D:Choroideremia

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Disease Term
Synonyms Choroideraemia, Choroideraemias, Choroideremias, PROGRESSIVE CHOROIDAL ATROPHY
Documents 5
Hot Single Events 103
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Choroideremia. They are ordered first by their relevance to Choroideremia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT290045 RAB27A Positive_regulation of CHM 1 0.16 0.92 0 100.00
2 INT172465 Binding of Rab27a and Rab27b 2 0.41 1.71 0.27 97.52
3 INT290046 RAB27A Regulation of RPE 1 0.03 0.75 0 92.96
4 INT290104 Myo7a Regulation of RPE 1 0.03 0.75 0 92.96
5 INT234795 Negative_regulation of CHM Negative_regulation of RAB27A 1 0.01 0.8 0 84.04
6 INT298858 Positive_regulation of Binding of VAPA and RILP 1 0.07 0.54 0 54.48
7 INT298847 Binding of VAPA and RILP 1 0.05 0.54 0 54.48
8 INT298845 VAPA Regulation of Negative_regulation of RAB7A 1 0.12 0.32 0 34.72
9 INT298864 VAPB Regulation of Negative_regulation of RAB7A 1 0.32 0.32 0 34.72
10 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22 20.80
11 INT234831 Binding of SPTLC1 and Abo 1 0.00 1.61 0.23 15.96
12 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15 5.00
13 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07 5.00
14 INT298831 Binding of MTOR and RAB7A Positive_regulation of MTOR 1 0.02 0.35 0.03 5.00
15 INT298878 Binding of MTOR and RAB7A 1 0.07 0.35 0.03 5.00
16 INT298872 RAB7A Regulation of Protein_catabolism of GFM1 1 0.47 0.22 0.03 5.00
17 INT298873 RAB7A Regulation of Protein_catabolism of NTRK1 1 0.12 0.25 0.03 5.00
18 INT298854 Binding of LAMP2 and RAB7A 1 0.16 0.56 0 5.00
19 INT298862 Binding of MCC and VPS13C 1 0.00 0.36 0 5.00
20 INT298879 Binding of MCC and MTG1 1 0.00 0.37 0 5.00
21 INT298863 Binding of VAPB and RILP 1 0.13 0.21 0 5.00
22 INT298875 Binding of RAB7A and VPS13C 1 0.21 0.49 0 5.00
23 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0 5.00
24 INT298868 Binding of RAB7A and GOPC 1 0.07 1.64 0 5.00
25 INT298848 Binding of SPG21 and RILP 1 0.10 0.21 0 5.00
26 INT298849 Binding of APOB and MCC 1 0.00 0.38 0 5.00
27 INT298859 Positive_regulation of Binding of MCC and VPS13C 1 0.01 0.36 0 5.00
28 INT298853 Binding of AGFG1 and RILP 1 0.02 0.21 0 5.00
29 INT172464 Binding of Rab27a and Myc 1 0.13 0.69 0 5.00
30 INT298856 Binding of APOB and MTG1 1 0.00 0.38 0 5.00
31 INT298866 Binding of AGFG1 and RAB7A 1 0.04 0.21 0 5.00
32 INT298846 Binding of MCC and RILP 1 0.01 0.36 0 5.00
33 INT298850 Binding of RAB7A and MTG1 1 0.01 0.24 0 5.00
34 INT234790 B4GALNT1 Positive_regulation of AGFG1 1 0.00 0.08 0 5.00
35 INT298877 Positive_regulation of Binding of RAB7A and VPS13C 1 0.22 0.49 0 5.00
36 INT298851 Binding of IK and RAB7A 1 0.02 0.57 0 5.00
37 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0 5.00
38 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0 5.00
39 INT298871 ALOX5AP Positive_regulation of RAB7A 1 0.09 0.35 0 5.00
40 INT298869 Binding of RAB7A and RILP 1 0.25 1.07 0 5.00
41 INT298857 Binding of RILP and MTG1 1 0.01 0.35 0 5.00
42 INT298855 Positive_regulation of Binding of MCC and MTG1 1 0.00 0.37 0 5.00
43 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0 5.00
44 INT234794 Binding of GDI1 and AGFG1 1 0.01 0 0 5.00
45 INT298865 Positive_regulation of Binding of RILP and MTG1 1 0.01 0.35 0 5.00
46 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0 5.00
47 INT298852 Binding of AGFG1 and MTG1 1 0.00 0 0 5.00
48 INT234797 AVP Regulation of GOPC 1 0.01 0.65 0 5.00
49 INT298861 Binding of APOB and RAB7A 1 0.00 0.32 0 5.00
50 INT298870 Binding of PDB1 and RAB7A 1 0.51 0.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Choroideremia. They are ordered first by their pain relevance and then by number of times they were reported in Choroideremia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT52349 Gene_expression of CHM 7 0.77 17.33 0.28 100.00
2 INT203271 Transcription of CHM 3 0.72 11.28 0.17 100.00
3 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 100.00
4 INT21660 Regulation of CHM 14 0.61 8.51 0.93 100.00
5 INT135568 Localization of CHM 5 0.65 6.51 1.76 100.00
6 INT72947 Binding of CHM 9 0.42 5.86 0.06 100.00
7 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
8 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 100.00
9 INT290074 Protein_catabolism of CHM 1 0.77 2.13 0.04 100.00
10 INT52348 Positive_regulation of CHM 7 0.44 4.18 0.25 100.00
11 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 100.00
12 INT290092 Negative_regulation of Localization of NUDT6 2 0.02 0.82 0.07 100.00
13 INT290103 Positive_regulation of Gene_expression of CHM 1 0.50 1.01 0 100.00
14 INT15610 Localization of GOPC 223 0.65 68.26 28.7 100.00
15 INT90897 Regulation of Rab27a 6 0.45 3.28 0.5 99.84
16 INT65698 Localization of CCL2 118 0.81 77.54 32.69 99.80
17 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.80
18 INT94835 Localization of NUDT6 13 0.52 11.57 2 99.80
19 INT290069 Regulation of Localization of NUDT6 1 0.01 0.81 0.07 99.80
20 INT290089 Positive_regulation of Negative_regulation of CHM 1 0.50 0.98 0 99.80
21 INT7773 Localization of SERPINF1 18 0.55 8.54 3.25 99.74
22 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 99.58
23 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 99.58
24 INT290073 Gene_expression of CHML 1 0.05 2.58 0 99.56
25 INT290079 Negative_regulation of Gene_expression of CHML 1 0.04 1.77 0 99.56
26 INT127986 Regulation of CSF3R 2 0.33 5.91 0.22 99.52
27 INT201955 Regulation of DPP4 18 0.45 11.91 1.18 99.52
28 INT161102 Regulation of MMP7 4 0.37 6.79 0.37 99.52
29 INT290081 Regulation of NRG1 7 0.26 5.24 0.59 99.52
30 INT101362 Regulation of CFI 5 0.27 2.46 1.24 99.52
31 INT290044 Regulation of Tsg101 1 0.26 2.46 0.07 99.52
32 INT89926 Regulation of IL1A 10 0.60 7.12 1.72 99.52
33 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07 99.52
34 INT290096 Regulation of Gene_expression of NRG1 2 0.06 2.21 0.35 99.52
35 INT290082 Negative_regulation of Gene_expression of CHM 1 0.58 2.72 0 99.40
36 INT12339 Localization of IL8 437 0.81 251.87 117.39 99.26
37 INT90899 Gene_expression of Rab27a 49 0.78 26.71 0.74 99.06
38 INT290076 Gene_expression of LECT2 1 0.25 0.72 0 99.04
39 INT202935 Gene_expression of SERPINF1 12 0.50 7.53 1.54 98.96
40 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.96
41 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 98.96
42 INT160533 Gene_expression of NUDT6 24 0.20 18.6 1.7 98.96
43 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 98.96
44 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 98.96
45 INT290094 Regulation of NCAM2 1 0.03 5.01 0.05 98.92
46 INT290093 Regulation of FMN1 1 0.05 5.01 0.05 98.92
47 INT290097 Regulation of ELOVL2 1 0.08 4.83 0.05 98.92
48 INT290090 Regulation of NR2F6 1 0.08 4.77 0.17 98.92
49 INT290098 Regulation of MLLT4 1 0.09 4.79 0.05 98.92
50 INT290091 Regulation of TSPAN5 1 0.06 4.78 0.05 98.92
51 INT290100 Regulation of MRO 1 0.06 4.75 0.16 98.92
52 INT290072 Regulation of HOXD11 1 0.10 4.75 0.16 98.92
53 INT290099 Regulation of SYT6 1 0.02 4.73 0.05 98.92
54 INT290080 Regulation of RGS11 1 0.07 3.28 0 98.92
55 INT290068 Regulation of NLRC3 1 0.07 3.19 0.11 98.92
56 INT290085 Regulation of Regulation of HOXD11 1 0.10 1.75 0.05 98.92
57 INT290071 Regulation of Regulation of TSPAN5 1 0.06 1.72 0 98.92
58 INT290086 Regulation of CYFIP2 1 0.07 1.6 0 98.92
59 INT290083 Regulation of ANKRD28 1 0.06 1.59 0 98.92
60 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 98.84
61 INT19189 Localization of IL1A 14 0.78 9.02 3.78 98.84
62 INT234822 Positive_regulation of CHML 2 0.06 1.76 0 98.64
63 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53 98.64
64 INT84465 Localization of DPP4 8 0.75 7.28 2.29 98.64
65 INT14688 Gene_expression of CSF3R 7 0.46 3.93 0.06 98.40
66 INT14689 Localization of CSF3R 5 0.56 3.85 1.02 98.40
67 INT109904 Localization of RPE 5 0.73 4.9 0.56 98.00
68 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17 97.80
69 INT282594 Localization of WNT5A 2 0.18 0.89 0.1 97.80
70 INT172463 Gene_expression of RAB27A 6 0.65 3.95 0.03 97.68
71 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93 97.52
72 INT185825 Localization of MMP7 10 0.78 2.85 1.11 97.52
73 INT298884 Binding of RAB7A 1 0.45 9.82 0.14 97.36
74 INT298906 Negative_regulation of Binding of RAB7A 1 0.40 0.99 0 97.36
75 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12 97.28
76 INT290102 Localization of NRG1 1 0.15 0.76 0.06 97.28
77 INT184345 Gene_expression of Tsg101 10 0.58 3.56 0.57 97.04
78 INT290043 Localization of Tsg101 1 0.68 0.76 0.06 97.04
79 INT57163 Gene_expression of AGFG1 11 0.75 2.45 0.48 96.96
80 INT62718 Gene_expression of CFI 7 0.75 2.06 1.84 96.84
81 INT290095 Localization of CFI 1 0.15 0.75 0.06 96.84
82 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98 96.24
83 INT234826 Positive_regulation of Regulation of AGFG1 1 0.10 0.87 0 96.24
84 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 96.12
85 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 95.88
86 INT201261 Regulation of AGFG1 4 0.09 2.72 0.9 95.48
87 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 95.46
88 INT224827 Regulation of SALL1 2 0.37 3.36 0.62 95.46
89 INT290087 Regulation of GBF1 1 0.08 3 0.1 95.46
90 INT290088 Protein_catabolism of RPE 1 0.07 1.06 0 94.72
91 INT290101 Regulation of DIP2A 1 0.06 1.44 0.06 93.82
92 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 93.12
93 INT172438 Gene_expression of Rab27b 8 0.77 10.95 0.27 92.16
94 INT90898 Negative_regulation of Rab27a 5 0.43 1.99 1.04 92.08
95 INT234823 Negative_regulation of RAB1A 1 0.13 0.84 0 91.84
96 INT92428 Regulation of Myo7a 2 0.44 1.23 0.91 90.32
97 INT172455 Protein_catabolism of Rab27a 1 1.00 2.11 0 90.12
98 INT290075 Regulation of RAB27A 2 0.44 1.31 0 89.60
99 INT195619 Regulation of LAT2 3 0.44 0.75 0.17 88.76
100 INT234816 Phosphorylation of CHM 1 0.04 0.79 0 88.44
101 INT234815 Phosphorylation of RAB27A 1 0.37 0.77 0 86.96
102 INT64965 Binding of AGFG1 8 0.10 3.53 0.45 81.72
103 INT164229 Gene_expression of LECT1 8 0.67 3.08 0.96 81.12
104 INT290070 Regulation of Gene_expression of CHM 1 0.45 0.73 0 77.60
105 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 77.36
106 INT172451 Gene_expression of Rab5a 1 0.02 0.46 0 76.20
107 INT172461 Positive_regulation of Negative_regulation of Rab27b 1 0.33 0.54 0 74.64
108 INT172441 Negative_regulation of Rab27b 2 0.43 1.06 0.03 74.64
109 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 73.44
110 INT298893 Positive_regulation of Gene_expression of RAB7A 1 0.65 2.86 0 72.72
111 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21 72.08
112 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 70.92
113 INT234817 Gene_expression of GDI1 4 0.17 2.99 0.25 67.40
114 INT234814 Positive_regulation of AGFG1 6 0.10 2.33 0.07 65.44
115 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 65.44
116 INT172440 Negative_regulation of Binding of Myc 1 0.15 0.55 0 65.44
117 INT172453 Binding of Myc 6 0.48 2.36 0.08 64.60
118 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 63.84
119 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 58.88
120 INT234820 Localization of AGFG1 3 0.14 0.86 0.74 55.52
121 INT172460 Positive_regulation of Rab27b 2 0.46 1.55 0.04 51.40
122 INT234819 Regulation of Binding of AGFG1 1 0.05 0.19 0 46.72
123 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 46.48
124 INT172445 Positive_regulation of Gene_expression of Myc 58 0.70 39.62 0.25 44.08
125 INT172449 Positive_regulation of Gene_expression of Rab27a 4 0.50 2.37 0.03 44.08
126 INT234827 Positive_regulation of RAB5A 3 0.59 0.54 1.69 40.80
127 INT201259 Negative_regulation of RAB7A 2 0.41 2.45 0.54 34.72
128 INT298922 Negative_regulation of Protein_catabolism of NTRK1 1 0.11 0.44 0.22 20.60
129 INT298887 Protein_catabolism of NTRK1 1 0.25 1.1 0.56 20.12
130 INT61042 Localization of SPG21 5 0.78 1.42 0.89 18.08
131 INT298905 Localization of ANKFY1 1 0.14 0.25 0 18.08
132 INT119145 Binding of RAC2 2 0.13 0.47 0.14 6.00
133 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
134 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
135 INT13108 Binding of MTG1 35 0.47 6.36 20.5 5.00
136 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
137 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
138 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
139 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
140 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
141 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 5.00
142 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 5.00
143 INT234813 Gene_expression of RAB5A 58 0.66 3.67 6.48 5.00
144 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
145 INT25271 Positive_regulation of MTG1 21 0.67 13.59 5.96 5.00
146 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 5.00
147 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 5.00
148 INT143998 Binding of IK 11 0.34 2.44 3.42 5.00
149 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 5.00
150 INT234825 Positive_regulation of Gene_expression of RAB5A 16 0.59 1.15 2.71 5.00
151 INT114330 Binding of MPZ 21 0.32 25.58 2.14 5.00
152 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 5.00
153 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86 5.00
154 INT9466 Binding of APOB 27 0.41 19.36 1.56 5.00
155 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31 5.00
156 INT183046 Transcription of INS 25 0.70 11.14 1.13 5.00
157 INT279394 Positive_regulation of Localization of IK 5 0.09 2.67 1.03 5.00
158 INT76807 Binding of MCC 4 0.36 0.54 0.92 5.00
159 INT51704 Phosphorylation of AVP 2 0.79 0.33 0.86 5.00
160 INT111437 Positive_regulation of MCC 3 0.05 1.48 0.79 5.00
161 INT133089 Negative_regulation of MCC 3 0.41 0.72 0.64 5.00
162 INT246642 Binding of CLTCL1 3 0.17 1.32 0.63 5.00
163 INT201255 Binding of GDI2 2 0.17 0.2 0.55 5.00
164 INT169474 Localization of MTG1 2 0.73 1.12 0.43 5.00
165 INT56815 Gene_expression of ckrtgr 6 0.01 1.7 0.4 5.00
166 INT234828 Gene_expression of RAB3A 2 0.30 2.05 0.37 5.00
167 INT195413 Negative_regulation of ALOX5AP 5 0.37 1.39 0.37 5.00
168 INT53212 Negative_regulation of RAB27A 4 0.57 2.46 0.26 5.00
169 INT298929 Negative_regulation of Gene_expression of RAB7A 1 0.35 0.3 0.25 5.00
170 INT172442 Binding of Rab27a 3 0.37 1.5 0.21 5.00
171 INT203173 Localization of ALOX5AP 3 0.48 0.78 0.21 5.00
172 INT159860 Regulation of CDC42EP5 4 0.05 0.9 0.16 5.00
173 INT234810 Regulation of RAB5A 3 0.38 1.64 0.16 5.00
174 INT298923 Positive_regulation of Protein_catabolism of NTRK1 1 0.13 0.5 0.07 5.00
175 INT298891 Positive_regulation of Positive_regulation of RAB7A 1 0.47 2.65 0.07 5.00
176 INT228295 Negative_regulation of Transcription of INS 2 0.43 1.1 0.07 5.00
177 INT298902 Positive_regulation of Protein_catabolism of GFM1 1 0.49 0.44 0.06 5.00
178 INT255451 Positive_regulation of Positive_regulation of APOB 2 0.37 1.91 0.05 5.00
179 INT239411 Localization of APOB 10 0.76 5.71 0.04 5.00
180 INT298889 Negative_regulation of AGFG1 1 0.04 0.64 0.03 5.00
181 INT172456 Negative_regulation of Rpe 2 0.32 1.18 0.03 5.00
182 INT298907 Protein_catabolism of GFM1 1 0.86 0.22 0.03 5.00
183 INT173588 Negative_regulation of CDC42EP5 2 0.01 1.08 0.03 5.00
184 INT217732 Localization of MTOR 11 0.56 3.19 0.03 5.00
185 INT298927 Positive_regulation of GDI1 1 0.10 0.06 0 5.00
186 INT298924 Regulation of Gene_expression of RAB7A 1 0.42 0.54 0 5.00
187 INT298901 Positive_regulation of Binding of CLTCL1 1 0.05 0.51 0 5.00
188 INT234821 Positive_regulation of Gene_expression of AGFG1 1 0.10 0.07 0 5.00
189 INT298892 Regulation of Localization of RAB7A 1 0.58 0.54 0 5.00
190 INT298899 Binding of VPS13C 1 0.19 1.44 0 5.00
191 INT298909 Positive_regulation of Gene_expression of ARHGEF2 1 0.09 0.62 0 5.00
192 INT298917 Binding of CDC42EP5 1 0.01 0.3 0 5.00
193 INT298914 Regulation of Binding of RAB7A 1 0.58 1.2 0 5.00
194 INT234809 Phosphorylation of MYO5A 1 0.61 0.23 0 5.00
195 INT234812 Binding of AVPR2 1 0.17 0.55 0 5.00
196 INT298913 Regulation of Positive_regulation of RAB7A 1 0.42 1.12 0 5.00
197 INT298896 Positive_regulation of Localization of RAB7A 1 0.47 0.55 0 5.00
198 INT298885 Localization of LAMP2 1 0.31 1.02 0 5.00
199 INT298903 Negative_regulation of ARHGEF2 1 0.08 0.45 0 5.00
200 INT298895 Positive_regulation of RILP 1 0.33 0.42 0 5.00
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