D:Danon Disease

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Disease Term
Synonyms DISEASE DANON, Glycogen Storage Disease Iib, Glycogen Storage Disease Type 2b, GLYCOGEN STORAGE DISEASE TYPE IIB, Glycogen Storage Iib, Pseudo Pompe Disease, Vacuolar Cardiomyopathy Myopathy X Linked, X LINKED VACUOLAR CARDIOMYOPATHY MYOPATHY
Documents 6
Hot Single Events 0
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Danon Disease. They are ordered first by their relevance to Danon Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT335743 Binding of PDB1 and Salpa1 1 0.01 1.66 0.09 5.00
2 INT335742 Binding of PDB1 and Dpyd 1 0.02 1.75 0.09 5.00
3 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
4 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
5 INT335736 Binding of Map1lc3a and Map1lc3b 1 0.19 0.36 0 5.00
6 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
7 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
8 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
9 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 5.00
10 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
11 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
12 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 5.00
13 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
14 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
15 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 5.00
16 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 5.00
17 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
18 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 5.00
19 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 5.00
20 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
21 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 5.00
22 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 5.00
23 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Danon Disease. They are ordered first by their pain relevance and then by number of times they were reported in Danon Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 71.36
2 INT157306 Positive_regulation of Positive_regulation of Map1lc3a 3 0.35 1.21 0.44 71.36
3 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 69.80
4 INT157301 Negative_regulation of Map1lc3a 5 0.28 3.2 0.41 62.32
5 INT254887 Negative_regulation of Lamp1 2 0.20 3.17 0 62.32
6 INT254876 Negative_regulation of Localization of Lamp1 2 0.20 2.07 0 62.32
7 INT254878 Localization of Map1lc3a 5 0.57 3.32 0.2 61.68
8 INT254882 Localization of Lamp1 3 0.43 2.05 0 61.68
9 INT335740 Negative_regulation of VCP 1 0.41 1 0.03 56.68
10 INT335733 Positive_regulation of Tardbp 8 0.69 28.41 0.41 44.60
11 INT237045 Positive_regulation of Vcp 7 0.62 6.96 0.12 44.60
12 INT335724 Positive_regulation of Localization of Tardbp 3 0.47 4.9 0.25 34.12
13 INT292763 Localization of Tardbp 6 0.80 12.51 0.91 32.36
14 INT335726 Regulation of Vcp 2 0.22 1.94 0.03 32.00
15 INT134915 Binding of Aif1 4 0.36 1.72 1.72 20.44
16 INT335734 Binding of Sh2b1 1 0.06 0.83 0.13 20.44
17 INT335731 Gene_expression of Vcp 1 0.73 12.21 0.18 16.00
18 INT68829 Binding of ELF3 14 0.47 7.96 2 12.00
19 INT168640 Positive_regulation of Gene_expression of Iba1 9 0.33 8.3 4.55 9.08
20 INT335723 Negative_regulation of Gene_expression of Iba1 2 0.47 1.97 0.98 9.08
21 INT168641 Gene_expression of Iba1 24 0.63 12.21 6.7 8.68
22 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
23 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
24 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
25 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
26 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
27 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
28 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
29 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
30 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
31 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
32 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 5.00
33 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
34 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
35 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 5.00
36 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
37 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
38 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
39 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 5.00
40 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
41 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 5.00
42 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14 5.00
43 INT51165 Binding of Gal 10 0.48 2.56 8.41 5.00
44 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
45 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
46 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 5.00
47 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 5.00
48 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
49 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
50 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 5.00
51 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
52 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 5.00
53 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
54 INT101301 Gene_expression of Aif1 17 0.42 16.43 4.06 5.00
55 INT123752 Regulation of Bax 19 0.60 16.45 4 5.00
56 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 5.00
57 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 5.00
58 INT151586 Positive_regulation of Prkag1 51 0.54 18.7 3.34 5.00
59 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
60 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 5.00
61 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93 5.00
62 INT142724 Negative_regulation of A4GALT 11 0.53 8.23 2.61 5.00
63 INT61465 Gene_expression of Acp5 22 0.75 7.06 2.55 5.00
64 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 5.00
65 INT65545 Localization of EGFR 35 0.79 20.8 1.88 5.00
66 INT167153 Gene_expression of A4GALT 10 0.49 10.45 1.71 5.00
67 INT121513 Positive_regulation of A4GALT 21 0.63 16.06 1.59 5.00
68 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
69 INT101302 Positive_regulation of Gene_expression of Aif1 5 0.37 3.56 1.23 5.00
70 INT174156 Localization of Trp53 16 0.72 13.52 1.18 5.00
71 INT61466 Positive_regulation of Acp5 15 0.66 10.17 1.16 5.00
72 INT36179 Regulation of GLA 11 0.44 6.56 1.12 5.00
73 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 5.00
74 INT303287 Gene_expression of Tardbp 4 0.77 44.78 1.09 5.00
75 INT352186 Negative_regulation of Gene_expression of A4GALT 1 0.20 2.56 1.06 5.00
76 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04 5.00
77 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 5.00
78 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93 5.00
79 INT303326 Gene_expression of CHMP2B 25 0.75 10.08 0.76 5.00
80 INT236094 Localization of Gdnf 4 0.70 2.51 0.68 5.00
81 INT164258 Positive_regulation of Gene_expression of GLA 6 0.47 0.55 0.65 5.00
82 INT121514 Localization of A4GALT 7 0.25 4.77 0.58 5.00
83 INT282380 Binding of Atg16l1 4 0.38 2.06 0.58 5.00
84 INT86246 Binding of Bcl2l1 8 0.37 6.67 0.57 5.00
85 INT124774 Binding of Vcp 4 0.44 3.4 0.52 5.00
86 INT16671 Gene_expression of MBTPS1 7 0.30 4.8 0.52 5.00
87 INT24459 Positive_regulation of PDB1 7 0.46 7 0.5 5.00
88 INT243418 Binding of Htt 14 0.30 5.94 0.44 5.00
89 INT250447 Positive_regulation of Binding of Car2 3 0.11 0.36 0.39 5.00
90 INT236107 Binding of Pdpk1 2 0.26 1.38 0.39 5.00
91 INT135045 Gene_expression of Atxn3 34 0.78 11.59 0.36 5.00
92 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35 5.00
93 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35 5.00
94 INT179816 Positive_regulation of Pdpk1 4 0.31 0.36 0.35 5.00
95 INT207064 Gene_expression of Fkbp1a 2 0.32 1.52 0.34 5.00
96 INT22882 Negative_regulation of IMPA1 10 0.57 5.19 0.31 5.00
97 INT155201 Gene_expression of VCP 4 0.75 8.25 0.31 5.00
98 INT237038 Gene_expression of Becn1 18 0.36 13.68 0.31 5.00
99 INT123622 Negative_regulation of Vcp 5 0.42 2.51 0.3 5.00
100 INT263255 Negative_regulation of Negative_regulation of AGTR1 2 0.30 2.88 0.25 5.00
101 INT335735 Binding of Atp13a3 2 0.03 1.17 0.24 5.00
102 INT244330 Localization of ELF3 8 0.56 2.71 0.18 5.00
103 INT296853 Positive_regulation of Atg7 4 0.37 1.45 0.18 5.00
104 INT204987 Binding of Pink1 3 0.37 4.72 0.17 5.00
105 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13 5.00
106 INT352180 Negative_regulation of Gene_expression of GLA 1 0.42 1.06 0.13 5.00
107 INT243972 Binding of Ulk1 3 0.16 0.36 0.12 5.00
108 INT199082 Positive_regulation of Binding of Akt1 4 0.17 1.25 0.11 5.00
109 INT335728 Positive_regulation of Dpyd 1 0.17 1.74 0.09 5.00
110 INT287203 Negative_regulation of Gene_expression of Htt 7 0.37 5.08 0.07 5.00
111 INT245115 Positive_regulation of Gene_expression of ELF3 8 0.40 2.23 0.06 5.00
112 INT335738 Positive_regulation of VCP 1 0.06 1.88 0.06 5.00
113 INT282981 Positive_regulation of Gene_expression of Becn1 8 0.13 6.2 0.06 5.00
114 INT110764 Negative_regulation of Tbt1 2 0.09 1.08 0.05 5.00
115 INT254880 Negative_regulation of Impa1 2 0.05 1.58 0.05 5.00
116 INT352176 Localization of Cst3 1 0.78 1.71 0.04 5.00
117 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04 5.00
118 INT331204 Negative_regulation of Binding of Htt 1 0.04 0.64 0.04 5.00
119 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04 5.00
120 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 5.00
121 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04 5.00
122 INT282982 Binding of Map1lc3a 4 0.28 1.77 0.03 5.00
123 INT254873 Regulation of Map1lc3a 5 0.58 1.24 0.03 5.00
124 INT303303 Positive_regulation of Gene_expression of CHMP2B 2 0.49 0.97 0 5.00
125 INT243236 Localization of Nefl 3 0.73 1.57 0 5.00
126 INT331186 Binding of Atg13 1 0.10 0.09 0 5.00
127 INT335730 Positive_regulation of Map1lc3b 1 0.53 1.86 0 5.00
128 INT335741 Regulation of VCP 1 0.44 0.26 0 5.00
129 INT331196 Positive_regulation of Phosphorylation of Atg13 1 0.14 0.25 0 5.00
130 INT331187 Positive_regulation of Becn1 2 0.09 1.01 0 5.00
131 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0 5.00
132 INT282974 Binding of Becn1 24 0.07 7.43 0 5.00
133 INT331192 Negative_regulation of Atg13 1 0.12 0.1 0 5.00
134 INT331203 Positive_regulation of Binding of Pdpk1 1 0.15 0.17 0 5.00
135 INT282990 Negative_regulation of Binding of Becn1 6 0.08 1.44 0 5.00
136 INT123521 Phosphorylation of Bcl2 8 0.81 5 0 5.00
137 INT331181 Positive_regulation of Sh3glb1 1 0.04 0.46 0 5.00
138 INT306660 Binding of Rb1cc1 2 0.08 0.24 0 5.00
139 INT335722 Localization of Map1lc3b 1 0.61 0.34 0 5.00
140 INT306668 Negative_regulation of Phosphorylation of Ulk1 2 0.14 0.27 0 5.00
141 INT331185 Positive_regulation of Ambra1 1 0.10 0.46 0 5.00
142 INT352188 Negative_regulation of Localization of A4GALT 1 0.17 0 0 5.00
143 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0 5.00
144 INT335727 Gene_expression of Map1lc3b 1 0.59 0.57 0 5.00
145 INT282967 Negative_regulation of Gene_expression of Becn1 3 0.08 2.04 0 5.00
146 INT352187 Phosphorylation of A4GALT 1 0.27 0.13 0 5.00
147 INT306671 Positive_regulation of Phosphorylation of Rb1cc1 2 0.10 0.3 0 5.00
148 INT306662 Phosphorylation of Rb1cc1 2 0.17 0.3 0 5.00
149 INT331191 Negative_regulation of Phosphorylation of Atg13 1 0.12 0.1 0 5.00
150 INT352181 Regulation of NAGA 1 0.11 0.34 0 5.00
151 INT331194 Negative_regulation of Ulk1 1 0.14 0.1 0 5.00
152 INT331193 Negative_regulation of Gene_expression of Atxn3 1 0.17 0.73 0 5.00
153 INT306665 Positive_regulation of Phosphorylation of Ulk1 3 0.23 0.58 0 5.00
154 INT331199 Binding of Rraga 1 0.03 0.31 0 5.00
155 INT335725 Negative_regulation of Gene_expression of Vcp 1 0.55 0.99 0 5.00
156 INT331182 Phosphorylation of Atg13 1 0.23 0.25 0 5.00
157 INT331200 Regulation of Atg4a 1 0.01 0.39 0 5.00
158 INT331188 Positive_regulation of Atg10 1 0.10 0.08 0 5.00
159 INT335732 Positive_regulation of Gene_expression of Vcp 1 0.57 0.87 0 5.00
160 INT254879 Binding of Atg5 3 0.27 0.26 0 5.00
161 INT331195 Positive_regulation of Negative_regulation of Tsc1 1 0.18 0.15 0 5.00
162 INT306672 Phosphorylation of Ulk1 5 0.27 0.88 0 5.00
163 INT331183 Binding of Atg12 1 0.12 0.08 0 5.00
164 INT331206 Positive_regulation of Uvrag 1 0.07 0.46 0 5.00
165 INT352185 Negative_regulation of PCDH11X 1 0.01 0.83 0 5.00
166 INT331198 Negative_regulation of Dctn1 1 0.01 0.58 0 5.00
167 INT306664 Positive_regulation of Ulk1 3 0.23 0.61 0 5.00
168 INT303277 Protein_catabolism of Map1lc3a 3 0.94 0.31 0 5.00
169 INT331190 Positive_regulation of Rap2b 1 0.21 0.39 0 5.00
170 INT331197 Negative_regulation of Atg4a 1 0.02 0.74 0 5.00
171 INT352182 Regulation of A4GALT 1 0.15 0.18 0 5.00
172 INT331205 Protein_catabolism of Gdnf 1 0.03 0.57 0 5.00
173 INT335729 Gene_expression of Vmn1r155 1 0.01 2.54 0 5.00
174 INT352183 Positive_regulation of Gene_expression of A4GALT 1 0.23 0.84 0 5.00
175 INT306658 Binding of Map1lc3b 2 0.13 0.2 0 5.00
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