D:Chronic Pelvic Pain Syndrome

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Disease Term
Synonyms Chronic Abacterial Prostatitis, CPPS TYPE III, Male Chronic Pelvic Pain Syndrome, Nonbacterial Chronic Prostatitis, Pelvic Myoneuropathy, PROSTATODYNIA
Documents 527
Hot Single Events 46
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Pelvic Pain Syndrome. They are ordered first by their relevance to Chronic Pelvic Pain Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT102025 Ngf Regulation of Il10 1 0.01 0.2 0 66.92
2 INT102026 Ngf Regulation of IL6 1 0.00 0.2 0 66.92
3 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21 59.08
4 INT348881 Atpif1 Positive_regulation of If3 1 0.01 0.08 0.04 5.00
5 INT348885 Atpif1 Positive_regulation of EIF5B 1 0.01 0.08 0.04 5.00
6 INT299946 Binding of Tlr4 and Synj2bp 1 0.00 0.28 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Pelvic Pain Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Pelvic Pain Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 100.00
2 INT132725 Regulation of DDA1 1 0.02 0.45 0.42 99.58
3 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 99.28
4 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 99.28
5 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 99.28
6 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 99.28
7 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85 99.24
8 INT60136 Localization of CXCL5 2 0.10 0.68 1.48 99.12
9 INT3309 Binding of CP 25 0.47 17.87 6.62 98.46
10 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52 98.32
11 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 98.24
12 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 97.96
13 INT91825 Binding of HBEGF 4 0.31 2.39 2.52 97.16
14 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89 96.96
15 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77 96.78
16 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 96.72
17 INT10706 Regulation of Il6 150 0.62 93.23 62.34 96.48
18 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 95.08
19 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 95.04
20 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 95.04
21 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 94.92
22 INT47540 Binding of Cp 20 0.41 15.54 7.01 94.84
23 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 94.72
24 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 93.16
25 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 93.16
26 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 92.92
27 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 91.96
28 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 91.12
29 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25 91.08
30 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 90.56
31 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 90.56
32 INT16322 Gene_expression of Il2rb 19 0.51 15.88 12.18 90.56
33 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 90.52
34 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 90.52
35 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 90.20
36 INT132700 Positive_regulation of Trpc1 6 0.39 4.33 3.89 90.20
37 INT168262 Positive_regulation of Gene_expression of BPHL 10 0.24 10.72 0.83 89.60
38 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 89.56
39 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 88.84
40 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 85.96
41 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 85.44
42 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 84.80
43 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 84.20
44 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 84.20
45 INT99091 Regulation of AR 70 0.45 31.68 5.05 82.24
46 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 81.40
47 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 79.52
48 INT65698 Localization of CCL2 118 0.81 77.54 32.69 79.44
49 INT87199 Negative_regulation of PSS 9 0.50 5.66 0.68 79.32
50 INT49632 Negative_regulation of NBL1 11 0.57 1.11 5.67 76.64
51 INT96426 Negative_regulation of PSORS2 1 0.42 0.08 0 76.64
52 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 75.40
53 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 75.40
54 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15 75.40
55 INT91327 Positive_regulation of CCL4 12 0.67 8.55 4.1 75.40
56 INT137803 Positive_regulation of CCL17 4 0.36 1.15 0.35 75.40
57 INT137802 Positive_regulation of Ccl22 3 0.22 2.37 0.19 75.40
58 INT109806 Positive_regulation of Ppl 3 0.25 2.46 0.99 75.20
59 INT110803 Negative_regulation of Ppl 2 0.21 0.93 0.45 75.00
60 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 74.88
61 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 74.72
62 INT2609 Localization of ELANE 111 0.81 50.22 26.63 73.16
63 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 73.08
64 INT163366 Transcription of Foxp3 2 0.35 0.72 0.53 72.64
65 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 71.88
66 INT62511 Negative_regulation of MCS 20 0.50 6.77 2.35 71.88
67 INT8246 Positive_regulation of IL36RN 13 0.43 9.15 3.16 69.76
68 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4 67.48
69 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 67.36
70 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 67.36
71 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 67.36
72 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 67.36
73 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 66.84
74 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 66.44
75 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 65.52
76 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 64.12
77 INT156896 Gene_expression of Foxp3 11 0.76 7.62 2.92 58.72
78 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 57.04
79 INT159956 Phosphorylation of Rock2 3 0.79 1.57 0.2 55.56
80 INT126627 Gene_expression of Rock2 9 0.60 3.33 0.32 51.52
81 INT6481 Binding of TNF 624 0.48 510.2 214.82 50.00
82 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 50.00
83 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 50.00
84 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 50.00
85 INT50040 Localization of Il4 15 0.67 8.26 7.69 50.00
86 INT103289 Binding of Il10 15 0.35 13.67 7.42 50.00
87 INT56149 Localization of CD8A 56 0.74 30.41 5.75 50.00
88 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 50.00
89 INT75661 Regulation of CP 12 0.39 5.17 3.75 50.00
90 INT71717 Negative_regulation of Hbegf 15 0.39 3.63 3.18 50.00
91 INT101429 Positive_regulation of PST 10 0.40 2.14 0.6 50.00
92 INT119930 Negative_regulation of PST 3 0.34 0.26 0.22 50.00
93 INT88928 Regulation of Msmb 1 0.01 0.07 0 50.00
94 INT88927 Regulation of Acpp 3 0.06 0.56 0 50.00
95 INT11261 Positive_regulation of PTPLA 3 0.50 4.4 3.74 49.60
96 INT306177 Regulation of Gene_expression of Rock2 1 0.26 0.84 0 41.32
97 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
98 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 5.00
99 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
100 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
101 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
102 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
103 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
104 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
105 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
106 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
107 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
108 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
109 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
110 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
111 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
112 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
113 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
114 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82 5.00
115 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
116 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
117 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
118 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 5.00
119 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
120 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07 5.00
121 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
122 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68 5.00
123 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 5.00
124 INT84307 Binding of Cftr 31 0.47 26.19 12.8 5.00
125 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
126 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
127 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93 5.00
128 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
129 INT140338 Negative_regulation of Gene_expression of Il17a 34 0.46 23.82 9.87 5.00
130 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65 5.00
131 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55 5.00
132 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 5.00
133 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 5.00
134 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
135 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 5.00
136 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 5.00
137 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76 5.00
138 INT11150 Positive_regulation of Dlst 31 0.51 9.01 6.63 5.00
139 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59 5.00
140 INT86119 Regulation of Cftr 13 0.45 14.08 5.75 5.00
141 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 5.00
142 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 5.00
143 INT28176 Localization of Cp 17 0.73 14.3 4.86 5.00
144 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 5.00
145 INT170757 Positive_regulation of Gene_expression of Cftr 3 0.51 11.41 4.75 5.00
146 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32 5.00
147 INT140337 Negative_regulation of Cd8a 42 0.50 25.4 3.66 5.00
148 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69 5.00
149 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51 5.00
150 INT86315 Transcription of Cftr 7 0.53 4.24 2.3 5.00
151 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02 5.00
152 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91 5.00
153 INT36245 Negative_regulation of Gene_expression of ELANE 11 0.40 5.32 1.88 5.00
154 INT17452 Regulation of Dlst 14 0.46 1.5 1.68 5.00
155 INT84308 Localization of Cftr 12 0.75 6.16 1.65 5.00
156 INT17453 Localization of Dlst 20 0.59 4.54 1.46 5.00
157 INT108281 Negative_regulation of Binding of Cftr 4 0.43 3.1 1.38 5.00
158 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34 5.00
159 INT139625 Regulation of Gene_expression of Cftr 5 0.50 3.59 1.32 5.00
160 INT39834 Positive_regulation of Gene_expression of Cp 6 0.49 3.14 1.18 5.00
161 INT70327 Regulation of Gene_expression of CA2 11 0.28 1.92 1.05 5.00
162 INT45675 Regulation of Gene_expression of Shbg 6 0.15 4.65 1.03 5.00
163 INT47757 Transcription of CA2 5 0.67 1.16 0.97 5.00
164 INT70323 Negative_regulation of Gene_expression of CA2 13 0.41 6.55 0.97 5.00
165 INT86314 Regulation of Transcription of Cftr 2 0.33 1.81 0.83 5.00
166 INT287087 Localization of EEC1 2 0.61 1.6 0.72 5.00
167 INT215828 Regulation of Binding of Cftr 2 0.33 1.56 0.66 5.00
168 INT125709 Positive_regulation of Gene_expression of Col3a1 7 0.27 5.17 0.65 5.00
169 INT103841 Negative_regulation of Gene_expression of Cftr 3 0.43 1.93 0.63 5.00
170 INT170759 Positive_regulation of Binding of Cftr 2 0.50 1.82 0.6 5.00
171 INT167608 Regulation of Rock2 2 0.33 2.47 0.59 5.00
172 INT348872 Positive_regulation of Regulation of Cftr 1 0.34 1.3 0.55 5.00
173 INT299945 Negative_regulation of Localization of EEC1 1 0.06 1.33 0.53 5.00
174 INT126628 Positive_regulation of Rock2 4 0.70 3.56 0.52 5.00
175 INT235200 Positive_regulation of Negative_regulation of ELANE 3 0.38 1.68 0.46 5.00
176 INT348865 Regulation of Transcription of CA2 1 0.21 0.69 0.43 5.00
177 INT299942 Gene_expression of Synj2bp 1 0.01 1.3 0.32 5.00
178 INT299944 Regulation of Gene_expression of Synj2bp 1 0.01 1.31 0.32 5.00
179 INT133762 Gene_expression of Atpif1 3 0.17 0.34 0.21 5.00
180 INT218694 Binding of Col1a1 2 0.21 1.52 0.21 5.00
181 INT274775 Regulation of Positive_regulation of Gpx1 1 0.04 0.76 0.2 5.00
182 INT306176 Localization of Rock2 1 0.73 0.41 0.09 5.00
183 INT348854 Gene_expression of If3 1 0.08 0.27 0.07 5.00
184 INT348864 Gene_expression of EIF5B 1 0.07 0.27 0.07 5.00
185 INT348871 Regulation of Gene_expression of Slc26a3 1 0.15 0.31 0.06 5.00
186 INT348875 Gene_expression of Slc26a3 1 0.26 0.31 0.06 5.00
187 INT348870 Negative_regulation of Slc26a6 1 0.13 0.26 0.06 5.00
188 INT348873 Negative_regulation of Gene_expression of Atpif1 1 0.07 0.07 0 5.00
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