D:Chorea

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Choreas, Choreic Movement, CHOREIC MOVEMENTS, CHOREIFORM MOVEMENT, Choreiform Movements, Movement Choreic, Movement Choreiform, Movements Choreic, Movements Choreiform, SENILE CHOREA, Syndenham S Chorea
Documents 225
Hot Single Events 53
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chorea. They are ordered first by their relevance to Chorea and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT95125 Binding of KCNA6 and SGCG 1 0.40 2.73 0.18 100.00
2 INT145940 Binding of Gad1 and Abat 2 0.14 1.44 1.78 5.00
3 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
4 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 5.00
5 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00
6 INT338447 GAD1 Negative_regulation of Slc32a1 1 0.04 0.59 0.47 5.00
7 INT282505 Binding of ocd and Slc1a1 1 0.39 4.22 0.4 5.00
8 INT334737 Binding of Oprd1 and Gpi 1 0.01 0.71 0.28 5.00
9 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 5.00
10 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2 5.00
11 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2 5.00
12 INT338443 Binding of Gad1 and Slc32a1 1 0.31 0.64 0.18 5.00
13 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
14 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
15 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
16 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12 5.00
17 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
18 INT261892 Creb1 Regulation of Gene_expression of Ppp1r1b 1 0.31 1.46 0.09 5.00
19 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
20 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
21 INT251623 Car2 Regulation of Gene_expression of Fig4 1 0.02 0.31 0.08 5.00
22 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
23 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
24 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06 5.00
25 INT250150 Binding of IKBKG and SACM1L 1 0.00 2.78 0.06 5.00
26 INT287223 Pdx1 Regulation of Transcription of Insig1 1 0.03 0.56 0.05 5.00
27 INT287222 Cytip Regulation of Transcription of Insig1 1 0.02 0.56 0.05 5.00
28 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 5.00
29 INT287221 Tcf3 Regulation of Transcription of Insig1 1 0.03 0.56 0.05 5.00
30 INT250151 Binding of GSS and MCM3 1 0.01 1.38 0.04 5.00
31 INT345281 Binding of CASP1 and Nlrp3 1 0.02 0.31 0.03 5.00
32 INT282503 Binding of ocd and Dlgap3 1 0.28 1.58 0.03 5.00
33 INT345282 Binding of CASP1 and Pycard 1 0.01 0.3 0.03 5.00
34 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
35 INT282504 Binding of Grik2 and Grik3 1 0.27 0.61 0 5.00
36 INT282507 Binding of Grik3 and ocd 1 0.25 0.61 0 5.00
37 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
38 INT345283 Binding of Ads1 and BDNF-AS 1 0.00 0.26 0 5.00
39 INT282502 Negative_regulation of Binding of ocd and Slc1a1 1 0.30 0.48 0 5.00
40 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
41 INT261893 Binding of Htt and Hap1 1 0.13 0.49 0 5.00
42 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0 5.00
43 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chorea. They are ordered first by their pain relevance and then by number of times they were reported in Chorea. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 100.00
2 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 99.82
3 INT134064 Positive_regulation of Positive_regulation of CSRP1 1 0.47 1.38 0.26 99.82
4 INT95130 Positive_regulation of KCNA6 1 0.21 2.35 0.16 99.64
5 INT292 Localization of Penk 876 0.81 88.44 669.14 99.40
6 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68 99.40
7 INT48541 Positive_regulation of Kcna5 12 0.69 5.51 6.35 99.24
8 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 99.14
9 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 99.00
10 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 98.92
11 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 98.92
12 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 98.88
13 INT118818 Binding of HOXA10 1 0.10 1.26 0.29 98.76
14 INT7286 Regulation of Transcription of Penk 81 0.62 9.25 33.45 98.24
15 INT72275 Regulation of Transcription of TAC4 1 0.16 0.34 0.74 98.24
16 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 97.88
17 INT72274 Transcription of TAC4 2 0.63 0.4 1.04 97.64
18 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 97.56
19 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 97.28
20 INT95128 Positive_regulation of KCNA1 8 0.41 4.28 2.19 97.16
21 INT1616 Regulation of Gad1 46 0.61 10.2 28.64 96.96
22 INT89425 Positive_regulation of HLA-DRB3 2 0.59 2.38 0.42 96.52
23 INT5118 Regulation of SST 97 0.62 34.35 51.74 96.20
24 INT180160 Positive_regulation of Binding of Gast 2 0.32 2.72 0.12 95.92
25 INT165597 Positive_regulation of Htt 8 0.60 4.27 0.44 95.20
26 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 94.48
27 INT4803 Transcription of Penk 435 0.72 59.09 182.4 94.32
28 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 93.88
29 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 93.48
30 INT215340 Localization of Htt 10 0.61 5.12 0.55 92.16
31 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 90.80
32 INT282483 Regulation of ocd 1 0.33 2.43 0.24 90.12
33 INT233 Binding of Gast 31 0.42 17.07 5.21 88.80
34 INT4784 Gene_expression of TAC4 25 0.71 9.84 11.54 88.52
35 INT251604 Negative_regulation of Msn 1 0.36 1.25 0.49 88.40
36 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 87.52
37 INT21214 Negative_regulation of Gene_expression of PENK 21 0.58 9.14 9.53 87.52
38 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 87.04
39 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 87.04
40 INT132864 Binding of Htt 15 0.46 2.34 0.38 86.40
41 INT3244 Negative_regulation of eCB 37 0.03 16.69 12.61 85.96
42 INT72277 Negative_regulation of TAC4 3 0.53 0.74 2.05 85.24
43 INT6666 Negative_regulation of PENK 30 0.58 9.16 17.91 85.24
44 INT143316 Negative_regulation of Slc18a2 7 0.50 3.17 2.52 85.08
45 INT2105 Negative_regulation of Rhd 10 0.41 4.9 3.4 84.80
46 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 82.84
47 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 82.84
48 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 82.84
49 INT72276 Negative_regulation of Gene_expression of TAC4 1 0.15 0.36 0.8 82.00
50 INT256351 Negative_regulation of Agfg1 2 0.06 0.93 0.5 81.56
51 INT18848 Localization of LMOD1 5 0.69 1 2.49 81.40
52 INT2103 Localization of Rhd 35 0.77 3.16 23.5 81.04
53 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03 80.68
54 INT17962 Regulation of Car2 124 0.41 33.98 22.71 79.72
55 INT251609 Regulation of Msn 1 0.43 1.33 0.32 79.72
56 INT68332 Positive_regulation of GRM1 7 0.67 2.11 3.83 79.52
57 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 78.24
58 INT320840 Binding of Npc2 1 0.46 1.81 0 76.44
59 INT81206 Binding of ENPEP 11 0.47 5.19 0.88 75.84
60 INT304864 Gene_expression of Agfg1 5 0.08 1.78 0.1 75.80
61 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 75.68
62 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 75.00
63 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 75.00
64 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 75.00
65 INT70210 Negative_regulation of NEFL 3 0.30 1.11 1.8 75.00
66 INT70209 Negative_regulation of FYN 3 0.08 1.07 1.06 75.00
67 INT240424 Binding of Ctsa 4 0.20 3.94 0.16 74.80
68 INT133218 Binding of Slc18a2 2 0.48 2.96 1.99 73.64
69 INT191542 Binding of ABCA3 1 0.22 1.61 0.03 73.04
70 INT14690 Localization of CSF2 124 0.80 85.17 27.26 72.68
71 INT49573 Positive_regulation of Lsamp 1 0.20 0.45 0.78 72.08
72 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 70.88
73 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 70.40
74 INT258183 Negative_regulation of GCSH 1 0.02 2.33 0.05 68.72
75 INT243418 Binding of Htt 14 0.30 5.94 0.44 67.16
76 INT121334 Binding of HTT 11 0.47 6.66 0.78 66.80
77 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 65.68
78 INT335968 Binding of Slc18a1 1 0.05 1 0.6 64.48
79 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 63.28
80 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 62.80
81 INT259038 Negative_regulation of Positive_regulation of SH2B2 1 0.25 1.83 0.09 62.04
82 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 61.36
83 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12 61.12
84 INT259039 Positive_regulation of Binding of ACLY 1 0.09 1.85 0.09 61.04
85 INT35584 Binding of ACLY 22 0.35 31.78 7.17 60.48
86 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 60.40
87 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 56.64
88 INT119348 Binding of IKBKG 7 0.15 4.03 1.14 56.24
89 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 54.96
90 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36 54.44
91 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 48.72
92 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 48.20
93 INT128124 Gene_expression of Ccdc88a 1 0.11 0.71 0.08 48.08
94 INT101612 Protein_catabolism of HTT 3 0.86 1.44 0.05 43.96
95 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 38.24
96 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 35.52
97 INT121336 Positive_regulation of HTT 10 0.45 10.88 0.59 35.52
98 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 34.00
99 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 32.60
100 INT338445 Positive_regulation of parkinsonism 1 0.01 3.26 0.47 30.44
101 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 28.80
102 INT28358 Gene_expression of Nanog 25 0.70 3.52 7.85 28.80
103 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 25.00
104 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 25.00
105 INT118817 Positive_regulation of Apoc4 6 0.45 6.44 1.23 25.00
106 INT17561 Localization of Car2 303 0.79 60.95 44.52 24.92
107 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 24.88
108 INT259033 Gene_expression of LCA5L 1 0.01 2.71 0.16 24.40
109 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 23.60
110 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 23.48
111 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 23.12
112 INT154007 Gene_expression of da 46 0.56 15.28 28.22 22.92
113 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 20.96
114 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 14.28
115 INT345276 Binding of Ads1 1 0.03 2.5 0 10.56
116 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 10.12
117 INT345271 Localization of Ads1 1 0.05 2.18 0 8.00
118 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 6.08
119 INT169173 Gene_expression of ocd 9 0.50 4.49 1.28 5.12
120 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
121 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 5.00
122 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
123 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
124 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
125 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
126 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
127 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
128 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
129 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
130 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36 5.00
131 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
132 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
133 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
134 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 5.00
135 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
136 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
137 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 5.00
138 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
139 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 5.00
140 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
141 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
142 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
143 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
144 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
145 INT7028 Localization of Pdyn 90 0.81 8.89 73.54 5.00
146 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
147 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
148 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 5.00
149 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
150 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
151 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
152 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
153 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
154 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 5.00
155 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
156 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
157 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
158 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
159 INT19488 Localization of ABAT 56 0.69 21.51 50.56 5.00
160 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
161 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
162 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
163 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71 5.00
164 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
165 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
166 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
167 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
168 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
169 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
170 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 5.00
171 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
172 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
173 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
174 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
175 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
176 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
177 INT10453 Positive_regulation of Gad1 65 0.70 10.75 31.9 5.00
178 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31 5.00
179 INT8531 Transcription of PDYN 56 0.72 19.51 30.99 5.00
180 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
181 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
182 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
183 INT111359 Localization of Cnr1 55 0.81 11.25 27.41 5.00
184 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 5.00
185 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
186 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
187 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13 5.00
188 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
189 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 5.00
190 INT82461 Gene_expression of Gad2 40 0.78 19.12 22.79 5.00
191 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 5.00
192 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
193 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
194 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 5.00
195 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
196 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
197 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 5.00
198 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02 5.00
199 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
200 INT102203 Transcription of Bdnf 35 0.71 18.26 20.59 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox