D:Corneal Edema

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Disease Term
Synonyms CORNEAL EDEMAS, Edema Corneal, Edemas Corneal
Documents 124
Hot Single Events 30
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Corneal Edema. They are ordered first by their relevance to Corneal Edema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT272143 PTAFR Positive_regulation of Gene_expression of PTGS2 1 0.12 1.59 0.23 93.84
2 INT347297 ILK Regulation of Gene_expression of AKT1 1 0.21 0.62 0 65.12
3 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 64.72
4 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03 53.12
5 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 49.28
6 INT272144 PTAFR Positive_regulation of HRASLS 1 0.08 1.08 0.89 5.00
7 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71 5.00
8 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59 5.00
9 INT272148 PTAFR Regulation of Localization of CA2 1 0.14 0 0.38 5.00
10 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3 5.00
11 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22 5.00
12 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22 5.00
13 INT289997 CNTF Negative_regulation of Binding of CNTF and Casp3 1 0.05 0.99 0.22 5.00
14 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22 5.00
15 INT272150 Positive_regulation of PTAFR Positive_regulation of HRASLS 1 0.06 0.16 0.21 5.00
16 INT347301 AREG Positive_regulation of CCL16 1 0.01 0.86 0.16 5.00
17 INT354888 Amy1 Regulation of Il10 1 0.02 1.41 0.13 5.00
18 INT354885 Amy1 Regulation of Gene_expression of Il10 1 0.03 1.41 0.13 5.00
19 INT272145 Binding of PTAFR and HRASLS 1 0.04 0.06 0.13 5.00
20 INT272149 PTAFR Positive_regulation of Localization of IL6 1 0.24 0 0.12 5.00
21 INT236467 MMP9 Negative_regulation of SNRPB 1 0.01 0.45 0.1 5.00
22 INT294608 Binding of Serpinh1 and Col5a1 1 0.03 0.45 0.09 5.00
23 INT347302 PDGFA Positive_regulation of ITK 1 0.04 1.4 0.09 5.00
24 INT236466 SNRPB Positive_regulation of NFKB2 1 0.00 0.21 0.05 5.00
25 INT347300 Binding of ITK and CCL16 1 0.02 0.97 0.04 5.00
26 INT347291 Binding of AKT1 and CCL16 1 0.06 0.99 0.04 5.00
27 INT347299 Binding of AKT1 and ITK 1 0.04 0.99 0.04 5.00
28 INT347295 CCL16 Positive_regulation of Gene_expression of AKT1 1 0.12 0.29 0.03 5.00
29 INT354890 Binding of TNF and Tnfsf13b 1 0.01 2.05 0 5.00
30 INT347304 PDGFA Positive_regulation of Gene_expression of AKT1 1 0.19 0.6 0 5.00
31 INT275667 Binding of CYP1B1 and GLC3C 1 0.27 0.99 0 5.00
32 INT354887 Binding of Tnfsf13b and Gtf3a 1 0.01 2.05 0 5.00
33 INT347294 CCL16 Positive_regulation of Binding of ITK 1 0.02 0.78 0 5.00
34 INT347298 AREG Negative_regulation of TEP1 1 0.00 0.79 0 5.00
35 INT245722 Binding of Vsx2 and Mfrp 1 0.24 1.2 0 5.00
36 INT347292 AREG Negative_regulation of Gene_expression of TERT 1 0.02 0.78 0 5.00
37 INT347290 Positive_regulation of CCL16 Positive_regulation of PIK3CB 1 0.03 0.57 0 5.00
38 INT347303 Positive_regulation of CCL16 Positive_regulation of AKT1 1 0.08 0.57 0 5.00
39 INT261981 EP400 Negative_regulation of CYP1B1 1 0.01 0.22 0 5.00
40 INT236468 TP53 Positive_regulation of Protein_catabolism of SNRPB 1 0.00 0.52 0 5.00
41 INT347296 PDGFA Positive_regulation of CCL16 1 0.06 0.6 0 5.00
42 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Corneal Edema. They are ordered first by their pain relevance and then by number of times they were reported in Corneal Edema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT273153 Positive_regulation of CHED1 1 0.27 1.53 0 99.74
2 INT39414 Gene_expression of SNRPB 37 0.59 14.07 2.52 99.24
3 INT273158 Binding of COL8A2 1 0.33 2.02 0.22 98.40
4 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 98.36
5 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 98.28
6 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 97.72
7 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 97.60
8 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 96.68
9 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 96.68
10 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 96.28
11 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 94.52
12 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 92.76
13 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 90.08
14 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 90.08
15 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 90.04
16 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 88.68
17 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 88.68
18 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 88.44
19 INT49985 Transcription of Il6 62 0.72 40.13 20.29 88.44
20 INT99095 Binding of COL4A4 7 0.37 3.51 0.29 87.68
21 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 87.60
22 INT302231 Localization of AREG 4 0.25 4 0.08 87.48
23 INT347309 Negative_regulation of Localization of AREG 1 0.03 0.49 0 87.48
24 INT39369 Binding of NARFL 14 0.29 16.7 0.93 86.36
25 INT61500 Binding of FN1 39 0.48 27.33 3.13 86.00
26 INT272151 Transcription of PTAFR 1 0.51 1.43 0.21 85.00
27 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 84.44
28 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 84.44
29 INT24519 Negative_regulation of ERG 15 0.38 6.98 1.33 83.60
30 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 80.40
31 INT273144 Binding of CHED1 1 0.19 1.7 0 79.60
32 INT13302 Binding of PTAFR 20 0.48 7.03 3.7 76.16
33 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 74.64
34 INT259471 Localization of LAMA3 1 0.52 0.76 0.03 73.92
35 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 73.60
36 INT354856 Regulation of Cyp19a1 1 0.37 1.36 0.06 72.80
37 INT273159 Gene_expression of CHED1 1 0.36 1.83 0 71.60
38 INT9020 Binding of Tsv 2 0.25 1.28 0.48 71.44
39 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 71.12
40 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 69.88
41 INT81226 Gene_expression of Adk 9 0.64 9.28 4.81 69.68
42 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 69.20
43 INT228606 Positive_regulation of Gene_expression of ERG 4 0.02 1.96 0.37 68.40
44 INT209417 Gene_expression of ERG 21 0.20 6.69 1.26 68.40
45 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 68.40
46 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 68.40
47 INT66198 Negative_regulation of Gene_expression of Gfap 13 0.59 10.33 3.41 68.40
48 INT228607 Negative_regulation of Gene_expression of ERG 2 0.03 1.1 0.15 68.40
49 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 67.84
50 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 66.88
51 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 65.60
52 INT330979 Protein_catabolism of NARFL 1 0.02 0.84 0.06 65.56
53 INT289989 Positive_regulation of Narf 1 0.02 3.85 0.73 65.04
54 INT289993 Positive_regulation of Positive_regulation of Narf 1 0.02 0.85 0.08 65.04
55 INT116540 Binding of Twist1 35 0.48 16.32 2.85 63.72
56 INT273145 Negative_regulation of COL8A2 1 0.40 0.83 0.06 63.12
57 INT98592 Gene_expression of ILK 6 0.78 5.23 0.53 63.04
58 INT330977 Transcription of Aes 1 0.38 0.53 0.38 61.32
59 INT3776 Positive_regulation of Regulation of NARFL 2 0.37 2.44 0.93 61.28
60 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 60.64
61 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 60.64
62 INT315025 Gene_expression of Cacna1s 3 0.48 2.3 0.18 57.92
63 INT22159 Gene_expression of AMT 11 0.75 2.19 1.5 57.68
64 INT262003 Binding of CYP1B1 3 0.48 3.34 0 57.44
65 INT273155 Gene_expression of COL8A2 1 0.53 0.74 0.05 56.36
66 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 55.00
67 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54 54.56
68 INT297602 Positive_regulation of Tsv 3 0.07 3.36 0.33 54.04
69 INT347314 Regulation of Gene_expression of ILK 1 0.27 1.15 0 52.56
70 INT181642 Negative_regulation of Narf 2 0.01 28.07 4.01 52.32
71 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 50.24
72 INT291575 Negative_regulation of Gene_expression of Adk 1 0.32 1.05 0.03 50.24
73 INT73984 Positive_regulation of Serpinh1 2 0.35 5.92 0.1 50.04
74 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 49.60
75 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 49.28
76 INT248727 Positive_regulation of ECD 3 0.37 0.17 0 48.48
77 INT98597 Positive_regulation of Gene_expression of ILK 4 0.70 3.08 0.23 47.44
78 INT262004 Negative_regulation of CYP1B1 4 0.59 3.24 0 46.64
79 INT173533 Regulation of Gene_expression of CCL16 5 0.51 3.63 2.63 45.92
80 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41 45.20
81 INT273156 Gene_expression of SLC4A11 1 0.41 0.84 0 44.88
82 INT21545 Regulation of DNAH8 22 0.59 8.67 6.48 44.48
83 INT269226 Positive_regulation of ITK 13 0.12 11.23 0.4 44.48
84 INT70860 Binding of SNRPB 17 0.35 7 1.46 44.20
85 INT109917 Positive_regulation of Gene_expression of CCL16 17 0.66 11.87 2.94 44.16
86 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 43.24
87 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 43.20
88 INT109910 Gene_expression of CCL16 104 0.74 76.1 43.97 40.88
89 INT73977 Gene_expression of Serpinh1 14 0.54 8.14 0.69 38.44
90 INT35642 Regulation of BPIFA4P 4 0.26 3.85 1.6 35.56
91 INT12339 Localization of IL8 437 0.81 251.87 117.39 35.28
92 INT12082 Localization of IL6 365 0.81 241.78 105.78 35.28
93 INT52180 Binding of Aes 38 0.42 23.16 6.7 32.20
94 INT96873 Gene_expression of CYP1B1 28 0.78 11.81 1.09 30.24
95 INT347315 Binding of PIK3CB 2 0.19 1.57 0 29.28
96 INT123338 Regulation of HSP90B2P 4 0.26 1.52 0.47 29.24
97 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 29.16
98 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 29.16
99 INT215107 Gene_expression of Spir1 17 0.50 10.38 0.25 28.08
100 INT236475 Localization of SNRPB 1 0.04 2.85 0.13 27.68
101 INT236479 Positive_regulation of Localization of SNRPB 1 0.03 1.39 0 27.68
102 INT276437 Binding of Spir1 4 0.12 6.56 0 27.56
103 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 26.88
104 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 26.56
105 INT55434 Positive_regulation of Gene_expression of HSP90B2P 14 0.38 10.91 4.83 26.56
106 INT27882 Gene_expression of HSP90B2P 52 0.75 36.51 9.59 26.16
107 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 22.48
108 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 18.72
109 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 18.72
110 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 13.16
111 INT267996 Negative_regulation of HSP90B2P 2 0.42 1.5 0.14 10.52
112 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 10.32
113 INT126370 Localization of VSX1 6 0.56 1.7 1.28 8.36
114 INT218762 Localization of ZEB1 2 0.65 0.09 0.2 8.36
115 INT273157 Localization of COL8A2 1 0.26 0.09 0 8.36
116 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
117 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
118 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
119 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
120 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
121 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
122 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
123 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
124 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
125 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
126 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
127 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
128 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
129 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
130 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
131 INT4822 Localization of Ca2 417 0.80 99.57 96.45 5.00
132 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
133 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
134 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 5.00
135 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
136 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
137 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
138 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
139 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
140 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
141 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
142 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
143 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
144 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
145 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
146 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
147 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
148 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
149 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
150 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
151 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
152 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
153 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
154 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 5.00
155 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
156 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
157 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 5.00
158 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
159 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
160 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
161 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 5.00
162 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
163 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
164 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
165 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
166 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
167 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
168 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
169 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
170 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
171 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
172 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
173 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
174 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
175 INT81194 Binding of CPOX 40 0.29 23.7 18.95 5.00
176 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 5.00
177 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69 5.00
178 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
179 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 5.00
180 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
181 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
182 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
183 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
184 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
185 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
186 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
187 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 5.00
188 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 5.00
189 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
190 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
191 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56 5.00
192 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
193 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
194 INT860 Regulation of ALB 48 0.60 25.11 8.95 5.00
195 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 5.00
196 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
197 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
198 INT182229 Positive_regulation of CCL16 15 0.66 12.19 8.21 5.00
199 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19 5.00
200 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
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