D:Chronic Periodontitis

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Disease Term
Synonyms ADULT PERIODONTITIDES, Adult Periodontitis, Chronic Periodontitides, PERIODONTITIDES ADULT, Periodontitides Chronic, PERIODONTITIS ADULT, PERIODONTITIS CHRONIC
Documents 72
Hot Single Events 45
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Periodontitis. They are ordered first by their relevance to Chronic Periodontitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329341 UCN2 Positive_regulation of THAS 1 0.00 1.12 0 93.04
2 INT329340 UCN2 Positive_regulation of SOD1 1 0.02 1.12 0 92.72
3 INT329342 Binding of THAS and LRRFIP1 1 0.00 0.97 0.09 88.68
4 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
5 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64 5.00
6 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
7 INT345303 MMP15 Positive_regulation of MMP13 1 0.00 1.18 0.58 5.00
8 INT345302 MMP15 Positive_regulation of MMP2 1 0.06 1.17 0.57 5.00
9 INT173555 TIMP1 Negative_regulation of MMP7 1 0.01 0 0.56 5.00
10 INT173556 TIMP1 Negative_regulation of MMP9 1 0.02 0 0.56 5.00
11 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56 5.00
12 INT173554 TIMP1 Negative_regulation of MMP1 1 0.03 0 0.55 5.00
13 INT173553 TIMP1 Negative_regulation of MMP2 1 0.05 0 0.55 5.00
14 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52 5.00
15 INT173597 Negative_regulation of Binding of MMP2 and Mmp13 1 0.14 0.83 0.48 5.00
16 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48 5.00
17 INT173595 Binding of MMP2 and Mmp13 1 0.12 0.83 0.48 5.00
18 INT345301 Binding of MMP14 and TIMP2 Positive_regulation of MMP2 1 0.02 0.21 0.48 5.00
19 INT173596 Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
20 INT173598 Negative_regulation of Binding of MMP3 and Mmp13 1 0.06 0.84 0.48 5.00
21 INT345305 MMP14 Positive_regulation of MMP13 1 0.00 0.33 0.45 5.00
22 INT345304 MMP14 Positive_regulation of MMP2 1 0.08 0.2 0.45 5.00
23 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35 5.00
24 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35 5.00
25 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34 5.00
26 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33 5.00
27 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3 5.00
28 INT128644 Binding of Icam1 and Selp 2 0.39 0.57 0.25 5.00
29 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22 5.00
30 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17 5.00
31 INT173599 Binding of MMP1 and Mmp1a 1 0.06 0.5 0.15 5.00
32 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15 5.00
33 INT345307 CXCL12 Positive_regulation of Gene_expression of MMP15 1 0.00 2.5 0.05 5.00
34 INT240586 IRF7 Positive_regulation of Positive_regulation of IFNA1 1 0.01 0.44 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Periodontitis. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Periodontitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT190275 Positive_regulation of THAS 5 0.10 2.6 0.14 100.00
2 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 99.62
3 INT187055 Gene_expression of THAS 4 0.19 2.32 0.61 99.56
4 INT94163 Negative_regulation of UCN2 11 0.57 6.86 1.75 99.54
5 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 99.28
6 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 99.20
7 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 98.96
8 INT97474 Positive_regulation of UCN2 6 0.67 1.85 1.23 98.80
9 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 98.56
10 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 97.78
11 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 96.80
12 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 96.36
13 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 96.36
14 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34 96.04
15 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 96.04
16 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 95.80
17 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 95.80
18 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 95.60
19 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 95.60
20 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79 95.40
21 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 94.68
22 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 94.48
23 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 94.16
24 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 93.52
25 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 93.52
26 INT217764 Negative_regulation of RALA 6 0.28 3.34 0.08 93.36
27 INT217763 Regulation of RALA 3 0.29 1.48 0 92.80
28 INT329343 Regulation of THAS 1 0.09 1.7 0.04 92.64
29 INT27293 Regulation of SOD1 21 0.53 15.73 1.55 92.08
30 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 92.00
31 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8 91.80
32 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 90.56
33 INT53188 Regulation of Gene_expression of VSX1 4 0.40 1.41 1.66 90.56
34 INT217767 Regulation of Negative_regulation of VSX1 1 0.15 0.73 0 90.56
35 INT112003 Localization of ROS1 94 0.73 66.32 12.16 90.20
36 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 89.08
37 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 87.32
38 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 85.08
39 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 84.48
40 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 84.48
41 INT165402 Negative_regulation of THAS 2 0.42 0.72 0 82.84
42 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 81.56
43 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 81.56
44 INT240595 Gene_expression of CSPG4P2Y 1 0.03 1.87 0.41 81.56
45 INT150395 Binding of MEFV 55 0.44 31.18 3.42 80.40
46 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 79.44
47 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14 78.84
48 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 78.84
49 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 78.84
50 INT31989 Binding of SOD1 43 0.47 19.38 2.55 78.40
51 INT74286 Regulation of Il10 42 0.44 28.06 19.44 77.36
52 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 75.56
53 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 75.56
54 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92 75.00
55 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 75.00
56 INT11335 Regulation of Ptger2 46 0.51 22.3 15.42 75.00
57 INT36168 Regulation of Positive_regulation of Ptger2 5 0.45 0.19 1.76 75.00
58 INT76978 Negative_regulation of Regulation of Ptger2 1 0.01 0.07 0.44 75.00
59 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 74.80
60 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 74.80
61 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 73.12
62 INT860 Regulation of ALB 48 0.60 25.11 8.95 72.36
63 INT63177 Regulation of HP 71 0.44 39.48 5.86 72.36
64 INT24735 Regulation of TF 10 0.44 5.55 0.65 72.36
65 INT107417 Regulation of CAT 8 0.60 2.4 0.61 72.36
66 INT240593 Gene_expression of Naip1 1 0.02 2.01 0.49 71.20
67 INT329344 Positive_regulation of Positive_regulation of ARG1 1 0.01 0.73 0 70.88
68 INT74586 Negative_regulation of MMP8 6 0.27 1.68 1.64 70.72
69 INT258055 Positive_regulation of ARG1 7 0.49 3.45 0.19 70.60
70 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 69.60
71 INT108790 Gene_expression of RGS1 2 0.58 4.36 1.76 68.48
72 INT217765 Positive_regulation of RALA 1 0.32 0.38 0 67.80
73 INT70019 Binding of BCL2 25 0.47 17.55 0.79 66.96
74 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 65.88
75 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 64.64
76 INT192761 Positive_regulation of Gene_expression of SAA1 5 0.40 7.45 0.82 64.64
77 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 63.52
78 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 63.52
79 INT756 Gene_expression of C3 138 0.75 100.6 19.2 63.52
80 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 63.52
81 INT69723 Gene_expression of SERPINB2 7 0.60 4.54 1.28 63.52
82 INT240602 Gene_expression of RIPK1 2 0.58 0.69 0.16 63.52
83 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 62.96
84 INT103834 Regulation of RETNLB 4 0.04 3.87 1.02 60.96
85 INT91906 Regulation of Gene_expression of Il10 13 0.58 8.92 7.06 56.48
86 INT278301 Gene_expression of HDLBP 2 0.08 3.09 0.37 55.20
87 INT144767 Gene_expression of UCN2 5 0.65 1.78 1.04 54.24
88 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 50.00
89 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 50.00
90 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 50.00
91 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 50.00
92 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 50.00
93 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 50.00
94 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 50.00
95 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 47.28
96 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 43.16
97 INT110806 Positive_regulation of Mmp8 7 0.46 1.64 0.67 43.16
98 INT251907 Negative_regulation of Positive_regulation of MMP8 1 0.00 1.23 0.26 43.16
99 INT219610 Protein_catabolism of SAA1 2 0.90 4.47 0.54 42.96
100 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37 41.08
101 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 40.76
102 INT235200 Positive_regulation of Negative_regulation of ELANE 3 0.38 1.68 0.46 40.76
103 INT45444 Binding of VSX1 5 0.30 3.38 0.5 40.60
104 INT217766 Negative_regulation of Gene_expression of RALA 1 0.27 0.17 0 39.76
105 INT217768 Gene_expression of RALA 2 0.43 0.67 0.14 38.92
106 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 32.08
107 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 27.44
108 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94 27.04
109 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 26.80
110 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 25.96
111 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 23.32
112 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 19.64
113 INT91509 Localization of CYC1 39 0.78 34.74 7.17 17.68
114 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 16.32
115 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 15.24
116 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 14.88
117 INT5649 Negative_regulation of Positive_regulation of Mpo 31 0.59 26.62 11.92 11.04
118 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 10.24
119 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 10.00
120 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69 9.84
121 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 9.44
122 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
123 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
124 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
125 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
126 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
127 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
128 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
129 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
130 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
131 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
132 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
133 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
134 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 5.00
135 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
136 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
137 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
138 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
139 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
140 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
141 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
142 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
143 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
144 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
145 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
146 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
147 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
148 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
149 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
150 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
151 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
152 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
153 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
154 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
155 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
156 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
157 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
158 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 5.00
159 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
160 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
161 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
162 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
163 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 5.00
164 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
165 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 5.00
166 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 5.00
167 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
168 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 5.00
169 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
170 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
171 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
172 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
173 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
174 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
175 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 5.00
176 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35 5.00
177 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
178 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 5.00
179 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
180 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 5.00
181 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 5.00
182 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
183 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
184 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 5.00
185 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 5.00
186 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
187 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 5.00
188 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
189 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
190 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
191 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
192 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
193 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
194 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
195 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
196 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
197 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
198 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.00
199 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49 5.00
200 INT103210 Localization of MMP1 43 0.78 12.15 15.13 5.00
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