D:Congenital Myasthenic Syndromes

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pChart

Disease Term
Synonyms Congenital Myasthenia Gravis, Congenital Myasthenic Syndrome, Congenital Myasthenic Syndromes Postsynaptic, Congenital Myasthenic Syndromes Presynaptic, Congenital Slow Channel Myasthenic Syndromes, MYASTHENIA GRAVIS CONGENITAL, Myasthenic Syndrome Congenital, Myasthenic Syndromes Congenital Slow Channel, Postsynaptic Congenital Myasthenic Syndromes, Presynaptic Congenital Myasthenic Syndromes, Slow Channel Congenital Myasthenic Syndromes
Documents 21
Hot Single Events 43
Hot Interactions 15

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Congenital Myasthenic Syndromes. They are ordered first by their relevance to Congenital Myasthenic Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT312629 Agrn Positive_regulation of Musk 1 0.76 1.03 0 99.52
2 INT312628 Agrn Positive_regulation of Lrp4 1 0.22 0.66 0 99.52
3 INT312630 Agrn Positive_regulation of Ldlr 1 0.14 0.66 0 99.52
4 INT312635 Binding of Musk and Dok7 1 0.47 3.41 0 99.28
5 INT312639 Binding of Musk and Lrp4 1 0.23 0.91 0.06 99.28
6 INT312645 Binding of DNAJA3 and Musk 1 0.08 0.96 0.07 99.28
7 INT312637 Negative_regulation of Binding of Musk and Dok7 1 0.42 1.03 0 97.40
8 INT312644 Regulation of Binding of Musk and SYCP3 1 0.29 0.28 0 96.20
9 INT312643 Binding of Musk and SYCP3 1 0.39 0.28 0 96.20
10 INT312646 Agrn Positive_regulation of Phosphorylation of CHRNE 1 0.02 0.38 0 94.88
11 INT312631 Binding of Musk and Agrn 1 0.40 0.63 0.12 84.04
12 INT312627 Negative_regulation of Binding of Musk and Agrn 1 0.46 0.32 0.06 84.04
13 INT312636 Negative_regulation of Binding of Musk and Lrp4 1 0.21 0.32 0.06 81.92
14 INT312632 Binding of Agrn and Lrp4 1 0.17 0.32 0.06 81.56
15 INT312647 Binding of Agrn and SYCP3 1 0.39 0.32 0.06 81.56
16 INT312641 Binding of Dok7 and MIR605 1 0.01 0.28 0 79.44
17 INT312642 DNAJA3 Positive_regulation of Musk 1 0.08 0.37 0 75.84
18 INT312634 Dok7 Positive_regulation of Musk 1 0.68 0.37 0 75.84
19 INT312640 Positive_regulation of Binding of Musk and Dok7 1 0.46 0.27 0 75.00
20 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
21 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
22 INT314986 Ins1 Negative_regulation of CACNA1S 1 0.00 0.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Congenital Myasthenic Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Congenital Myasthenic Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT110871 Positive_regulation of Cms1 8 0.15 7.92 1.27 100.00
2 INT314984 Positive_regulation of Cd2ap 1 0.01 0.75 0.11 100.00
3 INT312608 Regulation of Phosphorylation of Musk 1 0.44 0.35 0 100.00
4 INT168001 Localization of Cms1 5 0.59 1.78 0.21 100.00
5 INT103716 Gene_expression of Cms1 14 0.65 8.52 1.3 100.00
6 INT286716 Localization of Musk 2 0.73 1.03 0.07 99.96
7 INT312625 Positive_regulation of Agrn 1 0.49 1.18 0 99.52
8 INT312605 Phosphorylation of Musk 1 0.80 3.12 0 99.32
9 INT312616 Binding of DNAJA3 1 0.07 0.58 0.07 98.96
10 INT254428 Binding of Lrp4 4 0.44 1.52 0.11 98.96
11 INT301733 Positive_regulation of Musk 2 0.68 1.76 0.09 98.88
12 INT142800 Positive_regulation of Ldlr 21 0.68 14.75 0.6 98.88
13 INT312610 Positive_regulation of Lrp4 1 0.21 0.66 0 98.88
14 INT312600 Negative_regulation of Phosphorylation of Musk 1 0.57 0.34 0 98.76
15 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 98.72
16 INT256033 Negative_regulation of Musk 2 0.42 0.92 0.44 98.70
17 INT312594 Binding of Dok7 1 0.42 1.05 0 98.44
18 INT301743 Binding of Musk 2 0.41 1.09 0.09 98.44
19 INT312599 Negative_regulation of Binding of Musk 1 0.37 0.24 0 98.44
20 INT312601 Phosphorylation of Dok7 1 0.62 1.39 0 97.96
21 INT312609 Negative_regulation of Phosphorylation of Dok7 1 0.37 0.52 0 97.96
22 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 97.20
23 INT286713 Gene_expression of Musk 3 0.66 2.56 0.1 97.04
24 INT312615 Negative_regulation of Phosphorylation of CHRNE 1 0.02 0.77 0 97.04
25 INT286721 Negative_regulation of Gene_expression of Musk 2 0.42 0.53 0 97.04
26 INT312598 Negative_regulation of Positive_regulation of Musk 1 0.42 0.38 0 97.04
27 INT37103 Gene_expression of CHRNE 5 0.67 4.32 0.12 96.60
28 INT279195 Binding of SYCP3 4 0.47 1.52 0.24 96.20
29 INT312607 Regulation of Binding of Lrp4 1 0.19 0.28 0 96.20
30 INT312621 Regulation of Binding of SYCP3 1 0.44 0.28 0 96.20
31 INT312624 Phosphorylation of Agrn 1 0.61 0.9 0 94.88
32 INT312617 Phosphorylation of CHRNE 1 0.02 0.7 0 94.04
33 INT132987 Positive_regulation of Positive_regulation of Acot1 5 0.39 1.43 1.12 91.24
34 INT45084 Positive_regulation of Chrnb1 4 0.40 1.32 0.99 91.24
35 INT68500 Regulation of Ar 6 0.27 4.16 1.32 90.56
36 INT3983 Positive_regulation of Acot1 30 0.68 5.83 8.34 90.08
37 INT312595 Positive_regulation of Positive_regulation of Musk 1 0.49 0.51 0 88.76
38 INT312596 Positive_regulation of Phosphorylation of Dok7 1 0.38 0.56 0 88.12
39 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21 83.08
40 INT193816 Gene_expression of SYCP3 4 0.65 3.55 1.09 83.08
41 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 81.92
42 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19 80.24
43 INT314985 Positive_regulation of Negative_regulation of Pam 1 0.05 2.1 0.15 80.24
44 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 79.16
45 INT69282 Binding of PHEX 4 0.15 1.43 0.41 79.16
46 INT312622 Binding of MIR605 1 0.01 0.28 0 78.72
47 INT312618 Negative_regulation of Binding of MIR605 1 0.01 0.28 0 78.72
48 INT312623 Negative_regulation of Phosphorylation of Agrn 1 0.42 0.26 0 75.00
49 INT312602 Positive_regulation of Phosphorylation of Musk 1 0.45 0.26 0 75.00
50 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 75.00
51 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74 75.00
52 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 50.00
53 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 50.00
54 INT220699 Positive_regulation of CHRNE 5 0.32 2.26 0.26 50.00
55 INT312606 Gene_expression of Dok7 1 0.59 0 0 50.00
56 INT312603 Regulation of Gene_expression of Musk 1 0.26 0 0 50.00
57 INT312597 Positive_regulation of Gene_expression of Dok7 1 0.44 0 0 50.00
58 INT312620 Gene_expression of MIR605 1 0.01 0 0 50.00
59 INT312619 Negative_regulation of Gene_expression of MIR605 1 0.01 0 0 50.00
60 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 44.08
61 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 28.16
62 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 21.72
63 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 7.64
64 INT220701 Regulation of Negative_regulation of ACHE 2 0.25 1.06 0 6.32
65 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 5.00
66 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
67 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 5.00
68 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 5.00
69 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
70 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 5.00
71 INT145971 Localization of Nav1 20 0.81 10.3 18.11 5.00
72 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
73 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
74 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
75 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52 5.00
76 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 5.00
77 INT37105 Binding of CHRNE 3 0.31 6.88 0.87 5.00
78 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
79 INT70104 Positive_regulation of CACNA1S 6 0.47 5.92 0.68 5.00
80 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64 5.00
81 INT15588 Regulation of PHEX 4 0.26 1.48 0.39 5.00
82 INT166755 Localization of PHEX 2 0.73 1.16 0.28 5.00
83 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 5.00
84 INT220702 Protein_catabolism of CHRNE 1 0.64 1.22 0.08 5.00
85 INT220704 Protein_catabolism of ACOT1 1 0.02 1.19 0.08 5.00
86 INT220700 Gene_expression of MUSK 3 0.75 6.67 0.07 5.00
87 INT207781 Gene_expression of CACNA1S 3 0.63 0.9 0.03 5.00
88 INT314979 Negative_regulation of Localization of Lp1 1 0.10 0.1 0 5.00
89 INT314978 Binding of Lp1 1 0.09 0.25 0 5.00
90 INT314980 Localization of Lp1 1 0.18 0 0 5.00
91 INT220703 Regulation of MUSK 1 0.34 1.48 0 5.00
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