D:Coccidioides Infection

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Disease Term
Synonyms Coccidioides Immitis, Coccidioides Infections, Coccidioidomycoses, Coccidioidomycosis, Desert Rheumatism, PROGRESSIVE COCCIDIOIDOMYCOSIS, San Joaquin Fever, Valley Fever
Documents 99
Hot Single Events 22
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Coccidioides Infection. They are ordered first by their relevance to Coccidioides Infection and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT319094 Binding of polymerase and RNPC3 1 0.00 0.13 0 82.56
2 INT319111 Binding of Yy1 and Sap30 1 0.01 0 0.04 50.00
3 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 5.00
4 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91 5.00
5 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
6 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
7 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
8 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44 5.00
9 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35 5.00
10 INT260433 Dbi Positive_regulation of Cd8a 1 0.00 0.13 0.3 5.00
11 INT260438 Binding of Cd4 and Mx1 1 0.00 1.52 0.29 5.00
12 INT260434 Binding of Cd8a and Mx1 1 0.00 1.52 0.29 5.00
13 INT260423 IFNA1 Positive_regulation of Gene_expression of VEGFA 1 0.01 1.28 0.26 5.00
14 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25 5.00
15 INT260437 Positive_regulation of Tlr7 Positive_regulation of Positive_regulation of Il12a 1 0.03 0.27 0.21 5.00
16 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
17 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21 5.00
18 INT260441 Negative_regulation of Tlr7 Negative_regulation of Positive_regulation of IFNA1 1 0.05 0.96 0.21 5.00
19 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
20 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
21 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2 5.00
22 INT353298 IFNA1 Positive_regulation of CD8A 1 0.04 0.75 0.19 5.00
23 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16 5.00
24 INT180715 Binding of SARS and CLEC4M 2 0.12 2.92 0.11 5.00
25 INT250804 Binding of CCL4L1 and AP5M1 1 0.01 1.48 0.08 5.00
26 INT250801 Binding of AP5M1 and MAPKAP1 1 0.00 1.48 0.08 5.00
27 INT260442 Binding of IFNA1 and Il6 1 0.01 1.07 0.07 5.00
28 INT260439 Positive_regulation of Binding of IFNA1 and Il6 1 0.01 1.08 0.07 5.00
29 INT260435 Binding of Tlr9 and Tlr7 1 0.09 0.71 0.05 5.00
30 INT250802 Binding of IL6 and AP5M1 1 0.01 1.47 0.05 5.00
31 INT250803 Binding of SARS and MBL3P 1 0.09 1.7 0.04 5.00
32 INT203978 Binding of Srebf1 and Scap 1 0.01 0.26 0 5.00
33 INT324413 Binding of MIOX and Miox 1 0.01 0 0 5.00
34 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Coccidioides Infection. They are ordered first by their pain relevance and then by number of times they were reported in Coccidioides Infection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT103716 Gene_expression of Cms1 14 0.65 8.52 1.3 100.00
2 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93 100.00
3 INT22118 Negative_regulation of Cms1 6 0.38 4.02 0.78 100.00
4 INT162801 Localization of CALR 7 0.73 8.69 0.6 98.34
5 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 97.88
6 INT192406 Regulation of Ighm 16 0.31 5.58 0.29 97.00
7 INT255232 Gene_expression of PRNT 1 0.65 1.64 0.13 97.00
8 INT255222 Regulation of Gene_expression of Cms1 1 0.10 1.55 0.07 95.84
9 INT150395 Binding of MEFV 55 0.44 31.18 3.42 94.00
10 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 90.56
11 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 90.56
12 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 89.84
13 INT148721 Binding of PSMD1 13 0.31 4.78 1.76 89.80
14 INT11689 Binding of PSMD2 16 0.36 2.77 0.34 89.80
15 INT110871 Positive_regulation of Cms1 8 0.15 7.92 1.27 88.24
16 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 85.96
17 INT174689 Gene_expression of Tlr7 11 0.67 8.24 1.56 84.32
18 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 83.84
19 INT168001 Localization of Cms1 5 0.59 1.78 0.21 82.76
20 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 81.68
21 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 81.36
22 INT183680 Localization of Tlr3 6 0.71 1.69 0.39 80.72
23 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 75.48
24 INT26069 Positive_regulation of Positive_regulation of IFNA1 26 0.50 16.61 4.76 75.48
25 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 74.24
26 INT38268 Positive_regulation of BEST1 16 0.17 14.54 1.93 74.24
27 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 73.88
28 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62 71.68
29 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 71.12
30 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 70.80
31 INT173087 Gene_expression of VHLL 5 0.62 8.44 0.67 70.48
32 INT26606 Gene_expression of RNASE1 19 0.65 7.18 1.46 69.84
33 INT260426 Regulation of Gene_expression of Tlr3 1 0.23 0.77 0 69.76
34 INT158595 Gene_expression of Tlr3 25 0.69 12.09 4.07 69.36
35 INT79693 Regulation of Il4 30 0.51 21.96 8.6 66.96
36 INT233349 Regulation of Il12b 5 0.05 3.71 0.98 66.96
37 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 65.28
38 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 58.80
39 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 55.68
40 INT182037 Localization of C3 10 0.68 6.69 1.54 51.24
41 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98 50.56
42 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 50.44
43 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 50.00
44 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 50.00
45 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 50.00
46 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 50.00
47 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 50.00
48 INT154805 Gene_expression of Polymerase 13 0.16 4.4 0.65 50.00
49 INT60289 Negative_regulation of PKLR 5 0.21 1.75 0.53 50.00
50 INT183679 Negative_regulation of Ducm1 3 0.57 1.49 0.47 50.00
51 INT77364 Positive_regulation of Negative_regulation of IFNA1 6 0.30 3.68 0.36 50.00
52 INT152957 Gene_expression of CUX1 4 0.75 0.18 0.21 50.00
53 INT232067 Gene_expression of RNPC3 6 0.65 0.95 0.2 50.00
54 INT319100 Positive_regulation of Gene_expression of RNPC3 2 0.05 0.39 0.05 50.00
55 INT319061 Localization of Yy1 1 0.12 0 0.04 50.00
56 INT319063 Localization of Sap130 1 0.01 0 0.04 50.00
57 INT319060 Localization of Crebbp 2 0.73 0 0.04 50.00
58 INT265372 Localization of Hdac3 3 0.55 0.6 0.04 50.00
59 INT319065 Localization of Sap30 1 0.12 0 0.04 50.00
60 INT319062 Positive_regulation of Binding of Sap30 1 0.08 0.05 0.03 50.00
61 INT319067 Binding of Sap30 1 0.06 0.05 0.03 50.00
62 INT319102 Phosphorylation of RNPC3 1 0.02 0 0 50.00
63 INT319099 Transcription of POLI 1 0.08 0 0 50.00
64 INT82996 Transcription of PKLR 2 0.51 0.6 0 50.00
65 INT232074 Localization of RNPC3 5 0.13 0.9 0 50.00
66 INT185348 Transcription of Ducm1 2 0.67 0.55 0 50.00
67 INT319068 Binding of Gtf2h3 1 0.03 0.17 0 50.00
68 INT319064 Negative_regulation of Transcription of Ducm1 1 0.41 0.24 0 50.00
69 INT319101 Gene_expression of POLI 1 0.10 0.31 0 50.00
70 INT319066 Positive_regulation of Binding of Gtf2h3 1 0.04 0.17 0 50.00
71 INT319097 Negative_regulation of Transcription of PKLR 1 0.05 0.24 0 50.00
72 INT319098 Protein_catabolism of PKLR 1 0.13 0.49 0 50.00
73 INT204472 Binding of RNPC3 6 0.06 1.65 0 50.00
74 INT319096 Positive_regulation of Localization of RNPC3 1 0.02 0.18 0 50.00
75 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 49.28
76 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 49.04
77 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 48.80
78 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 38.24
79 INT56160 Binding of Ifx 14 0.36 11.39 5.74 34.56
80 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 34.56
81 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18 31.72
82 INT203953 Localization of Srebf1 3 0.62 1.15 0.05 25.88
83 INT65927 Transcription of Gtf3a 20 0.47 9.27 4.97 25.00
84 INT72798 Binding of ADA 12 0.47 7.84 3.39 13.32
85 INT158596 Binding of Tlr3 24 0.47 11.66 3.69 11.60
86 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 10.88
87 INT147113 Binding of LTF 14 0.29 18.24 0.98 9.72
88 INT219192 Positive_regulation of Regulation of CD40LG 2 0.43 2.9 0.17 5.96
89 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.16
90 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 5.16
91 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
92 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
93 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
94 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
95 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
96 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
97 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
98 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
99 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
100 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
101 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
102 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
103 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
104 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
105 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
106 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
107 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
108 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
109 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
110 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
111 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
112 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
113 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
114 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
115 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
116 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
117 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
118 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
119 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 5.00
120 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
121 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
122 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
123 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
124 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
125 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
126 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
127 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 5.00
128 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
129 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
130 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
131 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
132 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
133 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
134 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
135 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
136 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
137 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
138 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 5.00
139 INT5989 Positive_regulation of Dbi 79 0.49 24.38 32.56 5.00
140 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
141 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
142 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
143 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
144 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
145 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
146 INT5988 Localization of Dbi 74 0.81 17.52 24.09 5.00
147 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
148 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
149 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
150 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
151 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
152 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
153 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
154 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
155 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
156 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
157 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
158 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
159 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
160 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
161 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
162 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
163 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
164 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
165 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
166 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
167 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 5.00
168 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
169 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
170 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
171 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
172 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
173 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
174 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
175 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86 5.00
176 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
177 INT18990 Positive_regulation of GRP 32 0.70 5.22 11.23 5.00
178 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
179 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
180 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
181 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
182 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
183 INT73497 Regulation of IL10 33 0.45 22.6 9.19 5.00
184 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 5.00
185 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 5.00
186 INT5512 Negative_regulation of Dbi 32 0.36 7.33 9.1 5.00
187 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
188 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 5.00
189 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
190 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
191 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58 5.00
192 INT224648 Gene_expression of Il21 15 0.39 18.71 7.47 5.00
193 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 5.00
194 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
195 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
196 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 5.00
197 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
198 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4 5.00
199 INT46721 Regulation of Csf2 26 0.45 20.4 6.18 5.00
200 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08 5.00
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