D:Connective Tissue Disease Affecting The Skin

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Disease Term
Synonyms Acquired Epidermolysis Bullosa, CONNECTIVE TISSUE DISEASES AFFECTING THE SKIN, Connective Tissue Naevi, Cutaneous Manifestations Of Connective Tissue Disease, Cutaneous Manifestations Of Connective Tissue Diseases, Cutaneous Manifestations Of Connective Tissue Disorder, Cutaneous Manifestations Of Connective Tissue Disorders, CUTANEOUS SIGNS OF CONNECTIVE TISSUE DISEASE, Cutaneous Signs Of Connective Tissue Diseases, Cutaneous Signs Of Connective Tissue Disorder, Cutaneous Signs Of Connective Tissue Disorders
Documents 2
Hot Single Events 0
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Connective Tissue Disease Affecting The Skin. They are ordered first by their relevance to Connective Tissue Disease Affecting The Skin and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08 71.68
2 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1 5.00
3 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07 5.00
4 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
5 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03 5.00
6 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0 5.00
7 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0 5.00
8 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0 5.00
9 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
10 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0 5.00
11 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0 5.00
12 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0 5.00
13 INT271982 Binding of Skp2 and Psmd9 1 0.01 0.68 0 5.00
14 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0 5.00
15 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0 5.00
16 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
17 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0 5.00
18 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0 5.00
19 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0 5.00
20 INT271979 Skp2 Positive_regulation of Protein_catabolism of Psmd9 1 0.01 0.35 0 5.00
21 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0 5.00
22 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0 5.00
23 INT272016 Mtor Negative_regulation of INS 1 0.00 0.61 0 5.00
24 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0 5.00
25 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0 5.00
26 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0 5.00
27 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0 5.00
28 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0 5.00
29 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0 5.00
30 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0 5.00
31 INT272005 Phosphorylation of Tsc1 Regulation of Binding of Cdk1 and Plk1 1 0.02 0.3 0 5.00
32 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0 5.00
33 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0 5.00
34 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0 5.00
35 INT271978 Positive_regulation of Racgap1 Regulation of Mtor 1 0.00 0.54 0 5.00
36 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0 5.00
37 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Connective Tissue Disease Affecting The Skin. They are ordered first by their pain relevance and then by number of times they were reported in Connective Tissue Disease Affecting The Skin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 7.76
2 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
3 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
4 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
5 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
6 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
7 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 5.00
8 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
9 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 5.00
10 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
11 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
12 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
13 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
14 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79 5.00
15 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 5.00
16 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 5.00
17 INT49250 Regulation of Atp6v0d2 5 0.08 1.54 2.04 5.00
18 INT216848 Gene_expression of TCIRG1 8 0.52 2.59 1.95 5.00
19 INT214073 Binding of TSC1 9 0.37 22 1.34 5.00
20 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16 5.00
21 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 5.00
22 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
23 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82 5.00
24 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
25 INT271917 Phosphorylation of Mtor 11 0.13 6.76 0.78 5.00
26 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74 5.00
27 INT184694 Gene_expression of Usf1 10 0.55 4.27 0.72 5.00
28 INT71497 Binding of Hspa1b 3 0.08 1.43 0.58 5.00
29 INT182435 Localization of OGG1 36 0.76 1.66 0.58 5.00
30 INT259408 Gene_expression of Atp6v0d2 5 0.09 2.01 0.54 5.00
31 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47 5.00
32 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 5.00
33 INT247798 Negative_regulation of Rasa1 3 0.09 1.05 0.44 5.00
34 INT90090 Gene_expression of ADO 4 0.58 1.41 0.42 5.00
35 INT230653 Phosphorylation of Rasa1 3 0.55 0.6 0.42 5.00
36 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39 5.00
37 INT184803 Localization of TSC1 5 0.37 6.13 0.32 5.00
38 INT126522 Positive_regulation of Phosphorylation of Mapkapk2 7 0.59 3.8 0.28 5.00
39 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28 5.00
40 INT70144 Gene_expression of Sry 4 0.63 1.15 0.28 5.00
41 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 5.00
42 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25 5.00
43 INT182413 Binding of OGG1 17 0.46 2.44 0.22 5.00
44 INT271929 Protein_catabolism of Psmd9 4 0.11 1.69 0.21 5.00
45 INT179044 Regulation of Cdkn1b 4 0.22 2.64 0.18 5.00
46 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13 5.00
47 INT271573 Binding of SCPEP1 3 0.35 1.21 0.13 5.00
48 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12 5.00
49 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12 5.00
50 INT271941 Binding of Tsc2 12 0.24 2.96 0.11 5.00
51 INT271938 Binding of Tsc1 1 0.43 3.18 0.07 5.00
52 INT211006 Binding of PKD1 6 0.22 2.69 0.05 5.00
53 INT197280 Regulation of Psmd9 2 0.07 0.1 0.05 5.00
54 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04 5.00
55 INT271930 Gene_expression of Tsc1 1 0.69 6.88 0.04 5.00
56 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04 5.00
57 INT271937 Positive_regulation of Binding of Tsc2 1 0.25 0 0.04 5.00
58 INT271960 Positive_regulation of Binding of TSC1 1 0.25 0.88 0.03 5.00
59 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03 5.00
60 INT249790 Protein_catabolism of Skp2 2 0.58 1.02 0.03 5.00
61 INT271964 Binding of HERC1 1 0.01 0.31 0 5.00
62 INT271935 Positive_regulation of Phosphorylation of Rps6 1 0.02 0.17 0 5.00
63 INT271924 Positive_regulation of Protein_catabolism of Psmd9 1 0.05 0.35 0 5.00
64 INT271905 Positive_regulation of Protein_catabolism of Tsc2 1 0.35 1.46 0 5.00
65 INT271965 Negative_regulation of Binding of TSC1 1 0.33 0.44 0 5.00
66 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0 5.00
67 INT271928 Binding of Plk1 1 0.07 0.29 0 5.00
68 INT264147 Gene_expression of CLCN7 1 0.35 0.73 0 5.00
69 INT271904 Localization of Tsc2 1 0.41 1.31 0 5.00
70 INT246774 Positive_regulation of Tsc2 6 0.41 2.4 0 5.00
71 INT228895 Binding of Tsc2 5 0.30 2.41 0 5.00
72 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0 5.00
73 INT246755 Regulation of Tsc2 4 0.50 1.01 0 5.00
74 INT161700 Positive_regulation of Psmd9 3 0.59 0.41 0 5.00
75 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0 5.00
76 INT271962 Localization of SLC7A6 1 0.73 0.08 0 5.00
77 INT242456 Binding of Cdk2 2 0.16 1.29 0 5.00
78 INT271913 Protein_catabolism of Tsc1 1 0.51 0.45 0 5.00
79 INT264145 Gene_expression of BSND 1 0.04 1.25 0 5.00
80 INT271940 Protein_catabolism of Tsc2 1 0.50 0.7 0 5.00
81 INT271906 Negative_regulation of Binding of Tsc1 1 0.38 0.06 0 5.00
82 INT182417 Positive_regulation of OGG1 2 0.44 0.83 0 5.00
83 INT214045 Negative_regulation of OGG1 5 0.36 3.49 0 5.00
84 INT271944 Negative_regulation of Phosphorylation of Tsc2 2 0.30 0.42 0 5.00
85 INT271927 Positive_regulation of Tsc1 1 0.44 0.4 0 5.00
86 INT271931 Negative_regulation of Gene_expression of Tsc1 1 0.38 0.44 0 5.00
87 INT271903 Positive_regulation of Protein_catabolism of Skp2 1 0.14 0.47 0 5.00
88 INT271910 Gene_expression of Hsf2 4 0.45 1.63 0 5.00
89 INT271920 Negative_regulation of Protein_catabolism of Skp2 1 0.12 0.37 0 5.00
90 INT246761 Positive_regulation of Gene_expression of Tsc2 2 0.41 1.17 0 5.00
91 INT271934 Binding of Psmd9 1 0.03 0.66 0 5.00
92 INT271923 Regulation of Binding of Plk1 1 0.09 0.29 0 5.00
93 INT271963 Phosphorylation of TSC1 2 0.31 2.02 0 5.00
94 INT271907 Phosphorylation of Rps6 4 0.09 0.67 0 5.00
95 INT271915 Negative_regulation of Pkd1 8 0.36 6.44 0 5.00
96 INT271926 Negative_regulation of Protein_catabolism of Psmd9 1 0.04 0.37 0 5.00
97 INT264146 Gene_expression of MYO7A 1 0.05 1.36 0 5.00
98 INT271961 Phosphorylation of PRKD1 1 0.02 0.6 0 5.00
99 INT271909 Positive_regulation of Tsc2 1 0.25 0.06 0 5.00
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