D:Chronic Progressive External Ophthalmoplegia

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Disease Term
Synonyms Cpeo, Disease Graefe, Dystrophies Ocular Muscular, Dystrophy Ocular Muscular, EXTERNAL OPHTHALMOPLEGIA PROGRESSIVE, EXTERNAL OPHTHALMOPLEGIAS PROGRESSIVE, Graefe Disease, Graefe S Disease, Graefes Disease, Mitochondrial Ocular Myopathies, Mitochondrial Ocular Myopathy
Documents 38
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Progressive External Ophthalmoplegia. They are ordered first by their relevance to Chronic Progressive External Ophthalmoplegia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0 71.60
2 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 5.00
3 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
4 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
5 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
6 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
7 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
8 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Progressive External Ophthalmoplegia. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Progressive External Ophthalmoplegia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 100.00
2 INT251833 Binding of C10orf2 1 0.37 0.47 0 99.76
3 INT102696 Binding of MRP63 4 0.46 3.68 0.27 99.56
4 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 97.20
5 INT158837 Binding of POLG 4 0.37 4.69 0.44 93.00
6 INT251832 Positive_regulation of Positive_regulation of POLG 1 0.35 0.28 0 92.44
7 INT251829 Positive_regulation of POLG 1 0.53 1.5 0.08 91.80
8 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 90.40
9 INT251827 Regulation of POLG 3 0.59 2.94 0.04 88.08
10 INT116655 Binding of NAA50 3 0.36 1.93 0.78 88.00
11 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 86.72
12 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 86.72
13 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 84.60
14 INT69282 Binding of PHEX 4 0.15 1.43 0.41 84.60
15 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27 79.40
16 INT69867 Gene_expression of Mip 36 0.75 24.54 10.38 78.80
17 INT210590 Positive_regulation of Gene_expression of Mip 10 0.67 8.09 1.68 78.80
18 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 73.00
19 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 71.64
20 INT302684 Negative_regulation of RRM2B 1 0.17 0.73 0.08 70.56
21 INT302686 Negative_regulation of Localization of RRM2B 1 0.38 0.73 0.08 70.56
22 INT302694 Localization of RRM2B 1 0.66 0.73 0.07 70.56
23 INT302698 Negative_regulation of MPV17 1 0.16 0.67 0.08 69.76
24 INT302690 Negative_regulation of Localization of MPV17 1 0.37 0.67 0.08 69.76
25 INT302685 Localization of MPV17 1 0.65 0.67 0.07 69.76
26 INT302705 Localization of SUCLG1 1 0.65 0.66 0.07 69.20
27 INT302702 Negative_regulation of SUCLG1 1 0.16 0.66 0.07 69.20
28 INT302691 Negative_regulation of Localization of SUCLG1 1 0.37 0.66 0.07 69.20
29 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 68.56
30 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86 68.56
31 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28 68.56
32 INT251826 Gene_expression of C10orf2 1 0.67 0.28 0 68.16
33 INT302696 Negative_regulation of Localization of TK2 1 0.37 0.65 0.07 67.92
34 INT302700 Localization of TK2 1 0.65 0.65 0.07 67.92
35 INT302689 Negative_regulation of TK2 1 0.16 0.65 0.07 67.92
36 INT302697 Negative_regulation of DGUOK 1 0.38 0.65 0.07 67.52
37 INT302681 Negative_regulation of Localization of DGUOK 1 0.38 0.65 0.07 67.52
38 INT302680 Localization of DGUOK 1 0.66 0.65 0.07 67.52
39 INT251831 Positive_regulation of C10orf2 1 0.50 1.23 0.08 67.12
40 INT224340 Localization of TYMP 3 0.62 2.86 0.3 66.96
41 INT302704 Negative_regulation of Localization of TYMP 1 0.35 0.64 0.07 66.96
42 INT211378 Negative_regulation of TYMP 2 0.56 1.45 0.07 66.96
43 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52 66.48
44 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 66.48
45 INT302699 Negative_regulation of Localization of SLC25A4 1 0.38 1.01 0.11 66.48
46 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 65.76
47 INT302693 Localization of C10orf2 1 0.59 1 0.11 65.76
48 INT302695 Negative_regulation of Localization of C10orf2 1 0.33 1 0.11 65.76
49 INT284528 Negative_regulation of POLG2 2 0.17 2.19 0.33 65.28
50 INT302682 Localization of POLG2 1 0.67 1 0.11 65.28
51 INT302706 Negative_regulation of Localization of POLG2 1 0.38 1 0.11 65.28
52 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11 64.72
53 INT302692 Localization of POLG 1 0.69 0.99 0.1 64.72
54 INT251830 Binding of TYMP 2 0.13 4.36 0.37 51.60
55 INT310734 Negative_regulation of Phosphorylation of Pol 1 0.04 0.06 0 40.64
56 INT310733 Phosphorylation of Pol 1 0.09 0.06 0 40.64
57 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 34.48
58 INT189923 Binding of Pol 5 0.20 2.09 0.04 33.04
59 INT266161 Regulation of Negative_regulation of POLG 1 0.38 0.56 0 29.76
60 INT310741 Gene_expression of POLG2 1 0.36 0.87 0.03 27.08
61 INT266162 Transcription of POLG 2 0.68 0.76 0 18.00
62 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 15.52
63 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 13.56
64 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 13.00
65 INT234577 Positive_regulation of Gene_expression of MRP63 1 0.10 0.58 0 11.44
66 INT234575 Gene_expression of MRP63 1 0.16 0.62 0 10.84
67 INT33854 Localization of OPA1 19 0.65 10.55 5.04 10.76
68 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
69 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
70 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
71 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
72 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
73 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
74 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
75 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
76 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
77 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
78 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
79 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
80 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
81 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
82 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
83 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
84 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
85 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
86 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
87 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
88 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
89 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
90 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 5.00
91 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
92 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
93 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 5.00
94 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
95 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
96 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
97 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
98 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
99 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
100 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 5.00
101 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
102 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
103 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
104 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52 5.00
105 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 5.00
106 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
107 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
108 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 5.00
109 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
110 INT5913 Binding of OPA1 12 0.41 9.33 2.92 5.00
111 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
112 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
113 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 5.00
114 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
115 INT12485 Binding of DNAH8 17 0.48 4.24 2.54 5.00
116 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
117 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
118 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 5.00
119 INT68865 Gene_expression of ACOX1 13 0.52 5.49 2.09 5.00
120 INT26364 Positive_regulation of CS 12 0.30 4.99 1.89 5.00
121 INT91550 Gene_expression of PPM1D 7 0.10 0.68 1.81 5.00
122 INT46605 Positive_regulation of NAA50 17 0.49 6.33 1.76 5.00
123 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
124 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
125 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 5.00
126 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
127 INT108559 Gene_expression of Pol 46 0.45 30.07 1.14 5.00
128 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12 5.00
129 INT37950 Regulation of PDSS1 3 0.44 1.24 0.91 5.00
130 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9 5.00
131 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 5.00
132 INT114017 Gene_expression of CD200 10 0.75 2.38 0.88 5.00
133 INT37105 Binding of CHRNE 3 0.31 6.88 0.87 5.00
134 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
135 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
136 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 5.00
137 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 5.00
138 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 5.00
139 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64 5.00
140 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 5.00
141 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
142 INT309253 Negative_regulation of Transcription of LMOD1 1 0.03 0.2 0.57 5.00
143 INT194794 Binding of TTPA 7 0.08 2.56 0.57 5.00
144 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 5.00
145 INT200435 Binding of polymerase 6 0.16 5.56 0.47 5.00
146 INT82177 Negative_regulation of H2-Q10 5 0.58 5.83 0.45 5.00
147 INT309242 Localization of Nat1 1 0.01 0.17 0.42 5.00
148 INT15588 Regulation of PHEX 4 0.26 1.48 0.39 5.00
149 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 5.00
150 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 5.00
151 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 5.00
152 INT290576 Positive_regulation of NPTX2 1 0.06 3.32 0.31 5.00
153 INT309249 Regulation of OGDHL 1 0.01 0.6 0.3 5.00
154 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 5.00
155 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 5.00
156 INT166755 Localization of PHEX 2 0.73 1.16 0.28 5.00
157 INT220699 Positive_regulation of CHRNE 5 0.32 2.26 0.26 5.00
158 INT204348 Gene_expression of PPARGC1A 10 0.75 2.73 0.19 5.00
159 INT175961 Protein_catabolism of polymerase 5 0.08 1.94 0.19 5.00
160 INT194332 Localization of MFN2 2 0.74 1.45 0.15 5.00
161 INT199644 Positive_regulation of Gene_expression of H2-Q10 3 0.37 2.6 0.15 5.00
162 INT302703 Binding of PLAA 1 0.13 0.87 0.15 5.00
163 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 5.00
164 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 5.00
165 INT302683 Negative_regulation of PLAA 1 0.15 0.4 0.13 5.00
166 INT37103 Gene_expression of CHRNE 5 0.67 4.32 0.12 5.00
167 INT277821 Positive_regulation of Negative_regulation of INCENP 2 0.03 0.89 0.12 5.00
168 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 5.00
169 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 5.00
170 INT220702 Protein_catabolism of CHRNE 1 0.64 1.22 0.08 5.00
171 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08 5.00
172 INT220704 Protein_catabolism of ACOT1 1 0.02 1.19 0.08 5.00
173 INT199656 Binding of Pnkp 1 0.07 1.36 0.07 5.00
174 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 5.00
175 INT220700 Gene_expression of MUSK 3 0.75 6.67 0.07 5.00
176 INT261026 Localization of Gclc 3 0.36 0.88 0.06 5.00
177 INT261017 Regulation of Gclc 2 0.22 0.88 0.06 5.00
178 INT309245 Binding of SETX 1 0.08 1.98 0.06 5.00
179 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05 5.00
180 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 5.00
181 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04 5.00
182 INT199648 Regulation of Fxn 1 0.29 2.14 0.04 5.00
183 INT268212 Negative_regulation of Gene_expression of Pol 3 0.25 2.13 0.04 5.00
184 INT309246 Localization of ATXN2 1 0.10 1.45 0.03 5.00
185 INT309254 Localization of ATXN1 1 0.09 1.45 0.03 5.00
186 INT309258 Localization of TBP 2 0.27 1.78 0.03 5.00
187 INT164193 Localization of ATN1 2 0.73 1.47 0.03 5.00
188 INT309250 Localization of ATXN3 1 0.14 1.46 0.03 5.00
189 INT199651 Binding of Fxn 3 0.30 1.45 0.03 5.00
190 INT266166 Negative_regulation of RPA1 2 0.08 1.65 0.03 5.00
191 INT309256 Localization of ATXN7 1 0.11 1.46 0.03 5.00
192 INT266168 Gene_expression of SSBP1 1 0.58 0.4 0 5.00
193 INT258134 Gene_expression of NPTX2 2 0.40 0.65 0 5.00
194 INT234572 Regulation of MRP63 1 0.09 0.08 0 5.00
195 INT302701 Positive_regulation of PLAA 1 0.18 0 0 5.00
196 INT220701 Regulation of Negative_regulation of ACHE 2 0.25 1.06 0 5.00
197 INT199661 Negative_regulation of TTPA 2 0.04 1.84 0 5.00
198 INT266169 Negative_regulation of PCYT1B 1 0.01 0.74 0 5.00
199 INT309255 Gene_expression of NDUFV1 1 0.01 2.33 0 5.00
200 INT199653 Positive_regulation of Tfrc 2 0.13 1.57 0 5.00
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