D:Chondrocalcinosis

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Disease Term
Synonyms Calcium Pyrophosphate Deposition In Osteoarthritis, Calcium Pyrophosphate Dihydrate Deposition, Chondrocalcinoses, DEPOSITION OF CALCIUM PYROPHOSPHATE, PSEUDOGOUT
Documents 165
Hot Single Events 53
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chondrocalcinosis. They are ordered first by their relevance to Chondrocalcinosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT225787 Ppi-rs Positive_regulation of Gene_expression of Ank 1 0.06 1.44 0.19 99.48
2 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44 95.84
3 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28 95.84
4 INT224531 Positive_regulation of Map2k1 Positive_regulation of Positive_regulation of Ankh 1 0.07 0.54 0.09 86.72
5 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14 84.04
6 INT13538 ASPRV1 Negative_regulation of Gene_expression of LTA 1 0.46 0.56 0.25 66.20
7 INT225786 Enpp3 Positive_regulation of Ppi-rs 1 0.00 0.32 0.05 42.16
8 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 8.76
9 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97 5.00
10 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7 5.00
11 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51 5.00
12 INT187108 TIMP1 Negative_regulation of ABCA1 1 0.02 0.28 0.51 5.00
13 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5 5.00
14 INT187102 Negative_regulation of Binding of MMP9 and TIMP2 1 0.36 0.69 0.3 5.00
15 INT187106 Binding of MMP9 and TIMP2 1 0.30 0.69 0.3 5.00
16 INT187113 Binding of IGHG3 and MMP9 1 0.01 0.63 0.3 5.00
17 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29 5.00
18 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29 5.00
19 INT225794 Il1 Negative_regulation of Gene_expression of Npp 1 0.02 0.99 0.28 5.00
20 INT225777 Il1 Negative_regulation of Npp 1 0.02 0.99 0.28 5.00
21 INT225798 Il1 Negative_regulation of Gene_expression of Ppi-rs 1 0.01 1 0.28 5.00
22 INT225796 Il1 Negative_regulation of Ppi-rs 1 0.01 1 0.28 5.00
23 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28 5.00
24 INT225784 Il1 Negative_regulation of Gene_expression of Enpp1 1 0.08 0.99 0.28 5.00
25 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22 5.00
26 INT225783 Enpp1 Regulation of Ppi-rs 1 0.07 0.68 0.13 5.00
27 INT225785 Enpp3 Regulation of Ppi-rs 1 0.00 0.69 0.11 5.00
28 INT187112 Binding of TIMP2 and Positive_regulation of TIMP1 1 0.32 0.26 0.1 5.00
29 INT225805 Binding of SNRNP70 and Enpp1 1 0.42 1.43 0.09 5.00
30 INT187104 Binding of IGHG3 and TIMP1 1 0.01 0.22 0.07 5.00
31 INT225781 Ppi-rs Positive_regulation of Gene_expression of Spp1 1 0.03 1 0.07 5.00
32 INT225793 Ank Positive_regulation of Ppi-rs 1 0.06 1.77 0.06 5.00
33 INT225799 Il1 Regulation of Ppi-rs 1 0.01 0.44 0.05 5.00
34 INT225779 Il1 Regulation of Npp 1 0.03 0.43 0.05 5.00
35 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05 5.00
36 INT225780 Il1 Regulation of Gene_expression of Npp 1 0.03 0.43 0.05 5.00
37 INT225806 Il1 Regulation of ALPI 1 0.00 0.44 0.05 5.00
38 INT225808 SNRNP70 Regulation of Enpp1 1 0.30 0.71 0.04 5.00
39 INT225791 Ppi-rs Positive_regulation of Spp1 1 0.02 0.49 0.04 5.00
40 INT225801 Binding of Enpp1 and Npp 1 0.17 0.46 0.04 5.00
41 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04 5.00
42 INT225774 SNRNP70 Regulation of Binding of Insr and Enpp1 1 0.03 0.77 0.04 5.00
43 INT225802 Binding of Enpp1 and Ppi-rs 1 0.04 1 0.03 5.00
44 INT171991 Binding of DMD and ERAL1 1 0.01 0.54 0 5.00
45 INT225807 Enpp2 Positive_regulation of ALPI 1 0.00 0.23 0 5.00
46 INT225782 Tnfrsf11b Regulation of Enpp1 1 0.12 0.74 0 5.00
47 INT225792 Gene_expression of Enpp2 Positive_regulation of Ppi-rs 1 0.01 0.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chondrocalcinosis. They are ordered first by their pain relevance and then by number of times they were reported in Chondrocalcinosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT224550 Negative_regulation of Ankh 1 0.43 0.73 0.48 99.78
2 INT171989 Gene_expression of Ank 8 0.78 11.76 4.36 99.48
3 INT129932 Binding of SLC12A3 1 0.33 1.92 0.08 99.20
4 INT221201 Binding of Ppi-rs 5 0.04 4.02 0.78 99.20
5 INT148070 Positive_regulation of Ppi-rs 14 0.08 9.46 1.67 99.14
6 INT224541 Regulation of Localization of Pcsk1 1 0.14 0.24 0.05 99.08
7 INT224564 Regulation of Localization of Ankh 1 0.45 0.24 0.05 99.08
8 INT129933 Negative_regulation of SLC12A3 2 0.38 3.67 0.08 98.24
9 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 98.24
10 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81 98.20
11 INT225757 Positive_regulation of Gene_expression of Ank 1 0.64 4.71 0.75 98.20
12 INT126577 Gene_expression of Ppi-rs 25 0.14 19.1 2.74 98.20
13 INT225754 Positive_regulation of Gene_expression of Ppi-rs 1 0.07 3.96 0.66 98.20
14 INT183937 Positive_regulation of Ank 3 0.50 3.39 1.81 98.20
15 INT225767 Negative_regulation of Ank 1 0.40 2.51 0.34 98.20
16 INT56906 Localization of Pcsk1 8 0.67 0.96 1.26 98.04
17 INT224537 Localization of Ankh 1 0.74 0.24 0.05 98.04
18 INT224553 Transcription of Ankh 1 0.68 1.62 1.05 98.00
19 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 97.86
20 INT13544 Localization of LTA 9 0.78 6.34 1.8 97.64
21 INT224545 Gene_expression of Ankh 1 0.77 3.03 4.33 97.56
22 INT13541 Positive_regulation of Localization of LTC4S 3 0.51 1.01 0.75 97.36
23 INT13543 Positive_regulation of LTC4S 5 0.58 2.26 0.88 97.36
24 INT225758 Localization of Ppi-rs 1 0.08 3.18 0.45 97.04
25 INT4807 Localization of LTC4S 23 0.58 6.89 7.59 96.80
26 INT224536 Regulation of Gene_expression of Ankh 1 0.45 0.31 0.35 96.66
27 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 95.60
28 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 95.60
29 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 95.28
30 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 93.04
31 INT224554 Binding of Ankh 1 0.35 0.8 0.15 92.80
32 INT13542 Negative_regulation of Localization of LTC4S 1 0.27 1.02 0.39 91.64
33 INT224534 Regulation of Ankh 1 0.45 0.47 0.28 90.88
34 INT56907 Gene_expression of Pcsk1 26 0.75 7.91 2.49 90.12
35 INT110600 Gene_expression of Alpl 7 0.32 1.35 0.9 90.12
36 INT224558 Positive_regulation of Ankh 1 0.69 0.97 0.27 89.76
37 INT224548 Regulation of Positive_regulation of Ankh 1 0.27 0.18 0 89.76
38 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 89.52
39 INT225752 Positive_regulation of Localization of Ppi-rs 1 0.05 1.02 0.15 87.52
40 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 87.04
41 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87 86.72
42 INT82141 Positive_regulation of Raf1 2 0.12 0.81 1.38 85.84
43 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 85.28
44 INT172001 Gene_expression of ANKH 2 0.38 11.92 3.12 84.28
45 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3 84.28
46 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15 84.28
47 INT225770 Negative_regulation of Localization of Ppi-rs 1 0.04 0.76 0.12 83.16
48 INT10606 Localization of Ltc4s 16 0.75 10.14 5.05 82.00
49 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 81.20
50 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 81.20
51 INT135444 Regulation of Map2k1 4 0.44 1.15 1.77 80.80
52 INT4863 Positive_regulation of ap 22 0.37 9.13 6.11 80.32
53 INT47371 Negative_regulation of ap 32 0.32 9.8 1.96 80.32
54 INT29833 Binding of Spna1 39 0.27 19.4 1.74 79.72
55 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 79.16
56 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 78.48
57 INT224552 Positive_regulation of Gene_expression of Ankh 1 0.69 1.42 2.69 78.40
58 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 78.32
59 INT160521 Regulation of Enpp1 3 0.26 0.75 0.72 78.32
60 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 77.84
61 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13 76.60
62 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 76.32
63 INT224538 Negative_regulation of Gene_expression of Smad7 1 0.09 0.25 0.43 75.76
64 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 75.68
65 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49 75.32
66 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 74.80
67 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76 74.40
68 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73 74.40
69 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08 74.32
70 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92 73.88
71 INT134512 Negative_regulation of Dct 4 0.22 2.31 0.22 73.08
72 INT117083 Localization of RTEL1 5 0.60 9.1 0.8 72.56
73 INT148087 Positive_regulation of RTEL1 9 0.17 5.13 0.41 71.24
74 INT226818 Negative_regulation of RTEL1 1 0.06 1.17 0.41 68.40
75 INT13540 Negative_regulation of Localization of LTA 1 0.30 0.47 0.26 67.52
76 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97 67.24
77 INT316776 Positive_regulation of Gene_expression of ANKH 1 0.31 5.29 1.49 67.24
78 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 66.44
79 INT13545 Negative_regulation of Gene_expression of LTA 5 0.34 3.23 0.86 66.20
80 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 65.64
81 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 57.76
82 INT99461 Positive_regulation of Gene_expression of Pcsk1 4 0.22 0.67 0.07 56.96
83 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16 53.80
84 INT756 Gene_expression of C3 138 0.75 100.6 19.2 52.88
85 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 52.88
86 INT109191 Positive_regulation of ANKH 1 0.50 1.36 0.44 50.80
87 INT225749 Protein_catabolism of Ppi-rs 1 0.10 0.49 0.06 49.52
88 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 46.96
89 INT150809 Localization of TIMP2 7 0.65 2.6 1.43 46.96
90 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61 45.76
91 INT46 Localization of Ren 233 0.81 46.15 62.44 45.36
92 INT224560 Regulation of Gene_expression of Alpl 1 0.06 0.3 0.07 45.36
93 INT169475 Localization of HRAS 14 0.73 9.02 3.9 44.72
94 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82 42.52
95 INT160705 Positive_regulation of Enpp3 2 0.20 1.26 0.56 42.16
96 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 40.48
97 INT224557 Positive_regulation of Idi1 1 0.02 0.35 0.05 37.60
98 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 36.32
99 INT224542 Positive_regulation of Transcription of Ankh 1 0.50 0.82 0.21 32.24
100 INT224563 Positive_regulation of Positive_regulation of Raf1 1 0.11 0 0.2 26.44
101 INT11657 Gene_expression of ALPI 11 0.71 5.13 0.74 26.32
102 INT40583 Regulation of ALPI 4 0.45 1.87 0.48 26.32
103 INT225803 Regulation of Gene_expression of ALPI 1 0.01 0.53 0.06 26.32
104 INT119703 Regulation of Gene_expression of VDR 4 0.44 2.43 0.06 25.72
105 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97 25.36
106 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 25.28
107 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96 24.32
108 INT265490 Localization of CSPG4 3 0.20 1.5 0.33 17.28
109 INT225773 Regulation of Gene_expression of Ppi-rs 1 0.03 0.62 0.13 16.36
110 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 15.52
111 INT126576 Regulation of Ppi-rs 8 0.10 6.05 1.68 12.48
112 INT225772 Regulation of Gene_expression of Enpp1 1 0.62 1.6 0.4 9.40
113 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
114 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
115 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
116 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 5.00
117 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
118 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
119 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
120 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
121 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16 5.00
122 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77 5.00
123 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
124 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
125 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
126 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 5.00
127 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05 5.00
128 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
129 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91 5.00
130 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
131 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06 5.00
132 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
133 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
134 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
135 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
136 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 5.00
137 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
138 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
139 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
140 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
141 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
142 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
143 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
144 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
145 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
146 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
147 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
148 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 5.00
149 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
150 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41 5.00
151 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
152 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 5.00
153 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41 5.00
154 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34 5.00
155 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 5.00
156 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 5.00
157 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 5.00
158 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
159 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26 5.00
160 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24 5.00
161 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 5.00
162 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 5.00
163 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 5.00
164 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
165 INT48555 Binding of SP1 30 0.46 11.38 6.53 5.00
166 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49 5.00
167 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33 5.00
168 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
169 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96 5.00
170 INT85777 Regulation of Negative_regulation of Prkaca 7 0.46 1.85 5.76 5.00
171 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 5.00
172 INT4342 Localization of ALPP 27 0.69 15.19 5.32 5.00
173 INT167755 Gene_expression of Enpp2 12 0.77 57.31 5.3 5.00
174 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
175 INT156850 Binding of VDR 40 0.47 24.86 4.87 5.00
176 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 5.00
177 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 5.00
178 INT47451 Positive_regulation of Positive_regulation of ras 18 0.35 10.07 4.6 5.00
179 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
180 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16 5.00
181 INT133312 Binding of MMP9 25 0.42 16.79 3.83 5.00
182 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
183 INT181001 Regulation of PRTN3 5 0.18 6.07 3.39 5.00
184 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
185 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33 5.00
186 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 5.00
187 INT126575 Negative_regulation of Ppi-rs 21 0.14 12.94 3.2 5.00
188 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73 5.00
189 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65 5.00
190 INT142908 Localization of FGFR1 18 0.38 11.46 2.57 5.00
191 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
192 INT102638 Regulation of VDR 21 0.44 9.92 2.54 5.00
193 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28 5.00
194 INT107597 Binding of Enpp1 5 0.37 3.35 2.23 5.00
195 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 5.00
196 INT101912 Regulation of TIMP2 8 0.44 5.55 2 5.00
197 INT52508 Positive_regulation of TIMP2 7 0.43 8.1 1.96 5.00
198 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 5.00
199 INT76993 Regulation of HRAS 8 0.60 7.81 1.95 5.00
200 INT187128 Binding of TIMP2 11 0.41 6.43 1.9 5.00
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