D:Chromosomal Instability

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Disease Term
Synonyms Chromosomal Instabilities, CHROMOSOMAL STABILITIES, CHROMOSOMAL STABILITY, Chromosome Instabilities, Chromosome Instability, Chromosome Stabilities, CHROMOSOME STABILITY, Instabilities Chromosomal, Instabilities Chromosome, Instability Chromosomal, Instability Chromosome
Documents 53
Hot Single Events 76
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chromosomal Instability. They are ordered first by their relevance to Chromosomal Instability and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0 90.56
2 INT253011 Negative_regulation of Binding of PTTG1 and Zic2 1 0.01 0.41 0 84.20
3 INT253018 Binding of PTTG1 and Zic2 1 0.01 0.76 0 83.72
4 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0 80.80
5 INT186989 Binding of Akt1 and Tert 1 0.00 0.61 0 71.76
6 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 51.52
7 INT287893 VEGFA Positive_regulation of Localization of WISP1 1 0.03 1.23 0.1 51.52
8 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1 49.80
9 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05 49.80
10 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05 49.80
11 INT189956 TP53 Positive_regulation of Gene_expression of Pttg1 1 0.06 1.21 0 38.40
12 INT268398 Binding of LRP1 and Wnt2 1 0.01 0.36 0 33.64
13 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0 26.60
14 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0 22.48
15 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0 22.48
16 INT253004 Anapc1 Positive_regulation of Binding of Pttg1 1 0.47 0 0 22.08
17 INT253006 Anapc1 Positive_regulation of Protein_catabolism of Pttg1 1 0.51 0 0 22.08
18 INT278243 HGF Positive_regulation of Gene_expression of Hsdr1 1 0.00 0.4 0.06 20.08
19 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 5.00
20 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66 5.00
21 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65 5.00
22 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61 5.00
23 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53 5.00
24 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5 5.00
25 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5 5.00
26 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5 5.00
27 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5 5.00
28 INT189681 Negative_regulation of PRKCA Negative_regulation of Gene_expression of METTL3 1 0.00 0.16 0.41 5.00
29 INT189689 CHKB Negative_regulation of Positive_regulation of PRKCA 1 0.11 0 0.4 5.00
30 INT285935 IL6 Positive_regulation of Gene_expression of POU5F1 1 0.14 2.68 0.37 5.00
31 INT189687 INSRR Negative_regulation of Transcription of TERT 1 0.00 0.24 0.35 5.00
32 INT172004 IL17A Positive_regulation of Gene_expression of IL6 2 0.14 1.35 0.34 5.00
33 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
34 INT189692 INSRR Positive_regulation of PRKCA 1 0.00 0 0.24 5.00
35 INT189646 CHKB Negative_regulation of ASAP1 Negative_regulation of Gene_expression of DAG1 1 0.04 0 0.24 5.00
36 INT189674 CHKB Negative_regulation of ASAP1 1 0.08 0 0.24 5.00
37 INT189693 CHKB Positive_regulation of PRKCA 1 0.11 0 0.24 5.00
38 INT189670 CHKB Negative_regulation of Gene_expression of DAG1 1 0.11 0 0.24 5.00
39 INT189700 CHKB Negative_regulation of PRKCA 1 0.11 0 0.24 5.00
40 INT189645 CHKB Negative_regulation of ASAP1 Negative_regulation of PRKCA 1 0.04 0 0.24 5.00
41 INT285945 IL17A Regulation of IL6 1 0.13 1.22 0.2 5.00
42 INT189694 Negative_regulation of INSRR Negative_regulation of CHKB 1 0.00 0.07 0.15 5.00
43 INT189695 INSRR Negative_regulation of CHKB 1 0.00 0.07 0.15 5.00
44 INT189647 INSRR Negative_regulation of CHKB Regulation of Negative_regulation of PRKCA 1 0.00 0.07 0.15 5.00
45 INT287890 THEMIS Regulation of Gene_expression of EPHB2 1 0.00 0.87 0.14 5.00
46 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14 5.00
47 INT252902 PTTG1 Regulation of MMP2 1 0.01 1.5 0.14 5.00
48 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13 5.00
49 INT253015 Egf Regulation of PTTG1 1 0.02 0.44 0.13 5.00
50 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13 5.00
51 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13 5.00
52 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12 5.00
53 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12 5.00
54 INT285948 IL17A Regulation of Gene_expression of TERT 1 0.00 0.58 0.11 5.00
55 INT189702 CHKB Regulation of Gene_expression of TERT 1 0.06 0.55 0.1 5.00
56 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09 5.00
57 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
58 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
59 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08 5.00
60 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08 5.00
61 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08 5.00
62 INT189957 Binding of LDHA and Pttg1 1 0.05 0.35 0.08 5.00
63 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07 5.00
64 INT285938 IL6 Positive_regulation of Gene_expression of TEP1 1 0.01 1.05 0.07 5.00
65 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07 5.00
66 INT326125 Binding of CXCL3 and IL1RAPL1 1 0.01 1.16 0.05 5.00
67 INT189677 CHKB Regulation of Transcription of TERT 1 0.10 1 0.05 5.00
68 INT285947 IL6 Regulation of IL17A 1 0.08 0.44 0.05 5.00
69 INT189679 INSRR Regulation of Transcription of TERT 1 0.00 1 0.05 5.00
70 INT326128 Binding of CXCL3 and CXCL6 1 0.06 1.18 0.05 5.00
71 INT326127 Binding of CXCL3 and CXCR1 1 0.13 1.16 0.05 5.00
72 INT245219 Binding of C3AR1 and C5AR1 1 0.34 1.21 0.04 5.00
73 INT253023 Binding of PTTG1 and Myc 1 0.16 0.22 0.04 5.00
74 INT252897 Binding of PTTG1IP and PTTG1 1 0.04 0.15 0.04 5.00
75 INT189665 CHKB Regulation of Gene_expression of CCND3 1 0.03 0.42 0.04 5.00
76 INT252892 PTTG1IP Regulation of PTTG1 1 0.05 0.49 0.04 5.00
77 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 5.00
78 INT285936 IL17A Positive_regulation of Gene_expression of POU5F1 1 0.10 0.34 0.04 5.00
79 INT245216 Binding of C3 and C3AR1 1 0.19 1.21 0.04 5.00
80 INT285944 IL6 Positive_regulation of Gene_expression of TERT 1 0.01 0.36 0.04 5.00
81 INT253017 PTTG1IP Regulation of Regulation of Fgf2 1 0.03 0.49 0.04 5.00
82 INT245218 Binding of C3 and C5AR1 2 0.29 2.94 0.04 5.00
83 INT253010 Binding of PTTG1 and Fgf2 1 0.07 0.51 0.03 5.00
84 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
85 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0 5.00
86 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0 5.00
87 INT294091 Binding of PGF and VEGFA 1 0.02 1.21 0 5.00
88 INT286113 Binding of Fap and Rpe65 1 0.04 1.97 0 5.00
89 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 5.00
90 INT253003 Pttg1 Regulation of Gene_expression of Id3 1 0.08 0.07 0 5.00
91 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
92 INT351602 TXK Positive_regulation of ERBB2 1 0.02 0.58 0 5.00
93 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0 5.00
94 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0 5.00
95 INT326163 Binding of Racgap1 and RAB12 1 0.00 0.68 0 5.00
96 INT252910 PTTG1 Negative_regulation of Transcription of SLC5A5 1 0.02 0.36 0 5.00
97 INT189648 CCND3 Regulation of CHKB Regulation of INSRR 1 0.00 0.06 0 5.00
98 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 5.00
99 INT245041 Binding of Xrcc1 and APTX 1 0.41 0.38 0 5.00
100 INT186999 Binding of KIT and Gtf3a 1 0.00 0.25 0 5.00
101 INT189703 MZF1 Regulation of TERT 1 0.03 0.46 0 5.00
102 INT252886 PTTG1IP Positive_regulation of Binding of SLC5A5 and USF1 1 0.00 0.22 0 5.00
103 INT189678 Positive_regulation of CHKB Regulation of INSRR 1 0.00 0.06 0 5.00
104 INT285941 IL6 Regulation of Gene_expression of TERT 1 0.01 0.12 0 5.00
105 INT252887 PTTG1IP Positive_regulation of Binding of SLC5A5 and PAX8 1 0.01 0.22 0 5.00
106 INT326162 Binding of ABHD2 and Scrib 1 0.00 1.07 0 5.00
107 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0 5.00
108 INT313596 ESR1 Positive_regulation of Gene_expression of PGR 1 0.05 1 0 5.00
109 INT351604 TXK Positive_regulation of EGFR 1 0.02 1.78 0 5.00
110 INT190137 Binding of S100A12 and Gfap 1 0.00 0.65 0 5.00
111 INT252898 Binding of SLC5A5 and USF1 1 0.01 0.22 0 5.00
112 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0 5.00
113 INT285942 IL6 Regulation of Gene_expression of FUT4 1 0.18 0.17 0 5.00
114 INT253021 PTTG1 Regulation of Gene_expression of Fgf2 1 0.04 0.35 0 5.00
115 INT252906 Binding of SLC5A5 and PTTG1 1 0.01 0.69 0 5.00
116 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
117 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 5.00
118 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0 5.00
119 INT189686 CHKB Regulation of Negative_regulation of INSRR 1 0.00 0.46 0 5.00
120 INT253007 Igf1 Regulation of Gene_expression of PTTG1 1 0.03 0.46 0 5.00
121 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 5.00
122 INT252889 Binding of PTTG2 and PTTG3P 1 0.06 0.08 0 5.00
123 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0 5.00
124 INT294095 Binding of TXK and Gtf3a 1 0.00 2.33 0 5.00
125 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 5.00
126 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0 5.00
127 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0 5.00
128 INT268397 Binding of Kras and Regulation of ARAF 1 0.03 1.16 0 5.00
129 INT189705 INSRR Negative_regulation of Gene_expression of TERT 1 0.00 0.46 0 5.00
130 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0 5.00
131 INT286110 Binding of Rpe65 and Gopc 1 0.01 1.97 0 5.00
132 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 5.00
133 INT189697 INSRR Regulation of Gene_expression of TERT 1 0.00 0.46 0 5.00
134 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0 5.00
135 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0 5.00
136 INT287891 Binding of CDH1 and KRT20 1 0.00 0.5 0 5.00
137 INT278242 MSC Regulation of Gene_expression of Cd36 1 0.08 1.17 0 5.00
138 INT189690 USF1 Regulation of TERT 1 0.05 0.46 0 5.00
139 INT189683 CHKB Negative_regulation of Negative_regulation of INSRR 1 0.00 0.46 0 5.00
140 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0 5.00
141 INT285949 IL6 Positive_regulation of Gene_expression of IL17A 1 0.14 0.23 0 5.00
142 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0 5.00
143 INT252888 Binding of SLC5A5 and PAX8 1 0.02 0.22 0 5.00
144 INT189669 INSRR Regulation of TERT 1 0.00 0 0 5.00
145 INT189685 USF1 Positive_regulation of Transcription of TERT 1 0.05 0.27 0 5.00
146 INT301178 UCP2 Negative_regulation of ROS1 1 0.29 1.41 0 5.00
147 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 5.00
148 INT252905 PTTG1IP Negative_regulation of Transcription of SLC5A5 1 0.01 0.35 0 5.00
149 INT189698 CHKB Regulation of TERT 1 0.06 0 0 5.00
150 INT253014 Binding of XRCC5 and Zic2 1 0.00 0.14 0 5.00
151 INT253008 PTTG1 Regulation of Gene_expression of Id3 1 0.03 0.2 0 5.00
152 INT285946 IL6 Regulation of POU5F1 1 0.05 0.12 0 5.00
153 INT189673 BCL2 Positive_regulation of Transcription of TERT 1 0.09 0 0 5.00
154 INT252900 PTTG1 Regulation of Gene_expression of TAF9 1 0.20 0.84 0 5.00
155 INT324605 Binding of CEACAM7 and SNCG 1 0.39 4.68 0 5.00
156 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0 5.00
157 INT189676 CCND3 Regulation of Transcription of TERT 1 0.02 0.06 0 5.00
158 INT277136 Ebp Positive_regulation of Gene_expression of Mlh1 1 0.01 1.45 0 5.00
159 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0 5.00
160 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0 5.00
161 INT253016 Binding of PTTG1 and Id3 1 0.04 0.07 0 5.00
162 INT210493 Binding of HGF and TEP1 1 0.01 0.19 0 5.00
163 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 5.00
164 INT189672 Positive_regulation of INSRR Regulation of Transcription of TERT 1 0.00 0.23 0 5.00
165 INT245217 Binding of CREM and TFAM 1 0.00 1.44 0 5.00
166 INT189682 CHKB Negative_regulation of Gene_expression of TERT 1 0.10 0.46 0 5.00
167 INT252896 INS Regulation of Gene_expression of PTTG1 1 0.00 0.47 0 5.00
168 INT252904 Binding of PRKDC and XRCC5 1 0.00 0.14 0 5.00
169 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 5.00
170 INT268395 Binding of APC and Kras 1 0.04 1.21 0 5.00
171 INT189684 RNF2 Regulation of TERT 1 0.02 0.46 0 5.00
172 INT326165 Binding of ABHD12 and Scrib 1 0.00 1.01 0 5.00
173 INT285934 IL6 Regulation of FUT4 1 0.30 0.17 0 5.00
174 INT210494 Binding of EGF and TEP1 1 0.02 0.19 0 5.00
175 INT351603 Binding of ERBB2 and KDR 1 0.13 0.55 0 5.00
176 INT253013 Binding of PRKDC and Zic2 1 0.00 0.14 0 5.00
177 INT294087 Negative_regulation of Binding of ERBB2 and ERBB3 1 0.08 0.6 0 5.00
178 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0 5.00
179 INT252907 Binding of PTTG1 and PTTG2 1 0.07 0.08 0 5.00
180 INT252893 PTTG1 Positive_regulation of Gene_expression of TAF9 1 0.21 0.9 0 5.00
181 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0 5.00
182 INT326164 Binding of S100A2 and Scrib 1 0.01 1.16 0 5.00
183 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0 5.00
184 INT287874 Binding of TCF4 and TP53 1 0.02 0.54 0 5.00
185 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 5.00
186 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0 5.00
187 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 5.00
188 INT285937 IL6 Regulation of TERT 1 0.01 0.12 0 5.00
189 INT189667 INSRR Regulation of CHKB 1 0.00 0.06 0 5.00
190 INT253005 Binding of Zic2 and Pttg1 1 0.02 0.57 0 5.00
191 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
192 INT252903 PTTG1IP Regulation of Gene_expression of SLC5A5 1 0.00 0.43 0 5.00
193 INT245039 Binding of Xrcc1 and Tdp1 1 0.39 0.77 0 5.00
194 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
195 INT252908 Binding of PTTG3P and GOPC 1 0.01 0.08 0 5.00
196 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0 5.00
197 INT189706 CHKB Regulation of INSRR 1 0.00 0.06 0 5.00
198 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0 5.00
199 INT278229 MSC Positive_regulation of Gene_expression of ALB 1 0.06 0.3 0 5.00
200 INT252899 PTTG1 Regulation of Gene_expression of SLC5A5 1 0.01 0.43 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chromosomal Instability. They are ordered first by their pain relevance and then by number of times they were reported in Chromosomal Instability. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT82798 Regulation of MYC 19 0.60 12.06 2.31 99.92
2 INT252944 Positive_regulation of Pttg1 1 0.46 2.53 0 99.80
3 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 99.50
4 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57 99.44
5 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 99.44
6 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.34
7 INT189948 Gene_expression of Pttg1 106 0.76 104.68 1.41 99.24
8 INT189946 Positive_regulation of Gene_expression of Pttg1 14 0.68 23.72 0.38 99.24
9 INT242821 Negative_regulation of Localization of Fap 1 0.11 1.91 0 99.22
10 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 99.06
11 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 98.96
12 INT242820 Localization of Fap 1 0.20 1.9 0 98.80
13 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84 98.68
14 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 98.02
15 INT252938 Phosphorylation of Pttg1 1 0.75 1.11 0 97.88
16 INT324609 Negative_regulation of Gene_expression of SNCG 1 0.43 5.2 0 97.12
17 INT234676 Gene_expression of SNCG 4 0.78 63.59 0.08 96.84
18 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 96.84
19 INT324607 Positive_regulation of Gene_expression of SNCG 1 0.61 10.34 0 96.84
20 INT252942 Phosphorylation of Chek1 1 0.14 0.63 0 96.76
21 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79 95.56
22 INT234186 Localization of BRCA2 2 0.69 1.48 0.07 95.56
23 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 95.48
24 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 95.48
25 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 95.48
26 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 95.48
27 INT221268 Localization of BRCA1 7 0.63 4.83 0.18 95.20
28 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68 93.88
29 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 93.60
30 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05 93.60
31 INT120717 Positive_regulation of TEP1 50 0.63 27.94 2.81 93.48
32 INT242823 Binding of CTNND2 1 0.36 6 0 93.44
33 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 92.72
34 INT186980 Transcription of Tert 1 0.34 0.34 0.11 92.16
35 INT186973 Regulation of Transcription of Tert 1 0.21 0.34 0.11 92.16
36 INT179885 Regulation of PTEN 8 0.26 11.88 2.18 92.08
37 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37 92.08
38 INT282953 Regulation of MSI1 2 0.03 1.63 0.03 92.08
39 INT236621 Regulation of KRAS 7 0.53 6.16 0 92.08
40 INT198037 Regulation of PIK3CA 2 0.28 2.63 0 92.08
41 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 91.80
42 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 90.36
43 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 90.36
44 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51 90.36
45 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 89.68
46 INT189943 Negative_regulation of Pttg1 2 0.53 5.8 0 89.60
47 INT186977 Gene_expression of Tert 1 0.36 1.49 0.05 89.12
48 INT350588 Negative_regulation of Mlh1 1 0.38 3.05 0 89.04
49 INT86368 Gene_expression of TEP1 31 0.50 16.36 1.63 88.96
50 INT268842 Negative_regulation of Pitpnc1 1 0.06 0.52 0 88.32
51 INT189944 Negative_regulation of Gene_expression of Pttg1 4 0.42 4.53 0 88.20
52 INT154805 Gene_expression of Polymerase 13 0.16 4.4 0.65 87.60
53 INT252948 Positive_regulation of Protein_catabolism of Pttg1 1 0.63 0.09 0 87.44
54 INT252952 Protein_catabolism of Pttg1 1 0.91 0.09 0 87.44
55 INT188001 Phosphorylation of H2afx 10 0.80 5.6 0.04 87.40
56 INT252949 Negative_regulation of Negative_regulation of Pttg1 1 0.39 0.34 0 86.96
57 INT268379 Gene_expression of ARAF 22 0.16 9.34 1.07 86.80
58 INT268371 Positive_regulation of Gene_expression of ARAF 1 0.12 1.4 0 86.80
59 INT28122 Gene_expression of MSC 111 0.58 26.83 6.57 86.52
60 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 86.32
61 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 86.04
62 INT268380 Positive_regulation of Positive_regulation of ARAF 3 0.12 3.49 0.25 85.32
63 INT268386 Positive_regulation of ARAF 6 0.17 4.84 0.33 84.88
64 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 84.72
65 INT60585 Regulation of TP53 59 0.59 54.55 5.21 84.72
66 INT9144 Localization of MSC 18 0.56 10.17 3.69 83.36
67 INT3818 Regulation of Apc 13 0.39 12.52 1.68 83.24
68 INT117563 Negative_regulation of Gene_expression of SMAD4 6 0.54 3.87 0 82.92
69 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69 82.92
70 INT38916 Positive_regulation of Tert 3 0.33 1.92 1.28 82.32
71 INT186978 Positive_regulation of Positive_regulation of Tert 1 0.22 0.44 0 82.32
72 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 82.24
73 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 81.32
74 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37 81.32
75 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 80.68
76 INT203687 Positive_regulation of H2afx 3 0.40 1.87 0 80.12
77 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 79.96
78 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 79.96
79 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 79.52
80 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 79.52
81 INT98901 Binding of Acta2 2 0.07 1.08 0.26 79.12
82 INT338716 Negative_regulation of SUZ12 1 0.08 0.78 0 78.56
83 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25 78.32
84 INT186988 Negative_regulation of Gene_expression of Tert 1 0.27 1.06 0 78.16
85 INT8103 Binding of TP53 46 0.44 40.2 2.96 77.92
86 INT113348 Negative_regulation of Binding of TP53 2 0.28 1.49 0 77.92
87 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1 77.60
88 INT100360 Negative_regulation of TF 19 0.42 10.43 2.68 77.56
89 INT338715 Negative_regulation of CYP4V2 1 0.00 0.39 0 77.56
90 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 77.52
91 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 76.96
92 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 76.72
93 INT185193 Positive_regulation of DCD 2 0.04 2.58 0.39 76.28
94 INT252966 Negative_regulation of Gene_expression of PTTG1 1 0.23 2.7 0.03 76.00
95 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17 75.68
96 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 75.56
97 INT286102 Positive_regulation of Fap 5 0.30 8.58 0.04 75.44
98 INT59137 Protein_catabolism of CTSB 5 0.96 3.92 0.62 75.44
99 INT115307 Gene_expression of Abcg2 3 0.75 1.37 0.88 74.72
100 INT186984 Negative_regulation of Gene_expression of Abcg2 1 0.29 0.49 0.26 74.72
101 INT268383 Gene_expression of MUTYH 1 0.46 2.56 0 74.40
102 INT268374 Gene_expression of FAP 2 0.37 6.6 0 74.40
103 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 74.32
104 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 74.32
105 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 74.28
106 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 72.24
107 INT268848 Localization of Pitpnc1 1 0.11 0.46 0 71.92
108 INT186976 Binding of Tert 1 0.17 0.55 0 71.76
109 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 70.56
110 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 70.52
111 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 70.32
112 INT220177 Binding of Apc 21 0.37 15.34 1.37 69.76
113 INT116836 Binding of FAP 6 0.37 6.76 1.47 69.52
114 INT186986 Negative_regulation of Tert 1 0.27 0.61 0 68.80
115 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 67.44
116 INT256127 Gene_expression of Hist2h4 2 0.02 1.59 0.18 66.80
117 INT210506 Negative_regulation of Positive_regulation of TEP1 3 0.28 1.76 0.08 66.28
118 INT63121 Binding of APC 29 0.41 23.02 3.8 63.20
119 INT289861 Negative_regulation of ECT2 1 0.26 1.3 0 63.12
120 INT3557 Positive_regulation of C1S 10 0.67 8.73 0.54 62.96
121 INT289872 Negative_regulation of Gene_expression of ECT2 1 0.26 0.71 0 62.48
122 INT268847 Binding of Top2a 2 0.24 0.6 0 61.76
123 INT268845 Positive_regulation of Binding of Top2a 1 0.05 0.33 0 61.76
124 INT201547 Gene_expression of ERI3 4 0.20 2.19 0 61.68
125 INT350584 Negative_regulation of Gene_expression of Mlh1 1 0.51 2.21 0 61.32
126 INT190039 Gene_expression of Mlh1 3 0.68 6.14 0 61.00
127 INT289868 Gene_expression of ECT2 1 0.42 0.7 0 60.88
128 INT318449 Gene_expression of Mir21 18 0.37 11.92 1.46 58.32
129 INT355903 Positive_regulation of Gene_expression of MIR10B 1 0.01 2.9 0 58.32
130 INT355905 Gene_expression of MIR10B 1 0.02 4.9 0 58.32
131 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 57.28
132 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 57.28
133 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 56.08
134 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 55.36
135 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 55.28
136 INT102816 Positive_regulation of TCEAL1 6 0.37 7.08 0.96 54.80
137 INT189954 Negative_regulation of Positive_regulation of TCEAL1 2 0.07 2.03 0.04 54.80
138 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 54.76
139 INT201859 Positive_regulation of Gene_expression of DNMT1 4 0.60 6.43 0.75 54.76
140 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 54.72
141 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 54.32
142 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22 54.32
143 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57 54.32
144 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 53.76
145 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55 53.68
146 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 53.36
147 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 53.36
148 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 53.36
149 INT253000 Negative_regulation of Binding of NFYA 1 0.01 0.34 0 53.16
150 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 53.04
151 INT201846 Positive_regulation of SFRP4 4 0.37 2.74 0.54 52.80
152 INT201858 Gene_expression of SFRP4 3 0.48 4.91 0.51 52.80
153 INT182428 Binding of NFYA 2 0.02 0.43 0 52.64
154 INT121494 Transcription of TERT 64 0.69 10.03 5.55 52.36
155 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 52.24
156 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05 52.24
157 INT268846 Negative_regulation of Top2a 6 0.29 3.06 0.07 51.92
158 INT304053 Gene_expression of KIAA1324 1 0.18 0.98 0 51.68
159 INT304064 Positive_regulation of KIAA1324 1 0.14 0.98 0 51.68
160 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 51.40
161 INT206869 Gene_expression of ALDH1A2 3 0.38 2.51 0.16 51.04
162 INT304063 Positive_regulation of ALDH1A2 1 0.29 0.97 0 51.04
163 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 50.16
164 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 50.08
165 INT161382 Localization of KRT20 25 0.61 12.97 2.13 49.24
166 INT287912 Localization of BMP4 1 0.18 1.13 0.1 49.24
167 INT173650 Localization of WISP1 2 0.15 0.65 0.05 49.24
168 INT97473 Positive_regulation of FAP 4 0.34 2.72 0.18 47.08
169 INT256114 Gene_expression of Sirt2 1 0.19 1.7 0.03 46.84
170 INT94896 Regulation of TEP1 12 0.39 8.04 0.69 44.04
171 INT13907 Gene_expression of SCLC1 16 0.59 16.58 1.89 43.60
172 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0 41.84
173 INT5320 Gene_expression of PTGFR 18 0.59 12.99 3.7 41.36
174 INT22110 Positive_regulation of Gene_expression of PTGFR 3 0.23 2.45 0.56 41.36
175 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 40.72
176 INT188050 Regulation of Gene_expression of Wnt2 9 0.37 3.13 0.44 40.72
177 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 39.88
178 INT268392 Regulation of Positive_regulation of Wnt2 2 0.09 0.87 0.18 39.44
179 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 39.36
180 INT232505 Regulation of Gene_expression of PROM1 3 0.27 2.12 0.11 39.36
181 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 38.96
182 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 38.40
183 INT252975 Positive_regulation of Gene_expression of PTTG1 36 0.28 31.96 0.74 38.04
184 INT256119 Localization of Sirt3 1 0.35 0.18 0 37.92
185 INT214067 Regulation of Scrib 11 0.20 12.48 0.45 37.20
186 INT256120 Localization of Sirt5 1 0.47 3.81 0.13 37.20
187 INT201524 Localization of Wnt2 14 0.62 9.24 0.46 37.00
188 INT242157 Regulation of Localization of Wnt2 3 0.37 1.08 0.11 37.00
189 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 35.92
190 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 35.92
191 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 35.92
192 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69 35.92
193 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 35.92
194 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76 35.92
195 INT230980 Positive_regulation of THY1 5 0.18 2.15 0.41 35.92
196 INT199656 Binding of Pnkp 1 0.07 1.36 0.07 35.52
197 INT225667 Transcription of Apc 3 0.52 3.73 0.32 34.88
198 INT71649 Localization of ERBB2 23 0.78 13.63 0.83 34.12
199 INT199084 Gene_expression of Cd36 31 0.53 16.94 1.94 33.88
200 INT216377 Transcription of POU5F1 9 0.69 0.58 0.05 33.72
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