D:Corneal Perforation

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Disease Term
Synonyms Corneal Perforations, PERFORATION CORNEAL, Perforations Corneal
Documents 41
Hot Single Events 13
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Corneal Perforation. They are ordered first by their relevance to Corneal Perforation and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27 91.44
2 INT126336 Negative_regulation of Binding of Pax3 and Tac1 1 0.01 0.66 0.49 91.44
3 INT126337 Pax3 Positive_regulation of Gene_expression of Ifng 1 0.05 0.56 0.44 87.16
4 INT126339 Pax3 Regulation of Insrr 1 0.00 0.56 0.44 87.16
5 INT126340 Pax3 Regulation of Gene_expression of Ifng 1 0.03 0.56 0.44 87.16
6 INT126338 Insrr Regulation of Gene_expression of Ifng 1 0.00 0.56 0.43 86.68
7 INT126341 Tac1 Regulation of Gene_expression of Tnfrsf10b 1 0.06 0.71 0.52 66.76
8 INT210029 PROC Negative_regulation of PRTN3 1 0.00 1.06 0.18 44.84
9 INT273772 BCKDHA Positive_regulation of Positive_regulation of NARFL 1 0.03 1.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Corneal Perforation. They are ordered first by their pain relevance and then by number of times they were reported in Corneal Perforation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT104547 Negative_regulation of Il18 24 0.59 17.89 6.01 99.20
2 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15 98.80
3 INT19509 Localization of Ifng 55 0.78 28.25 18.67 95.12
4 INT74629 Gene_expression of Mmp7 17 0.55 12.78 7.58 94.46
5 INT4850 Binding of Tac1 57 0.47 14.25 42.17 91.44
6 INT48806 Negative_regulation of Binding of Tac1 11 0.56 0.83 10.52 91.44
7 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 90.28
8 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 89.44
9 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 88.92
10 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 88.92
11 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 81.12
12 INT70555 Regulation of Pax3 13 0.35 3.62 12.05 81.12
13 INT110810 Positive_regulation of Gene_expression of Mmp1 9 0.52 4.2 5.11 80.16
14 INT104474 Gene_expression of Mmp8 15 0.71 3.1 2.76 79.76
15 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 79.76
16 INT110809 Gene_expression of Mmp1 20 0.75 18 14.49 79.76
17 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 79.76
18 INT15197 Regulation of Gene_expression of Ifng 8 0.34 2.66 2.69 66.76
19 INT126334 Gene_expression of Tnfrsf10b 8 0.58 8.68 1.42 66.76
20 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 66.32
21 INT42707 Gene_expression of Tbce 24 0.65 12.92 7.93 66.32
22 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 61.68
23 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 61.68
24 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 61.68
25 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 61.68
26 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 61.68
27 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 61.68
28 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51 61.68
29 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 59.60
30 INT207565 Negative_regulation of LIPG 8 0.10 7.83 0.76 51.76
31 INT106023 Localization of PPIG 8 0.57 4.08 0.96 50.52
32 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 46.28
33 INT128713 Positive_regulation of Gene_expression of Mmp7 2 0.02 0.05 0.2 46.20
34 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 36.68
35 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 35.16
36 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 35.16
37 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 34.76
38 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 34.36
39 INT321845 Gene_expression of Krt12 1 0.31 1 0.35 21.52
40 INT238458 Binding of GFM1 2 0.47 1.44 0 13.20
41 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
42 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
43 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
44 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 5.00
45 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 5.00
46 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
47 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
48 INT81194 Binding of CPOX 40 0.29 23.7 18.95 5.00
49 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
50 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
51 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
52 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 5.00
53 INT860 Regulation of ALB 48 0.60 25.11 8.95 5.00
54 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58 5.00
55 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
56 INT127062 Positive_regulation of Gene_expression of LTB4R 18 0.34 15.9 5.64 5.00
57 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 5.00
58 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 5.00
59 INT67144 Gene_expression of Cd44 17 0.76 8.94 4.48 5.00
60 INT5332 Negative_regulation of Gene_expression of NPEPPS 11 0.04 7.79 4.29 5.00
61 INT14837 Gene_expression of PLA2G1B 12 0.60 10.69 3.58 5.00
62 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 5.00
63 INT110811 Positive_regulation of Mmp1 5 0.60 2.96 2.83 5.00
64 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
65 INT130199 Negative_regulation of Binding of CPOX 4 0.30 1.89 2.1 5.00
66 INT5331 Positive_regulation of Gene_expression of NPEPPS 6 0.49 3.74 1.81 5.00
67 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 5.00
68 INT118430 Positive_regulation of Gene_expression of VIM 8 0.47 2.14 1.53 5.00
69 INT22159 Gene_expression of AMT 11 0.75 2.19 1.5 5.00
70 INT174242 Gene_expression of CYP4B1 4 0.49 3.54 1.32 5.00
71 INT272274 Localization of NARFL 24 0.60 27.55 1.18 5.00
72 INT272290 Positive_regulation of Gene_expression of CYP4B1 1 0.24 1.25 1.01 5.00
73 INT272289 Positive_regulation of CYP4B1 1 0.33 1.24 1 5.00
74 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 5.00
75 INT91762 Positive_regulation of Gene_expression of PLA2G1B 3 0.17 3.45 0.97 5.00
76 INT76216 Positive_regulation of Krt12 2 0.40 0.37 0.92 5.00
77 INT272275 Regulation of Positive_regulation of NARFL 8 0.36 16.68 0.86 5.00
78 INT79169 Binding of PLG 10 0.47 5.88 0.72 5.00
79 INT92348 Binding of NPEPPS 3 0.04 2.94 0.71 5.00
80 INT272291 Regulation of Binding of CPOX 1 0.11 0.37 0.67 5.00
81 INT110806 Positive_regulation of Mmp8 7 0.46 1.64 0.67 5.00
82 INT241467 Negative_regulation of Impdh1 1 0.01 1.45 0.27 5.00
83 INT151793 Gene_expression of KRT3 36 0.75 2.32 0.26 5.00
84 INT108300 Positive_regulation of BCKDHA 3 0.39 1.74 0.18 5.00
85 INT241468 Binding of Dhfr 2 0.13 1.41 0.17 5.00
86 INT210030 Negative_regulation of Binding of NPEPPS 1 0.05 0.49 0.13 5.00
87 INT321847 Positive_regulation of Gene_expression of Krt12 1 0.19 0.37 0.1 5.00
88 INT321846 Gene_expression of Krt13 1 0.02 0.21 0.08 5.00
89 INT321844 Positive_regulation of Krt13 1 0.01 0.15 0.07 5.00
90 INT99965 Positive_regulation of Negative_regulation of NARFL 6 0.40 4.5 0.04 5.00
91 INT304967 Gene_expression of SIM2 2 0.55 3.58 0 5.00
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