D:Crouzon Syndrome

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pChart

Disease Term
Synonyms Acrocephalosyndactyly Type 2, Acrocephalosyndactyly Type Ii, APERT CROUZON SYNDROME, CRANIOFACIAL DYSARTHROSIS, CRANIOFACIAL DYSOSTOSES, Craniofacial Dysostosis, Craniofacial Dysostosis Syndrome, Crouzon Craniofacial Dysostosis, Crouzon Disease, Crouzon S Disease, Crouzons Disease
Documents 14
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Crouzon Syndrome. They are ordered first by their relevance to Crouzon Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT301364 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.39 0 5.00
2 INT301365 Stat1 Positive_regulation of Cdkn1a 1 0.03 0.38 0 5.00
3 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Crouzon Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Crouzon Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147079 Gene_expression of Ext2 2 0.66 1.04 0.1 97.76
2 INT301360 Gene_expression of Ext1 3 0.68 1.01 0 97.76
3 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95 87.60
4 INT187087 Binding of Cd44 5 0.47 2.79 0.66 9.00
5 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
6 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
7 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
8 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
9 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 5.00
10 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 5.00
11 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 5.00
12 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 5.00
13 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15 5.00
14 INT124850 Gene_expression of Tpt1 42 0.77 14.51 0.79 5.00
15 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57 5.00
16 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 5.00
17 INT235835 Negative_regulation of Gene_expression of Hspg2 3 0.15 1.26 0.52 5.00
18 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4 5.00
19 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4 5.00
20 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33 5.00
21 INT189833 Negative_regulation of Phosphorylation of Stat1 4 0.51 1.1 0.3 5.00
22 INT301361 Phosphorylation of Cdkn1a 2 0.79 1.21 0.09 5.00
23 INT210587 Binding of Pthlh 1 0.18 1.17 0.03 5.00
24 INT301355 Binding of Ext1 2 0.37 4.07 0.03 5.00
25 INT172965 Negative_regulation of Positive_regulation of Cdkn1a 4 0.41 1.84 0 5.00
26 INT301354 Transcription of Ext1 1 0.46 1 0 5.00
27 INT301356 Binding of Ihh 1 0.08 0.06 0 5.00
28 INT301357 Negative_regulation of Positive_regulation of Fgfr3 1 0.16 0.35 0 5.00
29 INT301358 Negative_regulation of Ext1 2 0.42 1.09 0 5.00
30 INT301359 Positive_regulation of Fgfr3 1 0.19 0.64 0 5.00
31 INT301362 Negative_regulation of Positive_regulation of Cdkn1a 1 0.41 0.39 0 5.00
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