D:Closed Head Injuries

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Blunt Head Injuries, Blunt Head Injury, Closed Head Injury, Closed Head Trauma, Closed Head Traumas, Head Injuries Blunt, Head Injuries Nonpenetrating, Head Injury Blunt, HEAD INJURY CLOSED, Head Injury Nonpenetrating, HEAD TRAUMA CLOSED
Documents 129
Hot Single Events 52
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Closed Head Injuries. They are ordered first by their relevance to Closed Head Injuries and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT178822 TNF Regulation of Gene_expression of Il18 1 0.18 0.47 0.03 98.88
2 INT178823 TNF Regulation of Il18 1 0.18 3.28 0.41 96.80
3 INT104553 Il18 Negative_regulation of Il18bp 1 0.26 1.09 0.23 95.80
4 INT61976 TBP Negative_regulation of Tnf 1 0.24 1.17 0.17 92.00
5 INT178821 TNF Negative_regulation of Il18 1 0.29 0.64 0.08 88.84
6 INT61965 TBP Negative_regulation of TNF 1 0.07 1.01 0.14 77.08
7 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11 22.80
8 INT345060 Binding of SGCG and C2 1 0.00 0.93 0 5.00
9 INT345059 Binding of C3 and C2 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Closed Head Injuries. They are ordered first by their pain relevance and then by number of times they were reported in Closed Head Injuries. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 100.00
2 INT55154 Positive_regulation of Havcr1 3 0.07 1.22 0.3 100.00
3 INT62870 Binding of ZNRF1 3 0.14 2.68 0.98 100.00
4 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.74
5 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 99.74
6 INT104547 Negative_regulation of Il18 24 0.59 17.89 6.01 99.72
7 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.48
8 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 99.40
9 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3 99.40
10 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.36
11 INT178818 Regulation of Gene_expression of Il18 3 0.40 2.98 0.68 98.88
12 INT104550 Positive_regulation of Il18 67 0.70 55.14 17.48 98.80
13 INT104548 Positive_regulation of Positive_regulation of Il18 7 0.66 5.74 2.13 98.76
14 INT104549 Localization of Il18 16 0.78 13.01 4.64 98.36
15 INT207774 Gene_expression of Pacsin1 1 0.04 6.32 0.84 97.76
16 INT73544 Gene_expression of Grm7 34 0.64 31.28 8.04 97.60
17 INT223646 Regulation of Gene_expression of Grm7 1 0.01 4.41 0.32 97.60
18 INT9660 Regulation of TNF 363 0.62 312.94 139.99 97.56
19 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56 97.56
20 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 97.32
21 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 96.64
22 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 96.64
23 INT10062 Positive_regulation of PSMB5 6 0.45 3.88 1.41 96.32
24 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 96.08
25 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 95.76
26 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 95.56
27 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49 95.28
28 INT61975 Positive_regulation of TBP 5 0.28 4.01 0.4 95.28
29 INT61968 Negative_regulation of Gene_expression of Crhbp 1 0.04 1.19 0.18 95.28
30 INT61970 Positive_regulation of Gene_expression of Crhbp 1 0.04 1.19 0.18 95.28
31 INT61974 Positive_regulation of Negative_regulation of TBP 1 0.28 1.2 0.18 95.28
32 INT61966 Positive_regulation of Crhbp 1 0.04 1.19 0.18 95.28
33 INT61973 Positive_regulation of Gene_expression of TBP 2 0.49 1.5 0.18 95.28
34 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 95.08
35 INT104552 Negative_regulation of Il18bp 1 0.23 1.08 0.23 94.88
36 INT61971 Gene_expression of TBP 9 0.65 5.14 0.8 94.68
37 INT61969 Gene_expression of Crhbp 2 0.29 1.75 0.31 94.68
38 INT30312 Binding of Pdyn 30 0.37 4.2 18.23 94.52
39 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 93.76
40 INT62869 Negative_regulation of REG3A 4 0.57 4.31 0.82 93.08
41 INT61972 Negative_regulation of TBP 5 0.32 3.56 0.53 92.00
42 INT200835 Gene_expression of Cd59a 5 0.77 9.02 1.64 91.92
43 INT5254 Positive_regulation of Pla2g2a 22 0.68 10.42 6.37 91.44
44 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 91.12
45 INT145774 Positive_regulation of C5 7 0.67 4.88 2.79 87.36
46 INT35744 Binding of MAOB 13 0.46 7.52 4.26 84.96
47 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 81.56
48 INT45004 Gene_expression of Cfb 28 0.37 15.06 1.99 81.20
49 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 80.80
50 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 80.52
51 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 80.24
52 INT124705 Binding of Il18 29 0.47 19.02 5.59 80.16
53 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 78.08
54 INT25613 Gene_expression of Il1f5 32 0.77 13.29 10.44 77.68
55 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 75.60
56 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 75.12
57 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 75.00
58 INT214 Localization of AVP 370 0.81 208.51 91.09 75.00
59 INT91063 Gene_expression of Grm4 3 0.34 2.98 0.71 73.44
60 INT126999 Positive_regulation of Gene_expression of Cfb 4 0.28 2.37 0.29 71.04
61 INT565 Negative_regulation of Cfb 18 0.13 6.77 1.69 70.56
62 INT178819 Negative_regulation of Positive_regulation of Il18 1 0.38 0.58 0.13 70.32
63 INT46389 Positive_regulation of Cfb 20 0.23 8.29 1.49 69.60
64 INT218579 Regulation of Gene_expression of GYPC 1 0.33 1.3 0.08 68.96
65 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 68.64
66 INT218577 Gene_expression of GYPC 6 0.50 5.16 0.44 68.44
67 INT223647 Positive_regulation of Gene_expression of Grm4 1 0.18 1.3 0 64.16
68 INT14690 Localization of CSF2 124 0.80 85.17 27.26 61.40
69 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 60.00
70 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 40.64
71 INT223640 Positive_regulation of Gene_expression of Pla2g3 1 0.01 2.9 0.51 32.92
72 INT223643 Positive_regulation of Gene_expression of Grm6 1 0.49 1.22 0.37 32.92
73 INT223651 Gene_expression of Pla2g3 1 0.01 5.27 0.79 32.24
74 INT223650 Gene_expression of Grm6 1 0.65 1.21 0.37 32.24
75 INT223649 Positive_regulation of Grm4 2 0.45 1.1 0.48 28.72
76 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 28.32
77 INT91056 Negative_regulation of Gene_expression of Grm7 2 0.18 1.21 0.69 27.00
78 INT301337 Negative_regulation of Gene_expression of Cd59a 1 0.43 0.48 0.08 17.84
79 INT113516 Negative_regulation of Fas 16 0.51 8.37 5.32 16.32
80 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44 16.32
81 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61 14.28
82 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 13.96
83 INT27642 Regulation of Gene_expression of Dbi 10 0.44 2.55 3.66 12.12
84 INT74745 Gene_expression of Grm8 30 0.68 9.85 14.52 5.92
85 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 5.00
86 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
87 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
88 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
89 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
90 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
91 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
92 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
93 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
94 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
95 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
96 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
97 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
98 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
99 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
100 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
101 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 5.00
102 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
103 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
104 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
105 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
106 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
107 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 5.00
108 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 5.00
109 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
110 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 5.00
111 INT3920 Localization of Ldha 241 0.81 83.08 58.72 5.00
112 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
113 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
114 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 5.00
115 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7 5.00
116 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
117 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 5.00
118 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
119 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 5.00
120 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
121 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 5.00
122 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
123 INT8835 Localization of SFTPA1 65 0.68 32.81 38.65 5.00
124 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
125 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 5.00
126 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
127 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 5.00
128 INT316 Regulation of Cebpz 105 0.00 27.21 35.41 5.00
129 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
130 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
131 INT5989 Positive_regulation of Dbi 79 0.49 24.38 32.56 5.00
132 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
133 INT8698 Localization of Nka1 50 0.78 5.8 27.67 5.00
134 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44 5.00
135 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 5.00
136 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
137 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
138 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
139 INT14884 Positive_regulation of Gene_expression of SFTPA1 32 0.25 20.37 26.09 5.00
140 INT276 Regulation of Ache 83 0.62 16.75 25.99 5.00
141 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 5.00
142 INT8699 Gene_expression of Nka1 45 0.67 6.41 22.56 5.00
143 INT93485 Negative_regulation of Slc1a2 27 0.59 10.65 20.9 5.00
144 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
145 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
146 INT107930 Gene_expression of Slc17a7 39 0.78 6.53 18.86 5.00
147 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 5.00
148 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 5.00
149 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
150 INT4616 Regulation of Maoa 40 0.62 6.09 15.94 5.00
151 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66 5.00
152 INT4719 Positive_regulation of Nka1 27 0.67 4.16 15.42 5.00
153 INT11945 Regulation of Chat 38 0.62 7.75 14.97 5.00
154 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 5.00
155 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 5.00
156 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76 5.00
157 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
158 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35 5.00
159 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 5.00
160 INT39244 Gene_expression of TMPO 137 0.77 14.55 11.83 5.00
161 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83 5.00
162 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
163 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26 5.00
164 INT94545 Positive_regulation of C7orf49 37 0.69 12.91 11.19 5.00
165 INT48912 Localization of NOS1 52 0.77 24.14 10.92 5.00
166 INT54466 Negative_regulation of Gene_expression of Ltp 19 0.38 5.44 10.91 5.00
167 INT7411 Localization of FGFR3 40 0.78 4.77 10.24 5.00
168 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 5.00
169 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47 5.00
170 INT18121 Binding of Maoa 20 0.48 2.4 9.3 5.00
171 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
172 INT78570 Negative_regulation of Grm5 15 0.57 5.45 9.17 5.00
173 INT7090 Gene_expression of pcp 50 0.66 13.54 8.96 5.00
174 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
175 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45 5.00
176 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
177 INT119940 Positive_regulation of Gene_expression of Arc 36 0.70 18.87 7.85 5.00
178 INT15165 Positive_regulation of Localization of Nka1 7 0.66 1.19 7.78 5.00
179 INT98178 Localization of Casp3 32 0.65 21.01 7.77 5.00
180 INT10261 Negative_regulation of Pd 16 0.42 5.55 7.4 5.00
181 INT22275 Negative_regulation of TBXA2R 25 0.54 8.67 7.34 5.00
182 INT177600 Gene_expression of C7orf49 21 0.52 7.1 6.92 5.00
183 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 5.00
184 INT132468 Positive_regulation of Positive_regulation of Camk2a 20 0.70 2.76 6.7 5.00
185 INT8101 Binding of INCENP 42 0.31 16.2 6.68 5.00
186 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22 5.00
187 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
188 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 5.00
189 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
190 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87 5.00
191 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 5.00
192 INT521 Negative_regulation of Lrtomt 8 0.55 2.83 3.96 5.00
193 INT54848 Protein_catabolism of SGCG 12 0.96 3.8 3.78 5.00
194 INT34822 Regulation of Localization of Ldha 12 0.57 4.03 3.65 5.00
195 INT107074 Gene_expression of C5 14 0.75 9.87 3.64 5.00
196 INT214581 Negative_regulation of GYPC 32 0.32 21.93 3.62 5.00
197 INT9295 Regulation of MAOB 12 0.56 3.32 3.6 5.00
198 INT232667 Binding of Pd 17 0.16 20.76 3.58 5.00
199 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
200 INT196779 Phosphorylation of Ppp2ca 28 0.72 1.86 3.25 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox