D:Corneal Opacity

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Disease Term
Synonyms CORNEAL OPACITIES, Leukoma, LEUKOMAS, Opacities Corneal, OPACITY CORNEAL
Documents 118
Hot Single Events 37
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Corneal Opacity. They are ordered first by their relevance to Corneal Opacity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16 92.40
2 INT251349 Ifnar1 Positive_regulation of Rock1 1 0.01 1.27 0.16 84.40
3 INT251348 Ifnar1 Positive_regulation of Limk2 1 0.01 1.12 0.11 84.40
4 INT219230 Binding of Ecm1 and Ighv10-3 1 0.00 0.26 0.04 50.40
5 INT239470 LEFTY2 Positive_regulation of Tgfbi 1 0.02 0 0 32.40
6 INT219229 Binding of Col7a1 and Ighv10-3 1 0.00 0.46 0 30.88
7 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0 22.00
8 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18 20.92
9 INT340816 Tnfrsf14 Regulation of Gene_expression of Btla 1 0.11 1.09 0.18 5.00
10 INT210029 PROC Negative_regulation of PRTN3 1 0.00 1.06 0.18 5.00
11 INT340822 Trav6-3 Regulation of Gene_expression of Btla 1 0.07 0.97 0.15 5.00
12 INT340819 Regulation of Binding of Ly6g6d and Tnfrsf14 1 0.01 1.58 0.12 5.00
13 INT212139 Slc4a3 Positive_regulation of Cl 1 0.07 0 0.12 5.00
14 INT340818 Binding of Ly6g6d and Tnfrsf14 1 0.01 1.57 0.12 5.00
15 INT212138 Slc4a3 Positive_regulation of Gene_expression of Cl 1 0.07 0 0.12 5.00
16 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
17 INT294608 Binding of Serpinh1 and Col5a1 1 0.03 0.45 0.09 5.00
18 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
19 INT262939 PAX6 Regulation of CDH4 1 0.02 0.97 0.08 5.00
20 INT262937 PAX6 Regulation of CDH8 1 0.03 0.98 0.08 5.00
21 INT262944 PAX6 Regulation of CDH6 1 0.03 0.97 0.08 5.00
22 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
23 INT244328 ELF3 Negative_regulation of Positive_regulation of SH3GL3 3 0.20 1.26 0.04 5.00
24 INT340823 Btla Regulation of Ly6g6d 1 0.04 0.99 0.03 5.00
25 INT279885 Ctcf Regulation of H19 1 0.12 0 0 5.00
26 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
27 INT262938 Binding of PAX6 and SIX3 1 0.13 0.9 0 5.00
28 INT279891 Shbdp1 Negative_regulation of PCDHB@ 1 0.01 0.09 0 5.00
29 INT346595 Binding of Mapk3 and Sh2d1b2 1 0.19 0.2 0 5.00
30 INT244329 ELF3 Positive_regulation of Gene_expression of SH3GL3 1 0.27 0.66 0 5.00
31 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0 5.00
32 INT337916 sb Negative_regulation of Ctgf 1 0.00 0.13 0 5.00
33 INT225957 Binding of KRT3 and KRT12 1 0.18 0.06 0 5.00
34 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
35 INT279886 Shbdp1 Negative_regulation of Pcdhb1 1 0.10 0.09 0 5.00
36 INT346596 Sh2d1b2 Negative_regulation of Umod 1 0.23 0 0 5.00
37 INT318787 Binding of AKT1 and VEGFA 1 0.37 0.34 0 5.00
38 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0 5.00
39 INT337914 sb Negative_regulation of Phosphorylation of Smad2 1 0.00 0.13 0 5.00
40 INT279892 Shbdp1 Negative_regulation of Gene_expression of PCDHB@ 1 0.01 0.09 0 5.00
41 INT346598 Negative_regulation of Binding of Mapk3 and Sh2d1b2 1 0.22 0.2 0 5.00
42 INT346597 Binding of Sh3gl3 and Sh2d1b2 1 0.09 0 0 5.00
43 INT262940 Regulation of Binding of PAX6 and SIX3 1 0.16 0.91 0 5.00
44 INT337918 sb Positive_regulation of Negative_regulation of Smad2 1 0.00 0.15 0 5.00
45 INT262942 Binding of PAX6 and SOX2 1 0.18 0.9 0 5.00
46 INT346599 Sh2d1b2 Negative_regulation of Sh3gl3 1 0.10 0 0 5.00
47 INT262943 Regulation of Binding of PAX6 and SOX2 1 0.17 0.91 0 5.00
48 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0 5.00
49 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0 5.00
50 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Corneal Opacity. They are ordered first by their pain relevance and then by number of times they were reported in Corneal Opacity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT59175 Localization of TNMD 4 0.70 4.14 0.71 99.76
2 INT273151 Binding of GCDH 1 0.04 0.25 0 99.58
3 INT27882 Gene_expression of HSP90B2P 52 0.75 36.51 9.59 99.24
4 INT273142 Gene_expression of Smc3 1 0.09 0.35 0 99.12
5 INT126323 Regulation of TGFBI 6 0.59 3.17 2.9 96.96
6 INT346641 Protein_catabolism of TNMD 1 0.57 2.1 0 95.16
7 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 94.88
8 INT50290 Binding of Cpox 29 0.27 17.19 8.01 94.88
9 INT251327 Regulation of Binding of Bmpr2 1 0.20 2.27 0.27 92.68
10 INT251330 Regulation of Binding of Limk1 1 0.45 1.06 0.13 92.68
11 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34 92.40
12 INT251317 Binding of Limk1 1 0.37 1.69 0.23 92.40
13 INT219227 Localization of Ighv10-3 1 0.03 0.48 0.03 92.24
14 INT225988 Regulation of Del(7)Tyr<c-1DThWb>-p 6 0.03 8.79 0.58 91.16
15 INT256900 Gene_expression of TNMD 19 0.68 7.36 0.64 91.12
16 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 90.56
17 INT219224 Gene_expression of Ighv10-3 1 0.03 12.91 0.07 90.00
18 INT219223 Positive_regulation of Gene_expression of Ighv10-3 1 0.02 3.24 0 90.00
19 INT76216 Positive_regulation of Krt12 2 0.40 0.37 0.92 89.28
20 INT321847 Positive_regulation of Gene_expression of Krt12 1 0.19 0.37 0.1 89.28
21 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 89.08
22 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 88.56
23 INT321845 Gene_expression of Krt12 1 0.31 1 0.35 87.84
24 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56 87.72
25 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 87.60
26 INT340812 Binding of Btla 1 0.32 5.94 0.39 87.08
27 INT340801 Negative_regulation of Binding of Btla 1 0.37 2.7 0.27 87.08
28 INT140071 Negative_regulation of Positive_regulation of Cd4 5 0.39 3.9 0.42 86.24
29 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 85.92
30 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 85.68
31 INT273149 Localization of GCDH 1 0.06 0.77 0 84.96
32 INT256902 Positive_regulation of TNMD 3 0.44 5.27 0.13 84.08
33 INT346642 Positive_regulation of Positive_regulation of TNMD 1 0.44 1.28 0 84.08
34 INT273153 Positive_regulation of CHED1 1 0.27 1.53 0 82.40
35 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 81.36
36 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 80.88
37 INT121513 Positive_regulation of A4GALT 21 0.63 16.06 1.59 80.64
38 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 78.88
39 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 77.96
40 INT23638 Negative_regulation of GAL 17 0.42 5.68 5.04 76.24
41 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 76.24
42 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44 76.16
43 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 75.76
44 INT14746 Gene_expression of Krt12 4 0.42 0.74 0.31 75.72
45 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 75.68
46 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 75.20
47 INT21756 Regulation of Alb 15 0.43 8.21 1.19 74.96
48 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 74.48
49 INT67144 Gene_expression of Cd44 17 0.76 8.94 4.48 74.48
50 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 74.48
51 INT273624 Regulation of Lor 1 0.40 1.78 0.1 74.40
52 INT291839 Gene_expression of Krt4 1 0.36 1.13 0.17 73.68
53 INT273159 Gene_expression of CHED1 1 0.36 1.83 0 73.44
54 INT172328 Negative_regulation of Phl1 1 0.03 61.51 0.97 73.32
55 INT9205 Binding of DSP 12 0.44 9.9 1.21 70.96
56 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 70.32
57 INT149125 Gene_expression of Slc4a3 25 0.78 3.45 2.41 69.84
58 INT126322 Negative_regulation of TGFBI 4 0.41 2.12 1.63 67.32
59 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 67.00
60 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 66.96
61 INT143095 Positive_regulation of Gene_expression of Alb 8 0.40 1.53 0.66 66.96
62 INT273160 Binding of TNMD 4 0.42 1.72 0 65.40
63 INT84700 Positive_regulation of HSP90B2P 34 0.67 30.22 4.07 65.28
64 INT73984 Positive_regulation of Serpinh1 2 0.35 5.92 0.1 64.16
65 INT251322 Positive_regulation of Limk1 1 0.50 2.05 0.55 62.24
66 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04 61.68
67 INT103907 Negative_regulation of Upf1 15 0.37 4.3 1.4 61.44
68 INT238058 Negative_regulation of Shbdp1 4 0.10 1.36 0.42 61.44
69 INT279869 Negative_regulation of Nipbl 1 0.43 4.3 0.03 61.44
70 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 60.56
71 INT179337 Positive_regulation of Gene_expression of Ecm1 14 0.05 3.73 0.58 60.56
72 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 56.00
73 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 54.32
74 INT262959 Localization of PAX6 2 0.75 1.65 0 54.00
75 INT273630 Positive_regulation of Gene_expression of Lor 2 0.39 1.91 0.38 53.84
76 INT273628 Gene_expression of Lor 3 0.52 3.07 0.38 53.84
77 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 53.28
78 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0 53.28
79 INT321846 Gene_expression of Krt13 1 0.02 0.21 0.08 53.00
80 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 52.92
81 INT73977 Gene_expression of Serpinh1 14 0.54 8.14 0.69 52.56
82 INT219228 Negative_regulation of Gene_expression of CNOT1 1 0.41 0.43 0 52.32
83 INT89100 Gene_expression of CNOT1 7 0.65 1.76 0.59 51.68
84 INT340809 Gene_expression of Btla 1 0.77 27.14 1.69 51.24
85 INT291840 Negative_regulation of Krt4 1 0.20 0.5 0.05 50.04
86 INT291838 Negative_regulation of Krt12 1 0.27 0.5 0.05 50.04
87 INT20378 Localization of Hand1 53 0.71 41.96 13.31 49.88
88 INT321844 Positive_regulation of Krt13 1 0.01 0.15 0.07 47.24
89 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 46.20
90 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 43.72
91 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 43.60
92 INT123338 Regulation of HSP90B2P 4 0.26 1.52 0.47 43.36
93 INT192533 Positive_regulation of CLTA 4 0.13 4.98 0.1 41.84
94 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 40.68
95 INT55434 Positive_regulation of Gene_expression of HSP90B2P 14 0.38 10.91 4.83 40.68
96 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 40.28
97 INT279841 Transcription of Nipbl 1 0.63 1.21 0 38.32
98 INT279871 Negative_regulation of Transcription of Nipbl 1 0.43 1.22 0 38.32
99 INT251332 Negative_regulation of Limk1 1 0.59 16.43 4.66 37.08
100 INT289478 Protein_catabolism of TGFBI 1 0.75 0.52 0 36.28
101 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31 32.36
102 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22 32.04
103 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 31.80
104 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 30.88
105 INT289479 Binding of FAS-AS1 1 0.07 0.5 0 30.36
106 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 29.36
107 INT251228 Phosphorylation of Tgfb1 4 0.15 1.18 0.24 28.00
108 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 27.48
109 INT340804 Phosphorylation of Btla 1 0.71 0.67 0.05 27.36
110 INT340799 Positive_regulation of Phosphorylation of Btla 1 0.44 0.67 0.05 27.36
111 INT61903 Negative_regulation of Slc43a1 3 0.34 2.18 0.3 26.16
112 INT104026 Negative_regulation of Fn1 10 0.22 9.22 1.43 24.76
113 INT267996 Negative_regulation of HSP90B2P 2 0.42 1.5 0.14 24.64
114 INT273147 Binding of TBCD 1 0.05 0 0 23.76
115 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54 22.52
116 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 21.32
117 INT38366 Regulation of Cat 45 0.62 23.45 5.34 21.32
118 INT209418 Negative_regulation of CLTA 2 0.06 1.62 0.03 20.96
119 INT262962 Localization of PITX2 1 0.42 0.64 0.06 20.20
120 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 19.88
121 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89 19.84
122 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18 19.44
123 INT225986 Negative_regulation of Regulation of Del(7)Tyr<c-1DThWb>-p 3 0.03 3.14 0.1 17.00
124 INT137222 Positive_regulation of Sh2d1b2 5 0.30 1.26 0.6 12.24
125 INT340797 Positive_regulation of Gene_expression of Btla 1 0.69 12.73 0.95 11.12
126 INT225984 Gene_expression of Del(7)Tyr<c-1DThWb>-p 4 0.08 4.77 0.47 10.32
127 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31 7.32
128 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
129 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
130 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
131 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
132 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
133 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
134 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
135 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
136 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 5.00
137 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
138 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
139 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
140 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
141 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
142 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
143 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
144 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
145 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
146 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
147 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
148 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 5.00
149 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
150 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
151 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
152 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
153 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15 5.00
154 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 5.00
155 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 5.00
156 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
157 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 5.00
158 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
159 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98 5.00
160 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
161 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
162 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
163 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
164 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
165 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 5.00
166 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
167 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
168 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
169 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
170 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
171 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
172 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
173 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2 5.00
174 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 5.00
175 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 5.00
176 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93 5.00
177 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
178 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
179 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 5.00
180 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
181 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72 5.00
182 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
183 INT52924 Negative_regulation of GSR 49 0.58 28.08 9.28 5.00
184 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14 5.00
185 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77 5.00
186 INT51165 Binding of Gal 10 0.48 2.56 8.41 5.00
187 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
188 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
189 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 5.00
190 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
191 INT1973 Positive_regulation of NAGLU 36 0.65 14.78 7 5.00
192 INT264641 Binding of AES 25 0.42 18.56 6.98 5.00
193 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
194 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
195 INT8101 Binding of INCENP 42 0.31 16.2 6.68 5.00
196 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
197 INT16573 Regulation of Cl 18 0.07 8.69 6.03 5.00
198 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
199 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
200 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 5.00
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