D:Cryoglobulinemia

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Disease Term
Synonyms Cryoglobulinaemia, Cryoglobulinemias, CRYOIMMUNOGLOBULINAEMIA, Cryoimmunoglobulinemia
Documents 121
Hot Single Events 45
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cryoglobulinemia. They are ordered first by their relevance to Cryoglobulinemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21 99.42
2 INT249664 Binding of CD81 and CHCHD2 1 0.00 2.51 0 95.88
3 INT107425 Binding of ST3GAL4 and IFNK 1 0.08 1.12 0.17 93.40
4 INT47357 Binding of FN1 and ANGPTL5 1 0.20 0.48 0.16 83.88
5 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0 51.12
6 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 8.24
7 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 6.96
8 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
9 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27 5.00
10 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27 5.00
11 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
12 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
13 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
14 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
15 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 5.00
16 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
17 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
18 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
19 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 5.00
20 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 5.00
21 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cryoglobulinemia. They are ordered first by their pain relevance and then by number of times they were reported in Cryoglobulinemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9466 Binding of APOB 27 0.41 19.36 1.56 100.00
2 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 99.80
3 INT103779 Positive_regulation of MEMO1 2 0.01 3.77 0.3 99.80
4 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 99.30
5 INT15870 Regulation of PSS 6 0.25 3.22 0.85 99.16
6 INT107426 Gene_expression of ST3GAL4 3 0.49 1.24 0.24 99.06
7 INT98409 Binding of Rf 4 0.08 3.97 0.94 98.80
8 INT22075 Positive_regulation of Gene_expression of IFNA2 7 0.64 4.7 1.45 98.44
9 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 98.42
10 INT75742 Binding of RLS 86 0.42 95.27 19.04 98.12
11 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 98.02
12 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 97.80
13 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 97.64
14 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 97.32
15 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 97.18
16 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 96.72
17 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 96.52
18 INT87458 Binding of CD81 4 0.18 6.02 0.59 95.88
19 INT249680 Binding of CHCHD2 1 0.01 2.45 0 95.88
20 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13 95.88
21 INT177467 Negative_regulation of MTRF1 22 0.05 11.84 5.57 95.80
22 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 95.64
23 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 95.20
24 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 94.64
25 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 93.56
26 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 93.32
27 INT103527 Positive_regulation of Smcp 5 0.41 2.25 1.26 92.16
28 INT193358 Localization of ST3GAL4 2 0.52 1.65 0.05 91.64
29 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 89.88
30 INT35140 Protein_catabolism of ANGPTL5 7 0.32 3.78 1.51 89.84
31 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 89.84
32 INT70526 Binding of CALR 11 0.35 7.09 1.97 89.44
33 INT127667 Positive_regulation of Localization of CXCL10 5 0.59 5.89 4.09 88.92
34 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 88.76
35 INT120828 Localization of CXCL10 29 0.68 18.01 12.17 88.64
36 INT182037 Localization of C3 10 0.68 6.69 1.54 87.56
37 INT14727 Regulation of FN1 13 0.45 5.95 1.26 87.00
38 INT7368 Positive_regulation of Negative_regulation of IgG 2 0.36 1.36 0.09 85.44
39 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 84.44
40 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 84.44
41 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 83.92
42 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 82.88
43 INT33735 Binding of ANGPTL5 39 0.32 14.23 3.66 82.52
44 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 81.92
45 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 80.40
46 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 79.16
47 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 79.16
48 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 78.80
49 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 77.88
50 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 76.32
51 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 76.32
52 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 75.00
53 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 75.00
54 INT121422 Gene_expression of BIRC3 7 0.75 6.24 0.96 75.00
55 INT44600 Gene_expression of MALT1 6 0.75 6.14 0.42 75.00
56 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 75.00
57 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 75.00
58 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 75.00
59 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 74.36
60 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 74.36
61 INT51840 Positive_regulation of Localization of CD40LG 8 0.69 9.59 1.58 72.72
62 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 72.72
63 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 72.08
64 INT72024 Localization of EDNRA 11 0.57 8.22 0.96 69.12
65 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 68.48
66 INT19431 Positive_regulation of Gene_expression of MTRF1 5 0.05 3.13 0.95 66.56
67 INT19428 Gene_expression of MTRF1 42 0.08 27.17 10.43 66.24
68 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 64.96
69 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 60.92
70 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 60.92
71 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 54.48
72 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 54.48
73 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 54.48
74 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 54.08
75 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 54.08
76 INT12163 Positive_regulation of OLAH 8 0.68 6.91 1.67 50.00
77 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 48.72
78 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 46.84
79 INT190695 Localization of Abnormal 1 0.01 2.03 0.37 41.76
80 INT246353 Protein_catabolism of EDNRA 1 0.01 0.48 0.04 35.28
81 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
82 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
83 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
84 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
85 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
86 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
87 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
88 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
89 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
90 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
91 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
92 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
93 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
94 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
95 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
96 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
97 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
98 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
99 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
100 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
101 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
102 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
103 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
104 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
105 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
106 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
107 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
108 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
109 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
110 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
111 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
112 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
113 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
114 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
115 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 5.00
116 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
117 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
118 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
119 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
120 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25 5.00
121 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
122 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
123 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
124 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
125 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
126 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
127 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
128 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
129 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
130 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
131 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 5.00
132 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
133 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
134 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
135 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
136 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
137 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 5.00
138 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
139 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
140 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
141 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
142 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
143 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 5.00
144 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
145 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
146 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
147 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
148 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
149 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
150 INT83894 Positive_regulation of TRPM8 37 0.70 18.28 11.7 5.00
151 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
152 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 5.00
153 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
154 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
155 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
156 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
157 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
158 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
159 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
160 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 5.00
161 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
162 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51 5.00
163 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
164 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
165 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
166 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
167 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
168 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 5.00
169 INT69156 Localization of IL5 21 0.68 14.95 5.37 5.00
170 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
171 INT14753 Binding of GRP 15 0.48 2.28 5.09 5.00
172 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09 5.00
173 INT24741 Positive_regulation of Rf 16 0.17 18.23 4.75 5.00
174 INT85415 Positive_regulation of IL9 10 0.28 6.93 4.71 5.00
175 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 5.00
176 INT9837 Negative_regulation of Rf 12 0.11 8.41 4.55 5.00
177 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 5.00
178 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 5.00
179 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
180 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 5.00
181 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
182 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
183 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 5.00
184 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
185 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
186 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 5.00
187 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 5.00
188 INT58038 Binding of Drb1 5 0.22 3.42 3 5.00
189 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 5.00
190 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 5.00
191 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
192 INT90094 Gene_expression of Cytl1 14 0.75 12.75 2.81 5.00
193 INT19235 Negative_regulation of PDE1B 11 0.14 2.38 2.81 5.00
194 INT161840 Gene_expression of Tnfrsf11b 17 0.78 12.44 2.63 5.00
195 INT129161 Binding of TRPM8 7 0.48 1.32 2.48 5.00
196 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4 5.00
197 INT646 Binding of Mb 37 0.41 6.13 2.25 5.00
198 INT46088 Localization of F3 15 0.37 13.7 2.23 5.00
199 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 5.00
200 INT43612 Regulation of SERPINB1 12 0.11 3.26 2.21 5.00
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