D:Coronary Vasospasm

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Disease Term
Synonyms Artery Vasospasm Coronary, Artery Vasospasms Coronary, Coronary Artery Vasospasm, Coronary Artery Vasospasms, CORONARY VASOSPASMS, Vasospasm Coronary, Vasospasm Coronary Artery, VASOSPASMS CORONARY, VASOSPASMS CORONARY ARTERY
Documents 370
Hot Single Events 67
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Coronary Vasospasm. They are ordered first by their relevance to Coronary Vasospasm and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT142332 Binding of SERPINH1 and TNNI3 1 0.03 1.05 0.17 91.44
2 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34 85.40
3 INT161797 Binding of ECE1 and ING1 1 0.01 0.68 0.14 85.40
4 INT161795 Positive_regulation of Binding of ECE1 and ING1 1 0.02 0.68 0.14 85.40
5 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14 85.40
6 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03 84.32
7 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13 81.04
8 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13 80.52
9 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11 79.76
10 INT17014 AHSP Positive_regulation of Positive_regulation of RTCA 1 0.07 1.11 0.14 76.68
11 INT131787 Binding of Myo5a and Pon1 1 0.02 0.06 0 62.80
12 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27 62.40
13 INT291797 Binding of CA2 and Positive_regulation of MYLK 1 0.15 0.33 0.19 56.64
14 INT291798 Binding of CALM1 and Positive_regulation of MYLK 1 0.09 0.33 0.19 56.44
15 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22 56.16
16 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22 54.20
17 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12 53.80
18 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38 53.76
19 INT321969 Negative_regulation of Rock1 Negative_regulation of VEGFA 1 0.03 0.65 0 24.28
20 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33 5.00
21 INT180450 Positive_regulation of Acot1 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.01 0.44 0.2 5.00
22 INT180441 Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19 5.00
23 INT175909 Binding of ROS1 and CNBP 1 0.01 1.78 0.19 5.00
24 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
25 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
26 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19 5.00
27 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19 5.00
28 INT180440 Positive_regulation of Acot1 Positive_regulation of Gopc 1 0.03 0.43 0.19 5.00
29 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13 5.00
30 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09 5.00
31 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09 5.00
32 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0 5.00
33 INT321968 Rock1 Positive_regulation of EZR 1 0.42 1.02 0 5.00
34 INT321967 Binding of PDR and PVR 1 0.01 2.32 0 5.00
35 INT315889 Binding of B4GALNT1 and IKBKAP 1 0.00 0.68 0 5.00
36 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Coronary Vasospasm. They are ordered first by their pain relevance and then by number of times they were reported in Coronary Vasospasm. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5048 Binding of Edn1 55 0.47 18.86 19.16 100.00
2 INT53374 Binding of Edn1 17 0.43 11.66 2.98 100.00
3 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 100.00
4 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 99.68
5 INT63425 Positive_regulation of Gene_expression of SELP 23 0.67 15.34 3.48 99.40
6 INT100861 Binding of CRP 179 0.48 175.2 26.45 98.92
7 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97 98.64
8 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 98.64
9 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 98.64
10 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 98.64
11 INT20156 Positive_regulation of Negative_regulation of Serpine1 4 0.49 2.89 0.97 98.48
12 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93 98.16
13 INT9055 Positive_regulation of Cog1 22 0.68 14.08 2.95 97.88
14 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 97.80
15 INT83190 Gene_expression of Olr1 26 0.59 12.47 2.91 97.48
16 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 97.36
17 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 97.36
18 INT98580 Positive_regulation of CADM1 11 0.49 10.16 1.78 96.36
19 INT123563 Negative_regulation of Rock1 7 0.55 16.56 5.78 95.96
20 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02 95.64
21 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 94.84
22 INT9191 Localization of EDN1 94 0.81 57.01 14.78 94.56
23 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 94.48
24 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 94.48
25 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 94.48
26 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 94.48
27 INT22270 Regulation of IGKV1-5 13 0.39 3.56 3.54 94.28
28 INT6838 Binding of Atp2b4 4 0.08 0.8 0.18 93.44
29 INT174588 Gene_expression of GLG1 16 0.67 11.45 2.03 93.32
30 INT293082 Positive_regulation of Gene_expression of GLG1 1 0.42 1.08 0.42 93.32
31 INT17020 Localization of AHSP 11 0.80 3.82 4.34 93.04
32 INT17017 Negative_regulation of Gene_expression of AHSP 1 0.43 2.12 0.23 93.00
33 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 92.80
34 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 92.64
35 INT161803 Negative_regulation of Phosphorylation of ROS1 2 0.12 0.91 0.21 92.64
36 INT15786 Gene_expression of AHSP 8 0.78 5.12 0.4 92.44
37 INT54593 Positive_regulation of Gene_expression of TF 16 0.68 9.05 1.43 92.36
38 INT106637 Binding of Avpr1a 1 0.36 0.32 0.31 92.24
39 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 91.44
40 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 91.40
41 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 89.52
42 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 89.52
43 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72 89.20
44 INT11896 Negative_regulation of Atp7b 15 0.11 6.01 6.09 88.64
45 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 88.64
46 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 87.44
47 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 86.32
48 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 86.32
49 INT44705 Gene_expression of Olah 16 0.77 10.02 4.24 86.32
50 INT44704 Regulation of Olah 2 0.24 0.53 0.69 86.32
51 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 86.04
52 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 85.52
53 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12 85.40
54 INT87230 Localization of ECE1 5 0.80 1.51 0.53 85.40
55 INT161805 Positive_regulation of ECE1 1 0.12 0.61 0.13 85.40
56 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 83.40
57 INT348 Regulation of Adra1a 25 0.45 3.33 10.27 83.20
58 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 82.64
59 INT17019 Positive_regulation of AHSP 3 0.70 1.85 0.49 82.12
60 INT19265 Negative_regulation of Localization of AHSP 3 0.59 0.62 1.69 82.12
61 INT17021 Negative_regulation of AHSP 5 0.43 3.45 0.72 82.12
62 INT17018 Positive_regulation of Localization of AHSP 3 0.70 0.6 0.66 82.12
63 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 81.76
64 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 81.04
65 INT161804 Positive_regulation of ING1 2 0.39 0.83 0.57 81.04
66 INT82166 Regulation of NOS3 14 0.54 7.57 2.08 80.56
67 INT135470 Transcription of Icam1 10 0.63 12.04 2.41 80.48
68 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19 79.72
69 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71 78.48
70 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 78.48
71 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73 77.72
72 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28 77.56
73 INT3086 Binding of Pf4 14 0.47 7.1 0.86 77.16
74 INT20570 Binding of PPBP 5 0.30 1.75 0.82 77.16
75 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 77.12
76 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7 76.76
77 INT85348 Localization of RHOA 12 0.59 4.81 1.83 76.76
78 INT2774 Binding of Crp 241 0.48 195.89 44.39 76.04
79 INT55318 Localization of ADRA2C 3 0.73 1.39 1.3 75.92
80 INT306554 Regulation of Localization of ADRA2C 1 0.26 0.98 0.17 75.92
81 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 75.00
82 INT51474 Binding of Il6 55 0.48 44.99 20.52 75.00
83 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 75.00
84 INT13435 Positive_regulation of RTCA 31 0.60 7.19 8.5 74.68
85 INT175919 Negative_regulation of Positive_regulation of FGF2 1 0.22 0.96 0.22 74.44
86 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 72.36
87 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36 72.36
88 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 72.36
89 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04 72.28
90 INT132662 Binding of Hcm 11 0.31 14.41 0.73 70.24
91 INT113131 Transcription of TNNT1 1 0.52 0.73 0.21 70.24
92 INT57424 Positive_regulation of TNNT1 42 0.67 31.84 9.7 69.20
93 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97 68.88
94 INT321962 Negative_regulation of Positive_regulation of Rock1 1 0.33 1.17 0.07 65.16
95 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 65.12
96 INT32394 Regulation of Pf4 12 0.23 6.07 2.85 65.12
97 INT263403 Positive_regulation of Rock1 3 0.38 4.68 1.09 64.64
98 INT114227 Negative_regulation of Cc2d1b 3 0.01 0.4 1.52 64.28
99 INT99550 Regulation of FLNA 51 0.54 27.88 2.58 63.88
100 INT114993 Binding of Myo5a 15 0.30 11.46 5.48 62.80
101 INT124220 Binding of Pon1 9 0.47 7.84 0.99 62.80
102 INT26335 Binding of ITPR3 22 0.18 3.3 2.27 62.40
103 INT40832 Localization of ADRB2 5 0.73 2.21 1.81 61.44
104 INT9905 Gene_expression of DECR1 11 0.75 2.49 2.43 58.88
105 INT5490 Binding of CA2 52 0.36 9.73 5.53 56.64
106 INT32165 Binding of CALM1 92 0.48 24.19 29.57 56.44
107 INT106639 Negative_regulation of Negative_regulation of AVPR2 1 0.29 1.58 0.25 55.52
108 INT106638 Negative_regulation of AVPR2 2 0.39 2.05 0.2 55.52
109 INT91739 Positive_regulation of MYLK 9 0.54 2.89 1.58 55.48
110 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 55.16
111 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 52.72
112 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 51.92
113 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 51.36
114 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 51.32
115 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 50.16
116 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 49.56
117 INT17022 Regulation of AHSP 1 0.24 0.89 0.1 46.84
118 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 46.08
119 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 45.20
120 INT95271 Negative_regulation of Nos3 46 0.53 24.1 9.71 43.52
121 INT193486 Negative_regulation of Negative_regulation of Nos3 3 0.34 2.21 0.68 43.52
122 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 43.04
123 INT131456 Negative_regulation of MMRN1 14 0.19 9.49 2.29 42.88
124 INT291800 Positive_regulation of NEU2 2 0.01 0.57 1.26 42.16
125 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 41.20
126 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45 41.20
127 INT13434 Positive_regulation of Positive_regulation of RTCA 4 0.41 0.39 0.44 40.80
128 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 39.84
129 INT85855 Negative_regulation of Binding of NOS1 6 0.37 3.4 0.66 37.04
130 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 36.60
131 INT48911 Binding of NOS1 24 0.40 11.21 5.89 36.60
132 INT443 Localization of POMC 1020 0.81 284.52 443.17 36.24
133 INT42145 Negative_regulation of Positive_regulation of F13A1 4 0.13 1.55 0.53 34.04
134 INT240451 Positive_regulation of Localization of DSE 1 0.42 2.03 0.08 33.68
135 INT174589 Negative_regulation of GLG1 37 0.58 32.41 5.44 33.52
136 INT174592 Localization of GLG1 7 0.71 4.71 1.22 33.52
137 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99 29.60
138 INT17016 Binding of AHSP 1 0.31 0.58 0 29.56
139 INT55409 Localization of VWF 17 0.80 8.99 3.06 28.64
140 INT94010 Positive_regulation of Localization of VWF 9 0.70 4.23 2.5 28.64
141 INT240450 Localization of DSE 2 0.62 1.88 0.08 28.28
142 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 27.96
143 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 26.96
144 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78 26.64
145 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 25.00
146 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 25.00
147 INT22080 Regulation of ras 40 0.53 36.24 4.44 25.00
148 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 24.28
149 INT61418 Positive_regulation of ITGAL 24 0.14 12.86 2.3 24.28
150 INT14130 Regulation of ADRA2C 4 0.45 1.57 0.79 18.00
151 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22 12.76
152 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 12.44
153 INT173208 Binding of CNBP 9 0.25 11.01 1.23 11.76
154 INT60035 Regulation of VWF 6 0.42 6.26 0.4 7.60
155 INT332665 Negative_regulation of ALDH1B1 1 0.02 0.1 0.15 5.72
156 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
157 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
158 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
159 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 5.00
160 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
161 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
162 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
163 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
164 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
165 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
166 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
167 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
168 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
169 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
170 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
171 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
172 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
173 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
174 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
175 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
176 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
177 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 5.00
178 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
179 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
180 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
181 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 5.00
182 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
183 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
184 INT2140 Regulation of REN 104 0.62 28.24 24.49 5.00
185 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
186 INT45437 Localization of Acot1 84 0.79 17.37 22.18 5.00
187 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
188 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
189 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
190 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
191 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
192 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51 5.00
193 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
194 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
195 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
196 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
197 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
198 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
199 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 5.00
200 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
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