D:Cystic Fibrosis

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Disease Term
Synonyms Cystic Fibrosis Disorder, Cystic Fibrosis Of Pancreas, Cystic Fibrosis Of Pancreas Disorder, Cystic Fibrosis Pancreatic, CYSTIC FIBROSIS PULMONARY, Fibrocystic Disease, Fibrocystic Disease Of Pancreas, Fibrocystic Disease Of The Pancreas, Fibrosis Cystic, Mucoviscidosis, Mucoviscidosis Of Pancreas
Documents 930
Hot Single Events 200
Hot Interactions 24

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cystic Fibrosis. They are ordered first by their relevance to Cystic Fibrosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT274697 Binding of CFTR and Cftr 1 0.08 0.69 0.27 100.00
2 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19 100.00
3 INT341622 Binding of F2 and CTRC 1 0.06 1.22 0.46 100.00
4 INT341625 Binding of SPINK1 and CTRC 1 0.41 1.22 0.46 100.00
5 INT341623 Binding of CFTR and CTRC 1 0.35 1.22 0.46 100.00
6 INT170835 Cftr Positive_regulation of Cftr Negative_regulation of Slc10a2 1 0.55 0.31 0.56 99.82
7 INT170833 Cftr Negative_regulation of Slc10a2 1 0.47 0.31 0.56 99.82
8 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 99.68
9 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41 99.64
10 INT336925 Aggf1 Positive_regulation of Mir341 1 0.00 0.8 0.21 99.48
11 INT69291 Cftr Positive_regulation of Localization of Slc4a8 1 0.04 0.38 0.51 99.28
12 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1 98.24
13 INT72180 Binding of CTRC and Cela1 1 0.00 0.65 0.34 97.48
14 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28 96.40
15 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02 91.44
16 INT310695 Binding of Btk and Pla2g6 1 0.18 0.16 0.12 90.40
17 INT153116 Binding of SPINK1 and Abpa 1 0.01 1.32 0.4 89.00
18 INT153114 Binding of Abpa and Ctrc 1 0.00 1.22 0.4 88.56
19 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 88.32
20 INT170834 Cftr Regulation of Slc10a2 1 0.58 0.37 0.22 86.56
21 INT310697 Tlr4 Positive_regulation of Gene_expression of Ptger2 2 0.03 1.34 0.38 86.40
22 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91 85.64
23 INT341624 Binding of CFTR and PRSS1 1 0.39 1.01 0.45 84.52
24 INT168507 Binding of SPINK1 and Ctrc 1 0.03 0.93 0.76 81.12
25 INT183721 HPN Positive_regulation of MYO7A 1 0.02 1.55 0 78.96
26 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13 78.32
27 INT183695 Binding of Tlr3 and Ducm1 1 0.04 2.75 0.56 74.80
28 INT183700 Binding of Pilra and Ducm1 1 0.00 2.35 0.53 74.80
29 INT201512 Binding of PRSS1 and hcp 1 0.09 1.9 0.57 73.28
30 INT100725 TNF Positive_regulation of Localization of SPG21 1 0.28 0.66 0.31 73.20
31 INT275555 Binding of Ltb4r1 and COPD 1 0.01 1.02 0.3 72.16
32 INT35966 SCT Regulation of Localization of LIPF 1 0.32 0.24 0.22 72.00
33 INT35967 SCT Positive_regulation of Localization of LIPF 1 0.33 0.24 0.22 72.00
34 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46 71.84
35 INT337085 Binding of Cxcr4 and Mif 1 0.21 1.89 0.3 71.00
36 INT85531 Rian Negative_regulation of Mpo 1 0.03 1.36 0.27 70.80
37 INT231225 Binding of C1S and SFTPC 1 0.39 1.51 0.43 69.76
38 INT186712 INCENP Positive_regulation of PPARA 1 0.01 1.05 0.08 62.48
39 INT311010 SNRPB Positive_regulation of SERPINA10 1 0.00 0.69 0.07 61.88
40 INT186729 Csf2 Positive_regulation of PPARA 1 0.06 1.04 0.08 61.52
41 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21 61.16
42 INT216570 Gene_expression of cx Positive_regulation of Kcnma1 1 0.00 0.25 0.06 60.96
43 INT183708 Tlr3 Regulation of Binding of Tlr3 and Ducm1 1 0.02 0.99 0.14 60.48
44 INT215810 Positive_regulation of Binding of Ca2 and Orai1 1 0.01 0.06 0.03 55.04
45 INT215811 Binding of Ca2 and Orai1 1 0.01 0.06 0.03 55.04
46 INT127206 Negative_regulation of Cftr Negative_regulation of Positive_regulation of Mcf2l 1 0.16 0.62 0.16 54.40
47 INT211105 Binding of CRS and IGHE 1 0.02 3.63 0.66 49.92
48 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19 43.64
49 INT308745 Binding of Alb and Fas 1 0.00 0 0 40.56
50 INT229127 SPINK1 Positive_regulation of PRSS1 1 0.53 1.59 0.48 36.96
51 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 36.64
52 INT229129 SPINK1 Negative_regulation of PRSS1 1 0.49 0.79 0.24 35.44
53 INT249162 CYBB Regulation of CA2 1 0.17 0.31 0.08 27.92
54 INT308747 Binding of Cftr and Prkag1 1 0.02 0 0 23.04
55 INT196639 Negative_regulation of NA Negative_regulation of Transcription of CFTR 1 0.02 0.63 0.03 20.24
56 INT252425 Positive_regulation of AR Positive_regulation of Gene_expression of CXCL10 1 0.00 0.9 0.44 18.36
57 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67 16.96
58 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18 15.88
59 INT196629 PTGER2 Negative_regulation of Gene_expression of NA 1 0.00 0.24 0.22 12.88
60 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29 9.92
61 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29 9.92
62 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29 9.92
63 INT274470 Binding of IL12A and GOPC 1 0.02 0.6 0.09 8.24
64 INT183868 CAV1 Positive_regulation of PAF1 1 0.54 0.41 0 7.28
65 INT275850 Binding of NDUFAB1 and SNCA 1 0.00 3.78 3.16 5.00
66 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86 5.00
67 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 5.00
68 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83 5.00
69 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83 5.00
70 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
71 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
72 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
73 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
74 INT175553 Binding of CASR and CP 1 0.11 1.65 1.03 5.00
75 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99 5.00
76 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99 5.00
77 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98 5.00
78 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84 5.00
79 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84 5.00
80 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81 5.00
81 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
82 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
83 INT183698 Binding of Cxcr2 and Cxcl1 3 0.33 3.26 0.76 5.00
84 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75 5.00
85 INT228499 Binding of FAS and Fasl 1 0.15 2.75 0.73 5.00
86 INT228494 Binding of Ncoa5 and Rela 1 0.00 1.58 0.72 5.00
87 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
88 INT275554 Binding of CXCL10 and Cxcr3 1 0.03 2.18 0.71 5.00
89 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67 5.00
90 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
91 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
92 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
93 INT274167 Il13 Regulation of Il5 2 0.09 2.05 0.59 5.00
94 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59 5.00
95 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
96 INT228497 Il4 Regulation of Ncoa5 1 0.01 1.24 0.57 5.00
97 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55 5.00
98 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55 5.00
99 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
100 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53 5.00
101 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51 5.00
102 INT252426 Binding of SLURP1 and Negative_regulation of Gene_expression of TNF 1 0.01 1.13 0.49 5.00
103 INT186713 IK Positive_regulation of Gene_expression of NOS1 1 0.00 0.55 0.49 5.00
104 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
105 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
106 INT229128 Binding of CP and PRSS1 1 0.14 0.77 0.47 5.00
107 INT196634 IFNG Negative_regulation of DNAH8 1 0.03 1.49 0.47 5.00
108 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46 5.00
109 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46 5.00
110 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46 5.00
111 INT302421 IFNA1 Positive_regulation of Cxcl10 1 0.02 1.8 0.45 5.00
112 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
113 INT302422 IFNA1 Positive_regulation of Cxcl9 1 0.03 1.81 0.45 5.00
114 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
115 INT186711 IK Positive_regulation of Localization of IL8 1 0.00 0.39 0.44 5.00
116 INT302423 Etohi5 Positive_regulation of IFNA1 1 0.00 1.77 0.44 5.00
117 INT347563 Abat Positive_regulation of Gopc 1 0.04 0.2 0.43 5.00
118 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42 5.00
119 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42 5.00
120 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42 5.00
121 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 5.00
122 INT179207 KCNAB2 Regulation of Gene_expression of ATP1A4 1 0.00 1.25 0.37 5.00
123 INT275557 Negative_regulation of Binding of CXCL10 and Cxcr3 1 0.04 1.09 0.35 5.00
124 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35 5.00
125 INT196644 PTGER2 Positive_regulation of Gene_expression of NA 1 0.00 0.93 0.35 5.00
126 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34 5.00
127 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
128 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
129 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
130 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
131 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
132 INT322129 Binding of Prkcg and Ca2 1 0.00 0.57 0.33 5.00
133 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33 5.00
134 INT175552 Binding of CASR and UPF1 1 0.01 0.89 0.33 5.00
135 INT196618 Binding of KNG1 and Positive_regulation of NA 1 0.01 0.19 0.32 5.00
136 INT196623 Binding of KNG1 and Positive_regulation of DNAH8 1 0.01 0.19 0.32 5.00
137 INT258763 Binding of Drd5 and ADHD1 1 0.07 1.11 0.31 5.00
138 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31 5.00
139 INT332255 Ptger2 Positive_regulation of Localization of Col7a1 1 0.00 0.92 0.31 5.00
140 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
141 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
142 INT196605 Binding of DNAH8 and SPANXB1 Positive_regulation of DNAH8 1 0.00 0.08 0.3 5.00
143 INT347562 Abat Positive_regulation of Mki67 1 0.03 0 0.3 5.00
144 INT196604 Binding of DNAH8 and SPANXB1 Positive_regulation of NA 1 0.00 0.08 0.3 5.00
145 INT196641 Binding of KNG1 and Negative_regulation of DNAH8 1 0.01 0.19 0.29 5.00
146 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29 5.00
147 INT196612 Binding of KNG1 and Negative_regulation of NA 1 0.01 0.19 0.29 5.00
148 INT196621 PTGER2 Negative_regulation of Gene_expression of DNAH8 1 0.00 0.33 0.28 5.00
149 INT228500 Fadd Positive_regulation of FAS 1 0.14 1.12 0.28 5.00
150 INT275548 Il10 Regulation of Mmp9 1 0.00 0.86 0.28 5.00
151 INT196631 PTGER2 Negative_regulation of NFKB1 1 0.00 0.32 0.28 5.00
152 INT274172 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of TNF 1 0.02 0.72 0.28 5.00
153 INT275556 Il10 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
154 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
155 INT322132 Binding of Mbp and Trpv4 1 0.11 0.39 0.27 5.00
156 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27 5.00
157 INT196626 Binding of DNAH8 and KNG1 1 0.00 0.08 0.27 5.00
158 INT196695 Prkaca Positive_regulation of CFTR 1 0.46 0.13 0.27 5.00
159 INT196637 Binding of DNAH8 and SPANXB1 1 0.00 0.08 0.27 5.00
160 INT196613 Binding of KNG1 and NA 1 0.01 0.08 0.27 5.00
161 INT332246 Ros1 Positive_regulation of Stat1 1 0.02 0.46 0.27 5.00
162 INT258766 Binding of Csf2 and ADHD1 1 0.01 0.69 0.27 5.00
163 INT196616 Binding of NA and SPANXB1 1 0.00 0.08 0.27 5.00
164 INT322127 Binding of Mbp and Ca2 1 0.01 0.39 0.27 5.00
165 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26 5.00
166 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26 5.00
167 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25 5.00
168 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25 5.00
169 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25 5.00
170 INT332242 Binding of Egf and Pdgfa 1 0.07 0.97 0.25 5.00
171 INT319383 Binding of CCL18 and CCL22 1 0.19 1.07 0.25 5.00
172 INT196614 TNF Positive_regulation of Positive_regulation of NA 1 0.03 0.88 0.24 5.00
173 INT196615 TNF Positive_regulation of Negative_regulation of DNAH8 1 0.02 0.88 0.24 5.00
174 INT196609 IFNG Positive_regulation of Positive_regulation of NA 1 0.03 0.87 0.24 5.00
175 INT196622 IFNG Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.87 0.24 5.00
176 INT196647 IFNG Negative_regulation of NA 1 0.04 0.79 0.24 5.00
177 INT252427 IGKV2D-29 Regulation of Gene_expression of AR 1 0.02 0 0.24 5.00
178 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24 5.00
179 INT196620 TNF Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.88 0.24 5.00
180 INT196646 IFNG Positive_regulation of Negative_regulation of DNAH8 1 0.03 0.87 0.24 5.00
181 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24 5.00
182 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
183 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22 5.00
184 INT354544 Avp Positive_regulation of ADCY1 1 0.24 2.23 0.22 5.00
185 INT200637 Binding of Abpa and Ace 1 0.01 4.62 0.22 5.00
186 INT310939 Binding of ELANE and COPD 1 0.08 1.51 0.2 5.00
187 INT310938 Binding of ELANE and HRCT1 1 0.02 1.5 0.2 5.00
188 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19 5.00
189 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19 5.00
190 INT332253 Il13 Positive_regulation of Stat6 1 0.08 1.18 0.19 5.00
191 INT332245 Pdgfa Positive_regulation of Stat6 1 0.07 1.22 0.19 5.00
192 INT332251 Il13 Positive_regulation of Stat1 1 0.14 1.4 0.18 5.00
193 INT267660 CFTR Regulation of Gene_expression of P2RX2 1 0.25 0.51 0.18 5.00
194 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18 5.00
195 INT274168 Egf Positive_regulation of Gene_expression of Muc5ac 1 0.01 2.11 0.17 5.00
196 INT274169 Mapk1 Regulation of Pde4a 1 0.05 0.62 0.17 5.00
197 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17 5.00
198 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17 5.00
199 INT252423 Binding of TCIRG1 and SLURP1 1 0.00 0.33 0.16 5.00
200 INT221353 Tnf Positive_regulation of Gene_expression of RT1-CE1 1 0.05 0.39 0.16 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cystic Fibrosis. They are ordered first by their pain relevance and then by number of times they were reported in Cystic Fibrosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82 100.00
2 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73 100.00
3 INT84307 Binding of Cftr 31 0.47 26.19 12.8 100.00
4 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55 100.00
5 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 100.00
6 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79 100.00
7 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65 100.00
8 INT86119 Regulation of Cftr 13 0.45 14.08 5.75 100.00
9 INT89114 Binding of Cftr 13 0.37 11.29 4.99 100.00
10 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12 100.00
11 INT48993 Positive_regulation of Cftr 17 0.57 6.02 4.12 100.00
12 INT202522 Negative_regulation of Gene_expression of Cftr 11 0.57 5.9 2.24 100.00
13 INT89113 Regulation of Cftr 11 0.62 6.83 4.01 100.00
14 INT169756 Binding of CFTR 9 0.35 9.65 4.55 100.00
15 INT104694 Positive_regulation of Localization of TUBA4A 1 0.00 2.71 1.49 100.00
16 INT104691 Positive_regulation of Localization of CXCL1 1 0.06 2.69 1.48 100.00
17 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 100.00
18 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77 100.00
19 INT69290 Localization of Cftr 11 0.75 3.69 2.52 100.00
20 INT108281 Negative_regulation of Binding of Cftr 4 0.43 3.1 1.38 100.00
21 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 100.00
22 INT24946 Binding of PRSS1 23 0.47 16.75 6.41 100.00
23 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03 100.00
24 INT104695 Localization of TUBA4A 1 0.00 1.36 0.74 100.00
25 INT104696 Localization of CXCL1 2 0.09 1.68 0.92 100.00
26 INT12082 Localization of IL6 365 0.81 241.78 105.78 100.00
27 INT23654 Binding of SPINK1 27 0.48 30.85 11.53 100.00
28 INT46777 Localization of FECD7 1 0.61 2.09 0.16 100.00
29 INT151100 Negative_regulation of Positive_regulation of CFTR 1 0.43 1.11 0.73 100.00
30 INT103378 Binding of Spink1 24 0.40 15.3 6.19 100.00
31 INT151101 Regulation of CFTR 4 0.62 3.69 1.89 100.00
32 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 100.00
33 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33 100.00
34 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 100.00
35 INT86315 Transcription of Cftr 7 0.53 4.24 2.3 100.00
36 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48 100.00
37 INT108282 Negative_regulation of Binding of Spink1 1 0.34 1.3 0.62 100.00
38 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 100.00
39 INT330760 Positive_regulation of Gene_expression of LETMD1 1 0.04 1.46 0.38 100.00
40 INT330759 Gene_expression of LETMD1 1 0.04 1.39 0.35 100.00
41 INT38071 Positive_regulation of Localization of Gif 1 0.20 0.31 0.15 100.00
42 INT73572 Positive_regulation of S100A8 10 0.67 6.6 1 100.00
43 INT108283 Negative_regulation of Binding of PRSS1 2 0.28 0.82 0.31 100.00
44 INT108284 Negative_regulation of Binding of SPINK1 1 0.10 0.65 0.31 100.00
45 INT170828 Gene_expression of Cfm1 1 0.14 0.32 0.18 100.00
46 INT85428 Regulation of S100A8 9 0.44 4.84 0.73 100.00
47 INT146759 Positive_regulation of LCN2 18 0.69 18.44 1.08 100.00
48 INT347555 Positive_regulation of Localization of Cftr 1 0.14 0.63 0.09 100.00
49 INT147793 Localization of COPD 70 0.64 89.01 7.3 100.00
50 INT201499 Binding of Prss2 1 0.23 1.81 1.08 100.00
51 INT129678 Gene_expression of Hsf1 13 0.78 8.57 0.85 100.00
52 INT61290 Regulation of Phosphorylation of CFTR 1 0.44 0.25 0.81 100.00
53 INT61291 Phosphorylation of CFTR 1 0.80 0.25 0.8 100.00
54 INT103841 Negative_regulation of Gene_expression of Cftr 3 0.43 1.93 0.63 100.00
55 INT122587 Negative_regulation of Gene_expression of S100A8 2 0.41 1.57 0.6 100.00
56 INT132713 Negative_regulation of Regulation of LETMD1 1 0.00 0.1 0.27 100.00
57 INT132711 Regulation of LETMD1 1 0.00 0.1 0.27 100.00
58 INT132710 Negative_regulation of Regulation of Cftr 1 0.06 0.1 0.27 100.00
59 INT132712 Negative_regulation of LETMD1 1 0.00 0.1 0.27 100.00
60 INT170886 Gene_expression of AIRE 2 0.49 4.63 0.19 100.00
61 INT311014 Positive_regulation of Localization of LCN2 1 0.50 1.36 0.12 100.00
62 INT169575 Regulation of H1FNT 3 0.07 3.41 0.74 99.96
63 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 99.96
64 INT46132 Binding of PTCRA 3 0.30 2.88 0.45 99.90
65 INT11787 Positive_regulation of Positive_regulation of NA 14 0.21 2.97 2.46 99.90
66 INT196671 Positive_regulation of Positive_regulation of SCNN1G 2 0.04 1.04 0.13 99.90
67 INT196691 Positive_regulation of Positive_regulation of DNAH8 2 0.10 1.23 0.13 99.90
68 INT82743 Gene_expression of SPINK1 48 0.78 44.28 8.77 99.88
69 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 99.84
70 INT46207 Positive_regulation of Slc10a2 2 0.69 3.8 3.19 99.84
71 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 99.84
72 INT139625 Regulation of Gene_expression of Cftr 5 0.50 3.59 1.32 99.84
73 INT63812 Gene_expression of H1FNT 14 0.06 8.41 1.67 99.80
74 INT13826 Positive_regulation of Negative_regulation of Dbp 5 0.42 2.19 0.74 99.80
75 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 99.80
76 INT147213 Negative_regulation of Gene_expression of Dbp 5 0.34 2.88 1.16 99.80
77 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 99.80
78 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 99.76
79 INT310689 Positive_regulation of Negative_regulation of Cftr 1 0.47 1.41 0.4 99.76
80 INT59900 Binding of MATN3 13 0.42 17.19 3.59 99.76
81 INT104698 Positive_regulation of Localization of IL36B 3 0.04 2.56 1.42 99.72
82 INT104692 Localization of IL36B 2 0.05 1.28 0.71 99.72
83 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 99.72
84 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 99.70
85 INT44919 Negative_regulation of ALAD 5 0.43 3.11 0.8 99.70
86 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 99.70
87 INT330761 Positive_regulation of LETMD1 1 0.03 1.36 0.34 99.70
88 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 99.68
89 INT171998 Binding of DMD 58 0.47 38.13 3.35 99.68
90 INT130226 Positive_regulation of Gene_expression of Mif 4 0.58 15.75 3.03 99.68
91 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 99.68
92 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 99.64
93 INT38070 Localization of Gif 1 0.40 0.91 0.63 99.60
94 INT294931 Positive_regulation of Negative_regulation of Gc 1 0.05 0.62 0.26 99.60
95 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 99.60
96 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 99.60
97 INT46205 Negative_regulation of Slc10a2 2 0.37 1.41 0.37 99.60
98 INT174272 Negative_regulation of Gene_expression of F3 5 0.14 4.06 0.31 99.60
99 INT48994 Localization of Slc4a8 17 0.46 3.29 4.69 99.56
100 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 99.52
101 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 99.52
102 INT112760 Negative_regulation of Positive_regulation of Smpd1 2 0.38 1.45 0.84 99.48
103 INT86914 Positive_regulation of Smpd1 11 0.43 4.73 1.74 99.48
104 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79 99.44
105 INT127202 Negative_regulation of Mcf2l 8 0.50 6.7 4.15 99.36
106 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33 99.36
107 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 99.36
108 INT275865 Negative_regulation of Binding of PES1 1 0.19 1.33 0.63 99.34
109 INT84308 Localization of Cftr 12 0.75 6.16 1.65 99.32
110 INT301529 Positive_regulation of Gene_expression of Srebf1 7 0.42 1.59 0.32 99.32
111 INT176174 Gene_expression of Srebf1 16 0.66 6.53 0.82 99.32
112 INT65262 Gene_expression of Lox 47 0.74 36.59 5.65 99.28
113 INT311017 Localization of LCN2 1 0.75 1.83 0.18 99.28
114 INT186459 Positive_regulation of SFTPC 4 0.45 4.64 0.36 99.28
115 INT12339 Localization of IL8 437 0.81 251.87 117.39 99.24
116 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 99.20
117 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 99.20
118 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 99.20
119 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 99.20
120 INT196687 Positive_regulation of SCNN1G 6 0.06 3.85 1.32 99.20
121 INT57278 Localization of SERPINA1 4 0.81 2.59 0.21 99.20
122 INT275861 Binding of PES1 1 0.17 3.45 1.95 99.14
123 INT215828 Regulation of Binding of Cftr 2 0.33 1.56 0.66 99.12
124 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89 99.08
125 INT121379 Positive_regulation of Casr 13 0.66 2.92 2.34 99.04
126 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07 99.02
127 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9 99.02
128 INT10671 Regulation of CRX 4 0.53 6.29 1.78 99.00
129 INT65259 Positive_regulation of Gene_expression of Lox 7 0.66 2.8 0.67 99.00
130 INT172872 Positive_regulation of Lox 12 0.49 12.99 1.29 99.00
131 INT104697 Positive_regulation of Negative_regulation of TUBA4A 1 0.00 1.8 0.98 98.84
132 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86 98.84
133 INT55093 Negative_regulation of SPINK1 13 0.42 15.11 3.8 98.84
134 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 98.82
135 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 98.82
136 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 98.80
137 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 98.80
138 INT88559 Negative_regulation of Spink1 25 0.56 21.81 9.28 98.72
139 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78 98.72
140 INT12241 Negative_regulation of Positive_regulation of PRSS1 6 0.43 5.39 3.22 98.72
141 INT201497 Negative_regulation of Positive_regulation of Prss2 1 0.27 1.7 1 98.72
142 INT201501 Negative_regulation of Prss2 1 0.27 1.69 0.99 98.72
143 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 98.68
144 INT274693 Positive_regulation of Gene_expression of Cftr 6 0.49 2.93 0.8 98.68
145 INT336920 Negative_regulation of Mir341 1 0.03 3.02 0.55 98.64
146 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 98.60
147 INT226184 Protein_catabolism of Cftr 3 0.87 1.52 0.38 98.60
148 INT170900 Regulation of Positive_regulation of Gopc 10 0.20 3.44 1.24 98.54
149 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 98.52
150 INT231231 Regulation of SFTPB 1 0.27 1.47 0.22 98.52
151 INT104693 Negative_regulation of TUBA4A 1 0.00 1.78 0.98 98.40
152 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 98.40
153 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 98.36
154 INT149229 Localization of ipv 8 0.65 10.34 1.06 98.28
155 INT274193 Negative_regulation of PES1 7 0.57 3.25 0.77 98.28
156 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 98.24
157 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 98.24
158 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74 98.24
159 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 98.18
160 INT294726 Positive_regulation of Lts1 5 0.49 4.06 0.87 98.16
161 INT7457 Localization of Kcnma1 3 0.60 2.75 0.85 98.16
162 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 98.16
163 INT183467 Negative_regulation of TBK1 6 0.12 9.89 5.41 98.16
164 INT186456 Gene_expression of SFTPC 2 0.75 11.46 2.38 98.08
165 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 98.04
166 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 98.00
167 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 97.96
168 INT141862 Binding of Cav1 11 0.36 1.32 1.25 97.92
169 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 97.84
170 INT241724 Localization of Adora2b 2 0.75 1.21 1.14 97.82
171 INT127200 Localization of Mcf2l 7 0.64 4.8 3.25 97.76
172 INT2364 Localization of Sct 134 0.80 26.21 41.47 97.76
173 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 97.76
174 INT5205 Localization of AR 43 0.80 12.87 4.63 97.74
175 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 97.70
176 INT127016 Regulation of Grk4 3 0.60 2.59 1 97.60
177 INT114519 Gene_expression of Hcm 10 0.57 13.01 0.57 97.56
178 INT186461 Gene_expression of SFTPB 10 0.73 8.69 1.09 97.52
179 INT201504 Positive_regulation of Prss2 1 0.32 1.68 0.99 97.44
180 INT13952 Gene_expression of Nil 11 0.65 6.4 2.93 97.40
181 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 97.38
182 INT23744 Protein_catabolism of Ctrc 8 0.62 1.93 2.19 97.20
183 INT63839 Binding of CRS 31 0.41 34.05 4.7 97.12
184 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 97.00
185 INT86314 Regulation of Transcription of Cftr 2 0.33 1.81 0.83 97.00
186 INT122376 Localization of Pla2g4a 12 0.73 7.18 2.58 96.96
187 INT33111 Binding of Abpa 8 0.23 8.82 1.85 96.96
188 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 96.88
189 INT36978 Localization of Pah 9 0.73 7.43 0.82 96.88
190 INT170758 Positive_regulation of Localization of Cftr 2 0.50 2.4 0.35 96.84
191 INT170759 Positive_regulation of Binding of Cftr 2 0.50 1.82 0.6 96.80
192 INT8690 Localization of Tac1 71 0.80 22.98 50.75 96.80
193 INT27243 Positive_regulation of SPINK1 13 0.68 26.71 2.92 96.72
194 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 96.40
195 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 96.40
196 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31 96.12
197 INT175554 Binding of MCRS1 21 0.23 25.2 8.59 96.04
198 INT170756 Negative_regulation of Localization of Cftr 1 0.42 1.74 0.31 95.96
199 INT38362 Positive_regulation of Wbc1 19 0.06 13.24 2.95 95.84
200 INT243030 Binding of Mmp8 1 0.10 2.4 1.82 95.60
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