D:Crystal Associated Disease

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Disease Term
Synonyms Acute Synovitis, BASIC CALCIUM PHOSPHATE DEPOSITION, BPC DEPOSITION, Calcific Periarthritis, Calcium Pyrophosphate Dihydrate Crystal Deposition, CHRONIC TOPHACEOUS GOUT, Cppd Crystal Deposition, Crystalline Arthritis, Gout, Gouty Arthritis, Monosodium Urate
Documents 1096
Hot Single Events 200
Hot Interactions 35

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Crystal Associated Disease. They are ordered first by their relevance to Crystal Associated Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT316695 Binding of Il1 and gout 1 0.00 1.55 0.62 100.00
2 INT171125 Il1 Positive_regulation of Localization of TNF 1 0.00 1.22 0.41 100.00
3 INT291625 Binding of CSTA and RAPGEF5 1 0.03 4.81 0.37 99.84
4 INT209918 Positive_regulation of Nlrp3 Positive_regulation of Localization of Il1 1 0.42 1.06 0.4 99.80
5 INT240119 Prok2 Regulation of Trem1 1 0.04 0.66 0.13 99.16
6 INT240121 Hdc Regulation of Trem1 1 0.06 0.66 0.13 99.16
7 INT240120 Irg1 Regulation of Trem1 1 0.05 0.66 0.13 99.16
8 INT219193 Nlrp3 Positive_regulation of Positive_regulation of NLRP3 1 0.24 1.03 0.26 98.44
9 INT219156 NLRP3 Positive_regulation of IL1B 1 0.01 1.03 0.27 98.12
10 INT219194 Nlrp3 Positive_regulation of IL1B 1 0.04 1.03 0.26 97.88
11 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52 96.92
12 INT150244 POMC Positive_regulation of Mc3r Regulation of POMC 1 0.03 0.88 0.52 96.92
13 INT219151 IL18 Positive_regulation of CASP1 1 0.01 1.05 0.3 96.44
14 INT194537 Binding of PAEP and Uox 1 0.10 1.12 0.14 96.28
15 INT278398 Hps5 Positive_regulation of Nlrp3 1 0.26 1.38 0.16 95.40
16 INT324347 Binding of UMOD and Scr 1 0.20 2.23 0 93.88
17 INT264521 PTGDS Negative_regulation of Positive_regulation of MMP1 1 0.06 1.42 0.34 93.16
18 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3 93.16
19 INT183698 Binding of Cxcr2 and Cxcl1 3 0.33 3.26 0.76 92.72
20 INT194516 UOX Positive_regulation of Gene_expression of PAEP 1 0.12 0.21 0 90.76
21 INT194539 UOX Positive_regulation of Gene_expression of Uox 1 0.39 0.21 0 90.76
22 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66 90.36
23 INT126766 Binding of PTGDS and PTGDR2 4 0.40 1.62 0.93 90.16
24 INT264522 Binding of GPER and PTGDS 1 0.03 1.22 0.4 90.16
25 INT264525 Binding of PTGDS and PTGFR 1 0.02 1.22 0.39 90.16
26 INT291623 Binding of CRP and CSTA 1 0.03 0.38 0 89.88
27 INT291622 HSD11B1 Regulation of CSTA 1 0.00 0.6 0.11 89.28
28 INT194538 Binding of PAEP and Negative_regulation of Uox 1 0.13 0.31 0 88.64
29 INT316689 Gene_expression of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35 85.64
30 INT316691 Negative_regulation of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35 85.64
31 INT324340 Binding of SLC12A1 and Scr 1 0.00 1.42 0 84.48
32 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 84.44
33 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95 84.44
34 INT188803 Il1 Positive_regulation of Gene_expression of Crp 1 0.03 2.95 0.94 84.44
35 INT219152 NLRP3 Positive_regulation of Positive_regulation of CASP1 1 0.02 0.83 0.1 82.96
36 INT291624 SERPINH1 Regulation of CSTA 1 0.00 0.39 0.09 79.20
37 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 79.04
38 INT288266 Binding of AFA and CRYGD 1 0.08 1.85 0.64 78.64
39 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1 77.56
40 INT278403 Hps5 Positive_regulation of Il1 1 0.04 1.48 0.24 77.52
41 INT240122 Nab2 Regulation of Egr1 1 0.09 0.59 0 74.08
42 INT279268 CARD8 Positive_regulation of CASP1 1 0.32 0.3 0 73.28
43 INT171123 TNF Positive_regulation of Localization of Spg7 1 0.01 1.35 0.46 68.08
44 INT291621 RAPGEF5 Regulation of CSTA 1 0.04 0.43 0.03 67.28
45 INT240730 Binding of CRYGD and MTRF1 4 0.03 4.18 1.39 64.84
46 INT316694 Binding of BLZF1 and Nlrp2 1 0.00 0.75 0.45 64.72
47 INT288263 Binding of AFA and MTRF1 1 0.02 1.28 0.49 60.92
48 INT278407 Hps5 Positive_regulation of Gene_expression of Darc 1 0.01 0.22 0.19 50.08
49 INT324312 Binding of GATM and UMOD 1 0.02 1.62 0 40.16
50 INT324305 Binding of CST3 and UMOD 1 0.05 3.22 0 40.16
51 INT324313 Binding of STC1 and UMOD 1 0.29 3.22 0 40.16
52 INT324311 Binding of UMOD and SHROOM3 1 0.29 1.62 0 40.16
53 INT324306 Binding of GATM and STC1 1 0.02 1.61 0 36.32
54 INT324310 Binding of STC1 and SHROOM3 1 0.24 1.61 0 36.32
55 INT324309 Binding of CST3 and GATM 1 0.00 1.6 0 33.44
56 INT324308 Binding of CST3 and SHROOM3 1 0.04 1.6 0 33.44
57 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31 31.36
58 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45 30.00
59 INT352196 Igkv12-66 Negative_regulation of Gm10404 1 0.00 1.62 1.34 28.48
60 INT324345 Binding of STC1 and Scr 1 0.10 0.22 0 27.36
61 INT270777 Binding of DMD and BPs 1 0.01 0.33 0.09 22.56
62 INT264524 PTGDS Negative_regulation of Gene_expression of MMP1 1 0.09 0.5 0.22 14.48
63 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22 14.48
64 INT264517 PTGDS Positive_regulation of TFDP1 1 0.17 0.5 0.22 14.48
65 INT264516 PTGDS Positive_regulation of TFDP1 Negative_regulation of Gene_expression of MMP1 1 0.02 0.5 0.22 14.48
66 INT264519 PTGDS Negative_regulation of Positive_regulation of TFDP1 1 0.15 0.5 0.22 14.48
67 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31 13.32
68 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14 13.04
69 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03 10.32
70 INT326605 Binding of HTR1A and KCNH2 1 0.00 0.45 0.14 6.88
71 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28 5.20
72 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 5.00
73 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92 5.00
74 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89 5.00
75 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78 5.00
76 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78 5.00
77 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 5.00
78 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95 5.00
79 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
80 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87 5.00
81 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
82 INT221034 IL10 Positive_regulation of Localization of CCL18 1 0.19 1.3 0.84 5.00
83 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81 5.00
84 INT355704 Binding of Cia1 and Aia1 1 0.00 1.85 0.77 5.00
85 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76 5.00
86 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75 5.00
87 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75 5.00
88 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75 5.00
89 INT178575 CNTN2 Positive_regulation of PTHLH Positive_regulation of Positive_regulation of PTHLH 1 0.26 2.16 0.75 5.00
90 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73 5.00
91 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7 5.00
92 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 5.00
93 INT309663 Binding of Cia1 and Aia1 1 0.00 1.31 0.64 5.00
94 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64 5.00
95 INT310712 Gabrg1 Positive_regulation of Gene_expression of PMP22 1 0.35 0.56 0.61 5.00
96 INT327992 TRPV1 Positive_regulation of Gene_expression of ROS1 1 0.28 0.35 0.6 5.00
97 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56 5.00
98 INT203033 Cnr1 Regulation of Cnr2 1 0.15 0.29 0.56 5.00
99 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56 5.00
100 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56 5.00
101 INT310701 RPLP0 Regulation of Positive_regulation of PGR 1 0.01 0.49 0.53 5.00
102 INT221033 TNF Positive_regulation of Gene_expression of CCL18 1 0.29 0.76 0.52 5.00
103 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 5.00
104 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 5.00
105 INT203150 Binding of Ighg2b and IgG2a 1 0.11 1.35 0.47 5.00
106 INT288265 Binding of FLG and NEUROG1 1 0.02 1.06 0.46 5.00
107 INT327995 Positive_regulation of TRPV1 Positive_regulation of Tnfrsf1a 1 0.16 0.63 0.46 5.00
108 INT310711 Binding of RPLP0 and Gabrg1 1 0.04 0.37 0.45 5.00
109 INT221026 ELANE Positive_regulation of Gene_expression of CCL18 1 0.01 0.57 0.45 5.00
110 INT221024 TNF Negative_regulation of Gene_expression of CCL18 1 0.18 0.8 0.44 5.00
111 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4 5.00
112 INT221027 ELANE Positive_regulation of IL8 2 0.14 1.3 0.4 5.00
113 INT327991 Positive_regulation of TRPV1 Positive_regulation of ROS1 1 0.26 0.2 0.4 5.00
114 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39 5.00
115 INT203140 Binding of C5ar1 and C5 1 0.39 0.81 0.38 5.00
116 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38 5.00
117 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36 5.00
118 INT203151 Binding of Rnase1 and Trav6-3 1 0.03 1.51 0.36 5.00
119 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34 5.00
120 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32 5.00
121 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31 5.00
122 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28 5.00
123 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27 5.00
124 INT346196 AMELX Negative_regulation of CRP 1 0.04 0.36 0.26 5.00
125 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26 5.00
126 INT188802 Il1 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.71 0.26 5.00
127 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 5.00
128 INT310700 PGR Regulation of Gene_expression of RPLP0 1 0.01 0.37 0.25 5.00
129 INT171126 Lta Positive_regulation of NOSTRIN 1 0.01 0.76 0.24 5.00
130 INT171124 Spg7 Positive_regulation of NOSTRIN 1 0.01 0.76 0.24 5.00
131 INT221022 IL10 Positive_regulation of CCL18 1 0.19 0.38 0.22 5.00
132 INT278390 Hps5 Positive_regulation of Darc 1 0.01 0.49 0.22 5.00
133 INT278391 Hps5 Positive_regulation of Hrec 1 0.01 0.5 0.22 5.00
134 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21 5.00
135 INT219153 IL6 Positive_regulation of IL23A 1 0.02 0.45 0.21 5.00
136 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21 5.00
137 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2 5.00
138 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 5.00
139 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2 5.00
140 INT221020 IL13 Positive_regulation of Gene_expression of CCL18 1 0.06 0.12 0.19 5.00
141 INT221023 IL13 Positive_regulation of Gene_expression of IL10 1 0.01 0.13 0.19 5.00
142 INT221017 IL4 Positive_regulation of Gene_expression of CCL18 1 0.05 0.13 0.19 5.00
143 INT221021 IL4 Positive_regulation of Gene_expression of IL10 1 0.01 0.13 0.19 5.00
144 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 5.00
145 INT221032 IL10 Positive_regulation of Gene_expression of CCL18 1 0.14 0.13 0.19 5.00
146 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19 5.00
147 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18 5.00
148 INT221025 TNF Positive_regulation of ELANE 1 0.01 0.13 0.17 5.00
149 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15 5.00
150 INT221030 ELANE Positive_regulation of CXCL10 1 0.01 0.24 0.15 5.00
151 INT278394 Myd88 Regulation of Phosphorylation of Hps5 1 0.11 0.35 0.15 5.00
152 INT221035 ELANE Positive_regulation of CCL18 1 0.01 0.24 0.15 5.00
153 INT221019 ELANE Positive_regulation of CCL3 1 0.00 0.24 0.15 5.00
154 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14 5.00
155 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14 5.00
156 INT221031 IL10 Positive_regulation of Binding of TNF 1 0.05 0.28 0.14 5.00
157 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14 5.00
158 INT267973 Binding of CHKB and ESR1 1 0.02 1.67 0.13 5.00
159 INT352488 Binding of EPO and TNFRSF1A 1 0.14 0.18 0.12 5.00
160 INT219157 Binding of KLRB1 and CLEC2D 1 0.02 0.41 0.12 5.00
161 INT269784 Crp Positive_regulation of Vcam1 1 0.00 1.6 0.11 5.00
162 INT278397 Hps5 Positive_regulation of Tlr9 1 0.15 0.21 0.11 5.00
163 INT269783 Crp Positive_regulation of Sele 1 0.00 1.69 0.11 5.00
164 INT269785 Crp Positive_regulation of ICAM1 1 0.00 1.68 0.11 5.00
165 INT309662 C5 Positive_regulation of Akt1 1 0.30 0.43 0.11 5.00
166 INT258517 Negative_regulation of CPOX Negative_regulation of Binding of PTGIR 1 0.04 0.33 0.1 5.00
167 INT219155 Binding of HLA-G and LILRB2 1 0.15 0.23 0.1 5.00
168 INT219150 Binding of CXCL11 and CXCR7 1 0.09 1.77 0.09 5.00
169 INT278378 Hps5 Positive_regulation of Gene_expression of S100a8 1 0.00 0.42 0.09 5.00
170 INT278371 Binding of Il1 and Hps5 1 0.02 0.44 0.09 5.00
171 INT278368 Regulation of Binding of Il1 and Hps5 1 0.02 0.44 0.09 5.00
172 INT342232 Binding of POR and SEPP1 1 0.02 0.75 0.08 5.00
173 INT221016 TNF Positive_regulation of CCL18 1 0.29 0.15 0.08 5.00
174 INT221028 Binding of TNF and Positive_regulation of CCL18 1 0.21 0.15 0.08 5.00
175 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08 5.00
176 INT342231 Binding of SEPP1 and ARC 1 0.04 3.84 0.08 5.00
177 INT278376 Negative_regulation of Casp1 Negative_regulation of Hps5 1 0.05 0.05 0.08 5.00
178 INT342230 Binding of ARC and PKD1P4 1 0.01 5.72 0.07 5.00
179 INT267998 Binding of XDH and Nos1 1 0.02 0.46 0.06 5.00
180 INT332269 Cndp2 Negative_regulation of Tenc1 1 0.41 0.8 0.05 5.00
181 INT229711 Positive_regulation of Nr4a3 Regulation of Ins1 1 0.01 0.29 0.05 5.00
182 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05 5.00
183 INT229712 Nr4a3 Regulation of Ins1 1 0.01 0.29 0.05 5.00
184 INT219149 FBXO8 Positive_regulation of Localization of IL10 1 0.01 0.14 0.05 5.00
185 INT219195 Binding of PDC and fc 1 0.01 0.24 0.04 5.00
186 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03 5.00
187 INT270775 PTH Regulation of DMD 1 0.09 0.64 0.03 5.00
188 INT270776 PTH Regulation of Negative_regulation of DMD 1 0.09 0.3 0.03 5.00
189 INT278408 Hps5 Positive_regulation of Localization of Ctsb 1 0.05 0.11 0.03 5.00
190 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0 5.00
191 INT300191 Binding of C1S and HSD11B1 1 0.13 1.75 0 5.00
192 INT278385 Binding of Pycard and Nlrp3 1 0.06 0 0 5.00
193 INT324342 UMOD Positive_regulation of Scr 1 0.17 1.29 0 5.00
194 INT278369 Ctsb Positive_regulation of Casp1 1 0.03 0 0 5.00
195 INT332268 Binding of Cndp2 and Tenc1 1 0.05 0.17 0 5.00
196 INT300195 Binding of C1S and CHDH 1 0.23 2.51 0 5.00
197 INT278374 Msu Positive_regulation of Phosphorylation of Gopc 1 0.14 0.21 0 5.00
198 INT278384 Il1 Negative_regulation of Ctsb 1 0.01 0.12 0 5.00
199 INT229713 Binding of Agt and Ren 1 0.14 0 0 5.00
200 INT342229 SEPP1 Regulation of ARC 1 0.03 0.44 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Crystal Associated Disease. They are ordered first by their pain relevance and then by number of times they were reported in Crystal Associated Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 100.00
2 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 100.00
3 INT191589 Gene_expression of Msu 9 0.46 7.08 1.33 100.00
4 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 100.00
5 INT220273 Positive_regulation of Msu 9 0.33 5.83 1.41 100.00
6 INT144086 Positive_regulation of Prok2 12 0.69 9.54 6.06 100.00
7 INT240106 Positive_regulation of Irg1 1 0.44 3.68 0.17 100.00
8 INT254316 Binding of Msu 3 0.29 6.39 1.37 100.00
9 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 100.00
10 INT209913 Regulation of Msu 2 0.32 2.42 0.64 100.00
11 INT222847 Gene_expression of Irg1 2 0.49 2.38 0.51 100.00
12 INT344602 Negative_regulation of GOUT1 1 0.11 1.2 0.25 100.00
13 INT209917 Localization of Msu 2 0.45 1.81 0.66 100.00
14 INT220276 Negative_regulation of Msu 2 0.16 1.67 0.58 100.00
15 INT149816 Gene_expression of Prok2 21 0.78 18.99 15.68 100.00
16 INT344605 Binding of Tfg 1 0.07 0.81 0 100.00
17 INT220277 Negative_regulation of Positive_regulation of Msu 1 0.14 0.92 0.17 100.00
18 INT316693 Binding of gout 1 0.01 1.17 0.4 100.00
19 INT240108 Positive_regulation of Gene_expression of Msu 1 0.19 0.7 0 100.00
20 INT344606 Negative_regulation of Gene_expression of Tfg 1 0.08 0.6 0.12 100.00
21 INT240115 Regulation of Positive_regulation of Msu 1 0.17 0.5 0.03 100.00
22 INT344603 Negative_regulation of Tfg 1 0.08 0.6 0.12 100.00
23 INT344607 Gene_expression of Tfg 1 0.13 0.6 0.12 100.00
24 INT187095 Negative_regulation of Positive_regulation of Il1 8 0.14 6.17 1.82 100.00
25 INT223029 Gene_expression of gout 1 0.65 1.08 0 100.00
26 INT316686 Negative_regulation of Spg21 2 0.05 3.34 0.8 99.96
27 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 99.96
28 INT3811 Negative_regulation of PAEP 36 0.50 23.7 5.18 99.92
29 INT2836 Positive_regulation of PAEP 51 0.67 26.69 4.57 99.88
30 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.84
31 INT3837 Negative_regulation of su 5 0.40 3.39 1.36 99.84
32 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 99.84
33 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 99.82
34 INT53236 Positive_regulation of Binding of Il1 5 0.40 3.84 1.41 99.82
35 INT63719 Positive_regulation of Transcription of Hdc 3 0.52 3.91 1.01 99.80
36 INT240110 Positive_regulation of Positive_regulation of Trem1 1 0.25 0.9 0.19 99.80
37 INT20129 Regulation of Il1 53 0.53 44.14 19.89 99.76
38 INT194521 Negative_regulation of Uox 7 0.52 4.93 0.41 99.76
39 INT248072 Gene_expression of SLC2A9 1 0.76 2.91 0.06 99.76
40 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 99.70
41 INT27628 Gene_expression of IL2RG 28 0.75 20.95 6.16 99.68
42 INT19775 Localization of Il1 183 0.78 145.5 50.91 99.66
43 INT25607 Binding of Il1 82 0.47 64.4 23.9 99.66
44 INT63716 Transcription of Hdc 10 0.69 7.57 1.82 99.64
45 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.64
46 INT97596 Localization of S100a8 94 0.78 90.69 40.41 99.62
47 INT6991 Negative_regulation of Ptgds 5 0.55 3.83 1.32 99.62
48 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 99.58
49 INT146142 Positive_regulation of Trem1 11 0.44 7.75 1.46 99.56
50 INT3835 Positive_regulation of su 10 0.62 4.04 6.19 99.56
51 INT254317 Negative_regulation of Pycard 5 0.42 3.13 0.45 99.50
52 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 99.50
53 INT63037 Regulation of CSTA 10 0.37 13.37 0.92 99.48
54 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 99.44
55 INT82709 Negative_regulation of Slc37a4 17 0.34 3.41 8.6 99.38
56 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 99.36
57 INT194520 Gene_expression of Uox 8 0.60 3.72 0.25 99.36
58 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 99.34
59 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 99.34
60 INT294991 Negative_regulation of ABCC8 1 0.17 3.08 0.18 99.32
61 INT63035 Gene_expression of CSTA 10 0.56 11.56 0.57 99.32
62 INT320096 Negative_regulation of SAE1 10 0.12 3.85 0.59 99.28
63 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 99.28
64 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 99.22
65 INT163980 Gene_expression of Hdc 12 0.65 4.47 1.96 99.16
66 INT134264 Gene_expression of Trem1 18 0.43 13.26 2.72 99.16
67 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 99.08
68 INT15981 Positive_regulation of Positive_regulation of NLRP3 2 0.44 1.02 0.62 99.04
69 INT219136 Positive_regulation of Positive_regulation of Nlrp3 3 0.49 2.61 0.58 99.04
70 INT301934 Regulation of UCK2 1 0.02 1.74 0.19 99.04
71 INT224149 Negative_regulation of Trem1 2 0.37 3.44 0.56 99.00
72 INT3496 Negative_regulation of HPRT1 7 0.58 25.05 1.92 98.96
73 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43 98.96
74 INT8541 Gene_expression of Csrp1 42 0.76 23.72 6.9 98.96
75 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 98.92
76 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.92
77 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 98.92
78 INT2562 Positive_regulation of Gusb 9 0.69 2.92 1.59 98.92
79 INT4125 Gene_expression of Gusb 6 0.62 2.32 2.13 98.92
80 INT58632 Negative_regulation of Il1f5 3 0.13 3.5 0.96 98.88
81 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 98.80
82 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93 98.80
83 INT219135 Positive_regulation of Gene_expression of Nlrp3 4 0.49 3.52 0.93 98.76
84 INT126759 Negative_regulation of Nlrp3 5 0.41 2.95 1.58 98.76
85 INT23171 Negative_regulation of NLRP3 7 0.37 4.15 1.53 98.76
86 INT219134 Negative_regulation of Positive_regulation of Nlrp3 2 0.41 1.42 0.3 98.76
87 INT219173 Negative_regulation of Gene_expression of NLRP3 1 0.19 1.02 0.26 98.76
88 INT219174 Negative_regulation of Positive_regulation of NLRP3 1 0.19 1.02 0.26 98.76
89 INT219133 Negative_regulation of Gene_expression of Nlrp3 1 0.41 1.02 0.26 98.76
90 INT168447 Positive_regulation of Localization of Nlrp3 3 0.49 0.78 0.03 98.76
91 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 98.72
92 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 98.70
93 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.68
94 INT9140 Negative_regulation of PFKM 14 0.59 12.67 3.61 98.68
95 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 98.68
96 INT22916 Negative_regulation of CR1 12 0.57 6.31 2.42 98.68
97 INT53572 Negative_regulation of Localization of Il1 18 0.40 12.78 6.7 98.64
98 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 98.64
99 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 98.62
100 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68 98.60
101 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 98.54
102 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 98.48
103 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4 98.46
104 INT168448 Localization of Nlrp3 5 0.73 3.75 0.58 98.46
105 INT20550 Gene_expression of Vwa2 8 0.04 4.29 2.14 98.46
106 INT48081 Localization of Il1b 46 0.80 21.59 22.4 98.44
107 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 98.44
108 INT191527 Positive_regulation of Gene_expression of NLRP3 6 0.50 8.65 1.15 98.44
109 INT316692 Regulation of Localization of TGFB2 1 0.03 1.13 0.3 98.36
110 INT240117 Negative_regulation of Gzmd 1 0.13 0.66 0.15 98.32
111 INT184351 Localization of Hc 2 0.20 2.33 0.83 98.18
112 INT316114 Gene_expression of SAE1 6 0.14 2.95 0.09 98.16
113 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 98.12
114 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 98.12
115 INT205656 Regulation of UOX 2 0.44 1.3 0.04 98.12
116 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 98.08
117 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 98.08
118 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 98.04
119 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 98.04
120 INT130047 Localization of TGFB2 3 0.16 3.65 0.53 98.04
121 INT160420 Regulation of Gene_expression of su 1 0.31 0.68 0.16 97.92
122 INT3836 Gene_expression of su 8 0.46 2.8 2.32 97.92
123 INT205652 Localization of UOX 1 0.50 1.74 0.06 97.92
124 INT173927 Positive_regulation of Negative_regulation of Il1 2 0.35 1.13 0.34 97.80
125 INT69866 Positive_regulation of Ptgds 26 0.70 16.25 8.33 97.76
126 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11 97.72
127 INT3834 Regulation of su 3 0.18 1.85 1.16 97.64
128 INT96073 Localization of Casp1 11 0.78 4.91 1.29 97.56
129 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 97.52
130 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 97.52
131 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 97.52
132 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 97.52
133 INT50083 Binding of SLC12A1 2 0.01 1.01 0.15 97.44
134 INT185406 Regulation of ABCC8 2 0.13 2.21 0.05 97.42
135 INT169717 Binding of NLRX1 1 0.05 1.45 0.32 97.36
136 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 97.36
137 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 97.36
138 INT14888 Gene_expression of PSS 9 0.66 6.9 1.65 97.20
139 INT19804 Negative_regulation of Hprt 18 0.59 20.6 2.17 97.16
140 INT240112 Transcription of Trem1 1 0.43 1.52 0.59 97.16
141 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67 97.08
142 INT695 Binding of POMC 304 0.48 56.66 126.85 97.04
143 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 96.96
144 INT109580 Positive_regulation of Mc3r 2 0.48 1.09 0.69 96.92
145 INT6484 Binding of IL1B 122 0.47 75.84 35.07 96.88
146 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 96.88
147 INT240114 Transcription of Irg1 1 0.44 0.7 0.36 96.84
148 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61 96.84
149 INT46407 Binding of ATN1 4 0.36 5.85 1.81 96.80
150 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 96.64
151 INT91711 Transcription of Prok2 3 0.65 1.03 0.66 96.60
152 INT248076 Binding of SLC2A9 1 0.47 2.24 0 96.52
153 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 96.52
154 INT35175 Localization of IL18 18 0.80 12.96 3.83 96.44
155 INT248314 Negative_regulation of Slc22a12 1 0.01 1.47 0.04 96.40
156 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 96.32
157 INT48544 Negative_regulation of Olr1469 3 0.31 0.98 4.2 96.32
158 INT267995 Negative_regulation of Negative_regulation of XDH 2 0.30 0.77 0.15 96.24
159 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 96.16
160 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 96.16
161 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 96.12
162 INT261239 Binding of XDH 10 0.34 3.16 0.31 96.08
163 INT320095 Negative_regulation of Binding of XDH 1 0.16 0.46 0.1 96.08
164 INT19947 Negative_regulation of B3GAT2 10 0.57 4.2 7.95 96.04
165 INT181489 Localization of Spg21 16 0.12 10.89 6.84 96.00
166 INT248313 Positive_regulation of Slc22a12 1 0.02 1.55 0.04 95.76
167 INT65642 Binding of Dync1h1 27 0.41 15.83 2.68 95.72
168 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 95.68
169 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 95.68
170 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 95.68
171 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 95.68
172 INT61845 Transcription of Homer1 9 0.72 2.28 1.85 95.64
173 INT97312 Gene_expression of S100a8 19 0.78 16.26 8.88 95.64
174 INT69929 Gene_expression of S100a9 11 0.77 16.12 5.79 95.64
175 INT97618 Positive_regulation of Gene_expression of S100a8 6 0.70 3.2 1.97 95.64
176 INT148319 Positive_regulation of Gene_expression of S100a9 1 0.50 0.74 0.4 95.64
177 INT11386 Positive_regulation of RAE1 3 0.11 1.53 0.83 95.60
178 INT194523 Localization of Uox 1 0.30 0.42 0 95.32
179 INT49985 Transcription of Il6 62 0.72 40.13 20.29 95.16
180 INT52197 Negative_regulation of Transcription of Il6 8 0.43 3.8 2.05 95.16
181 INT205657 Negative_regulation of FUS 3 0.21 6.61 0.14 95.16
182 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 95.12
183 INT57008 Positive_regulation of HPRT1 11 0.50 2.81 0.74 95.04
184 INT20275 Negative_regulation of Abo 13 0.20 4.62 4.02 94.88
185 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 94.80
186 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 94.72
187 INT49404 Binding of Itgal 11 0.36 9.16 1.53 94.64
188 INT294994 Negative_regulation of Gene_expression of ABCC8 1 0.12 1.28 0.07 94.60
189 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 94.56
190 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 94.34
191 INT35028 Positive_regulation of IL2RG 14 0.47 10.05 4.36 94.32
192 INT36052 Positive_regulation of Gene_expression of IL2RG 7 0.28 4.72 2.32 94.32
193 INT9655 Regulation of Il6 98 0.62 70.92 31.95 94.24
194 INT110564 Transcription of Hprt 5 0.37 0.82 0.15 94.24
195 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 94.12
196 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02 94.12
197 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64 94.12
198 INT194343 Gene_expression of ABCC8 8 0.65 8.15 0.77 94.08
199 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 94.08
200 INT92260 Binding of Nlrp3 14 0.46 8.94 2.13 93.84
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