D:Chronic Lymphoid Leukemia

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Disease Term
Synonyms B CELL CHRONIC LYMPHOCYTIC LEUKAEMIA, B Cell Chronic Lymphocytic Leukemia, B CELL TYPE CHRONIC LYMPHOCYTIC LEUKAEMIA, B CELL TYPE CHRONIC LYMPHOCYTIC LEUKEMIA, Chronic Lymphatic Leukaemia, CHRONIC LYMPHATIC LEUKEMIA, Chronic Lymphoblastic Leukaemia, Chronic Lymphoblastic Leukemia, Chronic Lymphocytic Leukaemia, Chronic Lymphocytic Leukemia, CHRONIC LYMPHOGENOUS LEUKAEMIA
Documents 306
Hot Single Events 200
Hot Interactions 28

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Lymphoid Leukemia. They are ordered first by their relevance to Chronic Lymphoid Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 0.00 0.68 0 99.92
2 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03 99.84
3 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 99.52
4 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 99.52
5 INT298683 ecs Positive_regulation of Gene_expression of VEGFA 1 0.02 1.41 0.04 99.40
6 INT289099 KCNA1 Positive_regulation of Gene_expression of FZD5 1 0.00 0.84 0 99.08
7 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 0.00 0.44 0 98.36
8 INT347957 Binding of PTPRC and Cxcr4 1 0.39 0.37 0 97.92
9 INT289098 KCNA1 Regulation of LEF1 1 0.00 0.67 0 97.64
10 INT217139 Binding of MIR103A2 and MIR107 1 0.06 0.83 0 97.28
11 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 97.20
12 INT217150 MIR16-2 Regulation of BCL2 2 0.09 1.89 0 93.44
13 INT217141 Binding of BCL2 and MIR15B 1 0.21 1.26 0 93.16
14 INT268516 Gene_expression of MIR16-2 Positive_regulation of Gene_expression of BCL2 1 0.00 1.15 0 92.92
15 INT217146 Binding of BCL2 and MIR16-2 1 0.12 1.25 0 92.72
16 INT217137 MIR15B Regulation of BCL2 2 0.15 1.88 0 92.56
17 INT217781 Binding of MITF and TP53 1 0.00 1.2 0 91.56
18 INT217784 Binding of MITF and TSC1 1 0.00 1.21 0 91.56
19 INT217145 Gene_expression of MIR26B Negative_regulation of Gene_expression of MCL1 1 0.10 1 0 90.96
20 INT217143 MIR29A Regulation of Gene_expression of MCL1 1 0.24 1 0 87.20
21 INT139782 PRSS53 Negative_regulation of Positive_regulation of ASNA1 1 0.01 0.91 0.11 86.76
22 INT211993 Binding of Ppara and Rorb 1 0.00 1.13 0.54 85.28
23 INT107425 Binding of ST3GAL4 and IFNK 1 0.08 1.12 0.17 83.08
24 INT139790 PRSS53 Negative_regulation of Phosphorylation of NFKBIA 1 0.01 0.9 0.11 81.08
25 INT139784 PRSS53 Negative_regulation of Positive_regulation of NFKB1 1 0.09 0.9 0.11 81.08
26 INT217776 TP53 Regulation of MITF 1 0.00 1.28 0 80.56
27 INT217774 TP53 Regulation of TSC1 1 0.02 1.28 0 80.56
28 INT139787 Negative_regulation of TNFAIP8 Positive_regulation of IKBKG 1 0.10 0.89 0.11 80.28
29 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35 79.84
30 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35 79.84
31 INT139783 TNFAIP8 Positive_regulation of IKBKG 1 0.12 0.88 0.11 79.84
32 INT139786 TNFAIP8 Positive_regulation of Phosphorylation of IKBKG 1 0.12 0.89 0.11 79.84
33 INT139789 TNFAIP8 Positive_regulation of Phosphorylation of NFKBIA 1 0.02 0.89 0.11 79.84
34 INT139788 TNFAIP8 Positive_regulation of NFKBIA 1 0.01 0.88 0.11 79.84
35 INT139792 TNFAIP8 Positive_regulation of Protein_catabolism of IKBKG 1 0.12 0.89 0.11 79.84
36 INT139785 TNFAIP8 Positive_regulation of Positive_regulation of NFKB1 1 0.19 0.89 0.11 79.84
37 INT217786 TSC1 Regulation of MITF 1 0.00 1.27 0 79.68
38 INT217136 Negative_regulation of MIR221 Negative_regulation of Gene_expression of KIT 1 0.18 0.74 0 77.88
39 INT217138 Negative_regulation of MIR222 Negative_regulation of Gene_expression of KIT 1 0.16 0.74 0 77.88
40 INT198022 AKT1 Regulation of Gene_expression of MCL1 1 0.15 2.25 0 75.44
41 INT198020 PIK3CA Regulation of Gene_expression of MCL1 1 0.16 2.25 0 75.44
42 INT81998 Binding of F13A1 and F8 1 0.00 0.47 0.09 75.36
43 INT76761 Kctd1 Negative_regulation of RFFL 1 0.00 0.5 0.63 75.00
44 INT337092 Binding of HRES1 and Gtf3a 1 0.00 1.52 0 73.88
45 INT139791 PRSS53 Negative_regulation of NFKB1 1 0.09 0.71 0.13 72.84
46 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 67.28
47 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 67.28
48 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33 50.88
49 INT217149 MIR20A Regulation of Gene_expression of E2F1 1 0.19 0.86 0 49.04
50 INT217147 MIR17 Regulation of Gene_expression of E2F1 1 0.20 0.85 0 49.04
51 INT268510 PDCD4 Regulation of MIR21 1 0.01 1.17 0 48.32
52 INT198005 Binding of BID and MCL1 1 0.24 2.04 0 45.36
53 INT217787 Binding of TP53 and MIR208A 1 0.21 0.5 0 43.84
54 INT197999 Binding of BCL2 and MCL1 Negative_regulation of C12orf65 1 0.00 1.21 0 36.80
55 INT198021 Binding of BCL2 and MCL1 1 0.17 2.88 0 36.80
56 INT198015 Binding of BAK1 and MCL1 1 0.26 5.16 0 35.12
57 INT305632 Binding of BCL6 and MME 1 0.00 1.37 0 34.80
58 INT315054 TP53 Positive_regulation of MIR34A 1 0.02 0.47 0 32.64
59 INT198004 MCL1 Negative_regulation of C12orf65 1 0.01 1.12 0 30.96
60 INT340395 Binding of Bax and Tg(CAG-EGFP)D4Nagy 1 0.02 0.43 0.07 27.68
61 INT268595 Gene_expression of Mirlet7a-1 Negative_regulation of RASGRP1 1 0.00 0.59 0 25.80
62 INT278771 OR51S1 Negative_regulation of Gene_expression of RAP1A 1 0.01 0.22 0 21.28
63 INT278748 HOXA9 Negative_regulation of Gene_expression of RAP1A 1 0.38 0.44 0 20.88
64 INT278768 NUP98 Negative_regulation of Gene_expression of RAP1A 1 0.41 0.44 0 20.40
65 INT278772 NUP98 Regulation of HOXA9 1 0.42 0 0 15.80
66 INT278755 OR51S1 Regulation of NUP98 1 0.00 0 0 15.80
67 INT278750 HOXA9 Regulation of NUP98 1 0.11 0 0 15.80
68 INT278751 OR51S1 Regulation of HOXA9 1 0.00 0 0 15.80
69 INT278776 NUP98 Regulation of OR51S1 1 0.01 0 0 15.80
70 INT278754 HOXA9 Regulation of OR51S1 1 0.01 0 0 15.80
71 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 11.12
72 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04 11.12
73 INT217773 MIR208A Regulation of Gene_expression of RASGRP1 1 0.06 0.2 0 9.44
74 INT217783 MIR208A Regulation of Gene_expression of MAP3K3 1 0.26 0.2 0 9.44
75 INT268517 MYC Regulation of CTGF 1 0.03 0.92 0 9.36
76 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0 9.36
77 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55 8.88
78 INT337087 Negative_regulation of Binding of Mif and Cops5 1 0.13 1.64 0.08 8.88
79 INT337088 Binding of Mif and Cops5 1 0.12 1.63 0.08 8.88
80 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08 8.88
81 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0 8.80
82 INT217779 POLR2B Regulation of Gene_expression of RASGRP1 1 0.01 0.2 0 8.28
83 INT217785 POLR2B Regulation of Gene_expression of MAP3K3 1 0.06 0.2 0 8.28
84 INT217778 MAP3K3 Regulation of Gene_expression of RASGRP1 1 0.09 0.19 0 8.28
85 INT217777 EIF4E Regulation of Gene_expression of MAP3K3 1 0.05 0.19 0 8.28
86 INT217790 EIF4E Regulation of Gene_expression of RASGRP1 1 0.01 0.19 0 8.28
87 INT217775 CCNL1 Regulation of Gene_expression of RASGRP1 1 0.04 0.25 0 8.28
88 INT217789 CCNL1 Regulation of Gene_expression of MAP3K3 1 0.19 0.25 0 8.28
89 INT278760 EPO Positive_regulation of RAP1A 1 0.13 0.16 0 7.04
90 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25 5.00
91 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 5.00
92 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
93 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
94 INT307100 Trpv1 Regulation of Binding of Trpa1 1 0.31 1.81 0.97 5.00
95 INT307103 Trpa1 Regulation of Binding of Trpv1 1 0.31 1.81 0.97 5.00
96 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7 5.00
97 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67 5.00
98 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59 5.00
99 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58 5.00
100 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57 5.00
101 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
102 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
103 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
104 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
105 INT241853 Binding of SLC40A1 and HAMP 3 0.41 5.35 0.43 5.00
106 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39 5.00
107 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35 5.00
108 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33 5.00
109 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33 5.00
110 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
111 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3 5.00
112 INT337085 Binding of Cxcr4 and Mif 1 0.21 1.89 0.3 5.00
113 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29 5.00
114 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
115 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26 5.00
116 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26 5.00
117 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26 5.00
118 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26 5.00
119 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25 5.00
120 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25 5.00
121 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25 5.00
122 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 5.00
123 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21 5.00
124 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
125 INT342057 Binding of gr and Esrrb 1 0.00 0 0.2 5.00
126 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19 5.00
127 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19 5.00
128 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
129 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
130 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18 5.00
131 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18 5.00
132 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
133 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18 5.00
134 INT205712 CAMP Positive_regulation of Localization of Il1 1 0.00 0.32 0.14 5.00
135 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14 5.00
136 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
137 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
138 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
139 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11 5.00
140 INT205709 CAMP Positive_regulation of Positive_regulation of Casp1 1 0.00 0.27 0.11 5.00
141 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
142 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 5.00
143 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
144 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09 5.00
145 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09 5.00
146 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09 5.00
147 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08 5.00
148 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08 5.00
149 INT337090 Mif Positive_regulation of Gene_expression of Mapk1 1 0.10 1.11 0.08 5.00
150 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08 5.00
151 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08 5.00
152 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08 5.00
153 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08 5.00
154 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
155 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
156 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
157 INT276384 Binding of Mirlet7a-1 and MIR9-1 1 0.39 1.12 0.08 5.00
158 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
159 INT340401 Positive_regulation of Bax Positive_regulation of Binding of Hrk 1 0.01 0.79 0.07 5.00
160 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
161 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07 5.00
162 INT329839 Negative_regulation of Tnfsf13b Negative_regulation of Gene_expression of Ighm 1 0.05 2.28 0.06 5.00
163 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 5.00
164 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
165 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05 5.00
166 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 5.00
167 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 5.00
168 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
169 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04 5.00
170 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04 5.00
171 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04 5.00
172 INT205862 CNTN2 Positive_regulation of TNF 1 0.01 0.08 0.04 5.00
173 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04 5.00
174 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04 5.00
175 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
176 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04 5.00
177 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04 5.00
178 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04 5.00
179 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04 5.00
180 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 5.00
181 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03 5.00
182 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03 5.00
183 INT192167 Negative_regulation of Binding of BAK1 and BCL2 2 0.05 1.89 0.03 5.00
184 INT192164 Binding of BAK1 and BCL2 3 0.04 2.8 0.03 5.00
185 INT315066 AKT1 Negative_regulation of PAR4 1 0.39 1.8 0.03 5.00
186 INT280569 Binding of GEM and HIVEP1 1 0.00 1.59 0.03 5.00
187 INT237921 ROS1 Positive_regulation of TNFRSF10B 1 0.08 1.24 0.03 5.00
188 INT217148 MIR21 Regulation of BCL2 1 0.32 0.98 0.03 5.00
189 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03 5.00
190 INT280601 Binding of HIVEP1 and Dbi 1 0.00 1.57 0.03 5.00
191 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03 5.00
192 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03 5.00
193 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03 5.00
194 INT237920 PPARA Negative_regulation of STAT3 1 0.16 0.91 0.03 5.00
195 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03 5.00
196 INT197998 KDR Negative_regulation of KDR Negative_regulation of VEGFA 1 0.04 0.95 0 5.00
197 INT354622 CTSB Regulation of PRDX5 1 0.00 0.38 0 5.00
198 INT277693 Stat6 Positive_regulation of Positive_regulation of Casp3 1 0.01 1.01 0 5.00
199 INT198009 MTOR Regulation of HCC 1 0.09 1.1 0 5.00
200 INT198016 Localization of KDR Negative_regulation of VEGFA 1 0.08 0.95 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Lymphoid Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Lymphoid Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT143551 Binding of KCNA1 13 0.46 8.81 2.81 100.00
2 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39 100.00
3 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 100.00
4 INT217120 Gene_expression of Mir181a-2 3 0.58 2.52 0 100.00
5 INT164735 Gene_expression of MIR29A 4 0.75 2.98 0.24 100.00
6 INT164734 Positive_regulation of Gene_expression of MIR29A 3 0.67 2.1 0.24 100.00
7 INT217119 Positive_regulation of Gene_expression of Mir181a-2 1 0.10 0.95 0 100.00
8 INT217118 Positive_regulation of Gene_expression of Colec10 1 0.49 0.93 0 100.00
9 INT217123 Gene_expression of Colec10 1 0.65 0.93 0 100.00
10 INT217199 Gene_expression of TCL1A 1 0.66 1.92 0 99.98
11 INT217218 Positive_regulation of Gene_expression of TCL1A 1 0.43 0.98 0 99.98
12 INT182339 Gene_expression of Ms4a1 18 0.68 16.6 0.42 99.96
13 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54 99.92
14 INT287941 Gene_expression of FZD5 2 0.23 2.94 0.03 99.92
15 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 99.92
16 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 99.92
17 INT187049 Localization of SLC35B2 1 0.44 1.34 0 99.90
18 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 99.84
19 INT220802 Binding of LEF1 7 0.36 3.86 0.04 99.84
20 INT217230 Positive_regulation of MIR221 4 0.52 3.82 0 99.84
21 INT173975 Gene_expression of Cd52 5 0.28 5.63 0.21 99.84
22 INT318784 Gene_expression of ZAP70 2 0.13 1.33 0.44 99.84
23 INT289115 Gene_expression of ROR1 1 0.14 0.89 0 99.84
24 INT268573 Gene_expression of MIR16-2 11 0.11 11.79 2.01 99.84
25 INT169000 Gene_expression of MIR15B 13 0.65 9.24 0.67 99.84
26 INT217168 Gene_expression of MIR21 30 0.55 30.86 0.62 99.84
27 INT217165 Positive_regulation of MIR222 3 0.47 2.94 0 99.84
28 INT288804 Transcription of Vav1 1 0.68 3.37 0 99.84
29 INT287052 Positive_regulation of Vav1 2 0.50 3.51 0 99.84
30 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 99.84
31 INT217186 Gene_expression of MIR155 26 0.48 29.45 7.92 99.84
32 INT217208 Positive_regulation of Gene_expression of MIR155 3 0.31 2.7 0.29 99.84
33 INT217173 Negative_regulation of MIR15B 6 0.42 4.37 0.08 99.84
34 INT217206 Regulation of Gene_expression of TCL1A 1 0.39 0.94 0 99.84
35 INT217156 Positive_regulation of Gene_expression of MIR21 9 0.49 16.04 0.38 99.84
36 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95 99.84
37 INT117933 Positive_regulation of Gene_expression of Cd38 3 0.38 1.62 1.23 99.84
38 INT315098 Positive_regulation of MIR134 1 0.08 0.97 0 99.84
39 INT298651 Negative_regulation of GDE1 1 0.03 0.87 0 99.84
40 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 99.78
41 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81 99.78
42 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 99.76
43 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 99.76
44 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 99.72
45 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 99.70
46 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.70
47 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73 99.68
48 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86 99.68
49 INT307105 Gene_expression of AOC3 1 0.58 2.4 0.84 99.60
50 INT307097 Gene_expression of Adh3 1 0.31 2.41 0.7 99.60
51 INT17716 Gene_expression of Aldh2 14 0.77 4.38 3.61 99.60
52 INT288763 Gene_expression of Adh5 2 0.49 1.27 0.43 99.60
53 INT86006 Gene_expression of Aldh1a1 5 0.53 3.22 0.43 99.60
54 INT307104 Gene_expression of KDM1A 1 0.09 1.12 0.36 99.60
55 INT307098 Gene_expression of Kdm1a 1 0.17 1.12 0.36 99.60
56 INT76759 Positive_regulation of RFFL 31 0.35 29.15 9.9 99.56
57 INT76758 Positive_regulation of Positive_regulation of RFFL 6 0.35 6.29 3.34 99.56
58 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 99.54
59 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 99.52
60 INT279381 Regulation of Ms4a1 1 0.15 2.7 0 99.44
61 INT258317 Localization of Ms4a1 2 0.41 1.77 0.11 99.44
62 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.40
63 INT59790 Binding of BCR 16 0.36 15.34 1.75 99.40
64 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84 99.40
65 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 99.34
66 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 99.32
67 INT26318 Positive_regulation of CD19 7 0.67 5.61 1.8 99.32
68 INT327716 Gene_expression of Cd52 1 0.10 0.36 0.04 99.28
69 INT289129 Positive_regulation of Gene_expression of LEF1 1 0.13 0.76 0 99.18
70 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 99.18
71 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 99.16
72 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 99.16
73 INT264856 Positive_regulation of Gene_expression of Bst1 1 0.19 0.81 0 99.16
74 INT38672 Binding of KRT20 69 0.39 48.01 6.31 99.08
75 INT214 Localization of AVP 370 0.81 208.51 91.09 99.08
76 INT217231 Regulation of Positive_regulation of MIR29A 1 0.26 0.94 0 99.00
77 INT217117 Regulation of Positive_regulation of Mir181a-2 1 0.09 0.94 0 99.00
78 INT24926 Regulation of Csf3 17 0.52 10.41 3.04 99.00
79 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 98.96
80 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 98.96
81 INT268554 Regulation of Gene_expression of MIR15B 1 0.05 1.06 0 98.96
82 INT268589 Regulation of Gene_expression of MIR16-2 1 0.03 1.06 0 98.96
83 INT105884 Binding of Bcl2 19 0.35 15.67 3 98.90
84 INT135729 Gene_expression of Zap70 5 0.75 6.86 0.75 98.88
85 INT201277 Gene_expression of Nhlrc1 5 0.14 2.05 1.1 98.80
86 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 98.72
87 INT217190 Localization of MIR15B 1 0.42 1.88 0 98.64
88 INT217194 Localization of MIR16-2 1 0.24 1.88 0 98.64
89 INT315113 Negative_regulation of MIR34A 1 0.14 2.08 0 98.64
90 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 98.62
91 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 98.60
92 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 98.60
93 INT117661 Gene_expression of Cd22 7 0.30 5.69 0.62 98.60
94 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 98.60
95 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 98.60
96 INT8112 Regulation of EPO 38 0.58 22.04 2.76 98.58
97 INT197122 Transcription of CRS 2 0.49 3.09 0.18 98.56
98 INT53764 Gene_expression of SPN 5 0.75 5.62 0.38 98.52
99 INT45041 Gene_expression of IGLL1 18 0.66 15.45 1.59 98.52
100 INT16969 Negative_regulation of CRS 28 0.37 14.77 3.35 98.48
101 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 98.48
102 INT271570 Gene_expression of MIR1-1 21 0.65 11.49 1.03 98.44
103 INT217814 Gene_expression of MIR181A1 9 0.58 7.94 0.15 98.44
104 INT276324 Binding of Zap70 1 0.06 0.85 0 98.44
105 INT164445 Localization of Sost 1 0.17 0.37 0.2 98.42
106 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 98.40
107 INT315107 Negative_regulation of MIR100 1 0.09 1 0 98.40
108 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24 98.36
109 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47 98.36
110 INT54213 Gene_expression of Cda 1 0.54 1.13 0.1 98.32
111 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 98.20
112 INT111230 Transcription of LEF1 3 0.30 1.72 0.33 98.14
113 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71 98.14
114 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 98.08
115 INT287946 Positive_regulation of Gene_expression of FZD5 2 0.20 1.69 0.04 98.08
116 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 98.08
117 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79 98.08
118 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28 98.08
119 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 98.08
120 INT164584 Positive_regulation of Positive_regulation of PMAIP1 1 0.20 0.9 0.52 98.08
121 INT217170 Gene_expression of MIR15A 4 0.75 8.17 0.09 98.04
122 INT217197 Gene_expression of MIR16-1 5 0.45 3.93 0.09 98.04
123 INT164448 Localization of ABCA8 1 0.73 0.19 0.1 98.04
124 INT217121 Positive_regulation of Mir181a-2 1 0.10 0.88 0 97.96
125 INT167546 Positive_regulation of Gene_expression of ecs 6 0.07 5.78 0.92 97.92
126 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 97.92
127 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 97.88
128 INT149862 Regulation of CD52 2 0.26 2.33 0.07 97.88
129 INT131530 Gene_expression of Bst1 2 0.26 4.21 1.22 97.84
130 INT217154 Gene_expression of MIR103A2 2 0.18 1.42 0 97.84
131 INT217207 Gene_expression of MIR107 1 0.48 1.37 0 97.84
132 INT289119 Negative_regulation of WNT3A 1 0.11 0.97 0.04 97.80
133 INT153260 Gene_expression of CD22 19 0.70 8.35 0.39 97.76
134 INT164582 Negative_regulation of MCL1 56 0.56 67.11 2.82 97.68
135 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 97.64
136 INT276323 Binding of Igh 1 0.07 0.84 0 97.64
137 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98 97.64
138 INT76752 Negative_regulation of TOP2B 8 0.42 6.2 0.14 97.64
139 INT101243 Regulation of STAT3 12 0.62 9.98 1.92 97.60
140 INT298667 Negative_regulation of Gene_expression of GDE1 1 0.03 1.02 0 97.56
141 INT132333 Negative_regulation of KCNA1 8 0.47 0.87 0.71 97.52
142 INT217155 Positive_regulation of MIR29A 2 0.45 0.88 0 97.48
143 INT194892 Regulation of Mmp1a 5 0.22 4.93 2.67 97.40
144 INT164585 Regulation of PMAIP1 2 0.20 2.07 0.61 97.40
145 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 97.32
146 INT217228 Binding of MIR103A2 1 0.08 0.83 0 97.28
147 INT164588 Regulation of MCL1 12 0.43 14.09 2.63 97.20
148 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 97.00
149 INT226691 Positive_regulation of Gene_expression of Cxcr4 14 0.57 7.9 0.9 97.00
150 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61 97.00
151 INT298661 Gene_expression of GDE1 5 0.04 3.42 0.26 97.00
152 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 96.96
153 INT99291 Transcription of Slc6a4 7 0.46 1.16 3.28 96.96
154 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 96.92
155 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 96.92
156 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 96.80
157 INT217177 Binding of MIR107 1 0.22 0.82 0 96.80
158 INT10795 Positive_regulation of CD59 9 0.36 2.11 2.52 96.72
159 INT134339 Positive_regulation of CD55 8 0.56 3.19 0.54 96.72
160 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 96.68
161 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 96.56
162 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37 96.44
163 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 96.44
164 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 96.44
165 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 96.32
166 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59 96.32
167 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 96.32
168 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98 96.32
169 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 96.28
170 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 96.28
171 INT206742 Negative_regulation of PRDX2 5 0.04 5.04 0 96.24
172 INT298653 Positive_regulation of Binding of EP300 1 0.11 0.8 0.15 96.20
173 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95 96.20
174 INT126479 Regulation of Cxcr4 11 0.58 10.75 0.34 96.00
175 INT347956 Negative_regulation of Regulation of Cxcr4 1 0.40 1.25 0 96.00
176 INT226677 Regulation of Negative_regulation of Cxcr4 3 0.25 2.54 0 96.00
177 INT226637 Negative_regulation of Cxcr4 41 0.48 24.42 1.91 96.00
178 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 95.96
179 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 95.76
180 INT300345 Gene_expression of MIR331 2 0.12 1.96 0.22 95.76
181 INT134148 Gene_expression of FADD 4 0.66 3.35 1.54 95.76
182 INT217167 Negative_regulation of Gene_expression of MIR155 4 0.23 3.43 0.91 95.68
183 INT171514 Binding of EP300 13 0.32 4.32 2.01 95.64
184 INT17618 Gene_expression of B2M 36 0.66 16.39 6.68 95.64
185 INT199072 Negative_regulation of Vav1 2 0.58 9.64 0.07 95.28
186 INT288818 Gene_expression of Rasgrf2 1 0.77 12.76 0 95.20
187 INT217188 Negative_regulation of MIR26B 1 0.13 0.94 0 94.88
188 INT288820 Transcription of Rasgrf2 1 0.68 3.93 0 94.76
189 INT86219 Negative_regulation of GSTK1 25 0.41 8.99 4.97 94.72
190 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 94.68
191 INT130082 Regulation of Rxra 6 0.42 3.78 1.96 94.68
192 INT198568 Regulation of DCPS 17 0.34 16.26 1.86 94.68
193 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 94.64
194 INT105885 Binding of Bcl2l1 2 0.05 1.13 0.35 94.60
195 INT98134 Binding of BAX 17 0.39 11.45 0.93 94.60
196 INT43143 Binding of Bad 8 0.21 5.12 1.81 94.60
197 INT211097 Negative_regulation of Binding of Pnp 1 0.08 1.27 0.08 94.60
198 INT149861 Gene_expression of CD52 14 0.75 9.35 0.47 94.52
199 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04 94.08
200 INT105881 Phosphorylation of Bcl2l1 3 0.51 1.99 1.31 93.96
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