D:Cocaine Dependence

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Disease Term
Synonyms Abuse Cocaine, Addiction Cocaine, Cocaine Abuse, COCAINE ADDICTION, COCAINE RELATED DISORDER, COCAINE RELATED DISORDERS, COCAINE USE DISORDER, Cocaine User, Cocaine Users, CRACK ADDICTION, Crack Cocaine Addiction
Documents 626
Hot Single Events 72
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cocaine Dependence. They are ordered first by their relevance to Cocaine Dependence and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33 79.88
2 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98 77.04
3 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08 76.80
4 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08 76.80
5 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36 76.80
6 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03 76.80
7 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1 76.80
8 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8 76.80
9 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31 75.92
10 INT280451 IER5 Positive_regulation of Phc1 1 0.00 0.56 0.09 40.32
11 INT241614 CCNA2 Regulation of PRB3 1 0.06 0 0.37 31.92
12 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
13 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 5.00
14 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
15 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
16 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
17 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
18 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42 5.00
19 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4 5.00
20 INT300610 Rorb Regulation of Dnm2 1 0.01 0.27 0.37 5.00
21 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37 5.00
22 INT300608 Arc Regulation of Dnm2 1 0.15 0.27 0.37 5.00
23 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34 5.00
24 INT258763 Binding of Drd5 and ADHD1 1 0.07 1.11 0.31 5.00
25 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31 5.00
26 INT258766 Binding of Csf2 and ADHD1 1 0.01 0.69 0.27 5.00
27 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25 5.00
28 INT264569 Binding of STS and ATF7IP 1 0.03 0.15 0.25 5.00
29 INT179166 TFPI Positive_regulation of Gene_expression of IL6 1 0.03 0.18 0.25 5.00
30 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18 5.00
31 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18 5.00
32 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18 5.00
33 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18 5.00
34 INT200099 OLR1 Negative_regulation of Gene_expression of VCAM1 1 0.01 0.85 0.13 5.00
35 INT258761 Binding of Slc6a3 and ADHD1 1 0.03 0.51 0.12 5.00
36 INT179160 IL6 Regulation of Gene_expression of IL13 1 0.03 0.12 0.11 5.00
37 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11 5.00
38 INT179159 IL8 Regulation of Gene_expression of IL6 1 0.02 0.12 0.11 5.00
39 INT179165 IL8 Regulation of Gene_expression of IL13 1 0.02 0.12 0.11 5.00
40 INT258765 Lmo1 Regulation of ADHD1 1 0.05 1.98 0.09 5.00
41 INT258758 Binding of Drd4 and Lmo1 1 0.04 0.64 0.08 5.00
42 INT258756 Binding of Drd5 and Lmo1 1 0.03 0.64 0.08 5.00
43 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07 5.00
44 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06 5.00
45 INT290727 Binding of Prdm6 and Arsi 1 0.01 0.17 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cocaine Dependence. They are ordered first by their pain relevance and then by number of times they were reported in Cocaine Dependence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 99.92
2 INT2893 Localization of Oxt 219 0.80 28.96 79.43 99.92
3 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 99.92
4 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 99.76
5 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.68
6 INT3579 Localization of Oxt 555 0.81 43.35 292.44 99.52
7 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 99.52
8 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 98.92
9 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 97.96
10 INT82990 Binding of POLR3D 1 0.02 0.42 0.99 97.96
11 INT13703 Regulation of Phc1 7 0.23 3.92 2.71 97.84
12 INT133638 Gene_expression of Dbh 9 0.78 1.23 5.46 97.44
13 INT46291 Negative_regulation of Dbh 6 0.56 0.91 3.06 97.44
14 INT133637 Negative_regulation of Gene_expression of Dbh 2 0.43 0.25 1.46 97.44
15 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 97.32
16 INT142637 Positive_regulation of Gene_expression of PRTN3 8 0.46 6.23 1.75 97.32
17 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 97.12
18 INT12484 Binding of Drd2 45 0.48 15.17 24.72 97.04
19 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78 96.60
20 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 96.60
21 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79 96.60
22 INT79361 Negative_regulation of Prdm6 5 0.51 3.79 1.4 96.08
23 INT184815 Regulation of ETF1 3 0.40 1.83 0.54 95.56
24 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 94.72
25 INT738 Regulation of POMC 459 0.62 111.19 243.74 93.68
26 INT185986 Regulation of Melc 1 0.01 1.03 0.11 93.64
27 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 93.32
28 INT66782 Negative_regulation of Gene_expression of OPRK1 4 0.28 1.42 3.41 93.24
29 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18 93.24
30 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 92.40
31 INT6826 Transcription of Pdyn 130 0.71 22.19 54.88 92.40
32 INT168315 Binding of LOC684513 1 0.00 0.65 0.98 92.20
33 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 91.84
34 INT28770 Negative_regulation of Gene_expression of PDYN 16 0.57 4.95 12.06 91.56
35 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 91.56
36 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 91.12
37 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 91.12
38 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 90.72
39 INT21566 Regulation of Oprk1 10 0.62 3.4 8.63 90.72
40 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41 89.92
41 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63 89.28
42 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37 89.28
43 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95 88.40
44 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49 88.28
45 INT69498 Positive_regulation of DRD4 3 0.50 0.95 1.3 88.08
46 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 87.80
47 INT65324 Gene_expression of Tnni3 12 0.66 7.97 1.25 87.80
48 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 87.48
49 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 87.48
50 INT130444 Positive_regulation of MARCKS 2 0.12 0.61 1.02 87.48
51 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 87.04
52 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 87.00
53 INT130441 Phosphorylation of MARCKS 8 0.37 3.24 3.09 86.80
54 INT3244 Negative_regulation of eCB 37 0.03 16.69 12.61 86.04
55 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 85.28
56 INT134754 Positive_regulation of Gene_expression of PLAT 9 0.49 4.75 0.72 85.28
57 INT7585 Regulation of Crh 24 0.58 9.88 12.97 85.24
58 INT145502 Binding of dds 2 0.39 4.44 0.16 84.56
59 INT82989 Regulation of DRD3 1 0.23 0.45 0.99 83.32
60 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 83.04
61 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 82.48
62 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 82.48
63 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 81.92
64 INT10119 Positive_regulation of Positive_regulation of Pdyn 14 0.69 2.67 10.81 81.72
65 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 81.60
66 INT290728 Gene_expression of Depmq1 1 0.01 0.79 0.92 81.60
67 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 81.44
68 INT35140 Protein_catabolism of ANGPTL5 7 0.32 3.78 1.51 81.44
69 INT646 Binding of Mb 37 0.41 6.13 2.25 81.20
70 INT73897 Regulation of Binding of Mb 2 0.35 0.73 0.41 81.20
71 INT212930 Localization of ELL 2 0.15 0.87 0.04 80.72
72 INT2791 Regulation of Mb 53 0.61 23.03 10.73 80.60
73 INT38814 Positive_regulation of Aspt1 9 0.63 6.89 3.06 80.00
74 INT120483 Localization of ITIH4 11 0.69 12.05 2.51 79.96
75 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 79.76
76 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85 79.52
77 INT82991 Regulation of Gene_expression of DRD3 1 0.23 0.59 1.26 78.00
78 INT82988 Regulation of Transcription of DRD3 1 0.38 0.59 1.26 78.00
79 INT34132 Binding of Oprk1 6 0.48 2.15 4.78 77.64
80 INT82992 Gene_expression of DRD3 3 0.50 2.12 2.88 77.52
81 INT82987 Transcription of DRD3 1 0.58 0.59 1.25 77.52
82 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73 77.36
83 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75 77.04
84 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 77.04
85 INT6666 Negative_regulation of PENK 30 0.58 9.16 17.91 77.04
86 INT1510 Binding of PDYN 94 0.48 4.68 56.44 76.80
87 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 76.80
88 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15 76.20
89 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 76.16
90 INT63959 Regulation of Tnni3 11 0.21 4.69 1.57 76.16
91 INT202715 Binding of NMS 3 0.27 6.92 0.65 76.00
92 INT101414 Gene_expression of Phc1 27 0.60 9.55 7.58 75.96
93 INT280449 Positive_regulation of Gene_expression of Phc1 1 0.05 1.79 1.09 75.96
94 INT1590 Binding of PENK 27 0.47 2.99 12.81 75.92
95 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 75.28
96 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 75.16
97 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 75.12
98 INT5847 Transcription of FOS 31 0.69 11.11 6.41 75.00
99 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84 75.00
100 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43 75.00
101 INT82984 Gene_expression of Cartpt 27 0.78 3.93 11.55 75.00
102 INT18825 Gene_expression of PRLR 8 0.40 2 3.47 75.00
103 INT82983 Transcription of Cartpt 2 0.66 0.17 1.86 75.00
104 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 74.08
105 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 72.76
106 INT15179 Positive_regulation of Gene_expression of SELL 18 0.61 14.35 2.84 71.92
107 INT8101 Binding of INCENP 42 0.31 16.2 6.68 71.20
108 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 71.04
109 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 70.92
110 INT208125 Gene_expression of DDR1 10 0.06 8.15 1.03 70.92
111 INT17641 Gene_expression of NLRP1 33 0.73 8.85 6.02 70.56
112 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 70.40
113 INT125622 Regulation of NLRP1 7 0.44 1.84 3.62 69.32
114 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 68.96
115 INT16923 Positive_regulation of Tnni3 32 0.50 25.01 5.44 68.96
116 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09 68.12
117 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 67.04
118 INT105021 Binding of GOPC 187 0.40 60.39 20.38 66.64
119 INT155036 Localization of NT5E 6 0.73 4.1 1.35 65.84
120 INT155035 Binding of NT5E 3 0.36 1.78 0.61 65.44
121 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 65.08
122 INT64225 Positive_regulation of Localization of ABAT 15 0.60 4.46 11.28 64.80
123 INT19488 Localization of ABAT 56 0.69 21.51 50.56 64.48
124 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 64.32
125 INT75562 Regulation of FosB 8 0.52 2.38 4.07 64.32
126 INT101959 Regulation of Rorb 10 0.14 5.18 3.17 64.32
127 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65 64.24
128 INT99077 Transcription of FosB 2 0.50 1.04 1.67 63.92
129 INT53385 Positive_regulation of Gene_expression of FosB 26 0.70 9.18 26.33 62.88
130 INT15186 Negative_regulation of HRH2 8 0.51 2.26 0.99 62.88
131 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 60.16
132 INT22503 Positive_regulation of Hal 10 0.36 4.44 2.12 59.44
133 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 57.52
134 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 56.92
135 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 56.92
136 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 56.00
137 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 56.00
138 INT187026 Positive_regulation of Gene_expression of TIMP2 3 0.47 2.05 0.96 56.00
139 INT253 Regulation of PRL 184 0.62 47.27 65.79 55.92
140 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 55.36
141 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 55.36
142 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11 53.80
143 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 53.44
144 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 53.44
145 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 52.56
146 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 51.20
147 INT182811 Gene_expression of Hmdc 2 0.47 0.25 0.43 50.64
148 INT131966 Regulation of Regulation of Grik2 1 0.26 0.45 0.75 50.56
149 INT244283 Negative_regulation of Gene_expression of MAOA 2 0.27 1.7 2.5 50.48
150 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 50.48
151 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 50.24
152 INT131969 Regulation of Grik1 6 0.61 0.57 3.69 50.24
153 INT131970 Regulation of Grik2 3 0.26 0.65 1.15 50.24
154 INT84965 Gene_expression of MAOA 15 0.75 6.9 6.06 50.16
155 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 50.00
156 INT49706 Positive_regulation of TNNT2 22 0.69 12.65 1.56 50.00
157 INT62691 Transcription of Cpe 11 0.40 3.5 6.66 49.56
158 INT131968 Transcription of Grik1 3 0.51 1.44 1.51 49.56
159 INT131967 Transcription of Grik2 2 0.67 0.73 0.82 49.56
160 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 48.88
161 INT169643 Binding of Ods 3 0.18 2.89 1.15 48.68
162 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29 48.28
163 INT76625 Positive_regulation of Phc1 14 0.36 5.1 3.49 46.36
164 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 45.68
165 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 45.68
166 INT1438 Localization of Pomc 360 0.81 101.26 116.47 44.32
167 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01 44.32
168 INT102451 Localization of CALCRL 9 0.69 0 3.25 44.12
169 INT16184 Negative_regulation of CHKB 20 0.53 10.61 1.42 43.52
170 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 42.80
171 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84 42.76
172 INT214855 Regulation of Positive_regulation of CNOT4 1 0.02 0.66 0.53 42.76
173 INT241664 Negative_regulation of PRB3 1 0.08 0.33 0.77 42.12
174 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35 41.48
175 INT156641 Positive_regulation of CNOT4 4 0.07 3.19 0.9 41.48
176 INT184852 Positive_regulation of Gene_expression of ADHD1 6 0.40 5.06 1.66 41.40
177 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 41.08
178 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 40.76
179 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67 40.44
180 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 40.00
181 INT191252 Localization of DDR1 4 0.45 3.15 0.04 39.72
182 INT443 Localization of POMC 1020 0.81 284.52 443.17 39.68
183 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 39.68
184 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 39.20
185 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 35.44
186 INT177841 Gene_expression of CCNA2 2 0.50 0.64 1.97 32.52
187 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 32.20
188 INT257951 Localization of CUBN 1 0.07 0 0.71 31.96
189 INT241623 Gene_expression of Atf4 12 0.74 8.67 2.85 31.92
190 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 31.72
191 INT257948 Binding of CUBN 1 0.05 0 0.7 31.32
192 INT281849 Binding of RRM2 5 0.17 0.43 1.07 30.80
193 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95 30.36
194 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 30.08
195 INT258746 Binding of Rends1 1 0.01 1.57 0.68 28.80
196 INT219458 Negative_regulation of CCNA2 9 0.38 1.23 2.21 28.16
197 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 27.68
198 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 25.96
199 INT265696 Negative_regulation of Transcription of Oxt 2 0.39 0.57 1.11 25.96
200 INT6484 Binding of IL1B 122 0.47 75.84 35.07 25.72
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