D:Cockayne Syndrome

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Disease Term
Synonyms Cockayne Syndrome 1, Cockayne Syndrome Group A, Cockayne Syndrome Group B, Cockayne Syndrome Group C, Cockayne Syndrome Type A, Cockayne Syndrome Type B, COCKAYNE SYNDROME TYPE C, Cockayne Syndrome Type I, Cockayne Syndrome Type Ii, Cockayne Syndrome Type Iii, Dwarfism Retinal Atrophy Deafness Syndrome
Documents 19
Hot Single Events 54
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cockayne Syndrome. They are ordered first by their relevance to Cockayne Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0 79.84
2 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0 79.84
3 INT227843 Binding of ERCC6 and MLL 1 0.00 0.34 0 76.16
4 INT182403 Binding of OGG1 and XRCC1 1 0.35 0.14 0 74.20
5 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08 69.12
6 INT227841 PGBD1 Positive_regulation of ERCC6 1 0.44 0.29 0 67.56
7 INT189375 Rpa1 Regulation of ERCC6 1 0.04 0.05 0 50.00
8 INT189373 Rpa1 Negative_regulation of ERCC6 1 0.03 0 0 50.00
9 INT189330 PPA1 Positive_regulation of ERCC6 1 0.10 0 0 50.00
10 INT189333 CSNK2A1 Positive_regulation of Phosphorylation of ERCC6 1 0.10 0 0 50.00
11 INT189374 Binding of RAD51 and Rad54l 1 0.01 0 0 50.00
12 INT189331 PPA1 Negative_regulation of Phosphorylation of ERCC6 1 0.06 0 0 50.00
13 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0 37.80
14 INT227838 Binding of ERCC6 and PGBD3 1 0.40 0.23 0 28.04
15 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0 20.08
16 INT227833 Positive_regulation of CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0 20.08
17 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21 5.00
18 INT184704 Binding of Prrx2 and Sr1 1 0.21 1.65 0.13 5.00
19 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08 5.00
20 INT182404 NFYA Regulation of CCNE2 1 0.00 0.09 0 5.00
21 INT182397 NFYA Regulation of CCNB1 1 0.00 0.09 0 5.00
22 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 5.00
23 INT182402 E2F2 Regulation of CCNB1 1 0.00 0.09 0 5.00
24 INT182398 Binding of MPG and BPIFA4P 1 0.01 0.3 0 5.00
25 INT309515 Xrcc6 Regulation of Gene_expression of Htt 1 0.32 0.08 0 5.00
26 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0 5.00
27 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0 5.00
28 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0 5.00
29 INT182407 Binding of NFYA and OGG1 1 0.02 0.07 0 5.00
30 INT309517 Binding of Bax and Xrcc6 1 0.15 0.5 0 5.00
31 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0 5.00
32 INT309512 Negative_regulation of Xrcc6 Positive_regulation of Phosphorylation of Gopc 1 0.20 0.17 0 5.00
33 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0 5.00
34 INT227831 Binding of ERCC2 and PGBD3 1 0.07 0.23 0 5.00
35 INT182400 E2F2 Regulation of CDC25C 1 0.00 0.09 0 5.00
36 INT309518 Negative_regulation of Binding of Bax and Xrcc6 1 0.16 0.25 0 5.00
37 INT309520 Htt Negative_regulation of Binding of Xrcc6 and Xrcc5 1 0.15 0.47 0 5.00
38 INT309516 Htt Positive_regulation of Gene_expression of Xrcc6 1 0.49 0.06 0 5.00
39 INT309509 Negative_regulation of Binding of Xrcc6 and Htt 1 0.31 0.41 0 5.00
40 INT309510 Htt Regulation of Gene_expression of Xrcc6 1 0.19 0.15 0 5.00
41 INT309508 Htt Negative_regulation of Binding of Xrcc6 1 0.31 0.48 0 5.00
42 INT309514 Positive_regulation of Binding of Xrcc6 and Htt 1 0.33 0 0 5.00
43 INT182401 NFYA Regulation of CDC25C 1 0.00 0.09 0 5.00
44 INT182405 E2F2 Regulation of CCNE2 1 0.00 0.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cockayne Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Cockayne Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT130385 Gene_expression of ERCC6 7 0.77 8.36 0.63 100.00
2 INT108865 Gene_expression of CSH2 1 0.75 1.47 0.09 100.00
3 INT108864 Gene_expression of ERCC3 1 0.21 1.47 0.09 100.00
4 INT108866 Negative_regulation of CSH2 1 0.36 1.39 0.1 100.00
5 INT151702 Binding of ERCC6 6 0.37 1.47 0.09 99.92
6 INT66347 Gene_expression of MLL 29 0.65 14.82 3.18 99.86
7 INT169875 Negative_regulation of Ercc1 3 0.43 3.07 0.17 99.78
8 INT169876 Negative_regulation of Ercc4 1 0.42 1.34 0.08 99.78
9 INT141562 Negative_regulation of ERCC6 11 0.50 3.04 0 99.46
10 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 99.42
11 INT139312 Negative_regulation of Gene_expression of MLL 2 0.00 1.22 0.56 99.40
12 INT200133 Negative_regulation of Xpa 5 0.58 9.85 0.09 99.36
13 INT200129 Negative_regulation of Xpc 1 0.40 0.82 0 99.36
14 INT189346 Positive_regulation of ERCC6 6 0.60 3.37 0.23 98.88
15 INT227872 Positive_regulation of MLL 7 0.01 2.44 0.19 98.88
16 INT1649 Localization of CSH1 15 0.46 3.65 5.75 98.78
17 INT182408 Localization of ERCC6 4 0.72 2.31 0.14 98.78
18 INT141563 Regulation of ERCC6 6 0.59 2.54 0 98.64
19 INT227884 Positive_regulation of Gene_expression of PSMD1 2 0.06 0.4 0 98.48
20 INT176180 Negative_regulation of Nr1h2 6 0.16 7.47 0.69 98.36
21 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 98.36
22 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85 98.24
23 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 98.08
24 INT227883 Positive_regulation of Gene_expression of ERCC6 1 0.60 0.4 0 98.08
25 INT227880 Positive_regulation of Transcription of ERCC6 1 0.50 0.52 0.09 97.84
26 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 97.84
27 INT227876 Transcription of ERCC6 1 0.68 1.87 0.17 97.52
28 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 97.36
29 INT152045 Negative_regulation of Trav6-3 10 0.57 6.42 1.16 97.36
30 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07 97.08
31 INT227868 Localization of MAP6 1 0.09 1.04 0.07 96.96
32 INT182396 Localization of Polr2f 1 0.01 0.19 0 95.56
33 INT182410 Localization of ERCC3 1 0.12 0.19 0 95.56
34 INT33845 Binding of GPER 20 0.36 5.61 1.81 93.96
35 INT173384 Regulation of Binding of GPER 2 0.17 0.58 0.1 93.96
36 INT176212 Transcription of Nr1h2 5 0.29 2.92 0.15 92.72
37 INT157210 Positive_regulation of Gene_expression of CSH1 5 0.21 1.19 0.12 92.20
38 INT227866 Positive_regulation of Regulation of ERCC6 1 0.50 0.58 0 92.04
39 INT200132 Regulation of Ercc2 2 0.36 4.56 0.05 90.32
40 INT200135 Regulation of Ercc3 2 0.34 3.47 0.05 89.92
41 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88 89.84
42 INT309506 Positive_regulation of Tdp1 1 0.23 1.19 0 88.44
43 INT200205 Regulation of Ercc6 1 0.08 1.65 0.05 87.72
44 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 87.72
45 INT200188 Regulation of Ercc5 1 0.19 1.64 0.05 87.72
46 INT182413 Binding of OGG1 17 0.46 2.44 0.22 86.56
47 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 86.40
48 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 86.32
49 INT227857 Positive_regulation of Gene_expression of PGBD3 1 0.47 0.69 0 86.04
50 INT227865 Transcription of PGBD3 1 0.65 1.07 0.04 85.88
51 INT227882 Gene_expression of PGBD3 1 0.63 1.05 0 85.88
52 INT97519 Binding of WRN 2 0.27 1.92 0.14 82.24
53 INT309465 Gene_expression of Xrcc6 24 0.59 5.49 0.43 80.40
54 INT227860 Localization of PGBD3 1 0.71 0.34 0 80.32
55 INT74018 Binding of XRCC1 19 0.31 24.78 1.24 79.76
56 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 79.64
57 INT227875 Protein_catabolism of ERCC6 1 0.65 0.81 0 78.96
58 INT227879 Regulation of Protein_catabolism of ERCC6 1 0.27 0.38 0 77.84
59 INT189355 Phosphorylation of ERCC6 1 0.79 1.11 0.16 75.00
60 INT189349 Positive_regulation of HFM1 1 0.01 0.15 0 74.36
61 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 69.20
62 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 68.68
63 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 68.68
64 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 68.68
65 INT51232 Positive_regulation of Localization of CSH1 3 0.31 0.32 0.37 62.48
66 INT76915 Localization of Gpx3 6 0.14 4.48 0.89 61.52
67 INT309481 Binding of Rbm17 1 0.18 0.82 0 58.40
68 INT227886 Regulation of PGBD3 1 0.37 0.06 0 55.04
69 INT182435 Localization of OGG1 36 0.76 1.66 0.58 54.24
70 INT182433 Localization of POLI 1 0.29 0.05 0 54.24
71 INT182412 Localization of FBL 1 0.14 0.05 0 54.24
72 INT189357 Positive_regulation of Binding of ERCC6 1 0.42 0.15 0 52.48
73 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11 51.68
74 INT291518 Positive_regulation of Negative_regulation of Fxn 1 0.47 1.1 0.03 51.68
75 INT309502 Positive_regulation of Xrcc6 1 0.38 1.58 0 51.52
76 INT138319 Positive_regulation of Rpa1 3 0.07 2.75 3.07 50.00
77 INT189347 Phosphorylation of CSNK2A1 4 0.11 1.62 0.57 50.00
78 INT189335 Gene_expression of Rpa1 2 0.07 0.07 0.27 50.00
79 INT189352 Negative_regulation of Gene_expression of ERCC6 1 0.36 0 0 50.00
80 INT189345 Negative_regulation of Localization of ERCC6 1 0.41 0.06 0 50.00
81 INT189353 Binding of RAD51 11 0.40 0.93 0 50.00
82 INT189344 Positive_regulation of Phosphorylation of ERCC6 1 0.58 0 0 50.00
83 INT189354 Negative_regulation of Phosphorylation of ERCC6 1 0.49 0 0 50.00
84 INT189337 Localization of Rpa1 3 0.12 1.47 0 50.00
85 INT189358 Negative_regulation of Regulation of ERCC6 1 0.36 0 0 50.00
86 INT189350 Positive_regulation of Localization of RECQL 1 0.09 0 0 50.00
87 INT189360 Phosphorylation of PPA1 1 0.10 0 0 50.00
88 INT189336 Negative_regulation of Localization of Rpa1 1 0.03 0.06 0 50.00
89 INT189351 Localization of RECQL 1 0.13 0 0 50.00
90 INT189359 Negative_regulation of Phosphorylation of CSNK2A1 1 0.06 0 0 50.00
91 INT189334 Binding of Rad54l 1 0.06 0 0 50.00
92 INT189356 Regulation of Regulation of ERCC6 1 0.59 0 0 50.00
93 INT189361 Regulation of Phosphorylation of ERCC6 1 0.38 0.07 0 50.00
94 INT291507 Regulation of Negative_regulation of Fxn 1 0.37 0.87 0 49.04
95 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49 46.96
96 INT227878 Regulation of Transcription of PGBD3 1 0.37 0.44 0 44.88
97 INT182426 Regulation of Localization of OGG1 1 0.51 0 0 41.36
98 INT181809 Gene_expression of Atxn1 81 0.77 28.66 1.42 38.40
99 INT90491 Binding of Igf1 25 0.44 9.75 1.36 38.40
100 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07 36.48
101 INT181801 Regulation of Atxn1 3 0.29 1.08 0 33.32
102 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05 28.00
103 INT10553 Regulation of GPER 13 0.15 2.12 3.02 22.76
104 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 19.76
105 INT12412 Binding of MPG 21 0.47 3.92 4.94 19.04
106 INT182438 Localization of MPG 3 0.30 1.43 0.04 19.04
107 INT199811 Gene_expression of CFC1 3 0.11 0.27 0 18.48
108 INT227885 Positive_regulation of Gene_expression of CFC1 1 0.03 0 0 18.48
109 INT227864 Positive_regulation of CFC1 1 0.03 0 0 16.48
110 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 14.56
111 INT309486 Positive_regulation of Chek1 1 0.22 0.6 0 14.52
112 INT227859 Gene_expression of SETMAR 1 0.48 0.23 0 14.24
113 INT227856 Regulation of Transcription of ERCC6 1 0.45 0 0 10.80
114 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22 10.24
115 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68 7.36
116 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06 7.36
117 INT309503 Phosphorylation of Xrcc6 1 0.54 0.55 0 7.36
118 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 6.84
119 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 6.36
120 INT188242 Negative_regulation of Positive_regulation of CRP 4 0.23 3.94 0.22 6.36
121 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25 6.08
122 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.36
123 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47 5.36
124 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
125 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
126 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
127 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
128 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
129 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
130 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
131 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 5.00
132 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
133 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
134 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 5.00
135 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
136 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
137 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
138 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
139 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
140 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
141 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
142 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
143 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
144 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
145 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
146 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
147 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
148 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 61 0.55 13.63 8.17 5.00
149 INT175526 Phosphorylation of Gopc 73 0.53 21.08 7.86 5.00
150 INT52465 Negative_regulation of Dio1 17 0.58 4.45 7.76 5.00
151 INT182440 Gene_expression of CCNE2 39 0.53 22.07 7.44 5.00
152 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
153 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
154 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
155 INT14238 Positive_regulation of Cd69 19 0.60 17.75 6.07 5.00
156 INT39436 Positive_regulation of PISD 4 0.26 3.16 5.78 5.00
157 INT151032 Localization of Igf1 49 0.76 26.32 5.71 5.00
158 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 5.00
159 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
160 INT181414 Gene_expression of Ccl19 12 0.74 9.8 4.11 5.00
161 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
162 INT26891 Gene_expression of OGG1 21 0.74 2.08 3.64 5.00
163 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
164 INT72290 Localization of Sigmar1 21 0.74 4.35 3.54 5.00
165 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52 5.00
166 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 5.00
167 INT102634 Transcription of Hmox1 22 0.62 4.5 3.3 5.00
168 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97 5.00
169 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
170 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 5.00
171 INT141183 Gene_expression of Casp9 9 0.75 11.96 2.46 5.00
172 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 5.00
173 INT163063 Positive_regulation of C1qa 10 0.67 6.06 2.29 5.00
174 INT108250 Regulation of Prdx2 5 0.25 2.02 2.08 5.00
175 INT184676 Transcription of Prrx2 1 0.37 3.64 2.02 5.00
176 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01 5.00
177 INT154651 Negative_regulation of Nfe2l2 19 0.59 10.48 2.01 5.00
178 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99 5.00
179 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95 5.00
180 INT12413 Gene_expression of MPG 11 0.76 3.13 1.94 5.00
181 INT80221 Regulation of Eno2 4 0.35 4.64 1.89 5.00
182 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78 5.00
183 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62 5.00
184 INT69125 Gene_expression of Prlr 6 0.78 2 1.58 5.00
185 INT200186 Binding of Igfals 5 0.19 4.46 1.52 5.00
186 INT131968 Transcription of Grik1 3 0.51 1.44 1.51 5.00
187 INT184683 Gene_expression of Prrx2 1 0.37 7.9 1.5 5.00
188 INT182427 Binding of E2F2 7 0.23 2.78 1.49 5.00
189 INT131671 Negative_regulation of Prlhr 3 0.59 1.61 1.48 5.00
190 INT200185 Regulation of Igfals 10 0.26 11.4 1.47 5.00
191 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45 5.00
192 INT117148 Gene_expression of Eef1a1 6 0.07 2.32 1.42 5.00
193 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
194 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 5.00
195 INT75315 Regulation of Ghr 4 0.22 1.5 1.34 5.00
196 INT45083 Gene_expression of 10S 3 0.58 5.56 1.34 5.00
197 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21 5.00
198 INT181400 Negative_regulation of Ccl19 3 0.43 1.97 1.13 5.00
199 INT184686 Gene_expression of Sr1 1 0.60 2.97 1.06 5.00
200 INT184696 Positive_regulation of Xbp1 12 0.60 13.6 1.06 5.00
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