D:Delayed Puberty

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Disease Term
Synonyms Puberty Delayed
Documents 63
Hot Single Events 45
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Delayed Puberty. They are ordered first by their relevance to Delayed Puberty and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT41006 GNRH1 Negative_regulation of Localization of CGA 1 0.03 0.87 0.3 74.80
2 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35 5.00
3 INT352555 DKK1 Positive_regulation of Wnt2 1 0.01 0.25 0.1 5.00
4 INT224985 Binding of Ube3a and Snord116 1 0.34 0.45 0.08 5.00
5 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
6 INT218953 Esyt1 Negative_regulation of Ncor1 1 0.00 0.1 0.05 5.00
7 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
8 INT224988 Binding of Snord116 and Snurf 1 0.15 0.22 0.04 5.00
9 INT224991 Snord116 Positive_regulation of SNORD108 1 0.37 0.61 0.04 5.00
10 INT224986 Binding of Snrpn and Snord116 1 0.30 0.21 0.04 5.00
11 INT224990 Snord116 Positive_regulation of SNORD107 1 0.38 0.62 0.04 5.00
12 INT224987 Snord116 Positive_regulation of Snord64 1 0.55 0.62 0.04 5.00
13 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 5.00
14 INT218964 Dlst Regulation of AR 1 0.01 0 0.03 5.00
15 INT218963 Dlst Negative_regulation of AR 1 0.00 0.1 0 5.00
16 INT173771 Gh1 Regulation of Transcription of Esr1 1 0.00 0.13 0 5.00
17 INT218952 Dlst Negative_regulation of Igf1 1 0.03 0.1 0 5.00
18 INT173769 Dlat Regulation of Ghr 1 0.04 0 0 5.00
19 INT218954 Dlst Regulation of Gene_expression of Igf1 1 0.03 0 0 5.00
20 INT218951 Negative_regulation of Dlst Negative_regulation of Igf1 1 0.03 0.1 0 5.00
21 INT173772 Gh1 Regulation of Ift20 1 0.05 0.13 0 5.00
22 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
23 INT218960 Binding of AR and Esyt1 1 0.00 0 0 5.00
24 INT218965 Esyt1 Negative_regulation of AR 1 0.00 0 0 5.00
25 INT218961 Binding of ESR1 and Esyt1 1 0.00 0 0 5.00
26 INT173770 Gh1 Regulation of Esr1 1 0.00 0.13 0 5.00
27 INT218962 Dlst Regulation of Gene_expression of AR 1 0.01 0 0 5.00
28 INT173768 Gh1 Regulation of Igf1 1 0.04 0.13 0 5.00
29 INT269769 Gh Regulation of Gene_expression of Igf1 1 0.04 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Delayed Puberty. They are ordered first by their pain relevance and then by number of times they were reported in Delayed Puberty. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT108978 Positive_regulation of CUX1 16 0.57 5.93 1.73 100.00
2 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46 99.96
3 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 99.68
4 INT5127 Localization of Lhb 488 0.80 50.48 162.66 99.52
5 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 99.10
6 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 99.00
7 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 98.94
8 INT1793 Localization of CGA 379 0.81 67.38 114.69 98.88
9 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 98.88
10 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39 98.88
11 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 98.80
12 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 98.58
13 INT1893 Localization of Gh 1041 0.79 340.23 256.58 98.38
14 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98 97.36
15 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19 97.36
16 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 97.08
17 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 96.76
18 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 96.76
19 INT6299 Regulation of Localization of Lhb 104 0.61 8.98 48.79 96.56
20 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 96.36
21 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 96.12
22 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 96.08
23 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 96.08
24 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 96.08
25 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24 96.08
26 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 95.36
27 INT5711 Positive_regulation of Localization of Lhb 90 0.70 10.92 36.76 93.20
28 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 93.00
29 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 91.64
30 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 91.56
31 INT920 Localization of PLOD1 223 0.81 42.25 78.7 91.12
32 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 88.96
33 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 88.76
34 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 88.72
35 INT16915 Negative_regulation of NR0B1 6 0.36 2.32 0.17 87.92
36 INT255579 Negative_regulation of GK 1 0.03 0.65 0 87.92
37 INT255578 Negative_regulation of Binding of NR0B1 1 0.32 0.65 0 87.92
38 INT148717 Binding of NR0B1 6 0.34 5.4 0.25 87.64
39 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 87.44
40 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 87.28
41 INT255583 Binding of GK 1 0.03 0.54 0 86.40
42 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 85.20
43 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 82.72
44 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 82.32
45 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 81.24
46 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 79.44
47 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26 79.44
48 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 79.20
49 INT1782 Regulation of Gh1 125 0.62 22 55.74 77.88
50 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 77.88
51 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 77.88
52 INT95510 Regulation of Ghr 1 0.45 0.21 2.07 77.88
53 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43 77.88
54 INT9321 Transcription of Igf1 25 0.69 10.2 6.08 76.32
55 INT4611 Transcription of Gh1 12 0.68 1.04 4.97 76.32
56 INT117205 Transcription of Esr1 23 0.65 9.4 4.14 76.32
57 INT95512 Transcription of Ghr 24 0.69 3.1 4.12 76.32
58 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 75.00
59 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 74.64
60 INT251 Regulation of INS 398 0.62 232.47 55.04 74.64
61 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 74.48
62 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 74.48
63 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 74.00
64 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 73.36
65 INT173754 Regulation of Mki67 4 0.06 1.04 1.61 69.80
66 INT139391 Regulation of PCNA 10 0.60 3.12 0.33 69.80
67 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 68.80
68 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 66.84
69 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 66.04
70 INT163114 Positive_regulation of Gene_expression of GOT1 7 0.24 8.93 0.5 66.04
71 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 65.84
72 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 65.68
73 INT162 Regulation of Prl 794 0.62 165.01 322.24 63.40
74 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 58.56
75 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 55.60
76 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 55.24
77 INT615 Regulation of Alb 66 0.62 33.43 15.33 55.24
78 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 54.88
79 INT38564 Binding of AIS 36 0.38 27.77 9.31 53.28
80 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9 52.64
81 INT350951 Gene_expression of Rcc2 1 0.03 1.73 0.14 51.92
82 INT350952 Negative_regulation of Gene_expression of Rcc2 1 0.02 1.75 0.14 51.92
83 INT252 Localization of GH1 529 0.80 227.4 122.05 51.52
84 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 50.88
85 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 50.20
86 INT82932 Transcription of AR 14 0.67 5.75 1.34 50.20
87 INT152667 Negative_regulation of Transcription of AR 3 0.42 0.72 0.24 50.20
88 INT192084 Positive_regulation of Atr 4 0.40 0.83 0.17 46.44
89 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 44.48
90 INT215030 Negative_regulation of Ghrhr 2 0.42 2.33 0 39.44
91 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 37.84
92 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 32.88
93 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 29.52
94 INT224954 Gene_expression of Ghrhr 2 0.59 0.87 0.04 26.16
95 INT211972 Regulation of Best1 18 0.33 12.04 0.67 25.68
96 INT285398 Positive_regulation of HLA-DRB8 1 0.01 1.11 0 25.68
97 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 25.00
98 INT5126 Positive_regulation of Positive_regulation of Lhb 16 0.48 2.12 5.23 25.00
99 INT102353 Positive_regulation of HLA-DQA2 6 0.06 4.07 0.82 24.72
100 INT17452 Regulation of Dlst 14 0.46 1.5 1.68 21.72
101 INT183557 Localization of GABRB3 3 0.46 1.01 1.34 12.08
102 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0 11.36
103 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 11.00
104 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 11.00
105 INT183537 Gene_expression of SNRPN 16 0.64 5.07 0.28 10.04
106 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 8.80
107 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
108 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
109 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
110 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
111 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
112 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 5.00
113 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
114 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
115 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
116 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 5.00
117 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
118 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
119 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
120 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
121 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
122 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
123 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
124 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31 5.00
125 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
126 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
127 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
128 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
129 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
130 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
131 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
132 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
133 INT2165 Localization of Cga 41 0.80 4.02 19.53 5.00
134 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
135 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
136 INT912 Localization of FSHR 91 0.79 23.61 15.58 5.00
137 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
138 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
139 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
140 INT108917 Positive_regulation of CRX 23 0.50 21.32 10.5 5.00
141 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7 5.00
142 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 5.00
143 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
144 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 5.00
145 INT224964 Localization of Ghrl 30 0.59 7.71 8.77 5.00
146 INT191765 Regulation of CALM1 15 0.52 9.52 8.56 5.00
147 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 5.00
148 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
149 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 5.00
150 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 5.00
151 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 5.00
152 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 5.00
153 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 5.00
154 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
155 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
156 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
157 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
158 INT131944 Gene_expression of Mki67 30 0.53 6.58 5.63 5.00
159 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
160 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 5.00
161 INT147584 Localization of AIS 38 0.63 12.83 5.27 5.00
162 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12 5.00
163 INT99091 Regulation of AR 70 0.45 31.68 5.05 5.00
164 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 5.00
165 INT923 Positive_regulation of Localization of FSHR 14 0.43 2.48 4.96 5.00
166 INT84727 Negative_regulation of Gene_expression of AR 38 0.58 12.46 4.63 5.00
167 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6 5.00
168 INT169756 Binding of CFTR 9 0.35 9.65 4.55 5.00
169 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
170 INT49360 Localization of Igf1 22 0.76 6.96 4.26 5.00
171 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 5.00
172 INT52980 Positive_regulation of Dlat 20 0.37 5.14 4.06 5.00
173 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79 5.00
174 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77 5.00
175 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74 5.00
176 INT173751 Transcription of Fig4 31 0.46 8.28 3.7 5.00
177 INT82846 Negative_regulation of CRX 9 0.37 5.93 3.64 5.00
178 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
179 INT7365 Binding of Gh1 17 0.37 2.83 3.54 5.00
180 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 5.00
181 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 5.00
182 INT150395 Binding of MEFV 55 0.44 31.18 3.42 5.00
183 INT10594 Gene_expression of Dlst 33 0.57 6 3.38 5.00
184 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
185 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 5.00
186 INT28094 Binding of PTH 29 0.37 13.57 3.09 5.00
187 INT43907 Binding of CD79A 28 0.48 28.11 3.04 5.00
188 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
189 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 5.00
190 INT31541 Regulation of Esr1 15 0.54 4.12 2.82 5.00
191 INT215029 Negative_regulation of Ghrh 15 0.56 11.37 2.62 5.00
192 INT132411 Positive_regulation of Ghrl 25 0.69 12.05 2.59 5.00
193 INT15606 Localization of FSHB 24 0.78 9.16 2.49 5.00
194 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
195 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 5.00
196 INT2544 Localization of PTH 39 0.81 30.55 2.22 5.00
197 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 5.00
198 INT28739 Binding of Ins1 35 0.37 22.43 2.14 5.00
199 INT146660 Negative_regulation of Ctsk 9 0.43 6.01 2.07 5.00
200 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95 5.00
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