D:Chronic Myeloid Leukemia

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Disease Term
Synonyms Chronic Granulocytic Leukaemia, CHRONIC GRANULOCYTIC LEUKEMIA, CHRONIC GRANULOCYTIC LEUKEMIAS, Chronic Myelocytic Leukaemia, Chronic Myelocytic Leukemia, CHRONIC MYELOCYTIC LEUKEMIAS, Chronic Myelogenous Leukaemia, CHRONIC MYELOGENOUS LEUKEMIA, Chronic Myelogenous Leukemias, Chronic Myeloid Leukaemia, CHRONIC MYELOID LEUKAEMIA DISEASE
Documents 228
Hot Single Events 168
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Myeloid Leukemia. They are ordered first by their relevance to Chronic Myeloid Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT7204 Binding of IFNA1 and IFNG 1 0.01 1.34 0.11 88.16
2 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0 86.00
3 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0 86.00
4 INT198022 AKT1 Regulation of Gene_expression of MCL1 1 0.15 2.25 0 84.36
5 INT198020 PIK3CA Regulation of Gene_expression of MCL1 1 0.16 2.25 0 84.36
6 INT292723 Akt1 Positive_regulation of Localization of Hsf1 1 0.05 0.36 0 75.00
7 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0 75.00
8 INT309906 Binding of EGF and SRC 1 0.11 0.64 0 65.20
9 INT301245 Binding of FUT1 and Runx1 1 0.00 0.66 0 58.80
10 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0 50.00
11 INT292679 GOPC Positive_regulation of HSP90AA1 1 0.01 0.1 0 50.00
12 INT292727 GSK Positive_regulation of Negative_regulation of Hsf1 1 0.21 0 0 50.00
13 INT292722 Akt1 Regulation of Localization of Hsf1 1 0.06 0 0 50.00
14 INT292721 Mapk1 Negative_regulation of Phosphorylation of Hsf1 1 0.02 0.06 0 50.00
15 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0 50.00
16 INT347225 Hck Regulation of Positive_regulation of Bcr 1 0.15 0.07 0 50.00
17 INT292725 GOPC Positive_regulation of Protein_catabolism of Akt1 1 0.01 0.1 0 50.00
18 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0 50.00
19 INT284915 Binding of CDKN2B and HIST2H3C 1 0.05 0.43 0 37.36
20 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 28.56
21 INT198005 Binding of BID and MCL1 1 0.24 2.04 0 27.52
22 INT197999 Binding of BCL2 and MCL1 Negative_regulation of C12orf65 1 0.00 1.21 0 18.96
23 INT198021 Binding of BCL2 and MCL1 1 0.17 2.88 0 18.96
24 INT198015 Binding of BAK1 and MCL1 1 0.26 5.16 0 17.28
25 INT198004 MCL1 Negative_regulation of C12orf65 1 0.01 1.12 0 13.12
26 INT301241 Mir29a Positive_regulation of Runx1 1 0.00 2.85 0 11.64
27 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 9.88
28 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
29 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
30 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
31 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83 5.00
32 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77 5.00
33 INT184125 Il12a Positive_regulation of Stat4 2 0.11 1.04 0.7 5.00
34 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67 5.00
35 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58 5.00
36 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57 5.00
37 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52 5.00
38 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52 5.00
39 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52 5.00
40 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51 5.00
41 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51 5.00
42 INT184099 Il4 Positive_regulation of Stat4 1 0.13 0.28 0.49 5.00
43 INT184105 Il6 Positive_regulation of Socs3 2 0.42 1.34 0.48 5.00
44 INT184094 Gene_expression of Socs3 Negative_regulation of Positive_regulation of Il6 1 0.12 1.49 0.48 5.00
45 INT184117 Il12a Positive_regulation of Stat6 1 0.07 0.28 0.48 5.00
46 INT184124 Socs3 Regulation of Il6 1 0.13 1.4 0.43 5.00
47 INT184138 Ik Positive_regulation of Stat3 1 0.01 0.29 0.43 5.00
48 INT184135 Il11ra1 Positive_regulation of Stat3 1 0.20 0.3 0.4 5.00
49 INT184092 Il11ra1 Positive_regulation of Jak1 1 0.17 0.3 0.39 5.00
50 INT277985 Epo Positive_regulation of Epc1 1 0.03 1.36 0.36 5.00
51 INT184128 Socs3 Negative_regulation of Il6 1 0.12 1.14 0.36 5.00
52 INT184142 Il6 Negative_regulation of Positive_regulation of TNF 1 0.02 0.48 0.35 5.00
53 INT184095 Il10 Positive_regulation of Socs3 1 0.21 0.49 0.34 5.00
54 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33 5.00
55 INT184082 Binding of Socs3 and Il6 1 0.11 0.49 0.33 5.00
56 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33 5.00
57 INT184110 Jak1 Positive_regulation of Stat1 1 0.32 0.3 0.33 5.00
58 INT184107 Cish Negative_regulation of Ik 1 0.01 0.1 0.32 5.00
59 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
60 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3 5.00
61 INT184141 Il6 Positive_regulation of Gene_expression of IFNA1 1 0.01 0.43 0.28 5.00
62 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
63 INT181976 TNF Regulation of Transcription of Gpi1 1 0.00 0.64 0.26 5.00
64 INT181977 TNF Regulation of Gene_expression of Gpi1 1 0.00 0.64 0.25 5.00
65 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24 5.00
66 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 5.00
67 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22 5.00
68 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
69 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
70 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
71 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
72 INT184103 Binding of Socs3 and Il11ra1 1 0.12 0 0.17 5.00
73 INT277990 Binding of Cd3e and Hand1 1 0.01 0.5 0.16 5.00
74 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16 5.00
75 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15 5.00
76 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15 5.00
77 INT184109 Binding of Gopc and Sh2 1 0.03 0 0.14 5.00
78 INT184104 Binding of Socs3 and Gopc 1 0.10 0 0.14 5.00
79 INT184122 Binding of Socs1 and Sh2 1 0.14 0 0.14 5.00
80 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
81 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13 5.00
82 INT184091 Socs2 Negative_regulation of Gh 1 0.11 0.05 0.13 5.00
83 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
84 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12 5.00
85 INT277986 Negative_regulation of Epo Positive_regulation of Localization of Cd34 1 0.08 0.77 0.12 5.00
86 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
87 INT277988 Csf3 Positive_regulation of Epc1 1 0.00 0.51 0.11 5.00
88 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11 5.00
89 INT277987 Regulation of Csf3 Positive_regulation of Epc1 1 0.00 0.51 0.11 5.00
90 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1 5.00
91 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
92 INT278156 Negative_regulation of Trib3 Negative_regulation of Akt1 1 0.00 0.45 0.1 5.00
93 INT184139 Gh Positive_regulation of Gh Positive_regulation of Stat5b 1 0.06 1.31 0.1 5.00
94 INT191432 Binding of COX10 and EDIL3 1 0.01 1.79 0.1 5.00
95 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1 5.00
96 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
97 INT184140 Socs2 Negative_regulation of Gh Positive_regulation of Stat5b 1 0.10 1.33 0.1 5.00
98 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08 5.00
99 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08 5.00
100 INT251777 Negative_regulation of TXK Positive_regulation of PDGFA 1 0.04 1 0.08 5.00
101 INT251773 TXK Positive_regulation of PDGFA 1 0.04 1 0.08 5.00
102 INT309903 Binding of EGF and TXK 1 0.03 0.23 0.08 5.00
103 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
104 INT184108 Csf3 Positive_regulation of Mapk1 1 0.09 0.64 0.08 5.00
105 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
106 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
107 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08 5.00
108 INT184126 Gh Positive_regulation of Gene_expression of Socs2 1 0.14 1.25 0.08 5.00
109 INT184119 Socs3 Negative_regulation of Csf3 1 0.21 0.64 0.08 5.00
110 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
111 INT184097 Cish Negative_regulation of Il3 1 0.10 0.62 0.07 5.00
112 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07 5.00
113 INT251775 AGK Negative_regulation of INSRR 1 0.00 1.1 0.07 5.00
114 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
115 INT184102 Cish Negative_regulation of Thpo 1 0.14 0.62 0.07 5.00
116 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07 5.00
117 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07 5.00
118 INT251776 Negative_regulation of TXK Negative_regulation of ERBB4 1 0.04 1.07 0.06 5.00
119 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06 5.00
120 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05 5.00
121 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05 5.00
122 INT184133 Binding of Gh and Socs2 1 0.10 0.66 0.05 5.00
123 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
124 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05 5.00
125 INT304172 Il5 Positive_regulation of Bcl2l1 1 0.02 0.91 0.05 5.00
126 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05 5.00
127 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05 5.00
128 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
129 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04 5.00
130 INT184083 Positive_regulation of Gh Positive_regulation of Igf1 1 0.09 0.7 0.04 5.00
131 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
132 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04 5.00
133 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04 5.00
134 INT184115 Igf1 Positive_regulation of Gene_expression of Socs2 1 0.16 0.62 0.04 5.00
135 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04 5.00
136 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
137 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 5.00
138 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04 5.00
139 INT190046 Binding of Msh3 and Pms2 2 0.25 0.5 0.04 5.00
140 INT184101 Binding of Irs2 and Sh2 1 0.05 0.15 0.03 5.00
141 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03 5.00
142 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03 5.00
143 INT184136 Binding of Socs7 and Irs2 1 0.13 0.15 0.03 5.00
144 INT184118 Binding of Irs4 and Socs7 1 0.13 0.15 0.03 5.00
145 INT184131 Binding of Socs6 and Irs2 1 0.11 0.2 0.03 5.00
146 INT312346 FUT1 Positive_regulation of Gene_expression of COL11A1 1 0.17 1.02 0.03 5.00
147 INT184127 Binding of Irs4 and Sh2 1 0.05 0.15 0.03 5.00
148 INT184134 Binding of Cish and Rbx1 1 0.10 0 0.03 5.00
149 INT184087 Binding of Cish and Cul2 1 0.10 0 0.03 5.00
150 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00
151 INT312303 Positive_regulation of FLT1 Positive_regulation of VEGFA 1 0.38 0.73 0.03 5.00
152 INT234195 HSP90AA1 Regulation of AKT1 1 0.14 0.65 0.03 5.00
153 INT184081 Binding of Irs4 and Socs6 1 0.11 0.2 0.03 5.00
154 INT184112 Binding of Cish and Cul5 1 0.12 0 0.03 5.00
155 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0 5.00
156 INT197998 KDR Negative_regulation of KDR Negative_regulation of VEGFA 1 0.04 0.95 0 5.00
157 INT198009 MTOR Regulation of HCC 1 0.09 1.1 0 5.00
158 INT198016 Localization of KDR Negative_regulation of VEGFA 1 0.08 0.95 0 5.00
159 INT301243 Mir29a Positive_regulation of Mvd 1 0.03 1.66 0 5.00
160 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0 5.00
161 INT294091 Binding of PGF and VEGFA 1 0.02 1.21 0 5.00
162 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 0.01 0.51 0 5.00
163 INT301237 Mir29a Positive_regulation of Matn1 1 0.02 0.28 0 5.00
164 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
165 INT223577 TXK Negative_regulation of EGFR 1 0.08 0.18 0 5.00
166 INT198024 CDCP1 Negative_regulation of MTOR 1 0.00 0.97 0 5.00
167 INT251780 RRAD Negative_regulation of MTOR 1 0.00 0.62 0 5.00
168 INT301244 Rb1 Regulation of Hbp1 1 0.03 0.75 0 5.00
169 INT198014 Binding of MCL1 and BCL2L11 1 0.11 0.82 0 5.00
170 INT301246 Binding of HMGB1 and Hbp1 1 0.03 0.74 0 5.00
171 INT199581 Braf Negative_regulation of Phosphorylation of tk 1 0.05 0.6 0 5.00
172 INT304175 IL1B Positive_regulation of Gene_expression of Vcam1 1 0.02 0.96 0 5.00
173 INT288830 Binding of ras and Sergef 1 0.03 0.41 0 5.00
174 INT223575 AKT1 Regulation of MTOR 1 0.12 0.37 0 5.00
175 INT198011 Binding of BAX and MCL1 2 0.20 3.04 0 5.00
176 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0 5.00
177 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0 5.00
178 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0 5.00
179 INT206705 Negative_regulation of Binding of FLT1 and VEGFA 3 0.11 1.9 0 5.00
180 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0 5.00
181 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0 5.00
182 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0 5.00
183 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 5.00
184 INT294095 Binding of TXK and Gtf3a 1 0.00 2.33 0 5.00
185 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0 5.00
186 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0 5.00
187 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0 5.00
188 INT223582 Negative_regulation of MTOR Positive_regulation of Phosphorylation of ESR1 1 0.31 0.67 0 5.00
189 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 0.10 3.1 0 5.00
190 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0 5.00
191 INT198007 MTOR Regulation of Gene_expression of GOPC 1 0.08 1.33 0 5.00
192 INT301242 Mvd Positive_regulation of Gene_expression of Mir29a 1 0.04 0.1 0 5.00
193 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0 5.00
194 INT234214 Binding of HSP90AA1 and Tpt1 1 0.04 0.42 0 5.00
195 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 0.11 0.6 0 5.00
196 INT320824 VEGFA Positive_regulation of DLL4 1 0.40 0.41 0 5.00
197 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0 5.00
198 INT234215 Binding of HSP90AA1 and Tpt1 Positive_regulation of HSP90AA1 1 0.03 0.17 0 5.00
199 INT198025 PIK3CA Positive_regulation of Gene_expression of MCL1 1 0.28 1.24 0 5.00
200 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Myeloid Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Myeloid Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT174100 Gene_expression of YWHAE 14 0.31 12.42 0.08 99.90
2 INT284991 Localization of YWHAE 1 0.06 3.22 0 99.90
3 INT82806 Negative_regulation of ABL2 3 0.41 0.58 0.37 99.90
4 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 99.84
5 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 99.84
6 INT218998 Gene_expression of BCRP1 2 0.75 1.64 0.41 99.84
7 INT223601 Negative_regulation of Gene_expression of BCRP1 1 0.41 0.73 0.03 99.84
8 INT223606 Negative_regulation of Gene_expression of MTTP 2 0.41 0.97 0.03 99.84
9 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 99.68
10 INT235996 Negative_regulation of Gene_expression of Src 3 0.09 1.29 0.58 99.58
11 INT29402 Gene_expression of Src 16 0.74 4.57 2.29 99.58
12 INT248588 Gene_expression of LCK 9 0.28 4.9 0.98 99.58
13 INT278162 Negative_regulation of Gene_expression of LCK 1 0.15 0.64 0.12 99.58
14 INT101392 Binding of NDUFS7 2 0.47 0.8 0.09 99.52
15 INT158592 Negative_regulation of CSK 2 0.19 0.43 0.36 99.26
16 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 99.24
17 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 99.12
18 INT234461 Negative_regulation of Gene_expression of HDAC9 5 0.24 2.74 0.24 99.12
19 INT350500 Negative_regulation of Prss27 1 0.01 0.85 0 99.12
20 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1 99.10
21 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05 99.10
22 INT265538 Positive_regulation of BCRP1 1 0.67 0.59 0 99.10
23 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 99.08
24 INT292705 Regulation of Binding of Hsf1 1 0.10 0.89 0 98.98
25 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74 98.96
26 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93 98.96
27 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 98.96
28 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 98.88
29 INT187422 Negative_regulation of MTTP 23 0.57 11.75 0.24 98.72
30 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 98.70
31 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34 98.70
32 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 98.64
33 INT223598 Negative_regulation of BCRP1 3 0.57 2.56 0.11 98.56
34 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 98.52
35 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 98.44
36 INT103094 Binding of PPARA 308 0.47 177.26 34.75 98.28
37 INT134657 Localization of Akt1 37 0.68 11.58 4.62 98.28
38 INT288816 Regulation of Gene_expression of Rasgrf2 1 0.61 5.36 0 98.28
39 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 98.24
40 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 97.96
41 INT228104 Gene_expression of Vav1 13 0.77 12.18 0 97.68
42 INT288818 Gene_expression of Rasgrf2 1 0.77 12.76 0 97.68
43 INT62199 Binding of Hsf1 12 0.45 10.77 0.6 97.52
44 INT312302 Gene_expression of Prss27 2 0.02 3.95 0.19 97.52
45 INT241507 Positive_regulation of Abl1 5 0.40 2.69 0.05 97.36
46 INT24926 Regulation of Csf3 17 0.52 10.41 3.04 97.16
47 INT37430 Gene_expression of Gpi1 61 0.63 54.63 13.87 97.04
48 INT199557 Positive_regulation of Gene_expression of Bcr 6 0.68 4.21 0.3 96.88
49 INT199566 Positive_regulation of Gene_expression of tk 4 0.39 3.06 0.31 96.88
50 INT199561 Positive_regulation of Gene_expression of Abl1 8 0.36 4.77 0.16 96.88
51 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 96.76
52 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 96.76
53 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 96.72
54 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 96.44
55 INT199553 Gene_expression of Bcr 25 0.76 13.83 0.48 96.44
56 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75 96.44
57 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 96.36
58 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2 96.36
59 INT192348 Positive_regulation of Gene_expression of PDGFRB 5 0.64 3.57 0.3 96.36
60 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 96.00
61 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 95.84
62 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 95.76
63 INT25162 Positive_regulation of ACPP 7 0.41 4.51 0.62 95.76
64 INT312354 Regulation of Gene_expression of JAK2 1 0.25 1.17 0.1 95.72
65 INT35612 Gene_expression of REG3A 37 0.78 33.33 10.13 95.52
66 INT164582 Negative_regulation of MCL1 56 0.56 67.11 2.82 95.44
67 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81 95.40
68 INT303972 Positive_regulation of Gene_expression of JAK2 2 0.63 1.3 0.24 95.40
69 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 95.28
70 INT168975 Binding of Wt1 14 0.43 7.37 0.07 95.00
71 INT118291 Binding of TXK 19 0.10 11.77 1.94 94.40
72 INT176589 Negative_regulation of Binding of TXK 6 0.09 2.06 0.05 94.40
73 INT304147 Gene_expression of Fip1l1 1 0.32 2.07 0 94.40
74 INT119519 Positive_regulation of Gene_expression of TXK 3 0.09 2.92 1.02 94.20
75 INT62196 Positive_regulation of Positive_regulation of Hsf1 3 0.47 2.72 0.25 94.08
76 INT3703 Negative_regulation of Grhpr 38 0.50 11.43 9.2 94.00
77 INT188586 Negative_regulation of Gene_expression of CD28 6 0.34 1.9 0.69 94.00
78 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61 94.00
79 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65 94.00
80 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45 93.72
81 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 93.44
82 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 93.44
83 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 93.44
84 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13 93.40
85 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 92.96
86 INT102758 Negative_regulation of Abl1 2 0.51 1.13 1.1 92.96
87 INT62195 Positive_regulation of Hsf1 17 0.70 11.51 0.95 92.80
88 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 92.80
89 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 92.76
90 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72 92.64
91 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 92.48
92 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 92.24
93 INT312363 Positive_regulation of CELSR3 1 0.59 3.55 0.38 92.16
94 INT101390 Binding of Grhpr 1 0.03 0.18 0 92.12
95 INT19279 Negative_regulation of Negative_regulation of IL2 3 0.43 1.62 0.79 91.92
96 INT193678 Regulation of Transcription of NFE2L2 1 0.06 0.69 0.04 91.76
97 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 91.60
98 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 91.40
99 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 91.40
100 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7 91.36
101 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 91.16
102 INT8772 Positive_regulation of Gene_expression of HBG1 16 0.68 6.93 0.95 91.08
103 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41 91.00
104 INT292703 Regulation of Hsf1 5 0.26 1.78 0 90.96
105 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47 90.88
106 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 90.72
107 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 90.68
108 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19 90.68
109 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 90.56
110 INT46304 Regulation of Protein_catabolism of Hrh1 1 0.40 0.9 0.33 90.32
111 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 90.08
112 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 90.04
113 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 89.76
114 INT46303 Protein_catabolism of Hrh1 1 0.79 0.9 0.33 89.76
115 INT301228 Positive_regulation of Gene_expression of Mir29a 1 0.16 13.38 0 89.72
116 INT301208 Gene_expression of Mir29a 1 0.17 26.18 0 89.72
117 INT172476 Transcription of NFE2L2 7 0.69 2.47 0.11 89.60
118 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 89.56
119 INT23148 Gene_expression of RUNX1 10 0.10 6.58 1.71 89.08
120 INT215980 Positive_regulation of Gene_expression of RUNX1 1 0.08 0.89 0 89.08
121 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 89.04
122 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19 89.00
123 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 88.32
124 INT181964 Positive_regulation of Gene_expression of Gzmb 1 0.10 0.57 0.08 88.16
125 INT92476 Gene_expression of Gzmb 19 0.58 7.78 1.94 88.16
126 INT273550 Positive_regulation of Bcr 14 0.68 6.71 0.49 88.04
127 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 87.80
128 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 87.80
129 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 87.80
130 INT275621 Positive_regulation of Atcay 3 0.06 2.15 0.04 86.48
131 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 86.12
132 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 86.04
133 INT60542 Positive_regulation of Gene_expression of GSTK1 11 0.39 6.21 1.13 86.04
134 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 85.84
135 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 85.84
136 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 85.84
137 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 85.84
138 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82 85.84
139 INT91172 Positive_regulation of Gene_expression of Pdgfrb 4 0.38 2.83 0.68 85.84
140 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 85.76
141 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 85.76
142 INT97478 Positive_regulation of Tks 1 0.46 1.42 0.71 85.60
143 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 85.44
144 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 85.44
145 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39 85.44
146 INT199567 Binding of Kdr 18 0.47 13.81 1.34 85.12
147 INT129680 Transcription of Hsf1 2 0.53 1.68 0.17 84.96
148 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 84.84
149 INT131286 Binding of Egfr 26 0.44 13.58 0.78 84.44
150 INT201683 Phosphorylation of GSK 15 0.80 6.6 2.01 84.20
151 INT254930 Gene_expression of CELSR3 4 0.76 5.01 0.76 83.96
152 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 83.56
153 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 83.08
154 INT59790 Binding of BCR 16 0.36 15.34 1.75 82.80
155 INT241499 Binding of Abl1 23 0.47 8.86 0.75 82.80
156 INT18480 Positive_regulation of ANPEP 9 0.59 5.18 2.13 82.68
157 INT57105 Positive_regulation of CD33 7 0.45 5.08 0.63 82.68
158 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21 82.64
159 INT184017 Positive_regulation of Gene_expression of Socs1 7 0.63 2.47 0.62 82.64
160 INT193688 Positive_regulation of Gene_expression of GLRX2 1 0.04 0.7 0.03 82.60
161 INT193683 Gene_expression of GLRX2 1 0.05 0.7 0.03 82.60
162 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 81.92
163 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 81.56
164 INT142184 Regulation of TXK 10 0.11 8.25 0.59 81.12
165 INT292711 Regulation of Gene_expression of ABL1 1 0.06 1.02 0 81.12
166 INT128376 Binding of KIT 26 0.48 14.24 0.47 80.64
167 INT223616 Binding of PDGFRB 3 0.32 2.33 0.05 80.64
168 INT129679 Negative_regulation of Hsf1 9 0.43 3.22 0.22 80.24
169 INT129678 Gene_expression of Hsf1 13 0.78 8.57 0.85 79.88
170 INT292707 Negative_regulation of Gene_expression of Hsf1 1 0.16 0.55 0 79.88
171 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37 79.28
172 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 78.96
173 INT800 Negative_regulation of Grhpr 21 0.42 10.3 7.17 78.76
174 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81 78.20
175 INT287052 Positive_regulation of Vav1 2 0.50 3.51 0 77.68
176 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97 77.40
177 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08 76.88
178 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08 76.88
179 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 75.64
180 INT234471 Negative_regulation of Phosphorylation of IGF1R 1 0.04 0.76 0.03 75.64
181 INT234462 Phosphorylation of IGF1R 2 0.42 0.99 0.06 75.36
182 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 75.00
183 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 75.00
184 INT126060 Negative_regulation of Gene_expression of Cxcr4 9 0.42 3.14 1.99 75.00
185 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14 75.00
186 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 75.00
187 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 75.00
188 INT273555 Negative_regulation of Bcr 17 0.57 9.65 0.44 75.00
189 INT126059 Positive_regulation of Gata2 1 0.02 0.87 0.28 75.00
190 INT62070 Transcription of PTHLH 3 0.72 1.57 0.22 75.00
191 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 75.00
192 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19 75.00
193 INT126058 Positive_regulation of Ski 1 0.03 0.84 0.35 75.00
194 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73 75.00
195 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42 75.00
196 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 75.00
197 INT267202 Localization of Hsf1 14 0.68 7.8 0.28 75.00
198 INT206742 Negative_regulation of PRDX2 5 0.04 5.04 0 74.88
199 INT83680 Gene_expression of FUT1 40 0.26 25.45 4.98 74.60
200 INT147790 Positive_regulation of Gene_expression of FUT1 9 0.11 4.8 0.54 74.60
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