D:Choline Deficiency

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pChart

Disease Term
Synonyms Choline Deficiencies, Deficiencies Choline, Deficiency Choline
Documents 6
Hot Single Events 5
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Choline Deficiency. They are ordered first by their relevance to Choline Deficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68 5.00
2 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 5.00
3 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73 5.00
4 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52 5.00
5 INT331602 Binding of SSRP1 and Tlr4 1 0.03 0.9 0.21 5.00
6 INT331600 Il18 Regulation of IFN1@ 1 0.00 1.05 0.16 5.00
7 INT331601 Il10 Regulation of IFN1@ 1 0.00 1.05 0.16 5.00
8 INT331576 IFN1@ Positive_regulation of TNFSF10 1 0.00 0.27 0.08 5.00
9 INT331575 Negative_regulation of IFN1@ Positive_regulation of TNFSF10 1 0.00 0.27 0.08 5.00
10 INT334718 Binding of NOS1 and Bax 1 0.02 0.87 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Choline Deficiency. They are ordered first by their pain relevance and then by number of times they were reported in Choline Deficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 98.64
2 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 98.64
3 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 91.16
4 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 87.60
5 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09 87.60
6 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 79.92
7 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 79.52
8 INT28042 Gene_expression of Tsc22d3 14 0.77 6.54 6.4 76.84
9 INT46698 Positive_regulation of Negative_regulation of Pcyt2 1 0.49 0.27 0.09 71.76
10 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 71.44
11 INT233645 Transcription of Tsc22d3 11 0.71 5.83 7.97 70.24
12 INT46699 Negative_regulation of Pcyt2 1 0.41 0.26 0.08 68.48
13 INT46700 Negative_regulation of Pcyt1a 1 0.42 0.26 0.08 68.48
14 INT233620 Positive_regulation of Gene_expression of Tsc22d3 3 0.69 1.46 1.17 64.80
15 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 53.20
16 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 38.64
17 INT334716 Negative_regulation of NDUFV1 1 0.01 1.59 0.23 37.44
18 INT11937 Localization of Il6 228 0.81 139.83 64.39 35.36
19 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 24.24
20 INT135029 Positive_regulation of Gene_expression of Cd14 11 0.66 6.4 1.75 24.24
21 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29 22.56
22 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65 22.56
23 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33 13.96
24 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74 13.96
25 INT334713 Gene_expression of Fmn1 1 0.05 0 0 13.80
26 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
27 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
28 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
29 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
30 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
31 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
32 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
33 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
34 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
35 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 5.00
36 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
37 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
38 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43 5.00
39 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
40 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
41 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
42 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
43 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
44 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 5.00
45 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26 5.00
46 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
47 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
48 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 5.00
49 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
50 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
51 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
52 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
53 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
54 INT36262 Positive_regulation of Tbce 35 0.49 28.79 14.33 5.00
55 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3 5.00
56 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
57 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21 5.00
58 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
59 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
60 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 5.00
61 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 5.00
62 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41 5.00
63 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
64 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 5.00
65 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
66 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6 5.00
67 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 5.00
68 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 5.00
69 INT104549 Localization of Il18 16 0.78 13.01 4.64 5.00
70 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 5.00
71 INT183681 Positive_regulation of Tlr3 20 0.62 16.25 4.54 5.00
72 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48 5.00
73 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4 5.00
74 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13 5.00
75 INT158596 Binding of Tlr3 24 0.47 11.66 3.69 5.00
76 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 5.00
77 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92 5.00
78 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82 5.00
79 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18 5.00
80 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75 5.00
81 INT224501 Positive_regulation of Gene_expression of EPHB2 9 0.49 4.29 1.39 5.00
82 INT15990 Binding of Gfm1 10 0.31 8.53 1.37 5.00
83 INT25451 Negative_regulation of Gfm1 13 0.27 8.22 1.06 5.00
84 INT331594 Localization of Tlr9 1 0.41 1.66 0.71 5.00
85 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71 5.00
86 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33 5.00
87 INT331591 Transcription of Hmgb1 1 0.28 0.92 0.3 5.00
88 INT331590 Negative_regulation of Binding of Tlr9 1 0.24 1.52 0.28 5.00
89 INT299366 Positive_regulation of Transcription of Mapk8 2 0.70 1.29 0.22 5.00
90 INT334714 Negative_regulation of Trim21 1 0.00 0 0.16 5.00
91 INT239162 Positive_regulation of H2-Q10 5 0.49 1.25 0.15 5.00
92 INT331592 Binding of Tnfrsf13c 1 0.01 0.69 0.15 5.00
93 INT334712 Negative_regulation of Fmn1 1 0.04 1.04 0.03 5.00
94 INT315158 Positive_regulation of Cyct 3 0.67 3.03 0.03 5.00
95 INT334699 Positive_regulation of Positive_regulation of Cyct 1 0.49 0.82 0 5.00
96 INT334711 Gene_expression of Noa1 1 0.14 0 0 5.00
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