D:Colon Disease

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Disease Term
Synonyms Colon Diseases, COLON DISORDER, Colon Disorders, Colon Dysfunction, COLONIC DISEASE, Colonic Diseases, Colonic Disorder, Colonic Disorders, Colonic Dysfunction, Disease Colonic, Diseases Colonic
Documents 127
Hot Single Events 38
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Colon Disease. They are ordered first by their relevance to Colon Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT238005 Binding of Cxcr3 and Cxcl10 2 0.38 3.73 1.42 5.00
2 INT238009 Binding of Cxcr3 and Cxcl9 3 0.40 4.01 1.37 5.00
3 INT237999 Binding of Cxcr3 and Cxcl11 2 0.45 3.49 1.11 5.00
4 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9 5.00
5 INT238004 Positive_regulation of Binding of Cxcr3 and Cxcl11 1 0.30 1.86 0.51 5.00
6 INT277705 SMAP2 Regulation of TNF 1 0.01 1.23 0.25 5.00
7 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
8 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22 5.00
9 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22 5.00
10 INT238001 Cxcl10 Positive_regulation of Gene_expression of Cd40 1 0.17 0.91 0.21 5.00
11 INT238000 Cxcl10 Positive_regulation of Cd4 1 0.21 0.91 0.21 5.00
12 INT238006 Cxcl10 Positive_regulation of Gene_expression of Cd28 1 0.24 0.91 0.21 5.00
13 INT238002 Cxcl10 Positive_regulation of Positive_regulation of Cd4 1 0.21 0.91 0.21 5.00
14 INT238010 Binding of Cxcr3 and Hand1 1 0.12 1.55 0.19 5.00
15 INT299113 Binding of INPP5K and GOPC 1 0.18 2.69 0.19 5.00
16 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13 5.00
17 INT185454 IGHG1 Negative_regulation of Timp1 1 0.04 0.85 0.13 5.00
18 INT185416 MUC1 Negative_regulation of TIMP1 1 0.18 0.84 0.13 5.00
19 INT185418 IGHG1 Negative_regulation of TIMP1 1 0.11 0.84 0.13 5.00
20 INT238007 Binding of Cxcr3 and Saa 1 0.14 0.95 0.11 5.00
21 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08 5.00
22 INT238008 Myd88 Regulation of Hand1 1 0.03 0.82 0.04 5.00
23 INT238003 Aif1 Regulation of IgG 1 0.00 0.21 0.03 5.00
24 INT286113 Binding of Fap and Rpe65 1 0.04 1.97 0 5.00
25 INT267117 Lmx1b Regulation of Col7a1 1 0.02 1.29 0 5.00
26 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0 5.00
27 INT286111 Binding of Rpa3 and Mutyh 1 0.30 0 0 5.00
28 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0 5.00
29 INT286110 Binding of Rpe65 and Gopc 1 0.01 1.97 0 5.00
30 INT267115 Lmx1b Regulation of Gene_expression of Col4a1 1 0.09 1.37 0 5.00
31 INT286115 Binding of APEX1 and Mutyh 1 0.10 0 0 5.00
32 INT185453 Binding of PRKCB and Lhx1 1 0.35 1.99 0 5.00
33 INT267116 Binding of Lmx1b and Nps 1 0.30 1.95 0 5.00
34 INT267119 Lmx1b Regulation of Regulation of Col4a1 1 0.09 0.67 0 5.00
35 INT267118 Lmx1b Regulation of Regulation of Col7a1 1 0.06 0.47 0 5.00
36 INT286109 Binding of Pcna and Mutyh 1 0.30 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Colon Disease. They are ordered first by their pain relevance and then by number of times they were reported in Colon Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 98.48
2 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 98.48
3 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 98.48
4 INT224648 Gene_expression of Il21 15 0.39 18.71 7.47 98.48
5 INT254269 Gene_expression of Il17f 12 0.48 13.29 6.02 98.48
6 INT174807 Gene_expression of IL26 7 0.37 8.06 3.26 98.48
7 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 98.48
8 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 98.48
9 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 98.48
10 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 98.48
11 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 98.24
12 INT299115 Regulation of INPP5K 6 0.39 4.11 0.59 97.76
13 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 97.32
14 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 95.12
15 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 95.12
16 INT88947 Positive_regulation of Gene_expression of Pgr 22 0.64 7 4.39 94.76
17 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 93.96
18 INT87976 Regulation of Gene_expression of Cnr1 9 0.58 6.87 7.51 93.52
19 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 91.92
20 INT61946 Positive_regulation of HGF 57 0.69 38.93 11.99 88.84
21 INT185452 Regulation of CYLD 6 0.40 6.09 0.21 88.04
22 INT160852 Regulation of CD55 5 0.16 5.28 0.56 87.80
23 INT185433 Regulation of CTTNBP2NL 1 0.06 1.4 0.04 87.60
24 INT15157 Gene_expression of INPP5K 30 0.67 15.49 2.85 87.44
25 INT131421 Localization of INPP5K 9 0.74 4.3 0.59 87.44
26 INT89290 Regulation of MUC1 19 0.45 10.4 0.81 87.04
27 INT185448 Regulation of OCLN 1 0.26 1.39 0.04 86.80
28 INT78773 Regulation of PLA2G2A 11 0.61 9.76 1.91 86.56
29 INT73627 Binding of Fap 8 0.36 11.14 0.4 86.40
30 INT102825 Regulation of Timp1 10 0.38 5.49 1.79 86.20
31 INT185434 Regulation of ZCCHC4 1 0.21 1.37 0.04 85.76
32 INT17473 Negative_regulation of Ighd 1 0.08 0.42 0.11 85.68
33 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 82.36
34 INT22605 Regulation of Pgr 22 0.62 7.1 2.26 82.08
35 INT47077 Negative_regulation of CTNS 1 0.36 0.92 0.23 81.44
36 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 81.28
37 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 81.28
38 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 81.00
39 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 78.20
40 INT38241 Positive_regulation of TMPRSS15 1 0.66 0.97 0.18 75.28
41 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 75.24
42 INT171716 Regulation of Fap 4 0.27 4.05 0.23 74.68
43 INT181344 Gene_expression of Ccr6 28 0.61 24.34 9.78 74.36
44 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 73.44
45 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 73.44
46 INT10870 Regulation of IgG 67 0.59 43.27 12.74 73.04
47 INT112183 Gene_expression of CRCP 10 0.67 3.34 7.47 71.60
48 INT113815 Gene_expression of TFF1 23 0.75 17.53 0.87 71.60
49 INT185436 Gene_expression of ROCK1 5 0.52 6.85 0.29 71.60
50 INT185428 Gene_expression of Lhx1 4 0.75 2.6 0.28 71.60
51 INT175654 Gene_expression of CDH11 4 0.63 4.26 0.24 71.60
52 INT185435 Gene_expression of IGHG1 1 0.35 1.07 0.05 71.60
53 INT185444 Gene_expression of PLEKHO2 1 0.32 1.07 0.05 71.60
54 INT19483 Positive_regulation of Ppcs 3 0.37 14.1 1.36 66.64
55 INT115889 Binding of Fas 27 0.36 28.87 4.08 64.08
56 INT299114 Localization of FANCE 5 0.53 3.37 1.49 62.52
57 INT338411 Positive_regulation of Gene_expression of Il17f 5 0.29 4.58 1.21 61.60
58 INT215302 Gene_expression of PQBP1 15 0.53 3.93 0.31 60.80
59 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 58.32
60 INT181405 Gene_expression of Ccl20 26 0.65 23.02 9.46 57.92
61 INT206136 Positive_regulation of Gene_expression of STAT3 14 0.46 4.3 1.1 57.92
62 INT230434 Positive_regulation of Gene_expression of F5 2 0.10 2.35 0.11 53.24
63 INT230436 Positive_regulation of Gene_expression of SERPINC1 1 0.04 1.97 0.11 53.24
64 INT81965 Gene_expression of F5 16 0.65 13.29 0.48 52.32
65 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 51.64
66 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72 51.64
67 INT230435 Negative_regulation of DTNBP1 2 0.08 3.11 0.32 51.12
68 INT132881 Binding of INPP5K 7 0.48 4.35 0.33 48.72
69 INT13938 Positive_regulation of Nkx1-1 64 0.68 30.83 58.75 46.12
70 INT185446 Regulation of CEACAM1 2 0.29 1.72 0.1 42.52
71 INT27575 Positive_regulation of CEACAM1 2 0.45 1.57 0.03 42.52
72 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 40.92
73 INT139679 Positive_regulation of Ighg2b 11 0.55 10.57 1.1 40.92
74 INT219247 Positive_regulation of Ddx41 9 0.36 6.7 0.84 40.92
75 INT179428 Binding of FANCE 5 0.34 3.65 2.74 40.24
76 INT181325 Positive_regulation of TNFAIP1 4 0.36 4.64 0.52 38.48
77 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 37.44
78 INT138833 Binding of MTHFR 12 0.46 16.08 6.4 37.32
79 INT250993 Gene_expression of FANCE 8 0.48 4.41 0.27 36.60
80 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 35.36
81 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 35.36
82 INT108917 Positive_regulation of CRX 23 0.50 21.32 10.5 34.80
83 INT99784 Positive_regulation of Cxcr3 22 0.66 22.44 10.36 34.20
84 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 33.80
85 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 33.80
86 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 33.80
87 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 33.80
88 INT185441 Regulation of PLEKHO2 1 0.18 1.1 0.08 30.80
89 INT104395 Gene_expression of Cxcl9 83 0.76 73.1 19.79 28.76
90 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 28.48
91 INT237051 Gene_expression of Cxcl11 24 0.64 25.74 5.77 28.00
92 INT101301 Gene_expression of Aif1 17 0.42 16.43 4.06 27.72
93 INT10763 Localization of IL2 157 0.80 81.11 33.21 27.52
94 INT4931 Localization of IFNG 53 0.78 33.25 13.65 27.52
95 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 26.48
96 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 25.00
97 INT242134 Localization of Apc 8 0.74 4.83 0.88 22.12
98 INT252 Localization of GH1 529 0.80 227.4 122.05 21.28
99 INT425 Localization of PRL 455 0.81 189.64 144.8 20.96
100 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 19.28
101 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 19.28
102 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 19.28
103 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35 19.28
104 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 18.88
105 INT65889 Gene_expression of RETNLB 73 0.34 60.98 38.3 18.88
106 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 16.24
107 INT86815 Gene_expression of Pla2g2a 18 0.55 5.72 2.59 13.52
108 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 13.00
109 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
110 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
111 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
112 INT1562 Localization of Crh 499 0.81 126.74 236.68 5.00
113 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
114 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
115 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
116 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
117 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
118 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
119 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
120 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
121 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
122 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
123 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
124 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
125 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
126 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
127 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
128 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
129 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
130 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
131 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
132 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
133 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
134 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
135 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
136 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
137 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
138 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
139 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
140 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
141 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
142 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
143 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
144 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
145 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
146 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
147 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
148 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
149 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 5.00
150 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
151 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
152 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
153 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
154 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
155 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
156 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 5.00
157 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
158 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
159 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
160 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
161 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
162 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
163 INT50308 Binding of Cnr1 61 0.48 14.41 33.52 5.00
164 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
165 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
166 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
167 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
168 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
169 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
170 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 5.00
171 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28 5.00
172 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
173 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
174 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
175 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
176 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 5.00
177 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
178 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
179 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
180 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
181 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
182 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
183 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
184 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
185 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
186 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
187 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
188 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
189 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
190 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
191 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
192 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
193 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
194 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
195 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
196 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
197 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
198 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
199 INT74375 Positive_regulation of Gene_expression of Cnr1 24 0.70 14.25 13.66 5.00
200 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
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