D:Colorectal Cancer

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Disease Term
Synonyms Bowel Cancer, Cancer Colorectal, CANCERS COLORECTAL, CARCINOMA COLORECTAL, Carcinomas Colorectal, COLORECTAL CANCERS, Colorectal Carcinoma, Colorectal Carcinomas, Colorectal Dysplasia, Colorectal Hyperplasia, COLORECTAL NEOPLASIA
Documents 347
Hot Single Events 200
Hot Interactions 34

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Colorectal Cancer. They are ordered first by their relevance to Colorectal Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT337676 Binding of TIMP1 and Scrib 1 0.01 1.24 0.13 100.00
2 INT337677 Scrib Positive_regulation of Gene_expression of MMP9 1 0.03 1.12 0 100.00
3 INT337681 Scrib Positive_regulation of MMP9 1 0.01 1.12 0 100.00
4 INT337678 Scrib Positive_regulation of MMP7 1 0.03 1.11 0 100.00
5 INT337680 Binding of TP53 and Scrib 1 0.03 1.6 0 100.00
6 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0 100.00
7 INT190062 Binding of MLH1 and Msh2 1 0.01 0.91 0 100.00
8 INT337679 Binding of MSI1 and Scrib 1 0.00 1.61 0 100.00
9 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24 100.00
10 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0 99.52
11 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0 99.52
12 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0 99.08
13 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22 99.02
14 INT337638 Binding of CSF1 and PSG2 1 0.11 1.52 0 97.64
15 INT139719 Binding of CYP2C9 and UGT1A6 1 0.19 0.1 0 97.24
16 INT258173 Negative_regulation of Cpox Negative_regulation of Gene_expression of Gtf3a 1 0.00 1.44 0.33 96.92
17 INT287874 Binding of TCF4 and TP53 1 0.02 0.54 0 94.80
18 INT290671 Binding of Socs3 and Stat3 2 0.23 1.59 0.45 94.24
19 INT315200 Negative_regulation of Binding of Socs3 and Stat3 1 0.26 1.18 0.27 94.24
20 INT324525 PGE Positive_regulation of Positive_regulation of Egfr 1 0.41 1.05 0.33 89.76
21 INT324522 PGE Positive_regulation of Phosphorylation of Egfr 1 0.56 1.04 0.33 89.76
22 INT324524 PGE Positive_regulation of Egfr 1 0.38 1.05 0.33 89.76
23 INT324527 PGE Positive_regulation of Egfr Positive_regulation of Phosphorylation of Egfr 1 0.38 1.05 0.33 89.76
24 INT354309 Binding of MYC and PITX2 1 0.01 0.51 0 88.32
25 INT195446 Positive_regulation of SAT1 Positive_regulation of ODC1 1 0.47 0.82 0 88.28
26 INT268397 Binding of Kras and Regulation of ARAF 1 0.03 1.16 0 86.16
27 INT235304 Binding of Aldh1a1 and Cpa1 1 0.12 0.86 0 86.08
28 INT236720 Binding of Ctnnd2 and Tcf4 3 0.24 2.8 0 85.92
29 INT235305 Binding of Aldh3a1 and Cpa1 1 0.12 0.86 0 85.68
30 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0 84.60
31 INT300617 Binding of MSH6 and MLH1 1 0.28 0.53 0 84.12
32 INT300616 Binding of MLH1 and PMS2 1 0.36 0.53 0 83.76
33 INT217787 Binding of TP53 and MIR208A 1 0.21 0.5 0 83.04
34 INT195445 SAT1 Regulation of ODC1 1 0.27 0.8 0 82.56
35 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0 77.12
36 INT319319 Binding of EGFR and KRAS 1 0.22 0.27 0 76.40
37 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26 75.00
38 INT235303 Aldh1a1 Positive_regulation of Cpa1 1 0.17 0.4 0 74.16
39 INT308352 Binding of Ctnnd2 and Tcf7l2 1 0.15 0.74 0 73.00
40 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0 72.00
41 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89 69.68
42 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0 69.44
43 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0 69.44
44 INT337639 TP53 Regulation of Gene_expression of MIR34A 1 0.08 1.19 0 68.92
45 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51 68.84
46 INT309870 Arl6ip6 Negative_regulation of Pik3cb 1 0.00 0.73 0 68.76
47 INT268395 Binding of APC and Kras 1 0.04 1.21 0 66.72
48 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0 65.52
49 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0 64.92
50 INT315889 Binding of B4GALNT1 and IKBKAP 1 0.00 0.68 0 62.28
51 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 60.80
52 INT287893 VEGFA Positive_regulation of Localization of WISP1 1 0.03 1.23 0.1 60.80
53 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1 59.08
54 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05 59.08
55 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05 59.08
56 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 58.88
57 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0 58.64
58 INT179872 Binding of HGF and MET 7 0.09 4.69 0.07 55.60
59 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 54.08
60 INT199371 DST Regulation of Transcription of Igf2 1 0.05 1.47 0 50.16
61 INT327727 Atp6v0a2 Negative_regulation of Gene_expression of Kit 1 0.05 0.83 0.41 50.00
62 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0 50.00
63 INT268398 Binding of LRP1 and Wnt2 1 0.01 0.36 0 50.00
64 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 0.04 1.51 0 48.00
65 INT279419 RARB Regulation of PPARA 1 0.01 0.13 0.08 47.28
66 INT279416 NR1H4 Regulation of PPARA 1 0.01 0.13 0.08 47.28
67 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 45.12
68 INT279421 Binding of NR1H4 and MLXIPL 1 0.00 0.27 0.07 45.12
69 INT279413 Binding of RARB and MLXIPL 1 0.00 0.27 0.07 44.72
70 INT279418 Binding of PPARA and RARB 1 0.01 0.14 0.03 44.72
71 INT121650 Negative_regulation of Binding of CXCL12 and CXCR4 2 0.47 1.61 0 44.56
72 INT199359 Igf2 Regulation of Macf1 1 0.11 3.11 0 44.24
73 INT199361 Regulation of Igf2 Regulation of Macf1 1 0.11 1.59 0 44.24
74 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 43.20
75 INT245077 Binding of ESR1 and CXCL12 1 0.06 1.42 0 43.20
76 INT279417 Binding of PPARA and MLXIPL 3 0.00 0.33 0.07 42.56
77 INT199031 Binding of ALB and F2 1 0.05 1.78 0.08 40.56
78 INT199362 Igf2 Positive_regulation of Macf1 1 0.11 1.67 0 40.28
79 INT245071 Binding of CXCL12 and KDELR1 1 0.04 1.49 0 37.84
80 INT217781 Binding of MITF and TP53 1 0.00 1.2 0 36.96
81 INT217784 Binding of MITF and TSC1 1 0.00 1.21 0 36.96
82 INT214437 NCAM1 Regulation of CHGA 1 0.05 1.21 0.07 34.44
83 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05 33.44
84 INT199366 DST Positive_regulation of Macf1 1 0.01 1.14 0 32.52
85 INT269209 SNAI1 Regulation of Gene_expression of LOXL2 1 0.07 1.14 0 30.16
86 INT217776 TP53 Regulation of MITF 1 0.00 1.28 0 25.96
87 INT217774 TP53 Regulation of TSC1 1 0.02 1.28 0 25.96
88 INT217786 TSC1 Regulation of MITF 1 0.00 1.27 0 25.08
89 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0 24.48
90 INT269213 Binding of SNAI1 and Positive_regulation of Gene_expression of CDH1 1 0.37 1.03 0 20.16
91 INT296749 PTGER2 Positive_regulation of PTGER1 1 0.25 0 0.05 19.84
92 INT190049 Binding of Mlh1 and Msh3 1 0.24 0.22 0 17.40
93 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0 17.40
94 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04 17.20
95 INT190046 Binding of Msh3 and Pms2 2 0.25 0.5 0.04 17.20
96 INT199360 Igf2 Regulation of Gene_expression of Lyve1 1 0.30 1.13 0 16.60
97 INT190047 Binding of Msh2 and Msh3 1 0.24 0.23 0 14.88
98 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15 5.00
99 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
100 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7 5.00
101 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61 5.00
102 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54 5.00
103 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54 5.00
104 INT282285 Cpox Regulation of Gene_expression of Ptger2 1 0.00 0.84 0.5 5.00
105 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
106 INT279414 Binding of CPOX and ACTR1B 1 0.04 1.55 0.4 5.00
107 INT350814 Negative_regulation of TNF Positive_regulation of Gene_expression of Cpox 1 0.06 1.33 0.37 5.00
108 INT350816 TNF Positive_regulation of Gene_expression of Cpox 1 0.05 1.33 0.37 5.00
109 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35 5.00
110 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 5.00
111 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
112 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27 5.00
113 INT245072 PPARA Regulation of Gene_expression of CXCR4 1 0.07 0.68 0.26 5.00
114 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 0.06 0.2 0.2 5.00
115 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
116 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 0.01 0.07 0.18 5.00
117 INT254691 Gopc Positive_regulation of Positive_regulation of Map2k2 1 0.07 0.07 0.18 5.00
118 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 0.06 0.07 0.18 5.00
119 INT290672 Stat3 Negative_regulation of Il6 1 0.08 0.4 0.18 5.00
120 INT254685 Map2k2 Positive_regulation of Mmp3 1 0.04 0.08 0.18 5.00
121 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16 5.00
122 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
123 INT350815 Negative_regulation of Binding of TNF and Il1 1 0.05 0.37 0.16 5.00
124 INT287890 THEMIS Regulation of Gene_expression of EPHB2 1 0.00 0.87 0.14 5.00
125 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14 5.00
126 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13 5.00
127 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
128 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13 5.00
129 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12 5.00
130 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12 5.00
131 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12 5.00
132 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12 5.00
133 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12 5.00
134 INT173122 PPA1 Positive_regulation of HRAS 1 0.08 0.5 0.12 5.00
135 INT173125 PPA1 Positive_regulation of JUN 1 0.06 0.5 0.12 5.00
136 INT173119 PPA1 Regulation of IER3 1 0.00 0.36 0.12 5.00
137 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 5.00
138 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 5.00
139 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
140 INT173126 CYP8B1 Positive_regulation of PPARA 1 0.25 0.39 0.1 5.00
141 INT173124 PPA1 Regulation of ZFP37 1 0.00 0.44 0.1 5.00
142 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
143 INT290673 Ppara Positive_regulation of Gtf3a 1 0.01 0.58 0.09 5.00
144 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09 5.00
145 INT290674 Ppara Positive_regulation of Gtf3a Positive_regulation of Ppara 1 0.01 0.58 0.09 5.00
146 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09 5.00
147 INT234437 asa Negative_regulation of Ppara 1 0.13 0.4 0.09 5.00
148 INT279435 Positive_regulation of Binding of LTA4H and Lts1 1 0.00 0.16 0.08 5.00
149 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08 5.00
150 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08 5.00
151 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08 5.00
152 INT290669 Tlr4 Positive_regulation of Binding of Il6 1 0.02 0.07 0.08 5.00
153 INT173130 Binding of INS and PPARA 2 0.04 1.8 0.08 5.00
154 INT279436 Binding of LTA4H and Lts1 1 0.00 0.16 0.08 5.00
155 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
156 INT279420 CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07 5.00
157 INT279415 Gene_expression of CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07 5.00
158 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
159 INT269210 CDH1 Positive_regulation of Positive_regulation of ITK 1 0.06 0.84 0.06 5.00
160 INT185037 INHBA Negative_regulation of Inhba 1 0.26 0.32 0.05 5.00
161 INT256548 Regulation of Cd320 Positive_regulation of Ppara 1 0.28 0.43 0.05 5.00
162 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05 5.00
163 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
164 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
165 INT256551 Cd320 Regulation of Cd320 Positive_regulation of Ppara 1 0.31 0.43 0.05 5.00
166 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
167 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
168 INT256547 Cd320 Positive_regulation of Ppara 1 0.47 0.43 0.05 5.00
169 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
170 INT236722 Ppara Positive_regulation of Binding of Apoa1 1 0.10 0.18 0.04 5.00
171 INT236725 Binding of Ppara and KLK15 1 0.02 0.08 0.04 5.00
172 INT269214 SNAI1 Positive_regulation of Positive_regulation of CDH1 1 0.35 0.71 0.04 5.00
173 INT269211 SNAI1 Positive_regulation of Gene_expression of CDH1 1 0.40 0.73 0.04 5.00
174 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04 5.00
175 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
176 INT297377 Binding of PPARA and Rxra 1 0.02 0.25 0.03 5.00
177 INT297375 Binding of VDR and Rxra 1 0.02 0.2 0.03 5.00
178 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03 5.00
179 INT173199 CNOT4 Regulation of Regulation of Myc 1 0.01 0.66 0.03 5.00
180 INT245075 Binding of ESR1 and NR4A1 1 0.01 1.08 0.03 5.00
181 INT245076 CXCR4 Regulation of Gene_expression of VEGFA 1 0.16 1.05 0.03 5.00
182 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03 5.00
183 INT297374 Binding of TXNRD1 and Rxra 1 0.01 0.2 0.03 5.00
184 INT286113 Binding of Fap and Rpe65 1 0.04 1.97 0 5.00
185 INT302640 Rac1 Regulation of Gene_expression of VEGFA 1 0.03 0 0 5.00
186 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
187 INT254689 Gene_expression of Map2k2 Positive_regulation of Map2k1 1 0.30 0.4 0 5.00
188 INT245078 FGF2 Positive_regulation of CXCR4 1 0.07 1.36 0 5.00
189 INT287892 PRDX2 Positive_regulation of HNF4A 1 0.00 0.52 0 5.00
190 INT199365 Igf2 Positive_regulation of Phosphorylation of Macf1 1 0.13 1.84 0 5.00
191 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0 5.00
192 INT245073 VEGFA Positive_regulation of CXCR4 1 0.27 5.09 0 5.00
193 INT245074 Gene_expression of VHL Negative_regulation of Gene_expression of CXCR4 1 0.31 1.84 0 5.00
194 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0 5.00
195 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0 5.00
196 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
197 INT217779 POLR2B Regulation of Gene_expression of RASGRP1 1 0.01 0.2 0 5.00
198 INT254692 Positive_regulation of Map2k1 Regulation of Gene_expression of Mdk 1 0.05 0.42 0 5.00
199 INT264697 Binding of Hes1 and Mir199b Regulation of Notch1 1 0.00 0.86 0 5.00
200 INT217788 MIR181A1 Regulation of EIF5A 1 0.23 0.69 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Colorectal Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Colorectal Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT108325 Gene_expression of Scrib 26 0.39 48.33 1.39 100.00
2 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 100.00
3 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 100.00
4 INT108326 Positive_regulation of Gene_expression of Scrib 5 0.26 9.02 0.36 100.00
5 INT337654 Positive_regulation of Gene_expression of DPYSL2 1 0.17 4.26 0.11 100.00
6 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 100.00
7 INT190031 Binding of Scrib 19 0.36 21.9 1.01 100.00
8 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 100.00
9 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 100.00
10 INT214067 Regulation of Scrib 11 0.20 12.48 0.45 100.00
11 INT195976 Gene_expression of Aldh1a1 26 0.75 14.23 0.6 100.00
12 INT190017 Localization of Scrib 6 0.10 7 0.38 100.00
13 INT337658 Positive_regulation of Gene_expression of SEMA3D 1 0.04 2.15 0.05 100.00
14 INT337671 Gene_expression of DPYSL2 1 0.23 2.12 0.05 100.00
15 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 100.00
16 INT268374 Gene_expression of FAP 2 0.37 6.6 0 100.00
17 INT337649 Gene_expression of SEMA3D 1 0.05 1.07 0.03 100.00
18 INT235267 Positive_regulation of Gene_expression of Aldh1a1 1 0.67 3.95 0 100.00
19 INT296753 Protein_catabolism of Scrib 1 0.05 0.73 0.07 100.00
20 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 100.00
21 INT136403 Negative_regulation of DCC 1 0.01 0.87 0.14 100.00
22 INT170739 Gene_expression of Acsl1 8 0.65 7.02 0.5 100.00
23 INT235268 Positive_regulation of Gene_expression of Acsl1 2 0.49 1.96 0.17 100.00
24 INT84714 Negative_regulation of Transcription of Cpox 3 0.25 1.5 1.18 100.00
25 INT91043 Regulation of NDRG1 7 0.25 2.66 1.65 100.00
26 INT190036 Positive_regulation of Localization of Scrib 1 0.04 0.83 0 100.00
27 INT190058 Positive_regulation of Localization of MLH1 1 0.02 0.84 0 100.00
28 INT182621 Localization of MLH1 9 0.64 9.31 0.12 99.98
29 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 99.96
30 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 99.96
31 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 99.96
32 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 99.92
33 INT140753 Gene_expression of NTN1 2 0.05 4.67 0.06 99.88
34 INT337670 Positive_regulation of DEFA3 7 0.42 10.51 0 99.84
35 INT337660 Positive_regulation of Positive_regulation of DEFA3 4 0.42 5.4 0 99.84
36 INT46621 Positive_regulation of Gene_expression of CSF1 17 0.47 10.53 3.59 99.84
37 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08 99.84
38 INT224740 Protein_catabolism of PTGER2 2 0.58 2.46 0.79 99.84
39 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 99.84
40 INT239279 Regulation of Gene_expression of Abca1 2 0.44 2.42 0.26 99.84
41 INT67612 Binding of PPARG 38 0.48 22.67 8.94 99.84
42 INT224738 Negative_regulation of Protein_catabolism of PTGER2 2 0.29 1.72 0.3 99.84
43 INT212362 Positive_regulation of Gene_expression of CSF3 3 0.32 4.85 0.26 99.84
44 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 99.84
45 INT121372 Positive_regulation of Gene_expression of MIF 17 0.60 14.78 4.73 99.84
46 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 99.84
47 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92 99.84
48 INT66226 Positive_regulation of Gene_expression of COX18 10 0.31 4.41 2.11 99.84
49 INT66227 Gene_expression of COX18 41 0.50 26.91 6.26 99.84
50 INT72758 Positive_regulation of Transcription of Cpox 15 0.34 5.46 4.75 99.84
51 INT217387 Regulation of Abca1 3 0.27 2.01 0.15 99.84
52 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 99.84
53 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81 99.84
54 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 99.84
55 INT60060 Positive_regulation of KRAS 17 0.67 11.68 1.21 99.84
56 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17 99.84
57 INT197429 Gene_expression of TCF4 6 0.33 3.8 0.18 99.84
58 INT287952 Positive_regulation of Gene_expression of TCF4 1 0.17 0.69 0 99.84
59 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 99.84
60 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 99.84
61 INT175421 Positive_regulation of Positive_regulation of KRAS 2 0.34 1.45 0 99.84
62 INT203727 Negative_regulation of Phosphorylation of Ppara 4 0.42 3.54 0.07 99.80
63 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 99.78
64 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 99.78
65 INT179083 Positive_regulation of Myc 65 0.70 38.78 0.1 99.78
66 INT337655 Positive_regulation of PSG2 1 0.21 1.59 0.1 99.76
67 INT112993 Binding of Mrc1 7 0.21 6.55 0.12 99.76
68 INT190038 Binding of Mlh1 2 0.28 3.11 0 99.76
69 INT190015 Binding of Msh2 1 0.27 1.41 0 99.76
70 INT184982 Regulation of HGS 1 0.18 1.25 0 99.72
71 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 99.70
72 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 99.66
73 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 99.66
74 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 99.60
75 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 99.60
76 INT127060 Negative_regulation of Gene_expression of ATF3 3 0.58 4.27 0.5 99.60
77 INT287924 Negative_regulation of WIF1 1 0.13 1.62 0.04 99.60
78 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61 99.56
79 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17 99.56
80 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 99.52
81 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.52
82 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 99.52
83 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 99.52
84 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 99.52
85 INT235294 Localization of Cpa1 2 0.23 0.92 0 99.52
86 INT11154 Binding of EGFR 149 0.48 96.23 6.29 99.50
87 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 99.50
88 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34 99.48
89 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 99.48
90 INT184005 Negative_regulation of Gene_expression of Socs3 6 0.48 8.76 2.74 99.48
91 INT39048 Regulation of Gene_expression of PTGER1 3 0.45 2.55 1.31 99.48
92 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.48
93 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 99.48
94 INT114379 Negative_regulation of Gene_expression of CFLAR 7 0.57 7.31 0.97 99.48
95 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 99.48
96 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 99.44
97 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05 99.44
98 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 99.44
99 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 99.44
100 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 99.42
101 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63 99.42
102 INT240671 Binding of SLC10A2 1 0.36 1.91 0.16 99.40
103 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 99.40
104 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39 99.40
105 INT122041 Binding of Ppara 308 0.48 189.17 51.48 99.40
106 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 99.36
107 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78 99.32
108 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 99.28
109 INT72759 Transcription of Cpox 40 0.39 17.26 10 99.28
110 INT101988 Positive_regulation of GDF15 71 0.69 51.03 18.56 99.28
111 INT225312 Gene_expression of Alcam 11 0.50 7.91 0.15 99.28
112 INT124624 Positive_regulation of Gene_expression of ATF3 11 0.70 21.22 2.06 99.28
113 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.28
114 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 99.28
115 INT217834 Gene_expression of MIR208A 14 0.58 11.44 0 99.28
116 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 99.28
117 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 99.28
118 INT124622 Positive_regulation of ATF3 26 0.70 21.6 4.03 99.28
119 INT217828 Positive_regulation of Gene_expression of MIR208A 1 0.42 1.13 0 99.28
120 INT156805 Gene_expression of Ebp 6 0.40 6.09 1.07 99.26
121 INT226027 Positive_regulation of Gene_expression of Ebp 1 0.13 2.46 0.06 99.26
122 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 99.24
123 INT235261 Positive_regulation of Gene_expression of Alcam 1 0.12 0.89 0 99.24
124 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 99.20
125 INT296755 Positive_regulation of Gene_expression of PTGER4 2 0.33 2.03 1.34 99.20
126 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21 99.16
127 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64 99.16
128 INT175512 Positive_regulation of Gene_expression of Igf2 16 0.70 22.75 0.08 99.16
129 INT268360 Positive_regulation of SMAD4 3 0.55 1.55 0.03 99.16
130 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 99.16
131 INT171975 Negative_regulation of Gene_expression of INCENP 8 0.05 5.24 1.35 99.16
132 INT268383 Gene_expression of MUTYH 1 0.46 2.56 0 99.16
133 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 99.14
134 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 99.08
135 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 99.08
136 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.04
137 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 99.04
138 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 99.00
139 INT80712 Gene_expression of PTGER4 21 0.65 13.08 5.03 99.00
140 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21 99.00
141 INT38755 Regulation of Aldh1a1 3 0.44 2.14 0.55 98.94
142 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93 98.92
143 INT190032 Negative_regulation of Cdx2 2 0.38 0.74 0.3 98.92
144 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07 98.92
145 INT319329 Positive_regulation of EGI 1 0.04 0.95 0 98.88
146 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 98.80
147 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 98.80
148 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 98.76
149 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 98.76
150 INT109411 Gene_expression of SAT1 61 0.77 67.99 3.08 98.68
151 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 98.68
152 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4 98.68
153 INT128060 Regulation of Gene_expression of PER1 4 0.52 2.41 1.72 98.64
154 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 98.64
155 INT128058 Regulation of PER1 6 0.43 1.82 1.89 98.64
156 INT337656 Positive_regulation of DPYSL2 1 0.17 2.13 0.05 98.60
157 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96 98.60
158 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 98.56
159 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 98.56
160 INT227552 Regulation of Phosphorylation of Ppara 7 0.44 3.13 0.92 98.52
161 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 98.48
162 INT103094 Binding of PPARA 308 0.47 177.26 34.75 98.44
163 INT127692 Positive_regulation of Gene_expression of CXCL1 8 0.56 6.26 1.71 98.44
164 INT68277 Positive_regulation of CXCL1 6 0.56 6.98 2.14 98.44
165 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 98.40
166 INT172445 Positive_regulation of Gene_expression of Myc 58 0.70 39.62 0.25 98.40
167 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 98.38
168 INT216395 Negative_regulation of Gene_expression of KRT7 4 0.41 3.57 0.16 98.38
169 INT337663 Localization of NNMT 1 0.30 1.34 0.04 98.36
170 INT337645 Localization of Nnmt 1 0.78 1.33 0.04 98.36
171 INT263801 Localization of PSME1 2 0.07 1.72 0.04 98.36
172 INT337662 Localization of PSME3 1 0.52 1.26 0.04 98.36
173 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 98.36
174 INT65855 Localization of TP53 18 0.76 17.08 1.89 98.36
175 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47 98.32
176 INT60585 Regulation of TP53 59 0.59 54.55 5.21 98.32
177 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54 98.32
178 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0 98.32
179 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 98.32
180 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 98.28
181 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86 98.24
182 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08 98.24
183 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 98.24
184 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 98.24
185 INT341438 Positive_regulation of Slc25a16 1 0.32 0.9 0 98.22
186 INT206930 Negative_regulation of Gene_expression of MGMT 3 0.40 2.84 0.16 98.20
187 INT337653 Gene_expression of BAAT 1 0.06 1.51 0 98.20
188 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38 98.20
189 INT268366 Negative_regulation of Gene_expression of CRABP1 1 0.26 0.84 0.04 98.20
190 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 98.16
191 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 98.16
192 INT106667 Gene_expression of NDRG1 18 0.70 9.96 5.14 98.16
193 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 98.14
194 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 98.12
195 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 98.12
196 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 98.04
197 INT20214 Localization of Slc3a2 5 0.14 4.91 0.16 98.04
198 INT217805 Positive_regulation of Gene_expression of MIR191 1 0.28 0.59 0 98.04
199 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 98.02
200 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 98.00
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