negative_regulation of Gene_expression of CYLD 3 0.52 2.41 0.05 99.32
16 INT307229 Phosphorylation of CYLD 1 0.73 1.02 0.05 99.08
17 INT307240 Localization of CYLD 3 0.72 3.09 0.1 98.88
18 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.80
19 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 98.60
20 INT307231 Positive_regulation of Gene_expression of CYLD 1 0.45 2.37 0.14 98.44
21 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 97.40
22 INT181179 Binding of CYLD 4 0.43 7.06 0.39 97.32
23 INT215183 Positive_regulation of MUC5AC 4 0.45 2.78 0.6 97.28
24 INT267616 Positive_regulation of Positive_regulation of MUC5AC 1 0.14 1.15 0.16 97.28
25 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02 97.12
26 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 95.92
27 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 95.92
28 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 95.92
29 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 95.68
30 INT1285 Localization of Mmp13 12 0.78 8.98 4.93 95.36
31 INT185452 Regulation of CYLD 6 0.40 6.09 0.21 95.16
32 INT307235 Positive_regulation of Binding of CYLD 1 0.45 1.1 0 94.48
33 INT195531 Gene_expression of Rel 9 0.75 5.02 2.72 93.40
34 INT307227 Positive_regulation of Gene_expression of Rel 2 0.67 1.18 0.09 93.40
35 INT214073 Binding of TSC1 9 0.37 22 1.34 93.28
36 INT307232 Negative_regulation of BCL3 1 0.09 0.24 0 91.12
37 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 89.20
38 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31 89.20
39 INT139840 Positive_regulation of Negative_regulation of MAPK14 2 0.21 1.55 0.67 89.20
40 INT267610 Negative_regulation of Negative_regulation of MAPK14 1 0.03 1.08 0.15 89.20
41 INT38266 Localization of PTPRC 30 0.68 17.05 1.68 88.72
42 INT267615 Positive_regulation of Localization of PTPRC 3 0.01 3.41 0.46 88.72
43 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 79.72
44 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56 77.96
45 INT132163 Positive_regulation of Localization of MUC1 9 0.19 8.96 1.54 77.80
46 INT49802 Localization of MUC1 75 0.81 44.74 8.87 77.28
47 INT222845 Gene_expression of Chuk 27 0.52 25.15 2.67 69.24
48 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71 69.24
49 INT307233 Localization of BCL3 1 0.19 0.84 0.11 68.48
50 INT307236 Negative_regulation of Localization of BCL3 1 0.10 0.33 0.05 68.48
51 INT185432 Negative_regulation of CYLD 4 0.52 3.19 0.35 61.88
52 INT104402 Positive_regulation of CCND1 15 0.70 11.77 2.08 54.16
53 INT307230 Regulation of Localization of CYLD 1 0.40 0.11 0 53.88
54 INT217438 Binding of Chuk 24 0.25 7.29 1.29 50.00
55 INT252702 Binding of TRAF2 3 0.23 2.21 0.16 50.00
56 INT175210 Binding of TRAF6 2 0.17 0.73 0.08 50.00
57 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
58 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
59 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
60 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
61 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
62 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
63 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
64 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
65 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
66 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
67 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
68 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
69 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
70 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
71 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
72 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
73 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
74 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
75 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
76 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
77 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
78 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
79 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
80 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
81 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
82 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
83 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
84 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
85 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
86 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
87 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
88 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
89 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
90 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
91 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
92 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
93 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
94 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
95 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
96 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
97 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
98 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
99 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
100 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
101 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
102 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
103 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
104 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
105 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
106 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
107 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 5.00
108 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 5.00
109 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
110 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
111 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
112 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
113 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
114 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
115 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
116 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
117 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
118 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 5.00
119 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
120 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
121 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
122 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
123 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
124 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
125 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
126 INT99586 Binding of IRF6 60 0.36 27.87 13.2 5.00
127 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
128 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
129 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
130 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
131 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
132 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
133 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 5.00
134 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
135 INT186273 Negative_regulation of Il13 33 0.46 22.88 8.65 5.00
136 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
137 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2 5.00
138 INT14166 Positive_regulation of Ahr 32 0.61 20.78 7.47 5.00
139 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
140 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 5.00
141 INT81443 Positive_regulation of Vcam1 29 0.63 28.4 6.35 5.00
142 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
143 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 5.00
144 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
145 INT14165 Negative_regulation of Ahr 14 0.51 8.35 4.17 5.00
146 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
147 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49 5.00
148 INT16966 Positive_regulation of CRS 23 0.60 22.5 3.49 5.00
149 INT63425 Positive_regulation of Gene_expression of SELP 23 0.67 15.34 3.48 5.00
150 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 5.00
151 INT26312 Positive_regulation of PLA2G6 26 0.70 7.41 3.2 5.00
152 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
153 INT22875 Regulation of CRS 16 0.39 14.33 2.69 5.00
154 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 5.00
155 INT230758 Positive_regulation of Gene_expression of PTPRC 11 0.49 6.04 2.45 5.00
156 INT173005 Transcription of MUC1 11 0.63 10.15 2.24 5.00
157 INT104263 Regulation of Positive_regulation of NOS1 5 0.28 3.15 2.15 5.00
158 INT145650 Localization of PLA2G6 15 0.76 8.87 2.06 5.00
159 INT187095 Negative_regulation of Positive_regulation of Il1 8 0.14 6.17 1.82 5.00
160 INT78774 Gene_expression of PLA2G6 15 0.61 8.39 1.56 5.00
161 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 5.00
162 INT29693 Binding of Ahr 11 0.31 13.27 1.23 5.00
163 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 5.00
164 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 5.00
165 INT65286 Binding of ARIH1 10 0.48 4.3 0.76 5.00
166 INT179168 Regulation of Transcription of IL8 4 0.43 1.88 0.63 5.00
167 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43 5.00
168 INT109913 Positive_regulation of MAP3K14 2 0.67 0.51 0.37 5.00
169 INT202349 Positive_regulation of Map2k3 3 0.52 1.26 0.36 5.00
170 INT181304 Binding of CD48 3 0.08 2.43 0.34 5.00
171 INT200806 Binding of EEC1 6 0.39 4.24 0.29 5.00
172 INT173117 Binding of Ltf 4 0.12 1.85 0.28 5.00
173 INT261093 Positive_regulation of Gene_expression of PLA2G6 2 0.31 0.93 0.1 5.00
174 INT186056 Binding of MKI67 6 0.48 4.44 0.1 5.00
175 INT257450 Localization of MUC5B 2 0.62 1.14 0.09 5.00
176 INT184798 Positive_regulation of Localization of PLA2G6 2 0.16 2.41 0.05 5.00
177 INT267608 Positive_regulation of MUC2 1 0.11 0.86 0.04 5.00
178 INT267609 Positive_regulation of Transcription of MUC2 1 0.11 0.86 0.04 5.00
179 INT173007 Transcription of MUC2 2 0.64 0.98 0.04 5.00
180 INT292884 Positive_regulation of Binding of MKI67 1 0.06 0.52 0 5.00
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