D:Chordoma

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Disease Term
Synonyms CHORDOCARCINOMA, CHORDOEPITHELIOMA, Chordomas
Documents 196
Hot Single Events 92
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chordoma. They are ordered first by their relevance to Chordoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT298006 CHDM Positive_regulation of Gene_expression of PDGFRB 1 0.16 1.08 0.07 100.00
2 INT252851 Binding of GFAP and Ema 1 0.05 1.98 0 100.00
3 INT104536 Binding of Bcl2 and MIB1 1 0.00 1.61 0 97.68
4 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 95.80
5 INT354835 Binding of VEGFA and Pdgfa 1 0.00 1.5 0.03 5.00
6 INT354833 Csf2 Positive_regulation of Cd8a 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chordoma. They are ordered first by their pain relevance and then by number of times they were reported in Chordoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 100.00
2 INT298009 Gene_expression of CHDM 1 0.65 1.02 0.06 100.00
3 INT298008 Positive_regulation of Gene_expression of CHDM 1 0.49 1.02 0.06 100.00
4 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2 99.98
5 INT192348 Positive_regulation of Gene_expression of PDGFRB 5 0.64 3.57 0.3 99.98
6 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 99.86
7 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 99.86
8 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 99.86
9 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 99.84
10 INT15753 Negative_regulation of Ema 6 0.37 5.04 1.17 99.84
11 INT252844 Negative_regulation of Localization of Ema 1 0.05 1.71 0 99.84
12 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 99.80
13 INT67098 Regulation of MIB1 3 0.24 4.23 0.42 99.72
14 INT300638 Transcription of DVL1 1 0.33 1.11 0 99.70
15 INT300629 Transcription of Epha2 1 0.22 1.11 0 99.70
16 INT300640 Transcription of CASP9 1 0.23 1.11 0 99.70
17 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 99.52
18 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 99.48
19 INT216011 Regulation of TSC2 2 0.26 3.31 0 99.20
20 INT252845 Localization of Ema 1 0.08 1.7 0 99.04
21 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26 99.00
22 INT23955 Regulation of Vim 16 0.25 14.21 2.04 98.96
23 INT258949 Localization of OFD1 2 0.41 3.87 0 98.88
24 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 98.84
25 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03 98.68
26 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 98.64
27 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 98.52
28 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 98.52
29 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 98.52
30 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 98.52
31 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57 98.52
32 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 98.52
33 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 98.30
34 INT181808 Gene_expression of Pax7 18 0.54 6.22 0.26 98.12
35 INT14870 Positive_regulation of Gene_expression of TGFA 2 0.46 2.12 0.15 97.72
36 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37 97.68
37 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31 97.56
38 INT232945 Positive_regulation of Gene_expression of KRT18 2 0.49 3.54 0.23 97.56
39 INT232967 Positive_regulation of Gene_expression of KRT8 2 0.29 3.54 0.23 97.56
40 INT71389 Positive_regulation of KRT19 3 0.38 4.91 0.13 97.56
41 INT220533 Positive_regulation of OFD1 2 0.27 6.58 0.08 97.56
42 INT258948 Positive_regulation of Gene_expression of OFD1 1 0.27 5.05 0 97.56
43 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 97.38
44 INT11156 Gene_expression of TGFA 4 0.61 3.03 0.26 97.32
45 INT164349 Positive_regulation of KRT8 2 0.10 3.14 0.08 97.20
46 INT258945 Positive_regulation of KRT18 2 0.21 4.52 0 97.20
47 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 97.04
48 INT105761 Binding of GFAP 13 0.36 14.94 2.32 96.88
49 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 96.86
50 INT29637 Localization of KRT1 6 0.20 5.55 0.4 96.84
51 INT258950 Gene_expression of OFD1 1 0.37 7.19 0 96.76
52 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 95.84
53 INT214073 Binding of TSC1 9 0.37 22 1.34 95.80
54 INT242338 Binding of TSC2 2 0.22 1.56 0.04 95.44
55 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 94.48
56 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 93.80
57 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 92.84
58 INT125101 Gene_expression of CASP9 24 0.35 16.54 0.17 92.64
59 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 92.52
60 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 92.44
61 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 92.04
62 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 91.92
63 INT83375 Gene_expression of CALM3 3 0.58 1.57 0.78 91.56
64 INT132194 Positive_regulation of Gene_expression of KRT7 5 0.58 4.18 0.14 90.04
65 INT15584 Binding of S100A12 14 0.48 15.14 3 89.76
66 INT179888 Localization of KRT7 3 0.39 2.85 0.22 89.52
67 INT252846 Localization of SLC4A1 2 0.73 1.08 0.09 89.52
68 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 87.88
69 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13 87.52
70 INT216395 Negative_regulation of Gene_expression of KRT7 4 0.41 3.57 0.16 87.52
71 INT321203 Negative_regulation of Localization of SYT1 1 0.01 1 0 87.52
72 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 87.24
73 INT95693 Negative_regulation of SLC4A1 4 0.41 2.46 0.38 87.24
74 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83 87.20
75 INT321202 Localization of SYT1 1 0.01 1 0 86.92
76 INT244794 Gene_expression of Mnx1 2 0.29 0.54 0 86.88
77 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 86.64
78 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 86.48
79 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21 85.92
80 INT47311 Gene_expression of Sts 12 0.58 11.02 0.44 85.72
81 INT193822 Regulation of Gene_expression of Sts 1 0.03 1.04 0 85.72
82 INT300639 Negative_regulation of KIDINS220 1 0.04 0.46 0 85.68
83 INT200990 Gene_expression of CALM2 4 0.61 2.2 0.55 85.60
84 INT226068 Positive_regulation of CALM2 1 0.01 0.63 0 85.60
85 INT122813 Binding of Krt20 11 0.32 13.77 0.88 85.44
86 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 85.12
87 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 85.12
88 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 84.72
89 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 84.72
90 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 83.52
91 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 83.52
92 INT226069 Negative_regulation of KRT18 1 0.18 0.72 0 82.08
93 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 80.00
94 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 79.16
95 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 79.16
96 INT49676 Positive_regulation of TG 10 0.48 9.09 0.44 75.00
97 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 74.64
98 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03 72.40
99 INT51066 Binding of S100B 24 0.48 13.5 0.97 68.40
100 INT279296 Localization of PDGFRB 4 0.54 2.71 0.24 62.24
101 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 59.12
102 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 58.04
103 INT76690 Negative_regulation of Gene_expression of Vim 1 0.39 1.4 0.42 55.36
104 INT44872 Localization of Sts 5 0.64 5.2 0.2 51.80
105 INT223616 Binding of PDGFRB 3 0.32 2.33 0.05 50.00
106 INT66346 Binding of LIF 7 0.47 0.9 0 50.00
107 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 46.56
108 INT258947 Regulation of OFD1 1 0.25 3.47 0 44.16
109 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83 38.12
110 INT256900 Gene_expression of TNMD 19 0.68 7.36 0.64 38.12
111 INT244605 Gene_expression of BASP1 2 0.56 0.92 0 38.12
112 INT175651 Gene_expression of CDH2 5 0.36 2.59 0 38.12
113 INT50077 Gene_expression of Myb 21 0.66 7.68 1.54 35.80
114 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 35.40
115 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 26.56
116 INT56817 Regulation of Eno2 16 0.61 10.64 1.99 25.44
117 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 25.00
118 INT132885 Regulation of SYP 4 0.44 3.92 0.44 23.44
119 INT82686 Gene_expression of Sparc 4 0.75 6.14 2.34 18.84
120 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 18.64
121 INT269109 Negative_regulation of Cyp2b10 2 0.08 2.9 0.17 13.76
122 INT190703 Regulation of Negative_regulation of TSC1 3 0.06 3.08 0.07 10.72
123 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
124 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
125 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
126 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
127 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
128 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
129 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
130 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89 5.00
131 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
132 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
133 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
134 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
135 INT106097 Localization of pr 20 0.62 12.01 19.46 5.00
136 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
137 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 5.00
138 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
139 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
140 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
141 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
142 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
143 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
144 INT82829 Gene_expression of COMP 104 0.78 57 9.81 5.00
145 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
146 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 5.00
147 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
148 INT110202 Positive_regulation of Gene_expression of Abcb1a 13 0.67 2.08 5.01 5.00
149 INT17489 Regulation of F13A1 28 0.45 15.79 4.93 5.00
150 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 5.00
151 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 5.00
152 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55 5.00
153 INT39000 Regulation of pr 24 0.44 12.51 4.36 5.00
154 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23 5.00
155 INT12915 Gene_expression of MGP 18 0.75 7.53 4.15 5.00
156 INT95423 Negative_regulation of Bcl2l1 26 0.41 21.66 3.81 5.00
157 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
158 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55 5.00
159 INT190208 Positive_regulation of MMRN1 15 0.23 14.1 3.37 5.00
160 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 5.00
161 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 5.00
162 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 5.00
163 INT175655 Regulation of MMRN1 16 0.12 9.96 2.12 5.00
164 INT101582 Negative_regulation of SNAP25 9 0.57 4.34 2.12 5.00
165 INT175535 Gene_expression of GPC3 5 0.29 4.17 1.74 5.00
166 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 5.00
167 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 5.00
168 INT106359 Regulation of Plau 7 0.45 3.51 1.5 5.00
169 INT124407 Gene_expression of SSTR1 4 0.55 5.55 1.41 5.00
170 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 5.00
171 INT191678 Gene_expression of Xiap 60 0.71 57.25 1.37 5.00
172 INT160606 Localization of AFP 6 0.74 3.39 1.29 5.00
173 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28 5.00
174 INT123224 Gene_expression of TNFAIP6 12 0.70 7.13 1.21 5.00
175 INT199308 Gene_expression of Krt8 37 0.75 23.17 1.06 5.00
176 INT27387 Binding of Aecp 4 0.34 5.09 1 5.00
177 INT125244 Gene_expression of Ril2 4 0.30 1.9 0.87 5.00
178 INT8159 Binding of ELL 7 0.36 12.62 0.84 5.00
179 INT109133 Gene_expression of VCAN 52 0.75 53.11 0.84 5.00
180 INT254930 Gene_expression of CELSR3 4 0.76 5.01 0.76 5.00
181 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 5.00
182 INT183399 Gene_expression of Cyp2b10 17 0.39 18.39 0.71 5.00
183 INT69880 Positive_regulation of Positive_regulation of Gtf3a 8 0.03 5.25 0.68 5.00
184 INT203118 Positive_regulation of Gene_expression of ACAN 5 0.49 1.7 0.61 5.00
185 INT147796 Gene_expression of Ccndbp1 5 0.05 3.9 0.4 5.00
186 INT178027 Negative_regulation of Xiap 14 0.54 11.62 0.24 5.00
187 INT297648 Localization of CEACAM3 1 0.57 0.6 0.16 5.00
188 INT145147 Negative_regulation of Gene_expression of TP63 4 0.42 2.91 0.15 5.00
189 INT256902 Positive_regulation of TNMD 3 0.44 5.27 0.13 5.00
190 INT182694 Regulation of Gene_expression of Vim 2 0.24 1.01 0.12 5.00
191 INT180895 Positive_regulation of VCAN 5 0.28 5.45 0.1 5.00
192 INT293259 Negative_regulation of Gene_expression of SNAP25 4 0.49 5.08 0.09 5.00
193 INT121678 Gene_expression of SRY 15 0.68 5.61 0.06 5.00
194 INT230117 Binding of KRT8 6 0.31 2.44 0.05 5.00
195 INT312192 Protein_catabolism of ADAMTS1 1 0.11 0.05 0.03 5.00
196 INT228692 Negative_regulation of EWSR1 4 0.27 4.73 0.03 5.00
197 INT193821 Positive_regulation of Gene_expression of pr 3 0.24 2.8 0 5.00
198 INT312190 Positive_regulation of ADAMTS1 1 0.09 0 0 5.00
199 INT312193 Gene_expression of FOXF2 1 0.40 0.79 0 5.00
200 INT258944 Negative_regulation of OFD1 1 0.23 6.08 0 5.00
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