D:Consciousness Disorder

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Disease Term
Synonyms ALTERED LEVEL OF CONSCIOUSNESS, Consciousness Disorders, Consciousness Level Altered, Consciousness Level Depressed, Depressed Level Of Consciousness, Semiconsciousness
Documents 142
Hot Single Events 7
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Consciousness Disorder. They are ordered first by their relevance to Consciousness Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT319963 Binding of IGFALS and Vcan 1 0.03 2.99 0.13 82.88
2 INT328501 Sumo1 Negative_regulation of Gene_expression of Pglyrp1 1 0.00 1.54 0.83 5.00
3 INT328500 Sumo1 Positive_regulation of Negative_regulation of Cebpz 1 0.11 1.06 0.29 5.00
4 INT328499 Binding of Cebpz and Sumo1 1 0.08 0.84 0.27 5.00
5 INT335565 Binding of KDM5D and SPNS1 1 0.02 0 0.13 5.00
6 INT328498 Sumo1 Positive_regulation of Plg 1 0.07 0.61 0.04 5.00
7 INT297614 ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.56 0 5.00
8 INT297613 Negative_regulation of ZNF275 Positive_regulation of Gene_expression of TSC1 1 0.00 1.66 0 5.00
9 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Consciousness Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Consciousness Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262278 Negative_regulation of Localization of UGCG 1 0.03 0.74 0.17 100.00
2 INT262279 Localization of UGCG 2 0.30 0.9 0.17 99.96
3 INT1893 Localization of Gh 1041 0.79 340.23 256.58 95.60
4 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 93.84
5 INT14916 Binding of RASA1 15 0.37 13.64 1.44 93.16
6 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18 90.96
7 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 84.60
8 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 78.64
9 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 74.96
10 INT193582 Gene_expression of PVR 21 0.58 14 2.39 73.52
11 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 72.08
12 INT141894 Localization of CSF3 9 0.62 5.5 0.64 69.92
13 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 69.08
14 INT16404 Regulation of CD4 54 0.61 33.05 10.29 41.68
15 INT1530 Regulation of Gh 382 0.61 115.96 112.47 41.52
16 INT228875 Positive_regulation of RA1 4 0.29 4.13 0.92 38.72
17 INT55560 Binding of SLC25A4 8 0.36 1.94 0.79 25.00
18 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 24.00
19 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 23.04
20 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 10.92
21 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 10.92
22 INT133744 Gene_expression of Vcan 27 0.74 10.64 2.85 10.28
23 INT101895 Binding of SLC17A5 5 0.36 7.08 0.18 9.76
24 INT16729 Positive_regulation of LOC308670 10 0.65 1.63 3.11 8.68
25 INT44540 Binding of GPT 3 0.36 6.14 0.23 8.68
26 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 7.16
27 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 6.48
28 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.80
29 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
30 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
31 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
32 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
33 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
34 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
35 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
36 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 5.00
37 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
38 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
39 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
40 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
41 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
42 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
43 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
44 INT4822 Localization of Ca2 417 0.80 99.57 96.45 5.00
45 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
46 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 5.00
47 INT3441 Regulation of Localization of Abat 117 0.38 8.67 87.59 5.00
48 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
49 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
50 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
51 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
52 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
53 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
54 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
55 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
56 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 5.00
57 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
58 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
59 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 5.00
60 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
61 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
62 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
63 INT47764 Binding of Jun 106 0.48 22.62 31.39 5.00
64 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
65 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
66 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
67 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
68 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
69 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09 5.00
70 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
71 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 5.00
72 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
73 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
74 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
75 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
76 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
77 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
78 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
79 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
80 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
81 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
82 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
83 INT94573 Negative_regulation of Pik3cb 42 0.50 15.83 15.4 5.00
84 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
85 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
86 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
87 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
88 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85 5.00
89 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 5.00
90 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
91 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
92 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
93 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
94 INT52233 Transcription of Jun 37 0.66 6.39 11.15 5.00
95 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 5.00
96 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
97 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 5.00
98 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.00
99 INT138889 Positive_regulation of Slc12a2 23 0.65 18.53 8.85 5.00
100 INT12861 Gene_expression of Cish 40 0.57 23.01 8.48 5.00
101 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 5.00
102 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
103 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 5.00
104 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
105 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
106 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 5.00
107 INT16268 Binding of HTR3A 15 0.47 7.38 7.18 5.00
108 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
109 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 5.00
110 INT105287 Positive_regulation of Slco1c1 24 0.34 15.41 6.81 5.00
111 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
112 INT60692 Gene_expression of Pglyrp1 15 0.10 8.47 6.51 5.00
113 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
114 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 5.00
115 INT16568 Positive_regulation of HTR3A 14 0.67 4.82 6.01 5.00
116 INT124825 Transcription of Plat 8 0.70 3.15 5.68 5.00
117 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
118 INT116229 Gene_expression of C1qa 28 0.77 18.53 5.35 5.00
119 INT3275 Negative_regulation of Slco1c1 28 0.37 10.93 5.15 5.00
120 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 5.00
121 INT104668 Negative_regulation of Plat 27 0.49 17.18 4.83 5.00
122 INT23126 Regulation of HTR3A 10 0.60 5.42 4.81 5.00
123 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 5.00
124 INT16569 Negative_regulation of HTR3A 14 0.57 6.91 4.42 5.00
125 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
126 INT103463 Localization of CPP 16 0.66 9.63 4.08 5.00
127 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 5.00
128 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
129 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 5.00
130 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 5.00
131 INT184894 Localization of MCRS1 9 0.47 10.04 3.31 5.00
132 INT72141 Binding of Apoe 11 0.37 10.91 3.27 5.00
133 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17 5.00
134 INT45503 Binding of EPO 42 0.48 24.85 2.88 5.00
135 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 5.00
136 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 5.00
137 INT50080 Binding of APOE 38 0.45 29.61 2.67 5.00
138 INT214355 Binding of Akt1 13 0.36 3.72 2.59 5.00
139 INT11787 Positive_regulation of Positive_regulation of NA 14 0.21 2.97 2.46 5.00
140 INT83236 Localization of PGR 14 0.73 8.26 2.23 5.00
141 INT74425 Gene_expression of SPHAR 8 0.08 7.81 2.15 5.00
142 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 5.00
143 INT83468 Gene_expression of ELK3 22 0.66 2.91 2.03 5.00
144 INT11905 Protein_catabolism of EPO 6 1.00 2.36 2 5.00
145 INT17326 Binding of Plg 14 0.43 11.72 1.94 5.00
146 INT9261 Gene_expression of CR1 15 0.73 15.58 1.85 5.00
147 INT191154 Binding of HDAC9 20 0.36 14.12 1.83 5.00
148 INT179222 Gene_expression of AMIGO2 7 0.66 7.68 1.77 5.00
149 INT57063 Negative_regulation of HTR7 6 0.57 1.21 1.76 5.00
150 INT217070 Gene_expression of Acsm3 8 0.25 6.27 1.75 5.00
151 INT194242 Positive_regulation of Gene_expression of MBP 9 0.45 4.1 1.71 5.00
152 INT122500 Protein_catabolism of Slco1c1 17 0.52 16.7 1.7 5.00
153 INT46640 Negative_regulation of Cebpz 9 0.37 2.67 1.52 5.00
154 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4 5.00
155 INT16388 Protein_catabolism of Plg 6 0.79 3.46 1.4 5.00
156 INT22513 Gene_expression of asp1 8 0.58 4.36 1.26 5.00
157 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 5.00
158 INT15502 Regulation of asp1 6 0.19 2.29 1.2 5.00
159 INT257543 Negative_regulation of Gene_expression of NeuN 6 0.36 1.77 1.18 5.00
160 INT100051 Binding of MUC5AC 20 0.32 14.21 1.14 5.00
161 INT199315 Binding of Plat 8 0.34 7.02 1.14 5.00
162 INT212093 Positive_regulation of CASP2 6 0.17 6.87 1.14 5.00
163 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12 5.00
164 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 5.00
165 INT171686 Binding of asp1 8 0.31 11.88 1.07 5.00
166 INT149380 Localization of Cish 3 0.64 3.44 1.06 5.00
167 INT120175 Negative_regulation of HK1 10 0.57 2.57 0.92 5.00
168 INT200738 Gene_expression of HIST2H4A 7 0.18 4.65 0.91 5.00
169 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 5.00
170 INT171851 Gene_expression of Sumo1 13 0.30 10.7 0.89 5.00
171 INT123463 Gene_expression of ATP5G3 5 0.37 2.25 0.75 5.00
172 INT262276 Negative_regulation of CASP2 1 0.01 2.98 0.73 5.00
173 INT171612 Gene_expression of Cebpz 5 0.58 2.61 0.62 5.00
174 INT85285 Positive_regulation of Gene_expression of ENO2 4 0.50 4.15 0.61 5.00
175 INT160963 Negative_regulation of UGCG 3 0.57 1.69 0.58 5.00
176 INT124487 Negative_regulation of Gene_expression of Plat 4 0.43 1.88 0.55 5.00
177 INT201307 Negative_regulation of Vcan 4 0.41 1.71 0.43 5.00
178 INT64977 Gene_expression of TFF3 9 0.75 3.54 0.39 5.00
179 INT262273 Positive_regulation of Strs1 1 0.01 1.52 0.39 5.00
180 INT334405 Phosphorylation of Ikbkg 1 0.08 0.95 0.35 5.00
181 INT334404 Protein_catabolism of Ikbkg 1 0.06 0.95 0.35 5.00
182 INT262272 Phosphorylation of Strs1 1 0.01 1.07 0.34 5.00
183 INT262277 Regulation of CASP2 1 0.01 1.27 0.33 5.00
184 INT297626 Gene_expression of RLN3 3 0.11 5.07 0.3 5.00
185 INT256540 Regulation of Gene_expression of TSC1 4 0.07 4.74 0.3 5.00
186 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29 5.00
187 INT265661 Positive_regulation of Gene_expression of HIST2H4A 2 0.09 2.69 0.28 5.00
188 INT262275 Negative_regulation of GAPDH 1 0.01 1.54 0.28 5.00
189 INT180536 Positive_regulation of Gene_expression of CR1 1 0.45 1.13 0.28 5.00
190 INT308545 Gene_expression of Tbxas1 1 0.02 0.76 0.25 5.00
191 INT201308 Binding of Vcan 5 0.34 1.05 0.24 5.00
192 INT262274 Gene_expression of UGCG 8 0.27 1.62 0.22 5.00
193 INT243243 Regulation of NeuN 6 0.22 2.55 0.21 5.00
194 INT203283 Binding of KDM5D 3 0.11 1.22 0.21 5.00
195 INT171849 Negative_regulation of Gene_expression of Sumo1 2 0.19 1.81 0.2 5.00
196 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14 5.00
197 INT331162 Negative_regulation of Gene_expression of AMIGO2 1 0.14 3.28 0.14 5.00
198 INT223937 Transcription of PVR 1 0.60 1.53 0.14 5.00
199 INT219522 Localization of KDM5D 3 0.23 0.16 0.14 5.00
200 INT289345 Positive_regulation of Negative_regulation of Trib3 2 0.03 0.54 0.13 5.00
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