D:Cryopyrin-associated Periodic Syndromes

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Disease Term
Synonyms Chronic Infantile Neurological Cutaneous Articular Syndrome, Cinca Syndrome, Cold Urticaria Familial, COLD URTICARIAS FAMILIAL, CRYOPYRIN ASSOCIATED PERIODIC SYNDROME, Cryopyrin Associated Periodic Syndromes, Cryopyrinopathies, Cryopyrinopathy, Familial Cold Autoinflammatory Syndrome, Familial Cold Urticaria, Familial Cold Urticarias
Documents 22
Hot Single Events 55
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cryopyrin-associated Periodic Syndromes. They are ordered first by their relevance to Cryopyrin-associated Periodic Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28 92.24
2 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67 90.48
3 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33 87.44
4 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 69.60
5 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31 55.60
6 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45 54.24
7 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25 50.52
8 INT279268 CARD8 Positive_regulation of CASP1 1 0.32 0.3 0 49.84
9 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28 47.52
10 INT220115 Mefv Regulation of Gene_expression of Il1 1 0.01 1.85 0.13 28.00
11 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19 22.08
12 INT282398 Binding of Mefv and Nlrp3 1 0.40 6.8 1.72 5.00
13 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 5.00
14 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7 5.00
15 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 5.00
16 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63 5.00
17 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58 5.00
18 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57 5.00
19 INT333477 CXCL10 Positive_regulation of TH1L 1 0.14 0.32 0.56 5.00
20 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 5.00
21 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 5.00
22 INT282397 Binding of Irgm1 and Atg16l1 1 0.17 1.18 0.39 5.00
23 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35 5.00
24 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33 5.00
25 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33 5.00
26 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31 5.00
27 INT282399 Binding of Mefv and Uncv 1 0.07 1.02 0.26 5.00
28 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 5.00
29 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 5.00
30 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14 5.00
31 INT205712 CAMP Positive_regulation of Localization of Il1 1 0.00 0.32 0.14 5.00
32 INT205709 CAMP Positive_regulation of Positive_regulation of Casp1 1 0.00 0.27 0.11 5.00
33 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1 5.00
34 INT220116 Tnfrsf1a Negative_regulation of TNF 1 0.06 0.56 0.09 5.00
35 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cryopyrin-associated Periodic Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Cryopyrin-associated Periodic Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244159 Transcription of NLRP3 3 0.64 5.61 0.39 100.00
2 INT23171 Negative_regulation of NLRP3 7 0.37 4.15 1.53 99.80
3 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 99.72
4 INT6849 Localization of IL1B 229 0.81 112.56 69.63 99.70
5 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.28
6 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 98.80
7 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 98.00
8 INT236277 Positive_regulation of Gene_expression of CADPS 5 0.42 9.17 1.29 98.00
9 INT313894 Transcription of CADPS 1 0.44 2.72 0.19 97.36
10 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 97.36
11 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 96.88
12 INT236278 Negative_regulation of CADPS 4 0.36 2.16 0.22 96.04
13 INT92260 Binding of Nlrp3 14 0.46 8.94 2.13 95.84
14 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 95.44
15 INT10612 Localization of NLRP3 13 0.78 8.91 2.27 95.44
16 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 95.24
17 INT80005 Gene_expression of MVK 4 0.09 1.79 1.34 95.24
18 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 94.88
19 INT149669 Positive_regulation of MEFV 12 0.46 14.17 2.07 94.88
20 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34 94.88
21 INT222205 Positive_regulation of PSTPIP1 8 0.69 4.69 0.62 94.88
22 INT95338 Positive_regulation of Positive_regulation of CASP1 9 0.49 4.61 1.43 94.72
23 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 94.72
24 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 94.48
25 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 94.04
26 INT257406 Localization of TNFRSF1A 3 0.46 2.6 0.55 94.04
27 INT19775 Localization of Il1 183 0.78 145.5 50.91 93.88
28 INT257407 Localization of MVK 1 0.22 1.78 0.18 93.64
29 INT20129 Regulation of Il1 53 0.53 44.14 19.89 92.36
30 INT25607 Binding of Il1 82 0.47 64.4 23.9 91.68
31 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 91.00
32 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12 90.84
33 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4 90.56
34 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 90.48
35 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 90.48
36 INT313892 Localization of CADPS 1 0.48 2.37 0.2 90.36
37 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 90.28
38 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41 89.84
39 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92 89.84
40 INT274601 Regulation of PSTPIP1 3 0.45 3.76 0.28 89.72
41 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 89.12
42 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 89.12
43 INT17561 Localization of Car2 303 0.79 60.95 44.52 88.28
44 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 88.04
45 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 87.60
46 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84 87.60
47 INT205685 Regulation of Positive_regulation of Casp1 3 0.11 1.62 0.78 87.44
48 INT6484 Binding of IL1B 122 0.47 75.84 35.07 87.20
49 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 86.56
50 INT282384 Negative_regulation of Gene_expression of Pain1 3 0.42 2.7 1.59 86.56
51 INT1901 Binding of Mefv 24 0.48 32.26 4.5 84.40
52 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 83.28
53 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1 83.28
54 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 80.48
55 INT9660 Regulation of TNF 363 0.62 312.94 139.99 80.48
56 INT53236 Positive_regulation of Binding of Il1 5 0.40 3.84 1.41 79.04
57 INT191589 Gene_expression of Msu 9 0.46 7.08 1.33 75.20
58 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 73.64
59 INT96073 Localization of Casp1 11 0.78 4.91 1.29 72.64
60 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 72.16
61 INT209912 Gene_expression of Pycard 17 0.22 12.04 1.04 68.40
62 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26 68.40
63 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 67.68
64 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 67.68
65 INT187992 Binding of CADPS 2 0.31 2.05 0.06 62.24
66 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77 61.68
67 INT254309 Gene_expression of Cxcr5 1 0.65 0.67 0.04 60.08
68 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41 59.76
69 INT254317 Negative_regulation of Pycard 5 0.42 3.13 0.45 58.32
70 INT298971 Positive_regulation of Localization of Casp1 2 0.06 0.97 0.28 57.92
71 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59 57.44
72 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 57.20
73 INT209503 Positive_regulation of CADPS 3 0.42 7 1.11 57.08
74 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 56.68
75 INT173693 Localization of Gopc 249 0.65 70.49 38.81 56.48
76 INT168448 Localization of Nlrp3 5 0.73 3.75 0.58 56.48
77 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 55.84
78 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 54.68
79 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78 54.44
80 INT144829 Localization of P2rx7 12 0.79 2.92 2.12 54.20
81 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42 52.16
82 INT279271 Positive_regulation of CARD8 1 0.33 0.3 0 49.04
83 INT213886 Binding of IL23R 7 0.46 16.79 6.94 45.56
84 INT22383 Binding of IL2 59 0.48 39.06 8.56 45.28
85 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 44.80
86 INT69034 Regulation of Casp1 3 0.27 3.56 1.36 40.80
87 INT53572 Negative_regulation of Localization of Il1 18 0.40 12.78 6.7 40.40
88 INT126759 Negative_regulation of Nlrp3 5 0.41 2.95 1.58 36.44
89 INT97513 Localization of Mefv 6 0.71 8.14 1.55 30.80
90 INT67374 Gene_expression of Mefv 15 0.74 49.1 8.07 29.20
91 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3 28.96
92 INT209915 Protein_catabolism of Il1 6 0.57 3.97 1.17 28.28
93 INT192785 Regulation of Myo5a 4 0.05 9.05 0.93 27.44
94 INT67373 Regulation of Gene_expression of Mefv 2 0.39 6.28 0.75 22.00
95 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 19.52
96 INT97514 Positive_regulation of Gene_expression of Mefv 2 0.47 10.98 1.97 15.76
97 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 14.56
98 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.68
99 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
100 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
101 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
102 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
103 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
104 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
105 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
106 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
107 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
108 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
109 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
110 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
111 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
112 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
113 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
114 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
115 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
116 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
117 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
118 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
119 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
120 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
121 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
122 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
123 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
124 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
125 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
126 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
127 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
128 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
129 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
130 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
131 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
132 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 5.00
133 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
134 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
135 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
136 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 5.00
137 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
138 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
139 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
140 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
141 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
142 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
143 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 5.00
144 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
145 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
146 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25 5.00
147 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
148 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
149 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
150 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
151 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
152 INT5904 Localization of MPO 62 0.81 36.37 14.64 5.00
153 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44 5.00
154 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
155 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
156 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
157 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 5.00
158 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 5.00
159 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
160 INT137181 Gene_expression of CXCL9 25 0.65 13.09 9.56 5.00
161 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
162 INT91337 Gene_expression of CCL4 29 0.75 16.23 8.64 5.00
163 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 5.00
164 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67 5.00
165 INT7376 Positive_regulation of CAMP 17 0.67 6.39 6.6 5.00
166 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25 5.00
167 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 5.00
168 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
169 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 5.00
170 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81 5.00
171 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61 5.00
172 INT114993 Binding of Myo5a 15 0.30 11.46 5.48 5.00
173 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41 5.00
174 INT92234 Regulation of CXCL10 15 0.42 8.37 5.09 5.00
175 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 5.00
176 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
177 INT17742 Localization of S100B 44 0.80 17.14 4.65 5.00
178 INT104549 Localization of Il18 16 0.78 13.01 4.64 5.00
179 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
180 INT182898 Regulation of Gene_expression of IFN1@ 18 0.44 9.49 4.46 5.00
181 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 5.00
182 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26 5.00
183 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
184 INT20275 Negative_regulation of Abo 13 0.20 4.62 4.02 5.00
185 INT25464 Binding of SAA1 11 0.42 6.89 3.72 5.00
186 INT174477 Negative_regulation of IL7 11 0.47 10.35 3.69 5.00
187 INT155011 Negative_regulation of IL17A 8 0.54 6.43 3.64 5.00
188 INT176386 Positive_regulation of Gene_expression of TH1L 14 0.32 9.17 3.4 5.00
189 INT16976 Negative_regulation of IL36RN 6 0.49 5.08 3.31 5.00
190 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 5.00
191 INT144828 Binding of P2rx7 19 0.47 7.84 3.16 5.00
192 INT171888 Binding of Il1rn 13 0.38 5.53 3.13 5.00
193 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 5.00
194 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 5.00
195 INT110210 Negative_regulation of CSRP1 12 0.59 8.96 2.81 5.00
196 INT156876 Positive_regulation of Gene_expression of Casp1 10 0.50 10.25 2.58 5.00
197 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 5.00
198 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 5.00
199 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 5.00
200 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44 5.00
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