D:Cystinosis

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pChart

Disease Term
Synonyms Cystine Diathesis, Cystine Disease, Cystine Storage Disease, Cystinoses, CYSTINOSIS DISORDER
Documents 13
Hot Single Events 5
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cystinosis. They are ordered first by their relevance to Cystinosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
2 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
3 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
4 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00
5 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
6 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
7 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cystinosis. They are ordered first by their pain relevance and then by number of times they were reported in Cystinosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 100.00
2 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 100.00
3 INT158 Localization of Prl 2431 0.81 378.96 952.2 98.34
4 INT340363 Regulation of Clcn5 1 0.45 0.85 0 95.04
5 INT340371 Regulation of Tal 1 0.10 0.85 0 94.16
6 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 78.96
7 INT2059 Positive_regulation of Negative_regulation of Prl 24 0.70 5.7 9.37 78.96
8 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 76.72
9 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 75.44
10 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 75.20
11 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 74.12
12 INT164753 Negative_regulation of Clcn5 2 0.58 5.13 0.2 67.40
13 INT340369 Negative_regulation of Tal 1 0.09 1.04 0 67.40
14 INT340366 Gene_expression of Clcn5 1 0.77 4.8 0 63.04
15 INT340360 Positive_regulation of Clcn5 1 0.50 1.62 0 60.56
16 INT118576 Positive_regulation of H6PD 2 0.45 0.49 0.1 25.00
17 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
18 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
19 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
20 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
21 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
22 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
23 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 5.00
24 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
25 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 5.00
26 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 5.00
27 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 5.00
28 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
29 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
30 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 5.00
31 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
32 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
33 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
34 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
35 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 5.00
36 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
37 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
38 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
39 INT121335 Localization of SCD 10 0.68 6.81 1.51 5.00
40 INT126370 Localization of VSX1 6 0.56 1.7 1.28 5.00
41 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
42 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
43 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
44 INT27919 Positive_regulation of Mbis1 6 0.02 2.28 0.9 5.00
45 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 5.00
46 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 5.00
47 INT59175 Localization of TNMD 4 0.70 4.14 0.71 5.00
48 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
49 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
50 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
51 INT189634 Regulation of DCN 3 0.25 1.69 0.49 5.00
52 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42 5.00
53 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 5.00
54 INT56433 Negative_regulation of Cl 3 0.13 1.87 0.35 5.00
55 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 5.00
56 INT273158 Binding of COL8A2 1 0.33 2.02 0.22 5.00
57 INT218762 Localization of ZEB1 2 0.65 0.09 0.2 5.00
58 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 5.00
59 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16 5.00
60 INT273145 Negative_regulation of COL8A2 1 0.40 0.83 0.06 5.00
61 INT273155 Gene_expression of COL8A2 1 0.53 0.74 0.05 5.00
62 INT340358 Negative_regulation of Positive_regulation of Cl 1 0.13 0.79 0.04 5.00
63 INT340375 Negative_regulation of Cubn 1 0.24 0.77 0.03 5.00
64 INT232943 Binding of KRT12 3 0.47 0.88 0 5.00
65 INT232980 Binding of KRT3 2 0.29 0.43 0 5.00
66 INT273142 Gene_expression of Smc3 1 0.09 0.35 0 5.00
67 INT273144 Binding of CHED1 1 0.19 1.7 0 5.00
68 INT273146 Positive_regulation of Binding of TNMD 1 0.02 0.21 0 5.00
69 INT273147 Binding of TBCD 1 0.05 0 0 5.00
70 INT273148 Localization of LCAT 1 0.38 0.91 0 5.00
71 INT273149 Localization of GCDH 1 0.06 0.77 0 5.00
72 INT273150 Regulation of CHED1 1 0.24 0.09 0 5.00
73 INT273151 Binding of GCDH 1 0.04 0.25 0 5.00
74 INT273152 Positive_regulation of Localization of LCAT 1 0.26 0.91 0 5.00
75 INT273153 Positive_regulation of CHED1 1 0.27 1.53 0 5.00
76 INT273154 Positive_regulation of Localization of SCD 1 0.03 0.94 0 5.00
77 INT273156 Gene_expression of SLC4A11 1 0.41 0.84 0 5.00
78 INT273157 Localization of COL8A2 1 0.26 0.09 0 5.00
79 INT273159 Gene_expression of CHED1 1 0.36 1.83 0 5.00
80 INT273160 Binding of TNMD 4 0.42 1.72 0 5.00
81 INT283060 Positive_regulation of Atp5s 1 0.20 1.81 0 5.00
82 INT340359 Binding of Clcn5 1 0.48 1.91 0 5.00
83 INT340361 Binding of Clcn4-2 1 0.30 0.82 0 5.00
84 INT340362 Gene_expression of Ocrl 3 0.67 2.27 0 5.00
85 INT340364 Negative_regulation of Gene_expression of Ocrl 1 0.43 1.16 0 5.00
86 INT340365 Protein_catabolism of Clcn5 1 0.99 1.03 0 5.00
87 INT340367 Regulation of Gene_expression of Ocrl 1 0.45 1.11 0 5.00
88 INT340368 Binding of Ocrl 1 0.37 2.61 0 5.00
89 INT340370 Negative_regulation of Ocrl 1 0.43 2.31 0 5.00
90 INT340372 Negative_regulation of Protein_catabolism of Clcn5 1 0.43 1.07 0 5.00
91 INT340374 Binding of Rabep1 1 0.05 0.61 0 5.00
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