D:Cutaneous Melanoma

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Disease Term
Synonyms CUTANEOUS MALIGNANT MELANOMA, Cutaneous Malignant Melanomas, Cutaneous Melanomas, Malignant Melanoma Of Skin, Malignant Melanomas Of Skin, Melanoma Of Skin, MELANOMAS OF SKIN, Skin Melanoma, Skin Melanomas
Documents 82
Hot Single Events 25
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cutaneous Melanoma. They are ordered first by their relevance to Cutaneous Melanoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57 99.20
2 INT160829 Tyr Regulation of RYBP 1 0.04 0.75 0.53 35.44
3 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
4 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
5 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
6 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
7 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
8 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
9 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
10 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
11 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
12 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0 5.00
13 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
14 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0 5.00
15 INT248387 CHD5 Regulation of Gene_expression of TP53 1 0.20 0.83 0 5.00
16 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cutaneous Melanoma. They are ordered first by their pain relevance and then by number of times they were reported in Cutaneous Melanoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 99.64
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 99.34
3 INT161378 Binding of BRAF 1 0.08 2.24 0.48 99.20
4 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 98.84
5 INT84712 Regulation of MC1R 36 0.62 9.34 16.91 98.76
6 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76 98.60
7 INT139549 Positive_regulation of Mc1r 2 0.17 0.7 0.94 97.84
8 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 97.28
9 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 96.84
10 INT124944 Regulation of KIT 15 0.60 11.84 0.24 96.76
11 INT197766 Binding of Sln 5 0.32 1.6 0.25 96.04
12 INT19359 Binding of BRCA2 5 0.47 2.63 0.19 92.64
13 INT263905 Gene_expression of SLN 33 0.63 23.21 0.74 92.24
14 INT263904 Negative_regulation of Gene_expression of SLN 1 0.14 7.18 0.47 92.24
15 INT97264 Binding of Mc1r 9 0.36 4.27 4.53 91.36
16 INT21737 Binding of MC1R 129 0.48 45.45 56.54 90.20
17 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99 89.84
18 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 89.64
19 INT64450 Gene_expression of Mc1r 13 0.77 9.22 5.43 87.24
20 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 86.00
21 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 86.00
22 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 84.56
23 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 83.28
24 INT79016 Gene_expression of Gstt1 4 0.44 0.59 0.7 83.28
25 INT236620 Regulation of BRAF 2 0.46 1.96 0 81.84
26 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 77.92
27 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75 77.92
28 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 77.80
29 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 76.32
30 INT443 Localization of POMC 1020 0.81 284.52 443.17 75.00
31 INT695 Binding of POMC 304 0.48 56.66 126.85 75.00
32 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 75.00
33 INT92075 Regulation of GSTM1 12 0.50 16.18 2.27 75.00
34 INT51137 Negative_regulation of GSTM1 39 0.43 14.74 6.5 75.00
35 INT143357 Binding of Ros1 48 0.36 27.76 6 62.56
36 INT18774 Gene_expression of RYBP 67 0.65 47.66 37.59 58.24
37 INT68181 Binding of Nf1 6 0.48 8.14 1.88 51.76
38 INT248395 Regulation of CHD5 1 0.24 0.96 0 38.88
39 INT248392 Positive_regulation of Gene_expression of CHD5 1 0.45 0.87 0 30.92
40 INT248394 Gene_expression of CHD5 1 0.70 2.3 0 30.92
41 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 29.96
42 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 28.12
43 INT248391 Positive_regulation of Gene_expression of Cdkn2d 1 0.05 0.85 0 28.12
44 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38 27.84
45 INT248390 Negative_regulation of Gene_expression of Cdkn2d 2 0.31 0.8 0 27.84
46 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 27.44
47 INT224579 Gene_expression of Cdkn2d 6 0.41 4.23 0.68 27.44
48 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15 24.44
49 INT185370 Gene_expression of ANC 28 0.65 13.28 0.4 10.56
50 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 8.48
51 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
52 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
53 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
54 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
55 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
56 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
57 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
58 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
59 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
60 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
61 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 5.00
62 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
63 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
64 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
65 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
66 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
67 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 5.00
68 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
69 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 5.00
70 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
71 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
72 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
73 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
74 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
75 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
76 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
77 INT2491 Regulation of Cea 38 0.61 26.18 10.95 5.00
78 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
79 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
80 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89 5.00
81 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
82 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 5.00
83 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 5.00
84 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
85 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
86 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
87 INT17182 Binding of Cea 25 0.48 14.98 4.16 5.00
88 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28 5.00
89 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 5.00
90 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
91 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21 5.00
92 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 5.00
93 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
94 INT104524 Localization of FSCN1 3 0.13 1.76 1.75 5.00
95 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
96 INT113147 Positive_regulation of Acta2 6 0.34 4.24 1.66 5.00
97 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 5.00
98 INT214073 Binding of TSC1 9 0.37 22 1.34 5.00
99 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 5.00
100 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 5.00
101 INT166261 Localization of SLN 2 0.66 1.23 1.07 5.00
102 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04 5.00
103 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 5.00
104 INT263912 Positive_regulation of SLN 6 0.39 0.66 0.99 5.00
105 INT96649 Gene_expression of ARSA 5 0.65 2.82 0.8 5.00
106 INT61910 Binding of Slc3a2 6 0.01 3 0.7 5.00
107 INT246036 Positive_regulation of GRN 3 0.17 2.04 0.69 5.00
108 INT179133 Localization of Nf1 2 0.80 2.18 0.68 5.00
109 INT129848 Negative_regulation of CD5 3 0.42 3.01 0.67 5.00
110 INT75043 Binding of Msx1 6 0.35 2.36 0.65 5.00
111 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
112 INT214707 Gene_expression of Slc2a8 5 0.24 2.76 0.61 5.00
113 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53 5.00
114 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
115 INT245223 Negative_regulation of Gene_expression of TLR7 3 0.37 2.81 0.5 5.00
116 INT210 Positive_regulation of Sln 10 0.43 4.06 0.49 5.00
117 INT197765 Gene_expression of Sln 26 0.58 12.11 0.45 5.00
118 INT279985 Transcription of BCL2L1 5 0.69 3.76 0.34 5.00
119 INT158766 Localization of GRN 2 0.73 1.59 0.28 5.00
120 INT166125 Gene_expression of PHOSPHO1 4 0.75 3.06 0.24 5.00
121 INT173956 Negative_regulation of Gene_expression of CTLA4 3 0.37 0.91 0.2 5.00
122 INT263884 Gene_expression of Slc2a3 2 0.18 0.86 0.19 5.00
123 INT228901 Positive_regulation of RPS6KB1 5 0.55 2.44 0.18 5.00
124 INT165361 Positive_regulation of APAF1 4 0.39 4.8 0.16 5.00
125 INT20214 Localization of Slc3a2 5 0.14 4.91 0.16 5.00
126 INT182865 Localization of ARSA 1 0.24 1.27 0.15 5.00
127 INT197627 Localization of RB1 3 0.69 4.16 0.13 5.00
128 INT263871 Negative_regulation of Car9 1 0.07 0.54 0.12 5.00
129 INT263908 Positive_regulation of Gene_expression of SLN 1 0.16 1.4 0.12 5.00
130 INT263872 Localization of Adra1d 1 0.01 2.5 0.11 5.00
131 INT228902 Gene_expression of RPS6KB1 5 0.75 2.32 0.1 5.00
132 INT165362 Gene_expression of APAF1 5 0.50 4.37 0.08 5.00
133 INT263878 Positive_regulation of Rigs1 1 0.05 2.57 0.07 5.00
134 INT223605 Negative_regulation of ARAF 5 0.05 3.87 0.05 5.00
135 INT214703 Positive_regulation of Gene_expression of Slc2a8 2 0.09 1.4 0.05 5.00
136 INT263879 Positive_regulation of Adra1d 1 0.00 0.47 0.04 5.00
137 INT263873 Positive_regulation of Gene_expression of Rigs1 1 0.05 1.27 0.03 5.00
138 INT263877 Gene_expression of Rigs1 1 0.08 11.58 0.03 5.00
139 INT228904 Positive_regulation of PHOSPHO1 1 0.45 0.84 0 5.00
140 INT263911 Localization of TMED7-TICAM2 1 0.01 1.02 0 5.00
141 INT263906 Gene_expression of TMED7-TICAM2 1 0.01 2.8 0 5.00
142 INT248393 Binding of CHD5 1 0.33 0.22 0 5.00
143 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0 5.00
144 INT263874 Regulation of Rigs1 1 0.03 1.36 0 5.00
145 INT228895 Binding of Tsc2 5 0.30 2.41 0 5.00
146 INT228899 Positive_regulation of Gene_expression of PHOSPHO1 1 0.49 0.84 0 5.00
147 INT263914 Binding of TMED7-TICAM2 1 0.01 1.56 0 5.00
148 INT308399 Gene_expression of MED23 1 0.58 1.26 0 5.00
149 INT308357 Positive_regulation of Trp53-ps 1 0.45 0.98 0 5.00
150 INT263910 Regulation of SLN 1 0.15 1.01 0 5.00
151 INT308403 Negative_regulation of Gene_expression of MED23 1 0.42 1.31 0 5.00
152 INT263883 Localization of Rigs1 1 0.08 2.36 0 5.00
153 INT228900 Positive_regulation of Gene_expression of RPS6KB1 2 0.49 1.6 0 5.00
154 INT263881 Binding of Rigs1 1 0.04 0.99 0 5.00
155 INT308398 Positive_regulation of Gene_expression of APAF1 2 0.39 1.8 0 5.00
156 INT308354 Gene_expression of Snai2 1 0.58 1.14 0 5.00
157 INT263876 Negative_regulation of Rigs1 1 0.04 0.98 0 5.00
158 INT351033 Regulation of SNRPE 1 0.12 0.81 0 5.00
159 INT308358 Positive_regulation of Gene_expression of Snai2 1 0.45 1.14 0 5.00
160 INT248397 Positive_regulation of CHD5 1 0.39 0.24 0 5.00
161 INT248389 Negative_regulation of Cdkn2d 1 0.04 1.75 0 5.00
162 INT248396 Negative_regulation of CHD5 1 0.39 0.93 0 5.00
163 INT228903 Negative_regulation of Gene_expression of PHOSPHO1 1 0.42 0.79 0 5.00
164 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0 5.00
165 INT308401 Positive_regulation of MED23 1 0.45 1.27 0 5.00
166 INT263909 Positive_regulation of Gene_expression of TMED7-TICAM2 1 0.01 0.87 0 5.00
167 INT278055 Negative_regulation of AGK 2 0.01 2.1 0 5.00
168 INT204257 Gene_expression of RTL1 3 0.08 3.09 0 5.00
169 INT263880 Regulation of Gene_expression of Rigs1 1 0.05 0.48 0 5.00
170 INT263915 Binding of SLN 2 0.12 0.81 0 5.00
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