D:Craniosynostosis

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pChart

Disease Term
Synonyms Acrocephaly, CONGENITAL OSSIFICATION OF CRANIAL SUTURES, Congenital Ossification Of Sutures, CONGENITAL OSSIFICATION OF SUTURES OF SKULL, CRANIOSTENOSIS, Craniostosis, Craniosynostoses, Craniosynostosis Syndrome, Oxycephaly, Premature Cranial Suture Closure Synostosis
Documents 75
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Craniosynostosis. They are ordered first by their relevance to Craniosynostosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0 52.44
2 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0 51.60
3 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03 5.00
4 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0 5.00
5 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0 5.00
6 INT195062 PTHLH Positive_regulation of Gene_expression of Pygm 1 0.00 0.67 0 5.00
7 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0 5.00
8 INT195052 PTHLH Positive_regulation of Positive_regulation of CPOX 1 0.07 0.67 0 5.00
9 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0 5.00
10 INT195053 PTHLH Regulation of Gene_expression of CPOX 1 0.03 0.71 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Craniosynostosis. They are ordered first by their pain relevance and then by number of times they were reported in Craniosynostosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT87357 Binding of MSX2 1 0.48 0.97 0.22 100.00
2 INT22096 Negative_regulation of SOS1 4 0.25 1.63 0.71 98.98
3 INT228404 Gene_expression of Slc12a3 6 0.35 7.18 1 95.64
4 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 93.12
5 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 92.92
6 INT311651 Positive_regulation of Fgf8 1 0.46 0.26 0 89.04
7 INT228403 Binding of Slc12a3 2 0.16 0.52 0.07 85.04
8 INT303538 Positive_regulation of Fgfr1 3 0.65 0.92 0.03 82.88
9 INT311636 Positive_regulation of Gene_expression of Slc12a3 1 0.23 0.62 0 82.52
10 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 71.84
11 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 71.84
12 INT4863 Positive_regulation of ap 22 0.37 9.13 6.11 70.96
13 INT47371 Negative_regulation of ap 32 0.32 9.8 1.96 70.96
14 INT193777 Negative_regulation of Fgf1 6 0.13 4.26 0.12 65.76
15 INT167084 Binding of Cbl 3 0.10 1.34 0.39 50.88
16 INT169355 Localization of Egfr 6 0.75 3.24 0.43 45.08
17 INT87356 Binding of PFM3 1 0.15 0.2 0.1 35.92
18 INT311633 Localization of Spry2 1 0.68 0.26 0 26.20
19 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86 22.84
20 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
21 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
22 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
23 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
24 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
25 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
26 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
27 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 5.00
28 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
29 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
30 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
31 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 5.00
32 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83 5.00
33 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
34 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
35 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 5.00
36 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
37 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 5.00
38 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
39 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 5.00
40 INT107619 Gene_expression of PTGER3 42 0.75 15 5.61 5.00
41 INT4342 Localization of ALPP 27 0.69 15.19 5.32 5.00
42 INT137549 Gene_expression of Pygm 12 0.05 6.74 3.16 5.00
43 INT57957 Localization of TXNRD1 14 0.64 4.01 2.7 5.00
44 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 5.00
45 INT18361 Positive_regulation of MRXS5 11 0.41 5.95 2.43 5.00
46 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42 5.00
47 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
48 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87 5.00
49 INT131916 Negative_regulation of ALPL 10 0.42 9.33 1.8 5.00
50 INT37350 Negative_regulation of ENPEP 7 0.42 1.15 1.7 5.00
51 INT3343 Regulation of PTH 24 0.62 11.18 1.62 5.00
52 INT181316 Positive_regulation of ALPL 5 0.65 1.65 1.6 5.00
53 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53 5.00
54 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45 5.00
55 INT37203 Negative_regulation of Pygm 3 0.06 1.64 1.33 5.00
56 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3 5.00
57 INT173877 Positive_regulation of Gene_expression of INCENP 14 0.08 7.83 1.28 5.00
58 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 5.00
59 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24 5.00
60 INT137548 Positive_regulation of Pygm 2 0.04 2.26 1.2 5.00
61 INT128937 Negative_regulation of PTGER3 8 0.23 4.49 1.01 5.00
62 INT107618 Positive_regulation of PTGER3 10 0.41 1.82 1.01 5.00
63 INT137551 Regulation of Pygm 2 0.01 1.59 0.87 5.00
64 INT195056 Positive_regulation of Gene_expression of Pygm 2 0.04 1.99 0.83 5.00
65 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82 5.00
66 INT10729 Positive_regulation of ENPEP 13 0.38 9.65 0.8 5.00
67 INT95617 Regulation of Msx1 2 0.56 1.05 0.73 5.00
68 INT137550 Negative_regulation of Gene_expression of Pygm 3 0.03 1.72 0.71 5.00
69 INT215844 Gene_expression of Ex 12 0.65 9.24 0.54 5.00
70 INT99909 Regulation of Positive_regulation of CPOX 2 0.35 1.88 0.53 5.00
71 INT81577 Regulation of ALPL 3 0.26 0.82 0.48 5.00
72 INT178834 Localization of MR1 8 0.21 6.52 0.48 5.00
73 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47 5.00
74 INT259832 Positive_regulation of Slc12a3 3 0.23 2.07 0.46 5.00
75 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 5.00
76 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43 5.00
77 INT195058 Positive_regulation of Gene_expression of ALPL 3 0.65 1.56 0.42 5.00
78 INT195059 Phosphorylation of ALPL 1 0.77 0.79 0.4 5.00
79 INT208643 Gene_expression of Gt(ROSA)26Sor 11 0.65 4.85 0.37 5.00
80 INT259848 Regulation of Slc12a3 2 0.12 2.1 0.3 5.00
81 INT294806 Gene_expression of Dlx5 6 0.71 2.07 0.3 5.00
82 INT214128 Negative_regulation of Gene_expression of Msx1 3 0.53 1.25 0.26 5.00
83 INT195061 Phosphorylation of PTHLH 1 0.35 0.46 0.21 5.00
84 INT294897 Negative_regulation of Slc12a3 2 0.20 1.77 0.2 5.00
85 INT196468 Protein_catabolism of ALPP 3 0.34 0.31 0.18 5.00
86 INT217569 Binding of Wnt1 2 0.36 1.07 0.15 5.00
87 INT311644 Positive_regulation of Gene_expression of Spry1 1 0.46 2.54 0.13 5.00
88 INT151522 Binding of NSD1 2 0.37 4.28 0.09 5.00
89 INT214056 Negative_regulation of NSD1 3 0.43 3.44 0.09 5.00
90 INT311643 Negative_regulation of Spry1 1 0.40 0.95 0.05 5.00
91 INT311641 Regulation of Gene_expression of Spry1 1 0.57 0.5 0.04 5.00
92 INT205607 Regulation of Fgf1 4 0.24 3.34 0.04 5.00
93 INT311648 Regulation of Gene_expression of Wnt1 1 0.39 0.09 0.04 5.00
94 INT311647 Negative_regulation of Gene_expression of Spry1 1 0.39 0.18 0.04 5.00
95 INT311635 Negative_regulation of Gene_expression of Dlx6 1 0.39 0.23 0 5.00
96 INT192805 Binding of PTMS 2 0.36 0.65 0 5.00
97 INT274682 Localization of PTMS 1 0.64 0.32 0 5.00
98 INT311629 Negative_regulation of Gene_expression of Dlx5 1 0.39 0.42 0 5.00
99 INT311653 Binding of Spry1 1 0.34 0.98 0 5.00
100 INT311627 Regulation of Barx1 1 0.56 0.88 0 5.00
101 INT284977 Binding of DNMT1 3 0.17 0.86 0 5.00
102 INT214055 Gene_expression of NSD1 8 0.67 4.46 0 5.00
103 INT305152 Regulation of NUPR1 3 0.44 0.08 0 5.00
104 INT311645 Gene_expression of Spry2 1 0.70 1.81 0 5.00
105 INT311639 Positive_regulation of Spry1 1 0.64 0.19 0 5.00
106 INT311640 Regulation of Binding of Spry1 1 0.42 0.77 0 5.00
107 INT311637 Positive_regulation of Gene_expression of Ex 1 0.49 0.18 0 5.00
108 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0 5.00
109 INT218745 Regulation of Gene_expression of ALPL 1 0.44 0.31 0 5.00
110 INT311634 Positive_regulation of Spry2 1 0.45 0.4 0 5.00
111 INT206911 Gene_expression of Msx2 4 0.71 1.26 0 5.00
112 INT202633 Positive_regulation of Gene_expression of Wnt1 3 0.43 0.85 0 5.00
113 INT175050 Regulation of Etv5 2 0.60 0.87 0 5.00
114 INT311628 Negative_regulation of Gene_expression of Spry2 1 0.39 0.43 0 5.00
115 INT311632 Positive_regulation of Wnt1 1 0.43 0.19 0 5.00
116 INT311652 Negative_regulation of Regulation of Fgf1 1 0.13 0.32 0 5.00
117 INT244080 Positive_regulation of Gene_expression of Gt(ROSA)26Sor 2 0.36 0.7 0 5.00
118 INT311654 Regulation of Spry2 1 0.21 0.75 0 5.00
119 INT311649 Regulation of Dlx6 1 0.41 0.22 0 5.00
120 INT311642 Binding of Gt(ROSA)26Sor 1 0.03 0.21 0 5.00
121 INT311646 Regulation of Dlx5 1 0.41 0.22 0 5.00
122 INT311631 Gene_expression of Dlx6 1 0.55 0.69 0 5.00
123 INT311630 Negative_regulation of Tfap2a 1 0.34 0.23 0 5.00
124 INT195057 Binding of ALPL 1 0.40 0.05 0 5.00
125 INT311626 Negative_regulation of Gene_expression of Tfap2a 1 0.34 0.29 0 5.00
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