D:Cutis Laxa

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Disease Term
Synonyms Chalastodermia, Chalazodermia, Dermatochalasia, DERMATOCHALASIS, Dermatolyses, Dermatolysis, Dermatomegaly, Generalised Dermatochalasia, GENERALISED DERMATOCHALASIS, Generalised Elastolysis, GENERALISED ELASTORRHEXIS
Documents 41
Hot Single Events 7
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cutis Laxa. They are ordered first by their relevance to Cutis Laxa and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT202930 Binding of LAMB1 and Fbln5 1 0.01 0.45 0.05 100.00
2 INT202927 Binding of Fbln2 and Fbn1 1 0.14 0.29 0.04 56.32
3 INT202928 Binding of Eln and Fbln2 1 0.11 0.29 0.04 55.04
4 INT202929 Binding of Eln and Fbln1 1 0.09 0.21 0.03 42.32

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cutis Laxa. They are ordered first by their pain relevance and then by number of times they were reported in Cutis Laxa. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT166109 Negative_regulation of Gene_expression of TIPRL 1 0.19 0.19 0 99.84
2 INT157482 Gene_expression of TIPRL 3 0.58 5.46 1.61 99.02
3 INT202918 Binding of Efemp2 1 0.37 1.23 0.14 98.60
4 INT202922 Regulation of Efemp2 1 0.45 0.67 0.12 91.92
5 INT202925 Localization of Fbln5 1 0.43 0.48 0.05 91.12
6 INT159002 Gene_expression of Fbln5 2 0.55 0.47 0.05 86.08
7 INT179664 Negative_regulation of Eln 3 0.19 2.35 0.12 80.72
8 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 76.92
9 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92 75.56
10 INT202920 Localization of Efemp2 2 0.80 1.2 0.05 63.68
11 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 62.88
12 INT179671 Binding of Eln 5 0.31 5.32 0.23 55.04
13 INT155565 Gene_expression of Efemp2 22 0.67 7.24 0.13 37.28
14 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
15 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
16 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 5.00
17 INT52179 Regulation of Lbp 39 0.61 25.4 18.32 5.00
18 INT111488 Gene_expression of HAS1 56 0.77 32.6 15.29 5.00
19 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
20 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 5.00
21 INT52924 Negative_regulation of GSR 49 0.58 28.08 9.28 5.00
22 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 5.00
23 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
24 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85 5.00
25 INT20981 Binding of HRAS 42 0.48 24.49 4.23 5.00
26 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
27 INT161960 Regulation of lg 5 0.26 1.18 2.84 5.00
28 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 5.00
29 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
30 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 5.00
31 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
32 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
33 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
34 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52 5.00
35 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
36 INT146479 Regulation of Gene_expression of HAS1 6 0.45 1.85 1.13 5.00
37 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06 5.00
38 INT181858 Binding of HYAL1 8 0.16 2.22 0.79 5.00
39 INT23468 Gene_expression of Fbn1 7 0.76 8.04 0.76 5.00
40 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 5.00
41 INT202924 Localization of Fbn1 2 0.69 1.12 0.19 5.00
42 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 5.00
43 INT334553 Localization of HAS1 1 0.11 1.07 0.09 5.00
44 INT164418 Protein_catabolism of CSH1 2 0.75 1.41 0.08 5.00
45 INT278654 Phosphorylation of SULT2A1 2 0.60 0.29 0.08 5.00
46 INT47483 Regulation of Gene_expression of CSH1 4 0.34 0.32 0.07 5.00
47 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05 5.00
48 INT183819 Negative_regulation of Positive_regulation of BCAR1 1 0.38 2.04 0.05 5.00
49 INT202921 Negative_regulation of Gene_expression of Efemp2 3 0.43 1.6 0.05 5.00
50 INT334551 Regulation of HAS1 1 0.04 0.46 0.04 5.00
51 INT334554 Positive_regulation of HAS1 1 0.07 0.46 0.04 5.00
52 INT155564 Negative_regulation of Efemp2 4 0.43 0.53 0.03 5.00
53 INT202919 Gene_expression of Fbln2 1 0.34 0.12 0 5.00
54 INT202923 Positive_regulation of Gene_expression of Efemp2 2 0.50 0.44 0 5.00
55 INT202926 Localization of Fbln2 1 0.40 0.1 0 5.00
56 INT310752 Binding of LARS 2 0.42 1.15 0 5.00
57 INT334552 Negative_regulation of Localization of HAS1 1 0.06 0.13 0 5.00
58 INT334555 Positive_regulation of Protein_catabolism of CSH1 1 0.04 0.48 0 5.00
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