D:Dacryocystitis

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Disease Term
Synonyms Dacryoadenitides, Dacryoadenitis, Dacryocystitides
Documents 39
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dacryocystitis. They are ordered first by their relevance to Dacryocystitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05 5.00
2 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
3 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 5.00
4 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18 5.00
5 INT354888 Amy1 Regulation of Il10 1 0.02 1.41 0.13 5.00
6 INT354885 Amy1 Regulation of Gene_expression of Il10 1 0.03 1.41 0.13 5.00
7 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09 5.00
8 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09 5.00
9 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08 5.00
10 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08 5.00
11 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08 5.00
12 INT276384 Binding of Mirlet7a-1 and MIR9-1 1 0.39 1.12 0.08 5.00
13 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05 5.00
14 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04 5.00
15 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04 5.00
16 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04 5.00
17 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04 5.00
18 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04 5.00
19 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03 5.00
20 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03 5.00
21 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03 5.00
22 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03 5.00
23 INT347577 Binding of MUC1 and MUC16 1 0.25 0.42 0 5.00
24 INT354890 Binding of TNF and Tnfsf13b 1 0.01 2.05 0 5.00
25 INT354887 Binding of Tnfsf13b and Gtf3a 1 0.01 2.05 0 5.00
26 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0 5.00
27 INT276300 TAT Regulation of Gene_expression of VEGFA 1 0.14 1.58 0 5.00
28 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
29 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
30 INT276387 ALK Positive_regulation of Gene_expression of Il22ra1 1 0.00 1.55 0 5.00
31 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0 5.00
32 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0 5.00
33 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0 5.00
34 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0 5.00
35 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0 5.00
36 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0 5.00
37 INT276333 Binding of Il10rb and Il22ra1 1 0.00 1.25 0 5.00
38 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0 5.00
39 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0 5.00
40 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dacryocystitis. They are ordered first by their pain relevance and then by number of times they were reported in Dacryocystitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9660 Regulation of TNF 363 0.62 312.94 139.99 97.88
2 INT144168 Gene_expression of CCL1 7 0.13 5.69 2.45 96.88
3 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.72
4 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 96.72
5 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 94.52
6 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 94.52
7 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 93.68
8 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 91.56
9 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44 90.32
10 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 81.64
11 INT6481 Binding of TNF 624 0.48 510.2 214.82 73.12
12 INT6852 Localization of TNF 883 0.81 705.95 270.84 72.64
13 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 68.40
14 INT52185 Gene_expression of DCR 4 0.66 2.03 0.09 60.88
15 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 60.32
16 INT60745 Gene_expression of Ltbr 10 0.61 7.86 3.21 59.44
17 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 58.96
18 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 55.72
19 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 50.20
20 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 43.44
21 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 43.44
22 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 41.76
23 INT354867 Positive_regulation of Gene_expression of Klk13 1 0.38 1.72 0.07 41.44
24 INT354869 Gene_expression of Klk13 1 0.42 1.72 0.07 41.08
25 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 40.72
26 INT95550 Negative_regulation of Positive_regulation of ALB 4 0.42 1.16 0.57 40.72
27 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 40.56
28 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 40.40
29 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 39.68
30 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 39.04
31 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 38.08
32 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 35.72
33 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 30.32
34 INT201347 Negative_regulation of Gene_expression of Chrm3 4 0.30 2.48 0.31 10.48
35 INT354861 Negative_regulation of Gene_expression of Trove2 1 0.41 1.4 0.04 10.48
36 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96 9.28
37 INT226028 Gene_expression of Trove2 4 0.65 9.97 0.54 7.92
38 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
39 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
40 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
41 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
42 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
43 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
44 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
45 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
46 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
47 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
48 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
49 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
50 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
51 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
52 INT117598 Regulation of ACR 118 0.26 41.25 48.01 5.00
53 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
54 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
55 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
56 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
57 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
58 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
59 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 5.00
60 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
61 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
62 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
63 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
64 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
65 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
66 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
67 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
68 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
69 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
70 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
71 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
72 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
73 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
74 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
75 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
76 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
77 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
78 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
79 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
80 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
81 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
82 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
83 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
84 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
85 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
86 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
87 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
88 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
89 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 5.00
90 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
91 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
92 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
93 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
94 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
95 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 5.00
96 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
97 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
98 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
99 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
100 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
101 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
102 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
103 INT276358 Gene_expression of MIR150 42 0.74 38.44 7.82 5.00
104 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
105 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
106 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
107 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
108 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
109 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
110 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 5.00
111 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 5.00
112 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
113 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 5.00
114 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 5.00
115 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54 5.00
116 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
117 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
118 INT266746 Binding of ACR 8 0.23 3.44 5.26 5.00
119 INT34358 Binding of MME 13 0.37 7.25 5.14 5.00
120 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 5.00
121 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 5.00
122 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
123 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 5.00
124 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
125 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66 5.00
126 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
127 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 5.00
128 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 5.00
129 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
130 INT5345 Positive_regulation of BRD2 14 0.67 6.72 3.43 5.00
131 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 5.00
132 INT170606 Regulation of Gene_expression of GOPC 31 0.37 6.08 3.31 5.00
133 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 5.00
134 INT266745 Regulation of Gene_expression of ACR 6 0.10 1.53 2.87 5.00
135 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 5.00
136 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
137 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
138 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
139 INT182224 Binding of CCL21 6 0.34 5.91 2.54 5.00
140 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51 5.00
141 INT169765 Gene_expression of Mir16-1 6 0.63 3.21 2.47 5.00
142 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46 5.00
143 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 5.00
144 INT100399 Gene_expression of CCL17 22 0.77 9.38 2.43 5.00
145 INT194586 Negative_regulation of ACR 8 0.26 2.04 2.41 5.00
146 INT182238 Binding of CXCL13 5 0.33 5.32 2.37 5.00
147 INT26434 Localization of MME 17 0.81 8.67 2.3 5.00
148 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
149 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 5.00
150 INT175388 Localization of Ugcg 22 0.37 13.84 2.24 5.00
151 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 5.00
152 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
153 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
154 INT106604 Protein_catabolism of CIB1 4 0.90 1.24 1.98 5.00
155 INT101432 Positive_regulation of Gene_expression of Atp9a 13 0.10 7.86 1.95 5.00
156 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9 5.00
157 INT46142 Gene_expression of Chka 18 0.19 16.4 1.84 5.00
158 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 5.00
159 INT28679 Gene_expression of Tnfsf13b 5 0.60 2.75 1.53 5.00
160 INT172953 Binding of Trp53 33 0.37 20.76 1.41 5.00
161 INT198453 Negative_regulation of MUC5AC 12 0.58 12.96 1.38 5.00
162 INT29898 Negative_regulation of C6orf25 16 0.29 9.58 1.33 5.00
163 INT45075 Gene_expression of Sugt1 24 0.27 8.5 1.33 5.00
164 INT276331 Gene_expression of Il22ra1 6 0.46 6.88 1.31 5.00
165 INT70954 Negative_regulation of Cd3e 11 0.41 4.22 1.31 5.00
166 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
167 INT3046 Gene_expression of LGALS1 20 0.75 12.48 1.11 5.00
168 INT28680 Positive_regulation of Tnfsf13b 5 0.39 6.46 1.1 5.00
169 INT70021 Localization of BCL2 23 0.74 21.6 1.09 5.00
170 INT183967 Positive_regulation of Btg3 9 0.58 9.04 1.03 5.00
171 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
172 INT46169 Transcription of IgG 14 0.67 7.71 1.01 5.00
173 INT121422 Gene_expression of BIRC3 7 0.75 6.24 0.96 5.00
174 INT180183 Regulation of Positive_regulation of GOPC 4 0.26 1.47 0.96 5.00
175 INT173014 Positive_regulation of Gene_expression of MUC5AC 10 0.45 4.82 0.94 5.00
176 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93 5.00
177 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 5.00
178 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87 5.00
179 INT101892 Gene_expression of PIM1 10 0.65 7.19 0.85 5.00
180 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83 5.00
181 INT254253 Transcription of Ighm 5 0.45 3.6 0.81 5.00
182 INT87321 Binding of ITGAX 4 0.47 3.72 0.8 5.00
183 INT70019 Binding of BCL2 25 0.47 17.55 0.79 5.00
184 INT154877 Binding of LGALS1 3 0.19 2.73 0.78 5.00
185 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75 5.00
186 INT118469 Gene_expression of Fgfr3 5 0.72 6.98 0.75 5.00
187 INT135729 Gene_expression of Zap70 5 0.75 6.86 0.75 5.00
188 INT179023 Gene_expression of FL 4 0.39 3.53 0.63 5.00
189 INT106603 Gene_expression of SKP2 5 0.63 6.99 0.62 5.00
190 INT148786 Negative_regulation of Csk 4 0.09 0.97 0.62 5.00
191 INT217168 Gene_expression of MIR21 30 0.55 30.86 0.62 5.00
192 INT132324 Localization of SYK 2 0.78 1.9 0.59 5.00
193 INT136102 Positive_regulation of Gene_expression of ALK 3 0.70 3.21 0.59 5.00
194 INT100055 Transcription of MUC4 5 0.69 3.04 0.58 5.00
195 INT213519 Gene_expression of Tlx3 4 0.70 5.15 0.54 5.00
196 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 5.00
197 INT163828 Localization of Cdkn1b 4 0.66 5.2 0.48 5.00
198 INT36686 Regulation of Tg 7 0.19 3.12 0.45 5.00
199 INT28694 Negative_regulation of CD2 2 0.37 1.21 0.45 5.00
200 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43 5.00
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