D:Cryptorchidism

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Disease Term
Synonyms Abdominal Cryptorchidism, Bilateral Cryptorchidism, Cryptorchidism Abdominal, Cryptorchidism Bilateral, Cryptorchidism Inguinal, Cryptorchidism Unilateral, Cryptorchism, Idt Imperfectly Descended Testis, Imperfectly Descended Testes, Imperfectly Descended Testicle, Imperfectly Descended Testicles
Documents 139
Hot Single Events 40
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cryptorchidism. They are ordered first by their relevance to Cryptorchidism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT41006 GNRH1 Negative_regulation of Localization of CGA 1 0.03 0.87 0.3 80.44
2 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 52.28
3 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 33.16
4 INT147235 Trpv1 Regulation of Ascc1 1 0.09 0.15 0.4 5.00
5 INT177396 Npy1r Positive_regulation of Negative_regulation of Npy 1 0.27 0.38 0.37 5.00
6 INT177400 RNY1 Positive_regulation of Negative_regulation of Npy 1 0.03 0.38 0.37 5.00
7 INT177398 Binding of Npy1r and Npy 1 0.18 0.73 0.24 5.00
8 INT177397 Binding of Npy5r and Npy 1 0.16 0.73 0.24 5.00
9 INT147236 Negative_regulation of Trpv1 Regulation of Ascc1 1 0.13 0.1 0.23 5.00
10 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
11 INT311399 Binding of Celf1 and Uts2r 1 0.08 0.26 0.12 5.00
12 INT174820 IL6 Positive_regulation of VEGFA 1 0.20 3.32 0.12 5.00
13 INT174821 VEGFA Positive_regulation of Gene_expression of IL6 1 0.20 3.13 0.12 5.00
14 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0 5.00
15 INT311390 Mbnl1 Positive_regulation of Celf1 1 0.26 0.48 0 5.00
16 INT311387 Binding of Celf1 and Mbnl1 1 0.20 0.25 0 5.00
17 INT311405 CCND3 Regulation of Celf1 1 0.41 0.14 0 5.00
18 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0 5.00
19 INT311389 Positive_regulation of Binding of Celf1 and Eif2s2 1 0.17 0.59 0 5.00
20 INT311381 Phosphorylation of Akt1 Regulation of Celf1 1 0.10 0.14 0 5.00
21 INT311379 Celf1 Negative_regulation of Mbnl1 1 0.24 0.26 0 5.00
22 INT311384 Binding of Cnbp and Eef2 1 0.07 0.15 0 5.00
23 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0 5.00
24 INT311385 Gopc Regulation of Celf1 1 0.04 0.14 0 5.00
25 INT272516 Binding of Celf1 and Tpt1 2 0.05 0.07 0 5.00
26 INT311380 Positive_regulation of Celf1 Negative_regulation of Mbnl1 1 0.26 0.26 0 5.00
27 INT311393 Binding of Eef2 and Rps17 1 0.02 0.15 0 5.00
28 INT311392 Binding of Cnbp and Pabpc1 1 0.04 0.14 0 5.00
29 INT311397 Binding of Celf1 and Gopc 1 0.04 0.09 0 5.00
30 INT311378 Binding of Cnbp and Rps17 1 0.06 0.14 0 5.00
31 INT311375 Phosphorylation of Prkca Positive_regulation of Celf1 1 0.04 0.1 0 5.00
32 INT331883 Binding of MAGEA4 and GOPC 1 0.03 0 0 5.00
33 INT311402 Binding of Celf1 and Eif2s2 Positive_regulation of Phosphorylation of Celf1 1 0.11 0.22 0 5.00
34 INT311394 Binding of Celf1 and Eif2s2 1 0.12 1.67 0 5.00
35 INT311391 Binding of Celf1 and Dmpk 1 0.34 0.09 0 5.00
36 INT311395 Binding of Esr1 and 20S 1 0.04 0.11 0 5.00
37 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0 5.00
38 INT311376 Binding of Ccnd3 and Celf1 1 0.06 0.07 0 5.00
39 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0 5.00
40 INT311388 Mbnl1 Positive_regulation of Binding of Celf1 1 0.26 0.13 0 5.00
41 INT311377 Binding of Eef2 and Pabpc1 1 0.01 0.15 0 5.00
42 INT311396 Akt1 Regulation of Celf1 1 0.04 0.14 0 5.00
43 INT317900 Binding of NCAPH2 and MCPH1 1 0.02 0.53 0 5.00
44 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cryptorchidism. They are ordered first by their pain relevance and then by number of times they were reported in Cryptorchidism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT35328 Gene_expression of KRTAP19-9P 9 0.52 9.08 1.44 99.60
2 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 98.24
3 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 94.76
4 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 94.56
5 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 94.40
6 INT35329 Positive_regulation of KRTAP19-9P 15 0.59 12.55 2.98 94.00
7 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 93.64
8 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 93.52
9 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 93.52
10 INT4771 Gene_expression of CGB 23 0.67 14.22 3.42 93.52
11 INT192614 Gene_expression of Atrx 1 0.77 1.75 0 92.92
12 INT251238 Gene_expression of Lvs 35 0.32 29.41 1.59 92.28
13 INT45899 Regulation of Localization of LGR6 3 0.27 1.85 0.64 90.24
14 INT45901 Localization of LGR6 5 0.80 2.48 1.64 90.24
15 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 90.20
16 INT317920 Localization of SNX19 1 0.73 1.88 0.2 89.72
17 INT317915 Binding of SNX19 1 0.36 2.04 0.2 89.72
18 INT920 Localization of PLOD1 223 0.81 42.25 78.7 89.72
19 INT15606 Localization of FSHB 24 0.78 9.16 2.49 89.72
20 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 89.20
21 INT317910 Localization of THYN1 1 0.65 0.88 0.1 88.68
22 INT317904 Binding of THYN1 1 0.32 0.96 0.1 88.68
23 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 88.64
24 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 88.48
25 INT51897 Binding of OPCML 8 0.43 5.59 1.11 87.20
26 INT51895 Localization of OPCML 6 0.68 3.43 0.54 87.20
27 INT244343 Localization of NTM 16 0.73 14.26 0.26 86.92
28 INT317911 Localization of VPS26B 1 0.47 0.88 0.1 86.92
29 INT317914 Localization of NCAPD3 1 0.65 0.88 0.1 86.92
30 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 86.36
31 INT183819 Negative_regulation of Positive_regulation of BCAR1 1 0.38 2.04 0.05 86.36
32 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 85.96
33 INT317919 Binding of VPS26B 1 0.23 0.93 0.1 84.80
34 INT116879 Gene_expression of MAGEA4 3 0.41 5.82 0.47 84.64
35 INT331886 Gene_expression of DDX4 1 0.12 2.38 0 83.68
36 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06 83.52
37 INT317908 Binding of NCAPD3 1 0.32 0.91 0.1 82.44
38 INT120011 Localization of MIF 6 0.58 5.72 2.6 81.68
39 INT120165 Binding of NTM 2 0.47 2.23 0.29 80.28
40 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 80.12
41 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 79.84
42 INT17574 Binding of CISH 23 0.31 4.3 0.93 79.36
43 INT1793 Localization of CGA 379 0.81 67.38 114.69 79.20
44 INT282576 Negative_regulation of Gene_expression of POU5F1 12 0.43 2.79 0.16 77.76
45 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05 77.12
46 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 75.00
47 INT192612 Regulation of Gene_expression of Hba-a1 1 0.07 0.99 0 72.44
48 INT192611 Negative_regulation of Gene_expression of Hba-a1 1 0.07 0.86 0 72.44
49 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 71.88
50 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 71.68
51 INT281255 Positive_regulation of Negative_regulation of CDY1 1 0.28 1.64 0 69.88
52 INT281257 Positive_regulation of Positive_regulation of DAZ1 1 0.16 1.58 0 69.88
53 INT204254 Localization of KIT 8 0.73 6.78 0.61 68.24
54 INT281252 Positive_regulation of DAZ1 1 0.16 1.56 0 67.96
55 INT281258 Negative_regulation of CDY1 1 0.23 1.61 0 67.16
56 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 61.96
57 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12 55.00
58 INT163290 Binding of MIF 9 0.31 7.57 2.8 55.00
59 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 50.00
60 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 50.00
61 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66 50.00
62 INT125431 Regulation of Scgb1d2 1 0.25 0 0 50.00
63 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 49.60
64 INT96649 Gene_expression of ARSA 5 0.65 2.82 0.8 49.44
65 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 49.28
66 INT211758 Binding of Mmd 1 0.13 3.09 0.1 49.04
67 INT182293 Binding of MAPK8 11 0.34 4.6 0.77 48.64
68 INT317909 Binding of MAPK8IP2 1 0.31 0.84 0.03 48.64
69 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 47.68
70 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 47.20
71 INT317918 Gene_expression of MAPK8IP2 2 0.59 1.43 0.09 44.80
72 INT317917 Gene_expression of RABL2B 1 0.61 0.68 0.03 44.00
73 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 43.36
74 INT317913 Gene_expression of SHANK3 1 0.64 2.19 0.13 42.96
75 INT26585 Gene_expression of Vim 117 0.77 39.97 6 41.44
76 INT214056 Negative_regulation of NSD1 3 0.43 3.44 0.09 37.96
77 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 36.28
78 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 33.16
79 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 33.16
80 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64 32.96
81 INT192617 Binding of Atrx 1 0.48 0.58 0 26.96
82 INT214055 Gene_expression of NSD1 8 0.67 4.46 0 26.56
83 INT317907 Gene_expression of DLGAP2 1 0.63 0.85 0 25.92
84 INT81155 Localization of CDCP1 5 0.08 4.49 1.4 23.80
85 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 18.20
86 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39 6.64
87 INT183549 Localization of DFNB31 1 0.01 0.24 0 5.04
88 INT183548 Localization of SLC9A1 1 0.01 0.24 0 5.04
89 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
90 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
91 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
92 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
93 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
94 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
95 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
96 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
97 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
98 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
99 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 5.00
100 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
101 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
102 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
103 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
104 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
105 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
106 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
107 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
108 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
109 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
110 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
111 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
112 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
113 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
114 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 5.00
115 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 5.00
116 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
117 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
118 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
119 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
120 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
121 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
122 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
123 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
124 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
125 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04 5.00
126 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
127 INT62861 Regulation of Gria2 45 0.60 13.35 16.07 5.00
128 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
129 INT115614 Binding of Gria2 25 0.43 8.97 9.91 5.00
130 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21 5.00
131 INT15189 Localization of Npy 26 0.79 9.09 8.28 5.00
132 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
133 INT131359 Positive_regulation of Gene_expression of Cd4 40 0.58 22.43 7.53 5.00
134 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 5.00
135 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
136 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
137 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
138 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
139 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
140 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
141 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
142 INT112102 Regulation of Gene_expression of Gria2 14 0.55 5.4 5.55 5.00
143 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 5.00
144 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 5.00
145 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89 5.00
146 INT111739 Negative_regulation of Npy 15 0.43 4.9 4.65 5.00
147 INT114499 Gene_expression of MCPH1 38 0.67 26.68 4.55 5.00
148 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
149 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
150 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93 5.00
151 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91 5.00
152 INT81213 Binding of Gpm6a 6 0.35 0.72 3.87 5.00
153 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 5.00
154 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 5.00
155 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 5.00
156 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49 5.00
157 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
158 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41 5.00
159 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 5.00
160 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
161 INT12033 Binding of PLOD1 15 0.48 8.04 2.3 5.00
162 INT147233 Gene_expression of Ascc1 3 0.39 0.38 2.03 5.00
163 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 5.00
164 INT58691 Positive_regulation of Gene_expression of CD8A 26 0.50 15.19 1.97 5.00
165 INT48787 Regulation of GRIA1 5 0.27 1.28 1.88 5.00
166 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
167 INT84722 Regulation of Gene_expression of AR 20 0.61 7.73 1.69 5.00
168 INT7033 Binding of FSHR 19 0.37 6.66 1.52 5.00
169 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 5.00
170 INT216123 Negative_regulation of Cd68 2 0.41 1.96 1.48 5.00
171 INT70860 Binding of SNRPB 17 0.35 7 1.46 5.00
172 INT140245 Binding of Gli3 3 0.36 2.65 1.46 5.00
173 INT48269 Negative_regulation of FANCB 16 0.56 5.34 1.38 5.00
174 INT183557 Localization of GABRB3 3 0.46 1.01 1.34 5.00
175 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32 5.00
176 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31 5.00
177 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 5.00
178 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 5.00
179 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 5.00
180 INT282572 Positive_regulation of POU5F1 24 0.70 5.8 1.13 5.00
181 INT19044 Positive_regulation of GGT5 10 0.65 7.7 1.11 5.00
182 INT122474 Negative_regulation of Npy1r 3 0.42 1.71 1.1 5.00
183 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 5.00
184 INT177392 Binding of Npy1r 2 0.47 1.14 0.98 5.00
185 INT42425 Gene_expression of Mmd 2 0.75 1.68 0.91 5.00
186 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 5.00
187 INT171100 Gene_expression of Rrad 7 0.75 6.64 0.85 5.00
188 INT255101 Positive_regulation of Celf1 23 0.56 11.91 0.84 5.00
189 INT147234 Negative_regulation of Ascc1 2 0.29 0.52 0.83 5.00
190 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 5.00
191 INT199812 Localization of CTSL1 2 0.30 0.16 0.73 5.00
192 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71 5.00
193 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
194 INT166140 Binding of Rrad 2 0.12 3.54 0.6 5.00
195 INT255120 Gene_expression of Celf1 29 0.62 10.82 0.59 5.00
196 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58 5.00
197 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 5.00
198 INT272475 Regulation of Mbnl1 15 0.61 5.39 0.56 5.00
199 INT272471 Binding of Celf1 5 0.39 4.97 0.56 5.00
200 INT255131 Gene_expression of Mbnl1 34 0.77 10.44 0.55 5.00
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