D:Cretinism

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pChart

Disease Term
Synonyms Congenital Hypothyroidism, Cretinism Endemic, Endemic Cretinism, Hypothyroidism Congenital, Myxedema Congenital
Documents 25
Hot Single Events 29
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cretinism. They are ordered first by their relevance to Cretinism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT307054 RHCE Regulation of AKTIP 1 0.00 0.6 0 64.72
2 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
3 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15 5.00
4 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
5 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
6 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
7 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
8 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
9 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cretinism. They are ordered first by their pain relevance and then by number of times they were reported in Cretinism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 99.80
2 INT45730 Transcription of PAH 3 0.68 2.4 0.33 99.80
3 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 99.52
4 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 99.28
5 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 98.72
6 INT148564 Localization of HAL 8 0.68 2.46 0.62 98.16
7 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61 94.84
8 INT217 Negative_regulation of Th 134 0.59 26.83 62.63 93.52
9 INT155195 Negative_regulation of THRSP 1 0.01 0.27 0.07 93.52
10 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 91.40
11 INT252 Localization of GH1 529 0.80 227.4 122.05 90.56
12 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59 88.48
13 INT180620 Positive_regulation of Positive_regulation of HAL 1 0.06 0.09 0 88.48
14 INT6866 Regulation of Gfap 51 0.61 19.6 23.56 87.28
15 INT23955 Regulation of Vim 16 0.25 14.21 2.04 87.28
16 INT155194 Regulation of Phosphorylation of Gfap 2 0.24 1.87 1.28 87.28
17 INT105156 Phosphorylation of Gfap 23 0.79 11.85 13.76 86.76
18 INT133792 Phosphorylation of Vim 2 0.32 1.34 0.3 86.76
19 INT155196 Phosphorylation of CFI 1 0.80 0.3 0.15 86.76
20 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0 86.44
21 INT50010 Negative_regulation of CHR 5 0.42 3.64 1.41 86.32
22 INT34777 Localization of IGF1 82 0.80 42.68 8.62 85.24
23 INT95495 Phosphorylation of Nefh 13 0.82 7.36 12.1 81.64
24 INT921 Regulation of GH1 172 0.60 52.88 51.04 81.52
25 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 81.52
26 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53 81.20
27 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 81.16
28 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 81.16
29 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 81.16
30 INT191542 Binding of ABCA3 1 0.22 1.61 0.03 77.92
31 INT2225 Binding of Gfap 31 0.47 11.78 8.53 77.72
32 INT136630 Regulation of Binding of Gfap 3 0.42 0.85 0.49 77.72
33 INT35295 Positive_regulation of RHCE 5 0.30 2.22 0.39 75.24
34 INT136153 Binding of Slc1a3 7 0.40 2.71 6.01 75.00
35 INT135673 Positive_regulation of Slc1a3 23 0.57 5.45 21.45 75.00
36 INT142525 Binding of Slc1a2 4 0.45 0.94 2.65 75.00
37 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52 75.00
38 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 75.00
39 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41 75.00
40 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 75.00
41 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 75.00
42 INT99539 Positive_regulation of Slc1a2 25 0.67 5.46 23.38 75.00
43 INT127013 Negative_regulation of Slc1a3 37 0.54 14.16 43.97 75.00
44 INT93485 Negative_regulation of Slc1a2 27 0.59 10.65 20.9 75.00
45 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05 75.00
46 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 75.00
47 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69 75.00
48 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 75.00
49 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86 75.00
50 INT1893 Localization of Gh 1041 0.79 340.23 256.58 75.00
51 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 75.00
52 INT1530 Regulation of Gh 382 0.61 115.96 112.47 75.00
53 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 75.00
54 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82 75.00
55 INT16220 Negative_regulation of Regulation of Gh 13 0.42 3.59 4.33 75.00
56 INT35353 Positive_regulation of Lass3 1 0.00 0.07 0.27 75.00
57 INT347732 Binding of Shc2 1 0.14 0.58 0 74.08
58 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78 72.72
59 INT14690 Localization of CSF2 124 0.80 85.17 27.26 71.00
60 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 65.84
61 INT49370 Localization of IGFBP3 21 0.81 9.85 0.71 57.20
62 INT307056 Positive_regulation of Localization of IGFBP3 1 0.39 0.99 0 57.20
63 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 45.76
64 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 39.76
65 INT153137 Positive_regulation of ESCO2 3 0.18 0.89 0.26 32.36
66 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 28.48
67 INT307059 Localization of AKTIP 1 0.01 0.48 0.14 22.12
68 INT300712 Negative_regulation of Gene_expression of Elpt 1 0.07 1.02 0.09 21.12
69 INT300716 Gene_expression of Elpt 1 0.11 1.02 0.09 20.76
70 INT132477 Negative_regulation of TSHB 5 0.45 3.24 0.05 20.32
71 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 19.92
72 INT299511 Negative_regulation of Elpt 2 0.07 1.79 0.4 9.36
73 INT54836 Regulation of RHCE 9 0.30 6.68 0.47 8.00
74 INT307057 Regulation of AKTIP 1 0.00 0.72 0.03 8.00
75 INT48728 Negative_regulation of IGFBP3 28 0.59 14.84 1.21 7.68
76 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 6.72
77 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
78 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
79 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
80 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 5.00
81 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
82 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
83 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
84 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
85 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 5.00
86 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
87 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
88 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
89 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
90 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
91 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
92 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
93 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
94 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
95 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
96 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
97 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92 5.00
98 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
99 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 5.00
100 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
101 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
102 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
103 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
104 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91 5.00
105 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
106 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
107 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
108 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
109 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17 5.00
110 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
111 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
112 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
113 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
114 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
115 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
116 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06 5.00
117 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
118 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
119 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
120 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
121 INT6869 Positive_regulation of Car3 34 0.61 5.15 14.21 5.00
122 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
123 INT9678 Positive_regulation of Positive_regulation of GH1 32 0.68 8.14 12.97 5.00
124 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.00
125 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 5.00
126 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
127 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
128 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9 5.00
129 INT18258 Negative_regulation of Thop1 20 0.56 1.6 8.61 5.00
130 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
131 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
132 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
133 INT12028 Regulation of Car1 28 0.43 9.01 7.84 5.00
134 INT90275 Negative_regulation of Ppp1cc 29 0.58 1.91 7.11 5.00
135 INT20840 Negative_regulation of Car3 14 0.47 4.35 6.83 5.00
136 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
137 INT151387 Gene_expression of Cav3 14 0.78 4 5.31 5.00
138 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
139 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09 5.00
140 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
141 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
142 INT4097 Localization of Pth 66 0.81 47.17 4.36 5.00
143 INT21817 Binding of Thop1 9 0.48 0.88 4.19 5.00
144 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
145 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
146 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 5.00
147 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 5.00
148 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 5.00
149 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
150 INT90276 Gene_expression of Ppp1cc 10 0.73 0.83 2.87 5.00
151 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73 5.00
152 INT90273 Positive_regulation of Ppp1cc 10 0.41 0.82 2.71 5.00
153 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
154 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 5.00
155 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99 5.00
156 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 5.00
157 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94 5.00
158 INT49371 Positive_regulation of Gene_expression of IGFBP3 27 0.70 23.13 1.9 5.00
159 INT29330 Positive_regulation of Thop1 6 0.46 1.05 1.8 5.00
160 INT59790 Binding of BCR 16 0.36 15.34 1.75 5.00
161 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
162 INT139254 Negative_regulation of Per1 12 0.56 3.17 1.62 5.00
163 INT53008 Gene_expression of Nr4a2 25 0.74 4.89 1.5 5.00
164 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 5.00
165 INT48269 Negative_regulation of FANCB 16 0.56 5.34 1.38 5.00
166 INT120075 Gene_expression of Itk 11 0.43 6.39 1.27 5.00
167 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 5.00
168 INT128000 Gene_expression of RHCE 9 0.75 1.39 1.18 5.00
169 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 5.00
170 INT163747 Negative_regulation of Cav3 3 0.54 0.56 1.16 5.00
171 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12 5.00
172 INT181879 Negative_regulation of Apoa1 8 0.55 8.18 1.11 5.00
173 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
174 INT24761 Positive_regulation of Negative_regulation of SST 2 0.49 0.86 1.01 5.00
175 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 5.00
176 INT30041 Binding of HAL 8 0.35 2.36 0.95 5.00
177 INT169706 Positive_regulation of Gene_expression of Itk 2 0.32 2.08 0.81 5.00
178 INT211972 Regulation of Best1 18 0.33 12.04 0.67 5.00
179 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66 5.00
180 INT196739 Regulation of Ppp1cc 5 0.19 0 0.63 5.00
181 INT290081 Regulation of NRG1 7 0.26 5.24 0.59 5.00
182 INT170475 Negative_regulation of Gene_expression of Mapk1 7 0.41 2.44 0.53 5.00
183 INT220506 Binding of Cav1 13 0.45 5.46 0.38 5.00
184 INT211968 Localization of Best1 11 0.40 9.33 0.38 5.00
185 INT290096 Regulation of Gene_expression of NRG1 2 0.06 2.21 0.35 5.00
186 INT211971 Binding of Best1 16 0.22 7.73 0.33 5.00
187 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 5.00
188 INT125804 Localization of Pth 9 0.69 3.93 0.29 5.00
189 INT246013 Transcription of Nr4a2 4 0.46 1.29 0.27 5.00
190 INT203557 Transcription of NRG1 2 0.31 0.7 0.24 5.00
191 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22 5.00
192 INT341756 Negative_regulation of Gene_expression of FANCB 1 0.03 0.06 0.21 5.00
193 INT239883 Transcription of SFTPC 3 0.69 1.11 0.18 5.00
194 INT300718 Negative_regulation of Ptrf 1 0.34 4.1 0.18 5.00
195 INT300717 Gene_expression of Ptrf 1 0.61 3.64 0.18 5.00
196 INT192842 Binding of Hspa5 3 0.33 1.48 0.16 5.00
197 INT231230 Localization of SFTPC 2 0.68 2.06 0.16 5.00
198 INT214975 Localization of Cav1 7 0.75 2.7 0.13 5.00
199 INT237337 Binding of Cav3 3 0.44 2.63 0.11 5.00
200 INT146139 Gene_expression of ETV4 11 0.12 8.43 0.11 5.00
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