D:Chronobiology Disorders

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Disease Term
Synonyms Biological Clock Disturbance, Biological Clock Disturbances, CHRONOBIOLOGY DISORDER, Circadian Dysregulation, Circadian Rhythm Disorder, CIRCADIAN RHYTHM DISORDERS, Disturbance Biological Clock, Disturbances Biological Clock, Dysregulation Circadian, INVERSION OF CIRCADIAN RHYTHM PSYCHOGENIC, PSYCHOGENIC INVERSION OF CIRCADIAN RHYTHM
Documents 25
Hot Single Events 3
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronobiology Disorders. They are ordered first by their relevance to Chronobiology Disorders and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT213606 CLOCK Regulation of Gene_expression of PROK2 1 0.20 0.3 0 89.16
2 INT213609 CLOCK Regulation of PROK2 1 0.20 0.3 0 89.16
3 INT213608 Binding of PER2 and CLOCK 1 0.22 0.65 0.04 11.76
4 INT213607 Binding of CSNK1D and CLOCK 1 0.27 0.65 0.04 10.24
5 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 5.00
6 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronobiology Disorders. They are ordered first by their pain relevance and then by number of times they were reported in Chronobiology Disorders. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 96.24
2 INT146563 Gene_expression of PROK2 15 0.75 4.12 0.61 89.16
3 INT157242 Localization of PER2 2 0.68 0.3 0 83.28
4 INT175737 Gene_expression of PER2 4 0.68 0.3 0.16 72.92
5 INT273025 Phosphorylation of RLS 1 0.67 4.2 0.38 49.84
6 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 47.56
7 INT213618 Binding of NPSR1 4 0.35 1.47 0.53 47.56
8 INT80032 Gene_expression of NPSR1 3 0.75 5.06 1.75 45.96
9 INT213613 Localization of NPS 2 0.62 1.11 0.23 32.56
10 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 22.40
11 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
12 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
13 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
14 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
15 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
16 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
17 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
18 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 5.00
19 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
20 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84 5.00
21 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
22 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 5.00
23 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94 5.00
24 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
25 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 5.00
26 INT75742 Binding of RLS 86 0.42 95.27 19.04 5.00
27 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 5.00
28 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
29 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
30 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
31 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 5.00
32 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
33 INT142735 Regulation of RLS 33 0.53 45.83 11.35 5.00
34 INT67101 Gene_expression of DST 47 0.54 25.92 9.59 5.00
35 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28 5.00
36 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16 5.00
37 INT7813 Regulation of SRI 25 0.61 6.18 8.13 5.00
38 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 5.00
39 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 5.00
40 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79 5.00
41 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 5.00
42 INT58622 Gene_expression of HTR7 13 0.75 2.86 4.7 5.00
43 INT34624 Negative_regulation of REM1 22 0.38 9.25 4.22 5.00
44 INT127047 Negative_regulation of P2RX7 10 0.39 7.17 4.01 5.00
45 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 5.00
46 INT117117 Positive_regulation of REM1 12 0.40 10.1 3.33 5.00
47 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 5.00
48 INT62652 Binding of HTR7 9 0.47 2.79 3.06 5.00
49 INT54370 Negative_regulation of VTA1 5 0.50 2.06 2.77 5.00
50 INT122656 Gene_expression of MTNR1A 21 0.75 6.37 2.46 5.00
51 INT44880 Gene_expression of REM1 21 0.30 5.3 2.43 5.00
52 INT80733 Binding of Scn2a1 11 0.30 1.09 2.3 5.00
53 INT106055 Negative_regulation of Gene_expression of Hcrt 15 0.46 5.64 2.09 5.00
54 INT71487 Positive_regulation of HTR7 3 0.67 0.73 2.06 5.00
55 INT117585 Regulation of Hcrt 10 0.56 6.16 1.77 5.00
56 INT62127 Localization of SRI 12 0.45 10.21 1.54 5.00
57 INT7812 Negative_regulation of SRI 10 0.59 4.28 1.46 5.00
58 INT148883 Gene_expression of HCRTR1 8 0.36 24.82 1.35 5.00
59 INT22962 Gene_expression of FXYD1 2 0.58 3.32 1.12 5.00
60 INT47027 Positive_regulation of BCHE 6 0.50 2.32 1.09 5.00
61 INT267808 Positive_regulation of Gene_expression of RLS 4 0.41 5.96 0.94 5.00
62 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9 5.00
63 INT213617 Gene_expression of PDE4D 3 0.53 1.98 0.62 5.00
64 INT310648 Negative_regulation of Negative_regulation of BCHE 2 0.27 1.79 0.59 5.00
65 INT274343 Localization of Mt1 1 0.11 0.84 0.48 5.00
66 INT274342 Gene_expression of Epha1 1 0.01 0 0.46 5.00
67 INT274341 Positive_regulation of Gene_expression of Epha1 1 0.01 0 0.46 5.00
68 INT273027 Regulation of Negative_regulation of FXYD1 1 0.05 1.19 0.35 5.00
69 INT247999 Negative_regulation of FXYD1 2 0.06 1.75 0.35 5.00
70 INT258092 Regulation of Gene_expression of Hcrt 2 0.44 2.6 0.29 5.00
71 INT295943 Negative_regulation of MTNR1A 4 0.21 2.66 0.24 5.00
72 INT213615 Localization of NPSR1 2 0.73 0.61 0.17 5.00
73 INT331573 Regulation of Localization of SRI 1 0.23 0.46 0.11 5.00
74 INT296126 Negative_regulation of Gene_expression of MTNR1A 2 0.21 0.77 0.11 5.00
75 INT213614 Negative_regulation of LRP1B 1 0.32 0.4 0.08 5.00
76 INT213612 Negative_regulation of FHIT 1 0.24 0.4 0.08 5.00
77 INT273026 Localization of FXYD1 1 0.08 1.53 0 5.00
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