D:Cranial Neuropathy

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Disease Term
Synonyms Cranial Nerve Disease, CRANIAL NERVE DISEASES, Cranial Nerve Disorder, Cranial Nerve Disorders, CRANIAL NERVE PALSIES, Cranial Nerve Palsy, Cranial Nerve Syndrome, CRANIAL NEUROPATHIES, CRANIAL NEUROPATHIES MULTIPLE, Cranial Neuropathy Multiple, MULTIPLE CRANIAL NEUROPATHIES
Documents 566
Hot Single Events 25
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cranial Neuropathy. They are ordered first by their relevance to Cranial Neuropathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT98410 Binding of AMBP and Rf 1 0.02 0.95 0.22 75.44
2 INT55809 Binding of Ttr and Fap 1 0.12 2.56 0.19 61.36
3 INT282712 Binding of MUC5AC and Csf2 1 0.01 2.63 1.07 5.00
4 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54 5.00
5 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52 5.00
6 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 5.00
7 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 5.00
8 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 5.00
9 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 5.00
10 INT282710 Mmp9 Regulation of Gene_expression of Csf2 1 0.15 0.16 0.2 5.00
11 INT278020 Binding of Gh and Sst 1 0.18 0.16 0.15 5.00
12 INT355579 VEGFA Positive_regulation of Gene_expression of IL8 1 0.04 1.22 0.1 5.00
13 INT355590 VEGFA Positive_regulation of Gene_expression of CCL2 1 0.07 1.35 0.1 5.00
14 INT355578 VEGFA Positive_regulation of Positive_regulation of IL8 1 0.03 1.42 0.1 5.00
15 INT355581 VEGFA Positive_regulation of CCR4 1 0.00 1.36 0.1 5.00
16 INT355585 VEGFA Positive_regulation of Positive_regulation of CCL2 1 0.07 1.35 0.1 5.00
17 INT355584 VEGFA Positive_regulation of Positive_regulation of CDH5 1 0.06 1.35 0.09 5.00
18 INT355580 VEGFA Positive_regulation of ICAM1 1 0.09 1.39 0.09 5.00
19 INT355604 VEGFA Regulation of Positive_regulation of Ptk2b 1 0.22 1.47 0.08 5.00
20 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
21 INT355582 VEGFA Regulation of Positive_regulation of PTK2 1 0.05 1.46 0.08 5.00
22 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
23 INT355577 ANGPT2 Positive_regulation of MMP1 1 0.04 0.79 0.05 5.00
24 INT355586 Binding of LTBP1 and ANGPTL4 1 0.10 2.15 0.05 5.00
25 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05 5.00
26 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05 5.00
27 INT355605 ANGPT2 Positive_regulation of Mmp9 1 0.10 0.79 0.05 5.00
28 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
29 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0 5.00
30 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0 5.00
31 INT355588 Binding of CDH1 and CTNNA1 1 0.00 1.12 0 5.00
32 INT355587 Binding of occludin and TJP1 1 0.01 1.12 0 5.00
33 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
34 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
35 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0 5.00
36 INT281402 Binding of AGRP and RAPGEFL1 1 0.05 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cranial Neuropathy. They are ordered first by their pain relevance and then by number of times they were reported in Cranial Neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 98.52
2 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 98.36
3 INT1261 Localization of Adh1 63 0.81 19.36 16.09 98.16
4 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 98.00
5 INT100051 Binding of MUC5AC 20 0.32 14.21 1.14 97.68
6 INT98409 Binding of Rf 4 0.08 3.97 0.94 95.88
7 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 95.68
8 INT18114 Gene_expression of NPC1 45 0.66 57.85 1.44 95.44
9 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 94.16
10 INT98072 Gene_expression of LAT 5 0.68 5.37 0.44 91.68
11 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 91.32
12 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 91.32
13 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 89.40
14 INT76227 Binding of NPC1 30 0.41 32.31 4.05 89.32
15 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 89.20
16 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 89.00
17 INT86503 Negative_regulation of Fcer2 3 0.09 2.49 0.55 89.00
18 INT93879 Positive_regulation of TRERF1 2 0.61 2.09 0.64 88.12
19 INT79167 Localization of TNC 8 0.78 4.15 1.44 87.48
20 INT59342 Negative_regulation of NPC1 20 0.44 20.21 2.79 86.88
21 INT169421 Positive_regulation of FOXC1 4 0.49 2.42 0.7 86.36
22 INT98071 Localization of LAT 1 0.62 0.63 0.09 84.64
23 INT57336 Gene_expression of Cd19 5 0.46 4.8 1.6 83.52
24 INT19341 Gene_expression of IGH@ 4 0.59 6.4 0.7 82.36
25 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 81.36
26 INT4097 Localization of Pth 66 0.81 47.17 4.36 78.28
27 INT12564 Localization of Pthlh 23 0.81 4.37 5.82 78.28
28 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 78.08
29 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 78.08
30 INT9837 Negative_regulation of Rf 12 0.11 8.41 4.55 77.64
31 INT39730 Gene_expression of PFDN4 4 0.75 2.4 0.59 75.20
32 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 75.00
33 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 75.00
34 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 75.00
35 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 75.00
36 INT14301 Binding of CSF2 82 0.48 67.95 8.98 74.36
37 INT188755 Positive_regulation of Binding of CSF2 6 0.44 8.79 0.35 74.36
38 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 73.64
39 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 72.60
40 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 71.44
41 INT46721 Regulation of Csf2 26 0.45 20.4 6.18 71.04
42 INT106952 Positive_regulation of NPC1 23 0.43 22.9 0.94 70.16
43 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04 68.68
44 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 67.12
45 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 66.80
46 INT53906 Positive_regulation of Negative_regulation of Gh 9 0.50 6.72 2.73 66.16
47 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22 66.16
48 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 66.12
49 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 65.72
50 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 65.72
51 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 64.68
52 INT93350 Binding of Lepr 17 0.05 27.21 1.5 61.92
53 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 61.00
54 INT66002 Binding of LAMC2 9 0.47 4.5 2.54 60.80
55 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 59.20
56 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 57.60
57 INT86947 Gene_expression of Arigg3 6 0.58 3.62 0.57 57.60
58 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 55.88
59 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 53.48
60 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 52.64
61 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 51.28
62 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 50.00
63 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 49.96
64 INT16452 Negative_regulation of SERPIND1 13 0.59 8.43 1.83 48.80
65 INT28861 Binding of Gh 61 0.46 25.61 6.38 48.16
66 INT89462 Negative_regulation of PLAG1 7 0.57 3.94 0.36 46.16
67 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 44.84
68 INT293961 Binding of PITX1 1 0.31 1.73 0.1 43.40
69 INT90491 Binding of Igf1 25 0.44 9.75 1.36 43.32
70 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 41.00
71 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 41.00
72 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 40.36
73 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 38.00
74 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 37.84
75 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 37.16
76 INT187050 Localization of RENBP 8 0.35 6.92 0.61 36.80
77 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 36.48
78 INT39244 Gene_expression of TMPO 137 0.77 14.55 11.83 36.40
79 INT310442 Gene_expression of POLA1 1 0.30 0.97 0 36.40
80 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 35.36
81 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 34.36
82 INT202426 Transcription of CD4 6 0.69 3.96 0.49 33.60
83 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 31.28
84 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 29.60
85 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 29.60
86 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 28.56
87 INT208142 Gene_expression of PITX1 3 0.65 9.36 0.73 27.12
88 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 23.48
89 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 21.60
90 INT1893 Localization of Gh 1041 0.79 340.23 256.58 17.52
91 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 17.52
92 INT33039 Regulation of Ptcra 3 0.04 1.16 0.37 17.08
93 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 15.44
94 INT310439 Regulation of POLA1 1 0.24 2.21 0 13.84
95 INT139738 Gene_expression of Ptcra 9 0.63 2.75 1.14 12.72
96 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 10.40
97 INT217070 Gene_expression of Acsm3 8 0.25 6.27 1.75 10.24
98 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 9.12
99 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 8.52
100 INT187161 Binding of SLEB1 9 0.05 11.8 1.09 8.28
101 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
102 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
103 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
104 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
105 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
106 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
107 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
108 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
109 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
110 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
111 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
112 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
113 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
114 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
115 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
116 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
117 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
118 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
119 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
120 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
121 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
122 INT10706 Regulation of Il6 150 0.62 93.23 62.34 5.00
123 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
124 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 5.00
125 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
126 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
127 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
128 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
129 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
130 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
131 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
132 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
133 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
134 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
135 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
136 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
137 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 5.00
138 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
139 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
140 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
141 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
142 INT13897 Localization of Sst 65 0.81 14.91 32.24 5.00
143 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
144 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
145 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
146 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
147 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
148 INT7832 Localization of Cck 39 0.81 6.81 26.54 5.00
149 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
150 INT19986 Negative_regulation of Cck 31 0.59 4.32 24.99 5.00
151 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
152 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 5.00
153 INT14506 Regulation of Sst 46 0.62 15.02 22.66 5.00
154 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
155 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
156 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
157 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 5.00
158 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
159 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
160 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
161 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
162 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
163 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 5.00
164 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
165 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
166 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
167 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 5.00
168 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
169 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
170 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
171 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 5.00
172 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
173 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 5.00
174 INT112103 Binding of Grin1 28 0.48 4.21 12.08 5.00
175 INT145281 Gene_expression of hb 89 0.59 63.22 11.96 5.00
176 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
177 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
178 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
179 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 5.00
180 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
181 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
182 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
183 INT111397 Localization of Timp1 17 0.70 11.67 8.76 5.00
184 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 5.00
185 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
186 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
187 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.00
188 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 5.00
189 INT17996 Binding of Crp 40 0.37 31.4 7.8 5.00
190 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
191 INT48882 Binding of GRIN3B 9 0.46 5.12 7.66 5.00
192 INT16869 Positive_regulation of Prl 24 0.70 15.7 7.63 5.00
193 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
194 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27 5.00
195 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 5.00
196 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 5.00
197 INT42038 Localization of ACE 26 0.80 8.88 7.06 5.00
198 INT39242 Negative_regulation of TMPO 29 0.58 5.15 7.04 5.00
199 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
200 INT66099 Transcription of Sst 8 0.25 4.86 6.96 5.00
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