D:Compression Fractures

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Disease Term
Synonyms Compression Fracture, Fracture Compression
Documents 718
Hot Single Events 57
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Compression Fractures. They are ordered first by their relevance to Compression Fractures and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18 100.00
2 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17 100.00
3 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 76.24
4 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 69.60
5 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 60.16
6 INT326460 NR1I2 Regulation of Cyp4f18 1 0.01 0.72 0.18 59.80
7 INT211067 Pth Regulation of DMD 1 0.01 0.12 0 51.36
8 INT287697 QRFP Regulation of Gene_expression of TNF 1 0.40 1.23 0.42 48.40
9 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 21.76
10 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 21.76
11 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 18.32
12 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
13 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
14 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
15 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48 5.00
16 INT307665 Binding of Mpz and Pmp22 1 0.34 0.39 0.08 5.00
17 INT307666 Binding of Pmp22 and Gjb1 1 0.31 0.38 0.08 5.00
18 INT307663 Binding of Pmp22 and Egr2 1 0.33 0.39 0.08 5.00
19 INT307664 Binding of Pmp22 and LOC689781 1 0.03 0.39 0.08 5.00
20 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 5.00
21 INT345060 Binding of SGCG and C2 1 0.00 0.93 0 5.00
22 INT345059 Binding of C3 and C2 1 0.00 0 0 5.00
23 INT333978 Binding of ELF3 and TRAP 1 0.15 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Compression Fractures. They are ordered first by their pain relevance and then by number of times they were reported in Compression Fractures. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43 100.00
2 INT23524 Positive_regulation of VCF 7 0.57 4.25 1.16 100.00
3 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82 100.00
4 INT2519 Negative_regulation of VCF 7 0.43 5.27 1.79 100.00
5 INT162568 Regulation of TBX1 3 0.35 1.54 0.11 100.00
6 INT218795 Regulation of VCF 2 0.43 1.49 0.33 100.00
7 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23 100.00
8 INT306427 Localization of TBX1 1 0.20 1.08 0.23 100.00
9 INT218794 Protein_catabolism of VCF 1 0.53 0.91 0.14 100.00
10 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11 100.00
11 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 99.88
12 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.36
13 INT326185 Binding of ST7L 2 0.08 1.46 1 99.26
14 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.06
15 INT50525 Positive_regulation of LR 5 0.07 1.5 0.73 98.90
16 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.88
17 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 97.92
18 INT125480 Regulation of HHIP 17 0.38 6.16 2.16 97.56
19 INT2649 Regulation of Calca 433 0.62 146.05 330.95 97.40
20 INT125834 Negative_regulation of FAM53C 1 0.11 0.78 0.24 96.96
21 INT35269 Localization of SGCG 38 0.78 14.68 9.01 96.40
22 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 96.36
23 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 95.52
24 INT12115 Localization of VCF 3 0.70 2.67 0.8 94.08
25 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 94.04
26 INT178763 Binding of HHIP 37 0.08 6.3 5.29 93.88
27 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 93.20
28 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 92.36
29 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 92.00
30 INT293564 Binding of ESCO1 1 0.33 1 0.44 91.72
31 INT211045 Positive_regulation of CD6 1 0.49 0.56 0.26 91.44
32 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 91.20
33 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 90.48
34 INT166582 Negative_regulation of Localization of SYTL1 1 0.05 1.09 0.27 89.72
35 INT166583 Negative_regulation of SYTL1 1 0.05 1.09 0.26 89.72
36 INT166580 Localization of SYTL1 1 0.09 1.09 0.26 89.72
37 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 89.68
38 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 89.20
39 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 88.68
40 INT9089 Positive_regulation of Ceacam1 17 0.69 7.09 2.49 88.48
41 INT196594 Localization of CFD 4 0.65 4.36 0.39 88.20
42 INT196595 Regulation of Localization of CFD 1 0.39 2.03 0.04 88.20
43 INT2774 Binding of Crp 241 0.48 195.89 44.39 87.76
44 INT37296 Binding of Esr1 117 0.43 62.51 27.33 87.76
45 INT4891 Transcription of Calca 81 0.72 35.27 53.75 87.36
46 INT22454 Regulation of Crp 213 0.62 160.67 49.24 87.16
47 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 86.76
48 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 86.72
49 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 86.44
50 INT288384 Binding of CHIT1 2 0.15 2.04 0.22 86.20
51 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 85.52
52 INT144689 Regulation of RCT 49 0.53 25.91 9.6 82.84
53 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 82.00
54 INT211971 Binding of Best1 16 0.22 7.73 0.33 81.20
55 INT166581 Positive_regulation of SYTL1 1 0.06 1.11 0.25 80.76
56 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 80.40
57 INT133826 Negative_regulation of Kdm5d 15 0.16 7.88 1.83 80.20
58 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 79.60
59 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 79.60
60 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 79.04
61 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 79.04
62 INT125980 Binding of CFD 8 0.42 10.96 1.39 78.80
63 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 78.28
64 INT69648 Positive_regulation of CA5P 10 0.58 6.41 1.57 76.68
65 INT15610 Localization of GOPC 223 0.65 68.26 28.7 76.60
66 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 76.44
67 INT62760 Localization of PLXNA3 3 0.78 2.06 0.8 74.36
68 INT69649 Regulation of CA5P 3 0.20 2.56 0.81 73.88
69 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 73.36
70 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 72.48
71 INT286991 Positive_regulation of Positive_regulation of CA5P 1 0.48 0.58 0 72.48
72 INT270300 Positive_regulation of Localization of VCF 1 0.57 0.13 0 72.24
73 INT100912 Regulation of Kdm5d 52 0.32 20.39 4.72 71.92
74 INT286992 Negative_regulation of CA5P 3 0.49 1.55 0 71.44
75 INT321885 Localization of Dkk1 1 0.56 0.87 0.04 69.60
76 INT321888 Localization of Slc3a2 1 0.04 0.93 0.04 69.20
77 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 67.04
78 INT286993 Localization of CA5P 23 0.63 14.38 0.89 66.92
79 INT286990 Negative_regulation of Localization of CA5P 3 0.36 1.57 0 66.92
80 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 64.40
81 INT129304 Gene_expression of CA5P 8 0.57 4.52 0.57 64.16
82 INT269464 Negative_regulation of Gene_expression of HHIP 4 0.10 0.74 0.16 62.28
83 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 61.92
84 INT139845 Negative_regulation of Cyp4f18 4 0.28 0.95 0.78 61.36
85 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 60.16
86 INT211055 Binding of PAX5 2 0.33 0.85 0.18 59.72
87 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 59.60
88 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 59.60
89 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42 59.60
90 INT38672 Binding of KRT20 69 0.39 48.01 6.31 58.40
91 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 58.40
92 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 58.16
93 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 57.08
94 INT286994 Regulation of Positive_regulation of CA5P 1 0.38 0.65 0 56.72
95 INT113319 Positive_regulation of QRFP 5 0.40 3.86 0.1 55.60
96 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 54.52
97 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 54.48
98 INT626 Localization of CALCA 289 0.81 125.39 221.15 54.32
99 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 52.96
100 INT125227 Positive_regulation of CHIT1 5 0.21 3.52 0.33 52.96
101 INT171998 Binding of DMD 58 0.47 38.13 3.35 52.28
102 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 51.88
103 INT65089 Positive_regulation of ACP5 4 0.50 1.67 0.57 50.28
104 INT126713 Binding of VCF 1 0.48 0 0 50.00
105 INT39513 Positive_regulation of TRAP 14 0.48 5.11 1.67 48.80
106 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 48.28
107 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 48.00
108 INT10173 Binding of Tnf 45 0.48 35.6 14.32 46.24
109 INT295324 Regulation of Binding of Tnf 2 0.44 1.11 0.09 46.24
110 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 46.08
111 INT51474 Binding of Il6 55 0.48 44.99 20.52 45.84
112 INT98448 Regulation of Binding of Il6 3 0.39 2.6 1.46 45.84
113 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 44.28
114 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 44.16
115 INT16165 Regulation of DMD 114 0.60 35.13 3.64 43.88
116 INT69478 Negative_regulation of GBA 16 0.55 7.9 0.59 43.12
117 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 41.48
118 INT53008 Gene_expression of Nr4a2 25 0.74 4.89 1.5 41.28
119 INT38056 Localization of Crp 71 0.78 53.14 17.03 40.76
120 INT95006 Regulation of Localization of Crp 3 0.60 0.82 0.73 40.76
121 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 40.08
122 INT241799 Negative_regulation of CHIT1 13 0.42 4.37 0.44 39.60
123 INT333984 Localization of CHIT1 1 0.26 0.32 0.09 39.60
124 INT39512 Negative_regulation of TRAP 22 0.56 8.18 4.76 38.80
125 INT86946 Localization of TRAP 5 0.74 2.87 0.34 38.80
126 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 38.00
127 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 38.00
128 INT139474 Negative_regulation of Tnfrsf11b 9 0.34 5.74 1.05 37.28
129 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 37.12
130 INT37615 Gene_expression of ESCO1 6 0.72 1.1 4.15 35.32
131 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4 34.64
132 INT2038 Localization of Esr1 104 0.79 40.12 13.27 34.48
133 INT211066 Negative_regulation of Positive_regulation of DMD 5 0.16 2.56 0.14 31.20
134 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 30.92
135 INT171994 Regulation of Positive_regulation of DMD 4 0.15 0.82 0 30.48
136 INT285409 Positive_regulation of Positive_regulation of ELF3 2 0.27 1.21 0 30.32
137 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 29.68
138 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 28.08
139 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 27.84
140 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 27.84
141 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 26.12
142 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 25.12
143 INT68829 Binding of ELF3 14 0.47 7.96 2 24.96
144 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 24.24
145 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 24.04
146 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 22.76
147 INT20664 Binding of ACE 60 0.48 35.27 9.16 22.76
148 INT161840 Gene_expression of Tnfrsf11b 17 0.78 12.44 2.63 22.56
149 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 20.96
150 INT1562 Localization of Crh 499 0.81 126.74 236.68 15.84
151 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 15.68
152 INT293563 Negative_regulation of Gene_expression of ESCO1 2 0.33 0.17 2.1 14.40
153 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 13.28
154 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 12.48
155 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 11.52
156 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 10.92
157 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 10.16
158 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 8.88
159 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 8.00
160 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 6.44
161 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 6.44
162 INT321886 Positive_regulation of F8 1 0.05 1.13 0.33 5.92
163 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.84
164 INT81578 Gene_expression of TRAP 25 0.72 9.75 2.82 5.84
165 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93 5.84
166 INT241797 Gene_expression of CHIT1 10 0.24 9.75 0.69 5.84
167 INT241798 Negative_regulation of Gene_expression of CHIT1 4 0.15 2.07 0.1 5.84
168 INT333986 Negative_regulation of Gene_expression of TRAP 3 0.32 0.77 0 5.84
169 INT196593 Phosphorylation of CFD 1 0.55 0.84 0.04 5.36
170 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.08
171 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
172 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
173 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
174 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
175 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
176 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
177 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
178 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
179 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
180 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
181 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 5.00
182 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
183 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
184 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
185 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
186 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
187 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 5.00
188 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
189 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
190 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
191 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 5.00
192 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
193 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
194 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
195 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
196 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
197 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 5.00
198 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
199 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
200 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
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