D:Conductive Hearing Loss

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Disease Term
Synonyms Eustachian Tube Block, Otosclerosis, Superior Canal Dehiscence
Documents 134
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Conductive Hearing Loss. They are ordered first by their relevance to Conductive Hearing Loss and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03 48.76
2 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21 5.00
3 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15 5.00
4 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07 5.00
5 INT335886 Binding of Sost and Lrp4 1 0.28 0.65 0.07 5.00
6 INT228212 Cpox Negative_regulation of Localization of Ptger2 1 0.00 0.88 0.04 5.00
7 INT228217 Nfkb1 Regulation of Gene_expression of Ptger2 1 0.01 1.22 0 5.00
8 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0 5.00
9 INT228214 Nfkb1 Positive_regulation of Gene_expression of Ptger2 1 0.01 0.97 0 5.00
10 INT240685 Binding of DIRAS3 and KCNQ4 1 0.18 0.95 0 5.00
11 INT228215 Tlr2 Positive_regulation of Gene_expression of Tlr4 1 0.19 1.47 0 5.00
12 INT227399 Binding of D5Mit424 and Alms1 1 0.01 0.71 0 5.00
13 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0 5.00
14 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0 5.00
15 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0 5.00
16 INT228213 Gopc Positive_regulation of Gene_expression of Ptger2 1 0.00 1.08 0 5.00
17 INT228218 Negative_regulation of Nfkb1 Negative_regulation of Gene_expression of Ptger2 1 0.01 1.13 0 5.00
18 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0 5.00
19 INT240684 Binding of NAT2 and DIRAS3 1 0.03 0.95 0 5.00
20 INT227398 Binding of H2afy and Alms1 1 0.01 1.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Conductive Hearing Loss. They are ordered first by their pain relevance and then by number of times they were reported in Conductive Hearing Loss. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172328 Negative_regulation of Phl1 1 0.03 61.51 0.97 100.00
2 INT172323 Gene_expression of Phl1 1 0.03 14 0.16 100.00
3 INT172325 Positive_regulation of Gene_expression of Phl1 1 0.02 2.65 0.04 100.00
4 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 95.92
5 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 95.92
6 INT335878 Localization of Sost 3 0.69 1.11 0.22 94.48
7 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 82.80
8 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 82.12
9 INT45813 Negative_regulation of Negative_regulation of Gabrg1 10 0.46 0.66 4.51 73.24
10 INT200491 Gene_expression of Eng 1 0.13 0.79 0.16 72.20
11 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 71.76
12 INT335868 Negative_regulation of Gene_expression of Sost 2 0.58 1.12 0.04 71.00
13 INT335864 Gene_expression of Sost 4 0.77 2.36 0.2 70.28
14 INT335876 Negative_regulation of Sost 11 0.51 6.77 0.67 65.40
15 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25 64.60
16 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 64.24
17 INT57343 Negative_regulation of ICK 1 0.15 0.16 0.08 63.68
18 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 60.60
19 INT108519 Binding of Lrp6 8 0.44 1.47 1.19 59.12
20 INT254427 Binding of Lrp5 10 0.48 5.43 0.26 59.12
21 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 58.56
22 INT200806 Binding of EEC1 6 0.39 4.24 0.29 58.12
23 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 56.48
24 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 56.04
25 INT335869 Binding of Sost 6 0.32 1.79 0.18 48.76
26 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19 47.52
27 INT97885 Regulation of LOC500077 7 0.16 2.93 4.33 44.16
28 INT200492 Negative_regulation of Regulation of LOC500077 1 0.17 0.93 0.54 44.16
29 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 38.32
30 INT57691 Regulation of Gene_expression of Ptger2 23 0.40 17.08 4.61 35.56
31 INT173117 Binding of Ltf 4 0.12 1.85 0.28 26.52
32 INT214056 Negative_regulation of NSD1 3 0.43 3.44 0.09 26.44
33 INT335861 Localization of Lrp6 1 0.69 0.54 0.17 26.00
34 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 21.44
35 INT173693 Localization of Gopc 249 0.65 70.49 38.81 21.44
36 INT49506 Regulation of Ptger2 29 0.44 17.38 6.75 19.12
37 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 16.80
38 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 16.48
39 INT214055 Gene_expression of NSD1 8 0.67 4.46 0 15.04
40 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
41 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
42 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 5.00
43 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
44 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
45 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
46 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
47 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
48 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
49 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
50 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
51 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
52 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
53 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
54 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
55 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
56 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
57 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
58 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
59 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 5.00
60 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
61 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
62 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
63 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
64 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 5.00
65 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
66 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 5.00
67 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 5.00
68 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 5.00
69 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
70 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 5.00
71 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
72 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 5.00
73 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
74 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4 5.00
75 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15 5.00
76 INT25396 Localization of Ptger2 83 0.78 46.81 14.81 5.00
77 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 5.00
78 INT39564 Negative_regulation of Gene_expression of Ptger2 50 0.42 30.9 12.97 5.00
79 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 5.00
80 INT75768 Transcription of Cpox 37 0.27 19.41 9.79 5.00
81 INT71878 Protein_catabolism of Nfkb1 24 0.65 10.85 9.46 5.00
82 INT180163 Positive_regulation of Nfasc 49 0.40 31.96 9.41 5.00
83 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 5.00
84 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
85 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
86 INT79166 Regulation of TNC 12 0.44 9.42 8.13 5.00
87 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26 5.00
88 INT88498 Protein_catabolism of Nfkbia 14 0.82 6.94 7.1 5.00
89 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67 5.00
90 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
91 INT61258 Transcription of Nfkb1 24 0.67 10.89 6.32 5.00
92 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 5.00
93 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 5.00
94 INT88873 Negative_regulation of Gene_expression of Nfkb1 24 0.56 9.93 5.97 5.00
95 INT16688 Positive_regulation of Cndp2 11 0.49 1.12 5.86 5.00
96 INT3731 Negative_regulation of Neu1 17 0.39 8.35 5.67 5.00
97 INT87211 Positive_regulation of Localization of Nfkb1 27 0.59 15.84 5.25 5.00
98 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 5.00
99 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
100 INT19391 Gene_expression of Nt5e 44 0.72 13.99 5.14 5.00
101 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 5.00
102 INT88496 Positive_regulation of Protein_catabolism of Nfkbia 8 0.53 3.05 4.78 5.00
103 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75 5.00
104 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61 5.00
105 INT133231 Regulation of PYCARD 18 0.39 5.02 4.44 5.00
106 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
107 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 5.00
108 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 5.00
109 INT71882 Phosphorylation of Nfkb1 20 0.81 11.46 4.1 5.00
110 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04 5.00
111 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 5.00
112 INT108761 Localization of Alms1 24 0.70 13.92 3.74 5.00
113 INT233945 Positive_regulation of Expi 5 0.04 2.53 3.46 5.00
114 INT25393 Positive_regulation of Localization of Ptger2 19 0.32 9.69 3.23 5.00
115 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 5.00
116 INT90402 Positive_regulation of Gene_expression of Ptgs1 13 0.31 4.83 2.88 5.00
117 INT78581 Positive_regulation of Binding of Nfkb1 13 0.66 7.37 2.79 5.00
118 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73 5.00
119 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73 5.00
120 INT69009 Regulation of Binding of Nfkb1 9 0.27 9.86 2.58 5.00
121 INT22082 Localization of Ceacam1 13 0.80 2.44 2.48 5.00
122 INT52441 Negative_regulation of Localization of Ptger2 10 0.21 5.23 2.41 5.00
123 INT71881 Positive_regulation of Phosphorylation of Nfkb1 5 0.45 1.38 2.24 5.00
124 INT121036 Positive_regulation of Transcription of Cpox 12 0.21 6.34 2.04 5.00
125 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
126 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91 5.00
127 INT169862 Regulation of NPC1 13 0.53 13.61 1.84 5.00
128 INT87214 Regulation of Positive_regulation of Nfkb1 7 0.43 5.85 1.79 5.00
129 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74 5.00
130 INT127724 Localization of CSF1 12 0.73 9.35 1.56 5.00
131 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
132 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45 5.00
133 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 5.00
134 INT180580 Binding of HEYL 7 0.17 4.49 1.15 5.00
135 INT147909 Gene_expression of Lpl 21 0.58 9.35 1.14 5.00
136 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11 5.00
137 INT165338 Binding of Dkk1 4 0.37 3.64 1.04 5.00
138 INT124374 Binding of Wnt2 21 0.31 10.16 0.99 5.00
139 INT17554 Regulation of ABR 6 0.54 2.21 0.98 5.00
140 INT178391 Localization of Mapk14 9 0.68 5.27 0.97 5.00
141 INT22081 Regulation of Ceacam1 8 0.23 4.11 0.95 5.00
142 INT67320 Positive_regulation of CAPRIN2 11 0.48 2.73 0.94 5.00
143 INT117735 Positive_regulation of Regulation of Nfkb1 3 0.44 2.93 0.91 5.00
144 INT143714 Phosphorylation of Nfkbia 4 0.64 2.94 0.87 5.00
145 INT115757 Negative_regulation of ABR 3 0.57 0.53 0.8 5.00
146 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71 5.00
147 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67 5.00
148 INT182010 Regulation of Tnfrsf11b 2 0.18 1.13 0.67 5.00
149 INT213739 Gene_expression of Expi 7 0.47 1.05 0.63 5.00
150 INT245721 Localization of FRZB 6 0.78 4.3 0.6 5.00
151 INT213503 Regulation of Wnt2 9 0.37 3.54 0.56 5.00
152 INT228180 Regulation of Localization of Ptger2 2 0.06 3.58 0.54 5.00
153 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49 5.00
154 INT201524 Localization of Wnt2 14 0.62 9.24 0.46 5.00
155 INT248346 Binding of PLXNA2 4 0.29 1.38 0.46 5.00
156 INT206821 Positive_regulation of Muc2 6 0.47 2.85 0.44 5.00
157 INT43141 Negative_regulation of Hrasls 5 0.14 1.26 0.41 5.00
158 INT58566 Regulation of Gene_expression of Pth 5 0.58 2.3 0.38 5.00
159 INT39911 Negative_regulation of Positive_regulation of Pth 5 0.41 2.57 0.37 5.00
160 INT277463 Localization of Sfrp1 2 0.23 0.64 0.36 5.00
161 INT187022 Positive_regulation of Transcription of MMP9 3 0.45 3.27 0.34 5.00
162 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27 5.00
163 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27 5.00
164 INT209527 Regulation of Muc5ac 4 0.51 2.17 0.25 5.00
165 INT335874 Regulation of Lrp4 1 0.18 0 0.23 5.00
166 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21 5.00
167 INT335879 Negative_regulation of Gene_expression of Tph1 1 0.19 0.15 0.21 5.00
168 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18 5.00
169 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18 5.00
170 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16 5.00
171 INT261721 Negative_regulation of Stl2 1 0.07 1.38 0.16 5.00
172 INT244657 Regulation of Lch 3 0.40 6.63 0.13 5.00
173 INT125391 Gene_expression of Rim5 2 0.01 1.94 0.11 5.00
174 INT254428 Binding of Lrp4 4 0.44 1.52 0.11 5.00
175 INT25530 Positive_regulation of ABR 3 0.33 0.34 0.1 5.00
176 INT328094 Positive_regulation of Gene_expression of ABR 1 0.33 0 0.09 5.00
177 INT151522 Binding of NSD1 2 0.37 4.28 0.09 5.00
178 INT264219 Regulation of HDC 1 0.14 0.07 0.09 5.00
179 INT264220 Gene_expression of HDC 1 0.17 0.14 0.08 5.00
180 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08 5.00
181 INT264221 Regulation of Gene_expression of HDC 1 0.10 0.15 0.08 5.00
182 INT228198 Regulation of Regulation of Ptger2 1 0.02 0.79 0.08 5.00
183 INT354592 Positive_regulation of Gene_expression of PLXNA2 1 0.04 0.37 0.07 5.00
184 INT335871 Negative_regulation of Sfrp2 1 0.18 0.91 0.06 5.00
185 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06 5.00
186 INT335860 Negative_regulation of Sfrp1 1 0.18 0.91 0.06 5.00
187 INT354590 Regulation of Gene_expression of Expi 1 0.02 0.34 0.05 5.00
188 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05 5.00
189 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05 5.00
190 INT201777 Phosphorylation of Wnt2 2 0.03 1.31 0.05 5.00
191 INT354591 Negative_regulation of Positive_regulation of PYCARD 1 0.05 0.34 0.05 5.00
192 INT349674 Regulation of Positive_regulation of PYCARD 2 0.11 0.34 0.05 5.00
193 INT183086 Regulation of HTL 3 0.24 1.46 0.05 5.00
194 INT228183 Regulation of Protein_catabolism of Nfkb1 1 0.12 0.24 0.05 5.00
195 INT354593 Regulation of Gene_expression of PLXNA2 1 0.04 0.34 0.05 5.00
196 INT172322 Negative_regulation of Gene_expression of Nt5e 1 0.41 1.03 0.04 5.00
197 INT228185 Regulation of Phosphorylation of Nfkb1 1 0.12 0.29 0.04 5.00
198 INT335867 Positive_regulation of Negative_regulation of Sfrp2 1 0.14 0.49 0.03 5.00
199 INT228192 Negative_regulation of Map2k2 2 0.35 0.96 0.03 5.00
200 INT335859 Regulation of Sfrp1 1 0.08 0.43 0.03 5.00
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