D:Chronic Hepatitis C

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Disease Term
Synonyms None
Documents 6
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Hepatitis C. They are ordered first by their relevance to Chronic Hepatitis C and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT342439 PPP2CA Negative_regulation of PRMT1 1 0.12 0.63 0 50.00
2 INT87808 Binding of Gpt and HCC 3 0.04 5.09 0.07 41.28
3 INT294445 KLK4 Negative_regulation of COL1A1 1 0.01 0 0.1 24.56
4 INT294457 KLK4 Negative_regulation of MMP2 1 0.01 0 0.1 23.60
5 INT294456 KLK4 Negative_regulation of SERPINB2 1 0.01 0 0.1 23.12
6 INT294446 KLK4 Negative_regulation of HAS2 1 0.01 0 0.1 22.64
7 INT294448 KLK4 Negative_regulation of CTGF 1 0.01 0 0.1 22.16
8 INT294449 KLK4 Negative_regulation of MMP9 1 0.01 0 0.1 21.68
9 INT294455 KLK4 Negative_regulation of HIF1A 1 0.01 0 0.1 21.20
10 INT294454 KLK4 Negative_regulation of PTGS2 1 0.01 0 0.1 20.64
11 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1 20.08
12 INT294450 KLK4 Negative_regulation of SERPINE1 1 0.01 0 0.1 19.52
13 INT294451 KLK4 Negative_regulation of IL8 1 0.01 0 0.1 17.52
14 INT294440 KLK4 Negative_regulation of LIF 1 0.00 0 0.1 17.52
15 INT294441 KLK4 Negative_regulation of CXCR4 1 0.01 0 0.1 17.52
16 INT294452 KLK4 Negative_regulation of CCL4 1 0.00 0 0.1 17.52
17 INT294438 KLK4 Negative_regulation of IL1A 1 0.00 0 0.1 17.52
18 INT294437 KLK4 Negative_regulation of CXCL1 1 0.00 0 0.1 17.52
19 INT294453 KLK4 Negative_regulation of CCL2 1 0.00 0 0.1 17.52
20 INT294442 KLK4 Negative_regulation of IL6 1 0.00 0 0.1 17.52
21 INT294443 KLK4 Negative_regulation of CXCL5 1 0.00 0 0.1 17.52
22 INT294444 KLK4 Negative_regulation of CCL3 1 0.00 0 0.1 17.52
23 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 5.00
24 INT345421 IFNA1 Positive_regulation of Eif2ak2 2 0.03 1.25 0.3 5.00
25 INT212584 IFNA1 Regulation of Gene_expression of CD4 1 0.21 0.98 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Hepatitis C. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Hepatitis C. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.20
2 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 97.96
3 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 97.20
4 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 97.16
5 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 94.56
6 INT11649 Negative_regulation of Positive_regulation of Gpt 25 0.59 13.94 10.87 94.12
7 INT22213 Localization of Gpt 52 0.78 34.05 12.94 91.56
8 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 91.44
9 INT56598 Transcription of Gpt 4 0.34 1.65 0.5 87.44
10 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 81.08
11 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 79.32
12 INT75831 Positive_regulation of Transcription of IL8 21 0.63 13.56 4.98 79.32
13 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 79.00
14 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 79.00
15 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 79.00
16 INT52107 Transcription of IL8 63 0.72 41.66 16.06 79.00
17 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 75.76
18 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 75.00
19 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 74.56
20 INT294470 Transcription of IHH 1 0.16 0.28 0.03 70.88
21 INT38303 Binding of Gpt 21 0.47 15.84 3.43 70.84
22 INT294469 Transcription of THBS1 2 0.66 0.46 0.03 70.16
23 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67 69.60
24 INT188319 Regulation of Negative_regulation of Gpt 2 0.09 1.91 0.21 66.92
25 INT278241 Regulation of IHH 2 0.31 1.16 0.14 64.72
26 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 63.92
27 INT10835 Regulation of IL8 79 0.49 53.04 24.14 63.92
28 INT15246 Regulation of FOS 32 0.60 15.34 12.94 63.92
29 INT75497 Regulation of JUN 28 0.61 11.04 7.09 63.92
30 INT11634 Regulation of SERPINE1 24 0.62 20.06 4.26 63.92
31 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 63.92
32 INT99767 Regulation of THBS1 18 0.42 11.51 1.03 63.92
33 INT294468 Regulation of URGCP 1 0.00 0.2 0.04 63.92
34 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 50.00
35 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 50.00
36 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 50.00
37 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 50.00
38 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 50.00
39 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46 50.00
40 INT38118 Negative_regulation of Positive_regulation of IFNA1 8 0.43 3.95 2.04 50.00
41 INT89308 Positive_regulation of Binding of IFNA1 12 0.49 10.64 2.04 50.00
42 INT183753 Regulation of HBM 24 0.39 13.13 1.79 50.00
43 INT121820 Binding of STAT1 9 0.46 2.54 1.4 50.00
44 INT8482 Positive_regulation of PIAS1 2 0.40 0.73 1.12 50.00
45 INT51089 Negative_regulation of PRMT1 3 0.24 1.18 0.98 50.00
46 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97 50.00
47 INT128424 Transcription of STAT1 5 0.37 3.28 0.9 50.00
48 INT77364 Positive_regulation of Negative_regulation of IFNA1 6 0.30 3.68 0.36 50.00
49 INT206142 Localization of STAT1 7 0.78 3.09 0.31 50.00
50 INT121817 Positive_regulation of Binding of STAT1 2 0.67 0.49 0.3 50.00
51 INT206148 Positive_regulation of Transcription of STAT1 2 0.21 0.72 0.06 50.00
52 INT341094 Gene_expression of B4GALT1 4 0.05 0.54 0.05 50.00
53 INT342438 Positive_regulation of Nr2e3 1 0.04 0.31 0 50.00
54 INT342452 Gene_expression of PPP2CA 1 0.20 0.49 0 50.00
55 INT342450 Positive_regulation of PPP2CA 1 0.15 1.07 0 50.00
56 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99 42.76
57 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87 42.76
58 INT40753 Gene_expression of GLI1 9 0.75 5.98 0.33 42.76
59 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21 42.76
60 INT294471 Gene_expression of GLI4 1 0.48 0.94 0.08 42.76
61 INT183069 Gene_expression of DHH 2 0.50 0.87 0.06 42.76
62 INT294473 Gene_expression of GLI3 1 0.37 0.63 0.03 42.76
63 INT294467 Transcription of DHH 1 0.32 0.45 0 32.04
64 INT294466 Positive_regulation of Rplp0 1 0.49 0 0 28.96
65 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 18.24
66 INT212597 Positive_regulation of Phosphorylation of IMPDH1 1 0.04 0.87 0.07 12.52
67 INT212587 Phosphorylation of IMPDH1 1 0.06 0.87 0.07 12.12
68 INT212593 Negative_regulation of IMPDH1 4 0.10 3.01 0.07 9.08
69 INT212589 Positive_regulation of Positive_regulation of POLG2 1 0.04 0.84 0.07 8.04
70 INT212588 Positive_regulation of POLG2 1 0.04 0.84 0.07 7.48
71 INT287187 Regulation of TBP 3 0.13 2.42 0 7.44
72 INT294465 Regulation of Rplp0 1 0.26 0.48 0 7.44
73 INT212595 Regulation of POLG2 1 0.05 0.84 0.07 7.08
74 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
75 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
76 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
77 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
78 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
79 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
80 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
81 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 5.00
82 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
83 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
84 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
85 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
86 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
87 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
88 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
89 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
90 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
91 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
92 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
93 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
94 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
95 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
96 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
97 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
98 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 5.00
99 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
100 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 5.00
101 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
102 INT108628 Regulation of MMP2 27 0.60 14.85 6.06 5.00
103 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96 5.00
104 INT139329 Phosphorylation of IFNA1 24 0.79 16.19 5.95 5.00
105 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
106 INT114311 Negative_regulation of Gene_expression of Gpt 33 0.38 17.83 4.94 5.00
107 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 5.00
108 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
109 INT45503 Binding of EPO 42 0.48 24.85 2.88 5.00
110 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 5.00
111 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 5.00
112 INT49556 Gene_expression of NOLC1 11 0.49 29.44 1.07 5.00
113 INT182211 Transcription of CXCR4 5 0.69 3.8 0.95 5.00
114 INT105697 Negative_regulation of KLK4 7 0.43 2.78 0.93 5.00
115 INT87240 Gene_expression of Aggf1 14 0.11 8.41 0.93 5.00
116 INT178209 Negative_regulation of Binding of IFNA1 7 0.39 4.8 0.89 5.00
117 INT81795 Negative_regulation of AGRP 23 0.41 10.93 0.87 5.00
118 INT240781 Negative_regulation of HGFAC 3 0.01 3.93 0.8 5.00
119 INT17051 Regulation of SERPINB2 2 0.41 2.41 0.74 5.00
120 INT316729 Positive_regulation of Phosphorylation of IFNA1 2 0.49 1.86 0.72 5.00
121 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59 5.00
122 INT9207 Negative_regulation of SERPINB2 2 0.38 2.34 0.51 5.00
123 INT212596 Positive_regulation of NOLC1 3 0.37 4.7 0.51 5.00
124 INT129012 Positive_regulation of Il28b 2 0.34 1.59 0.44 5.00
125 INT49557 Transcription of NOLC1 4 0.02 16.54 0.38 5.00
126 INT268558 Regulation of CTGF 5 0.23 4.7 0.37 5.00
127 INT98203 Negative_regulation of KRAS 5 0.42 2.38 0.34 5.00
128 INT294475 Regulation of HAS2 1 0.07 2.03 0.33 5.00
129 INT212592 Regulation of Binding of CD4 2 0.30 1.15 0.3 5.00
130 INT294474 Negative_regulation of HAS2 1 0.25 1.87 0.29 5.00
131 INT294476 Negative_regulation of CTGF 1 0.27 1.86 0.29 5.00
132 INT169582 Phosphorylation of POLG 2 0.54 1.98 0.18 5.00
133 INT345415 Positive_regulation of Cltc 1 0.11 1.06 0.17 5.00
134 INT114901 Binding of TBP 6 0.17 2.45 0.11 5.00
135 INT212591 Phosphorylation of AGRP 2 0.30 3.02 0.03 5.00
136 INT212594 Positive_regulation of Phosphorylation of polymerase 1 0.01 0.83 0 5.00
137 INT212586 Phosphorylation of polymerase 3 0.08 2.64 0 5.00
138 INT294464 Binding of Rplp0 1 0.36 0.73 0 5.00
139 INT279346 Regulation of Binding of IFNA1 3 0.31 3.3 0 5.00
140 INT212590 Negative_regulation of Negative_regulation of IMPDH1 1 0.04 1.42 0 5.00
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