D:Chronic Neutrophilic Leukemia

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pChart

Disease Term
Synonyms Chronic Neutrophilic Leukemias, Leukemia Chronic Neutrophilic, Leukemias Chronic Neutrophilic, Neutrophilic Leukemia Chronic, Neutrophilic Leukemias Chronic
Documents 9
Hot Single Events 0
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Neutrophilic Leukemia. They are ordered first by their relevance to Chronic Neutrophilic Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0 94.88
2 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0 94.88
3 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 13.88
4 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00
5 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0 5.00
6 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Neutrophilic Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Neutrophilic Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03 74.64
2 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 74.12
3 INT350510 Localization of ABL1 1 0.40 2.51 0 64.92
4 INT310747 Regulation of JAK2 2 0.33 1.58 0.05 62.64
5 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 43.56
6 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 43.20
7 INT277757 Gene_expression of Pmf1 3 0.12 4.14 0.23 42.04
8 INT312302 Gene_expression of Prss27 2 0.02 3.95 0.19 41.88
9 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 34.24
10 INT43907 Binding of CD79A 28 0.48 28.11 3.04 34.24
11 INT191601 Negative_regulation of Fdft1 2 0.04 2.13 0.33 20.36
12 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 13.88
13 INT332592 Binding of MND1 1 0.08 9.21 0.16 13.88
14 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
15 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
16 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
17 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
18 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
19 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
20 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
21 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
22 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
23 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
24 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
25 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
26 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
27 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
28 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
29 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 5.00
30 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
31 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
32 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
33 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
34 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
35 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
36 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
37 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
38 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
39 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
40 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
41 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93 5.00
42 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
43 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 5.00
44 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46 5.00
45 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
46 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
47 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
48 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 5.00
49 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11 5.00
50 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
51 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
52 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 5.00
53 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16 5.00
54 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 5.00
55 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95 5.00
56 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29 5.00
57 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
58 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54 5.00
59 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5 5.00
60 INT55952 Transcription of TP53 16 0.61 12.14 2.36 5.00
61 INT91836 Negative_regulation of Gene_expression of BCL2L1 9 0.49 8.59 2.25 5.00
62 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 5.00
63 INT73476 Transcription of MYC 18 0.69 12.14 2.13 5.00
64 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
65 INT104931 Binding of TNFSF10 15 0.36 17.44 2.07 5.00
66 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
67 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 5.00
68 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81 5.00
69 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8 5.00
70 INT332792 Positive_regulation of Gene_expression of HDAC9 5 0.45 4.61 1.44 5.00
71 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
72 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 5.00
73 INT135556 Localization of AKT1 38 0.69 12.78 1.17 5.00
74 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 5.00
75 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99 5.00
76 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 5.00
77 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 5.00
78 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63 5.00
79 INT165846 Regulation of HSP90AA1 4 0.27 2.19 0.58 5.00
80 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 5.00
81 INT179685 Positive_regulation of HDAC4 3 0.24 4.09 0.48 5.00
82 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 5.00
83 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 5.00
84 INT105888 Phosphorylation of BAX 9 0.80 4.78 0.4 5.00
85 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33 5.00
86 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29 5.00
87 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
88 INT144038 Transcription of STAT3 4 0.56 0.99 0.25 5.00
89 INT234461 Negative_regulation of Gene_expression of HDAC9 5 0.24 2.74 0.24 5.00
90 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 5.00
91 INT142384 Gene_expression of XRCC6 3 0.58 1.98 0.16 5.00
92 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 5.00
93 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 5.00
94 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 5.00
95 INT350501 Positive_regulation of Prss27 1 0.02 2.91 0.12 5.00
96 INT283245 Gene_expression of MND1 2 0.11 1.94 0.07 5.00
97 INT332590 Negative_regulation of Gene_expression of TCN2 1 0.05 1.2 0.06 5.00
98 INT234206 Localization of HSP90AA1 4 0.68 2.89 0.06 5.00
99 INT184061 Negative_regulation of Stat5a 2 0.29 1.85 0.04 5.00
100 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03 5.00
101 INT350515 Transcription of SMAD7 1 0.07 0.38 0.03 5.00
102 INT207276 Transcription of BCL6 3 0.45 0.64 0.03 5.00
103 INT350514 Positive_regulation of Phosphorylation of HSP90AA1 1 0.10 0.74 0 5.00
104 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0 5.00
105 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0 5.00
106 INT350511 Negative_regulation of XRCC6 1 0.08 0.58 0 5.00
107 INT350522 Positive_regulation of Gene_expression of XRCC6 1 0.11 0.53 0 5.00
108 INT350507 Positive_regulation of Binding of TNFSF10 1 0.05 0.59 0 5.00
109 INT350518 Phosphorylation of HSP90AA1 1 0.16 0.72 0 5.00
110 INT350502 Positive_regulation of Pmf1 1 0.02 1.26 0 5.00
111 INT350521 Negative_regulation of Negative_regulation of ABL1 1 0.23 0.55 0 5.00
112 INT332589 Localization of MND1 1 0.12 2.01 0 5.00
113 INT350506 Protein_catabolism of JAK2 1 0.48 1.55 0 5.00
114 INT350517 Negative_regulation of Gene_expression of ABL1 1 0.23 0.53 0 5.00
115 INT234209 Protein_catabolism of HSP90AA1 5 0.54 2.67 0 5.00
116 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0 5.00
117 INT350500 Negative_regulation of Prss27 1 0.01 0.85 0 5.00
118 INT292713 Phosphorylation of ABL1 2 0.44 1.04 0 5.00
119 INT350519 Positive_regulation of STK19 1 0.01 0.59 0 5.00
120 INT332591 Positive_regulation of MND1 1 0.11 1.56 0 5.00
121 INT350512 Positive_regulation of Phosphorylation of ABL1 1 0.27 0.75 0 5.00
122 INT350508 Protein_catabolism of ABL1 1 0.54 0.5 0 5.00
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