D:Demyelinating Disease

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Disease Term
Synonyms Acute Disseminated Encephalomyelitis, Acute Monophasic Demyelinating, Acute Transverse Myelitis, Demyelinating, Demyelinating Diseases, DEMYELINATING DISORDER, Demyelinating Disorders, Demyelination, Demyelinations, DISSEMINATED SCLEROSIS, Guillain Barre
Documents 4880
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Demyelinating Disease. They are ordered first by their relevance to Demyelinating Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 100.00
2 INT36999 Binding of HLA-DRB2 and TNFRSF25 1 0.05 3.46 0.91 100.00
3 INT208051 Binding of SNRNP70 and Accn1 1 0.01 1.81 0 100.00
4 INT329086 Binding of Gc and Scly 1 0.03 0.75 0.38 100.00
5 INT329956 Binding of IL2 and IL23R 1 0.33 4.58 1.21 100.00
6 INT329963 Binding of IL21 and IL23R 1 0.30 2.28 0.6 100.00
7 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5 100.00
8 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5 100.00
9 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44 100.00
10 INT262642 Binding of HLA-DOA and HLA-DQB3 1 0.00 0.63 0.13 99.92
11 INT345008 Binding of ACTN1 and CSF2 1 0.02 0.53 0.26 99.84
12 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42 99.84
13 INT181447 Ccl3 Positive_regulation of Csf2 1 0.06 1.89 0.45 99.84
14 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45 99.84
15 INT260870 Binding of HLA-E and IL7R 1 0.19 0.5 0.22 99.84
16 INT161166 Binding of Aqp4 and Igh-6 1 0.03 2.58 0.49 99.72
17 INT174501 Binding of HLA-B and HLA-DOA 2 0.03 1.84 0.42 99.68
18 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04 99.64
19 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2 99.64
20 INT334632 Binding of Kcna2 and Eae1 1 0.17 0.87 0.35 99.60
21 INT169101 Binding of HLA-A and HLA-DRB1 1 0.24 1.09 0.63 99.56
22 INT48304 Positive_regulation of MBP Positive_regulation of PLP1 1 0.10 0.97 0.64 99.48
23 INT45496 Binding of CSF2 and C6orf25 1 0.03 1.08 0.59 99.48
24 INT4975 Binding of ITIH4 and MAG 1 0.44 2.24 0.39 99.48
25 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93 99.36
26 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82 99.32
27 INT48303 MBP Positive_regulation of PLP1 1 0.10 0.97 0.64 99.28
28 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78 99.12
29 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88 99.02
30 INT161225 Ccl2 Positive_regulation of Ccl2 Positive_regulation of Ccr2 1 0.57 2.09 1.88 99.02
31 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58 98.98
32 INT350716 Binding of CD58 and Casp8 1 0.03 1.81 0.58 98.98
33 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 98.96
34 INT334153 Binding of AQP4 and CSF2 1 0.16 3 0.75 98.92
35 INT344974 Lpar1 Regulation of Gene_expression of Mag 1 0.25 0.98 0.76 98.84
36 INT345006 CSF2 Regulation of GSN 1 0.16 0.82 0.39 98.80
37 INT345007 CSF2 Regulation of DBP 1 0.14 0.82 0.39 98.80
38 INT355983 CSF2 Regulation of Gene_expression of DCPS 1 0.02 0.84 0.25 98.76
39 INT283539 Binding of Litaf and Mad2l1bp 1 0.00 0.67 0.11 98.72
40 INT140573 Positive_regulation of Ifng Positive_regulation of Ifnb1 1 0.01 0.83 0.36 98.68
41 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18 98.64
42 INT222248 Binding of Cxcr3 and Cxcl10 1 0.35 0.48 0.09 98.60
43 INT258861 Binding of HLA-DOA and HLA-DRB1 2 0.14 1.88 0.28 98.56
44 INT350693 Mir326 Positive_regulation of Regulation of thd 1 0.00 1.32 0.41 98.36
45 INT140569 Ifng Positive_regulation of Gene_expression of Il6 1 0.00 0.82 0.36 98.26
46 INT140571 Ifng Positive_regulation of Ifnb1 1 0.01 0.82 0.36 98.26
47 INT140572 Ifng Positive_regulation of Gene_expression of Ifnb1 1 0.01 0.82 0.36 98.26
48 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7 98.20
49 INT325807 CXCL13 Positive_regulation of CISH 1 0.16 3.65 0.89 98.16
50 INT181449 Ccl7 Regulation of Ccl2 1 0.24 0.73 0.25 98.08
51 INT93701 Binding of TNF and TNFAIP2 1 0.02 0.97 0.11 98.08
52 INT140575 Il6 Positive_regulation of Ifnb1 1 0.02 0.82 0.36 97.82
53 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66 97.36
54 INT181432 Csf2 Positive_regulation of Ccl5 1 0.03 0.81 0.29 97.32
55 INT181446 Csf2 Positive_regulation of Ccl3 1 0.05 0.81 0.29 97.32
56 INT262652 Negative_regulation of Binding of HLA-DQA1 and Lmx1a 1 0.01 1.59 0.05 97.00
57 INT128944 Binding of Mbp and Mog 1 0.08 0.8 0.43 96.92
58 INT139429 LPA Positive_regulation of Negative_regulation of MBP 1 0.00 0.78 0.56 96.80
59 INT319002 CSF2 Positive_regulation of Gene_expression of IFNA1 1 0.05 1.02 0.09 96.80
60 INT157343 Binding of AQP4 and HLA-DPB1 1 0.30 0.89 0.43 96.76
61 INT128945 Binding of MBP and Mog 1 0.01 1.59 0.86 96.72
62 INT181445 Binding of Ccr5 and Hand1 1 0.12 1.01 0.22 96.68
63 INT181436 Binding of Ccl2 and Eae1 1 0.05 5.14 1.27 96.48
64 INT328981 Binding of Mup1 and Cts 1 0.14 1.05 0.88 96.48
65 INT328982 Binding of Igfals and Cts 1 0.05 0.92 0.8 96.48
66 INT328976 Binding of Cst7 and Cts 1 0.08 0.92 0.79 96.48
67 INT328979 Binding of Muted and Cts 1 0.03 0.9 0.78 96.48
68 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16 96.44
69 INT262653 Binding of AICDA and Lmx1a 1 0.00 3.18 0.1 96.20
70 INT262654 Binding of HLA-DQA1 and Lmx1a 1 0.01 3.15 0.1 96.20
71 INT318028 Binding of IRF6 and Tlr4 1 0.00 0.61 0.06 96.08
72 INT169648 IGHG3 Regulation of AQP4 3 0.02 4.63 0.55 96.04
73 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32 95.96
74 INT206763 Binding of CSF2 and Nqo1 1 0.00 1.7 0.25 95.92
75 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99 95.92
76 INT80030 Binding of FAS and TNF 3 0.27 2.54 0.56 95.92
77 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16 95.92
78 INT262640 Binding of HLA-DQA1 and AICDA 1 0.03 5.29 0.2 95.80
79 INT240537 Binding of Il12a and Ebi3 1 0.08 1.23 0.49 95.72
80 INT345012 GSN Regulation of CCBE1 1 0.00 0.82 0.36 95.68
81 INT345009 DBP Regulation of CCBE1 1 0.00 0.81 0.36 95.68
82 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17 95.64
83 INT345010 GSN Regulation of DBP 1 0.26 0.81 0.36 95.60
84 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01 95.60
85 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 95.40
86 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 95.40
87 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 95.40
88 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35 95.40
89 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32 95.28
90 INT91810 Binding of FASLG and TNF 1 0.05 0.92 0.08 95.28
91 INT308708 DDX41 Regulation of AQP4 1 0.10 2.79 0.26 95.20
92 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 95.16
93 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 95.16
94 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59 94.84
95 INT262825 Serpinf1 Negative_regulation of Gfap 1 0.34 0.87 0.08 94.40
96 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16 94.32
97 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 94.24
98 INT308701 Binding of AQP4 and DDX41 1 0.15 3.53 0.32 94.12
99 INT167582 ENPP2 Regulation of Gene_expression of LPA 1 0.05 0.61 0.26 94.12
100 INT250253 Binding of AQP4 and SLC1A2 1 0.30 2.95 1.09 93.80
101 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67 93.64
102 INT330794 Positive_regulation of Gabrd Positive_regulation of Localization of Bdnf 1 0.02 0.78 0.33 93.64
103 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 93.60
104 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 0.20 0.89 0.92 93.52
105 INT228350 IFNA1 Positive_regulation of Transcription of Irf2 1 0.04 0.27 0.09 93.44
106 INT328978 Binding of Igfals and Muted 1 0.02 0.85 0.73 93.28
107 INT328980 Binding of Cst7 and Igfals 1 0.06 0.85 0.73 93.28
108 INT328975 Binding of Igfals and Mup1 1 0.11 0.85 0.73 93.28
109 INT328983 Binding of Cst7 and Muted 1 0.04 0.84 0.73 93.28
110 INT328977 Binding of Cst7 and Mup1 1 0.18 0.84 0.73 93.28
111 INT328974 Binding of Muted and Mup1 1 0.06 0.83 0.71 93.28
112 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9 93.20
113 INT62055 Mbp Positive_regulation of Lta 1 0.07 1.4 0.51 93.08
114 INT282128 Gene_expression of Il10 Positive_regulation of Positive_regulation of Icam1 1 0.37 1.12 0.28 93.04
115 INT188699 Binding of Cd40lg and Eae1 1 0.05 1.51 0.24 93.00
116 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63 92.96
117 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89 92.96
118 INT339070 Mog Positive_regulation of Eae1 1 0.01 3.81 0.61 92.96
119 INT339967 Binding of Mog and Eae1 1 0.02 1.67 0.6 92.84
120 INT350698 Mir326 Regulation of Ets1 1 0.01 1.27 0.4 92.80
121 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23 92.48
122 INT262821 Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.54 0.85 0.08 92.48
123 INT194324 Binding of MPZ and MAD2L1BP 1 0.02 0.62 0.04 92.36
124 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3 92.00
125 INT308965 Binding of Cnr2 and Gpbar1 1 0.03 0.61 0.25 91.96
126 INT262826 Serpinf1 Negative_regulation of Gene_expression of TNF 1 0.29 1.83 0.28 91.68
127 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27 91.28
128 INT96590 Mog Regulation of S100B 1 0.32 0.97 0.13 91.12
129 INT96589 Mbp Regulation of S100B 1 0.34 0.97 0.13 91.12
130 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35 91.12
131 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54 91.08
132 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54 91.08
133 INT308709 Positive_regulation of Binding of AQP4 and DDX41 1 0.18 1.19 0.14 90.80
134 INT191128 Positive_regulation of P2RX7 Positive_regulation of Localization of Il1b 1 0.02 0.71 0.34 90.68
135 INT350700 Binding of Bcl6 and thd 1 0.00 0.21 0.08 90.60
136 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08 90.60
137 INT350720 Binding of Bcl6 and TBX21 1 0.07 0.22 0.08 90.60
138 INT284689 Binding of Tspo and Map3k12 1 0.00 0.59 0.32 90.56
139 INT241911 Binding of Cat and Ros1 1 0.03 0.85 0.27 90.48
140 INT181443 Csf2 Positive_regulation of Cxcl10 1 0.02 1.69 0.39 90.40
141 INT181441 Csf2 Positive_regulation of Cxcl12 1 0.02 1.69 0.39 90.40
142 INT181439 Csf2 Positive_regulation of Ccl19 1 0.06 1.68 0.38 90.40
143 INT139683 Binding of Cldn11 and 2410016O06Rik 1 0.02 1.06 0.4 90.32
144 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78 90.32
145 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77 90.32
146 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32 90.28
147 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32 90.28
148 INT10363 Binding of Tmem33 and RT1-Db1 1 0.00 0.92 0.21 90.08
149 INT236833 Binding of CD19 and SDC1 1 0.26 0.54 0.15 90.00
150 INT236834 Binding of CD19 and CSF2 1 0.17 0.53 0.14 90.00
151 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16 89.84
152 INT250247 FCGR3A Negative_regulation of AQP4 1 0.01 0.87 0.62 89.84
153 INT181454 Eae7 Regulation of Positive_regulation of Eae1 1 0.06 0.9 0.26 89.80
154 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53 89.72
155 INT181437 Binding of Ccr7 and Ccl21b 1 0.01 2.23 0.87 89.72
156 INT139684 Binding of Cd4 and 2410016O06Rik 1 0.02 1.05 0.4 89.72
157 INT181451 Lck Regulation of Mbp 1 0.08 1.43 0.34 89.64
158 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75 89.60
159 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78 89.60
160 INT111802 Binding of CD40LG and TFPI 1 0.14 0.62 0.16 89.44
161 INT231390 Pla2g4a Regulation of Pla2g2a 1 0.08 0.92 0.77 89.44
162 INT344973 Negative_regulation of Mmp23 Regulation of Negative_regulation of Mag 1 0.01 1.14 0.99 89.36
163 INT181452 Binding of Ccl19 and Ccl21b 1 0.02 2.22 0.86 89.32
164 INT231388 Pla2g4a Regulation of Pla2g6 1 0.08 0.92 0.77 89.20
165 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7 89.20
166 INT350721 Binding of Hand1 and TBX21 1 0.13 0.22 0.08 89.16
167 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76 88.96
168 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33 88.80
169 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78 88.72
170 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25 88.64
171 INT282712 Binding of MUC5AC and Csf2 1 0.01 2.63 1.07 88.56
172 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54 88.56
173 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 88.40
174 INT350717 MIR219-1 Negative_regulation of Zfp238 1 0.01 0.4 0.16 88.40
175 INT262822 Serpinf1 Negative_regulation of Negative_regulation of 1190002H23Rik 1 0.07 1.27 0.18 88.32
176 INT222253 Binding of Cxcl10 and Fig4 1 0.09 0.66 0.65 88.08
177 INT321957 Binding of Sar1a and Ceacam1 1 0.01 0.96 0.16 87.96
178 INT313273 Binding of GRIN1 and MAP2 1 0.16 0.79 0.04 87.96
179 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79 87.56
180 INT350719 MIR219-1 Negative_regulation of Foxj3 1 0.01 0.4 0.15 87.44
181 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 87.28
182 INT167795 Negative_regulation of LPA Negative_regulation of Mag 1 0.01 0.84 0.64 87.08
183 INT167794 LPA Negative_regulation of Mag 1 0.01 0.77 0.63 87.08
184 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15 86.88
185 INT350723 MIR219-1 Negative_regulation of Sox6 1 0.01 0.4 0.15 86.88
186 INT326574 Binding of Akt1 and Hsp90ab1 1 0.13 0.17 0.08 86.76
187 INT355984 PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 86.72
188 INT355979 Negative_regulation of PDC Positive_regulation of Gene_expression of IL17A 1 0.06 1.57 0.31 86.72
189 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41 86.40
190 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 0.00 0.4 0.15 86.40
191 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18 86.00
192 INT236835 Binding of CISH and CSF2 1 0.06 1.43 1.25 85.76
193 INT295439 Binding of AES and IFNA1 1 0.25 0.46 0.17 85.56
194 INT83626 Ifng Positive_regulation of Gene_expression of Cd59 1 0.33 2.19 1.41 85.56
195 INT282713 Binding of MUC5AC and Mmp9 1 0.02 1.27 0.52 85.52
196 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18 85.48
197 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54 85.20
198 INT83628 TNF Positive_regulation of Gene_expression of Cd59 1 0.06 1.09 0.7 84.28
199 INT261400 Binding of nt and ADHD1 1 0.00 1.69 0.18 84.20
200 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69 83.16

Single Events

The table below shows the top 200 pain related interactions that have been reported for Demyelinating Disease. They are ordered first by their pain relevance and then by number of times they were reported in Demyelinating Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT21937 Positive_regulation of Scly 16 0.39 22.34 13.76 100.00
2 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 100.00
3 INT139493 Gene_expression of Scly 11 0.57 16.96 7.61 100.00
4 INT189230 Gene_expression of GSN 12 0.75 25.04 7.6 100.00
5 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
6 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 100.00
7 INT118343 Positive_regulation of Eae1 121 0.39 136.06 34.87 100.00
8 INT329080 Positive_regulation of Gene_expression of Scly 4 0.43 6.3 2.43 100.00
9 INT164881 Gene_expression of MS 8 0.75 9.01 4.72 100.00
10 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 100.00
11 INT12861 Gene_expression of Cish 40 0.57 23.01 8.48 100.00
12 INT329078 Positive_regulation of Positive_regulation of Scly 1 0.13 3.73 1.73 100.00
13 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 100.00
14 INT154094 Negative_regulation of Eae1 25 0.18 30.42 7.89 100.00
15 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 100.00
16 INT70529 Positive_regulation of Cish 16 0.59 14.43 3.8 100.00
17 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 100.00
18 INT303362 Regulation of Jag1 2 0.22 2.91 1.22 100.00
19 INT284274 Positive_regulation of Mir155 10 0.50 7.68 2.67 100.00
20 INT300370 Positive_regulation of MIR34A 8 0.45 8.13 1.44 100.00
21 INT254397 Negative_regulation of Gene_expression of GSN 2 0.41 3.56 1.28 100.00
22 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 100.00
23 INT236158 Positive_regulation of Mir326 3 0.06 2.79 1.21 100.00
24 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 100.00
25 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 100.00
26 INT24605 Negative_regulation of Scly 6 0.34 3.98 1.71 100.00
27 INT206760 Localization of Nqo1 8 0.09 15.76 2.4 100.00
28 INT96145 Positive_regulation of HLA-S 2 0.46 5.61 1.19 100.00
29 INT90865 Regulation of Scly 5 0.23 3.26 1.34 100.00
30 INT165490 Regulation of Lpar1 8 0.45 15.31 5.05 100.00
31 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04 100.00
32 INT252313 Positive_regulation of Cd47 4 0.22 3.95 0.87 100.00
33 INT25381 Localization of Csf2 62 0.76 47.48 9.03 100.00
34 INT120067 Positive_regulation of Gene_expression of CCR2 10 0.46 5.13 3.02 100.00
35 INT220376 Positive_regulation of Gene_expression of Cish 8 0.31 5.41 1.46 100.00
36 INT329079 Negative_regulation of Positive_regulation of Apod 1 0.03 1.54 0.54 100.00
37 INT191125 Gene_expression of Igfals 12 0.25 12.96 2.89 100.00
38 INT150817 Protein_catabolism of Il23r 1 0.69 1.7 0.58 100.00
39 INT344969 Positive_regulation of Regulation of Mag 1 0.33 1.15 0.7 100.00
40 INT344968 Regulation of Regulation of Lpar1 1 0.39 1.15 0.7 100.00
41 INT344970 Regulation of Regulation of Mag 1 0.32 1.15 0.7 100.00
42 INT228872 Negative_regulation of Gene_expression of Dmbx1 3 0.41 3.75 1.46 100.00
43 INT295239 Negative_regulation of Anxa1 2 0.02 1.6 0.81 100.00
44 INT344967 Positive_regulation of Negative_regulation of Mag 1 0.33 1.15 0.69 100.00
45 INT54720 Positive_regulation of HLA-DRB5 9 0.34 6.7 2.51 100.00
46 INT350681 Positive_regulation of MIR650 1 0.04 0.94 0.45 100.00
47 INT345017 Negative_regulation of Gene_expression of MS 1 0.13 1.26 0.44 100.00
48 INT181353 Positive_regulation of Gene_expression of Ccr8 1 0.32 1.18 0.26 100.00
49 INT345020 Binding of MS 1 0.11 0.76 0.34 100.00
50 INT183372 Regulation of Galc 1 0.44 1.86 0.56 100.00
51 INT345014 Regulation of Gene_expression of MS 1 0.13 1.09 0.4 100.00
52 INT345018 Regulation of MS 1 0.13 1.08 0.39 100.00
53 INT23072 Positive_regulation of Atm 2 0.40 1.76 0.24 100.00
54 INT4642 Regulation of Regulation of IGHE 1 0.45 1.88 0.53 100.00
55 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 100.00
56 INT163592 Localization of CISH 5 0.54 5.9 1.26 100.00
57 INT161221 Positive_regulation of Positive_regulation of Ccr2 3 0.50 4.55 3.98 100.00
58 INT74143 Positive_regulation of Positive_regulation of Atm 1 0.31 0.79 0.15 100.00
59 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 100.00
60 INT287730 Positive_regulation of Gene_expression of Tpnr1 1 0.01 1.43 1.08 100.00
61 INT27687 Regulation of Cp 20 0.53 9.75 10.8 100.00
62 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 100.00
63 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 100.00
64 INT191124 Positive_regulation of Gene_expression of Igfals 1 0.03 1.8 0.29 100.00
65 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 100.00
66 INT287133 Negative_regulation of Binding of Ifnb1 1 0.11 0.31 0.15 100.00
67 INT270030 Negative_regulation of Positive_regulation of Hmox1 3 0.30 2.49 0.47 100.00
68 INT110318 Gene_expression of CAPN1 1 0.04 1.97 0.82 100.00
69 INT112551 Protein_catabolism of Rac1 2 0.66 0.29 0.3 100.00
70 INT6322 Gene_expression of Ceacam1 46 0.75 32.13 12.46 99.98
71 INT188680 Positive_regulation of Binding of Cd40 1 0.46 1.33 0.32 99.98
72 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 99.96
73 INT174426 Gene_expression of Ccr8 11 0.49 11.68 3.65 99.96
74 INT156975 Gene_expression of SLEB1 31 0.65 38.83 6.73 99.96
75 INT233493 Gene_expression of Ccrl2 59 0.65 11.61 4.71 99.96
76 INT11807 Gene_expression of Il2 266 0.78 112 64.97 99.96
77 INT58459 Negative_regulation of Localization of IL2 13 0.41 6.46 4.88 99.94
78 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 99.92
79 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 99.92
80 INT116398 Gene_expression of Mog 25 0.77 23.11 6.33 99.92
81 INT302990 Protein_catabolism of MBP 5 0.88 3.75 1.42 99.92
82 INT29258 Positive_regulation of Gene_expression of Ifnb1 2 0.42 2.16 0.51 99.92
83 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 99.92
84 INT183375 Binding of Nppa 14 0.38 8.95 0.51 99.92
85 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 99.92
86 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57 99.92
87 INT29259 Gene_expression of Ifnb1 4 0.65 1.32 0.62 99.92
88 INT355015 Protein_catabolism of Mbp 1 0.21 2.47 0.61 99.92
89 INT168188 Gene_expression of PLXNA2 13 0.58 9 2.73 99.92
90 INT128946 Regulation of PNPLA6 1 0.27 2.14 0.36 99.92
91 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 99.92
92 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 99.90
93 INT4929 Binding of Mbp 25 0.48 18.01 9.41 99.90
94 INT2836 Positive_regulation of PAEP 51 0.67 26.69 4.57 99.90
95 INT133156 Binding of Cd40 77 0.48 45.92 13.77 99.90
96 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14 99.90
97 INT140414 Positive_regulation of AQP4 25 0.64 23.43 2.47 99.90
98 INT149832 Gene_expression of Tpnr1 3 0.02 4.78 3.75 99.90
99 INT39005 Negative_regulation of FBN1 7 0.42 4.97 2.6 99.90
100 INT71350 Positive_regulation of Tpnr1 3 0.01 3.92 4.08 99.90
101 INT191122 Localization of Igfals 2 0.20 2.16 0.5 99.90
102 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 99.88
103 INT108484 Gene_expression of CCL19 4 0.50 12.56 3.63 99.88
104 INT235938 Binding of Mog 3 0.34 9.61 3.09 99.88
105 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 99.88
106 INT287731 Regulation of Gene_expression of Tpnr1 1 0.00 1.47 1.25 99.88
107 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 99.88
108 INT14486 Localization of Mbp 23 0.74 11.24 6.14 99.86
109 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 99.86
110 INT261186 Positive_regulation of Niacr1 6 0.49 5.28 1.81 99.86
111 INT81314 Regulation of Gene_expression of NA 10 0.27 4.53 2.45 99.86
112 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16 99.84
113 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21 99.84
114 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.84
115 INT96148 Gene_expression of HLA-S 3 0.72 17.33 3.99 99.84
116 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 99.84
117 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04 99.84
118 INT670 Gene_expression of B2m 31 0.66 27.32 8.49 99.84
119 INT166114 Gene_expression of Dmbx1 36 0.74 29.64 12.28 99.84
120 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01 99.84
121 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 99.84
122 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 99.84
123 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 99.84
124 INT108481 Positive_regulation of CCL19 4 0.44 15.22 3.77 99.84
125 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 99.84
126 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 99.84
127 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.84
128 INT72250 Binding of Accn1 3 0.44 2.87 1.27 99.84
129 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 99.84
130 INT268582 Gene_expression of MIR17 8 0.58 9.99 0.9 99.84
131 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 99.84
132 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 99.84
133 INT100491 Positive_regulation of Cxcl10 8 0.41 3.97 3.93 99.84
134 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 99.84
135 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 99.84
136 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 99.84
137 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.84
138 INT108483 Positive_regulation of Gene_expression of CCL21 7 0.69 5.76 2.45 99.84
139 INT108486 Positive_regulation of Gene_expression of CCL19 2 0.45 6.2 1.79 99.84
140 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 99.84
141 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 99.84
142 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33 99.84
143 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.84
144 INT14488 Regulation of MBP 5 0.25 5.17 2.25 99.84
145 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 99.84
146 INT52115 Positive_regulation of tn 5 0.50 4.68 3.54 99.84
147 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 99.84
148 INT100493 Positive_regulation of Positive_regulation of Cxcl10 1 0.28 0.87 0.61 99.84
149 INT208024 Negative_regulation of Binding of Accn1 1 0.39 1.26 0.5 99.84
150 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88 99.84
151 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61 99.84
152 INT56160 Binding of Ifx 14 0.36 11.39 5.74 99.84
153 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 99.82
154 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 99.82
155 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14 99.80
156 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 99.80
157 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 99.80
158 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 99.80
159 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 99.80
160 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 99.80
161 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35 99.80
162 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 99.80
163 INT284265 Gene_expression of Mir155 29 0.64 10.7 2.84 99.80
164 INT81493 Transcription of CCL2 20 0.65 13.63 6.78 99.80
165 INT150818 Localization of Il23r 1 0.58 1.68 0.57 99.80
166 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 99.80
167 INT227781 Positive_regulation of GON4L 4 0.13 7.56 0.54 99.80
168 INT208041 Positive_regulation of Localization of UTS2R 1 0.04 0.45 0 99.80
169 INT79048 Positive_regulation of Localization of Accn1 2 0.46 0.45 0.05 99.80
170 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 99.80
171 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.80
172 INT73978 Positive_regulation of Gene_expression of Hsp90ab1 2 0.36 2.32 0.23 99.80
173 INT326549 Positive_regulation of Hsp90ab1 2 0.35 1.38 0.12 99.80
174 INT331780 Positive_regulation of Positive_regulation of Hsp90ab1 1 0.10 1.1 0.12 99.80
175 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.78
176 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 99.78
177 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31 99.78
178 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 99.78
179 INT214569 Positive_regulation of Localization of CD27 3 0.49 2.16 0.19 99.78
180 INT236840 Positive_regulation of Localization of CD19 1 0.45 0.78 0.19 99.78
181 INT790 Gene_expression of Mastl 22 0.68 4.56 10.23 99.78
182 INT190396 Positive_regulation of Gene_expression of Scn8a 2 0.45 0.77 0.86 99.78
183 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 99.76
184 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 99.76
185 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07 99.76
186 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34 99.76
187 INT167519 Gene_expression of Ubl4 7 0.43 5.28 3.2 99.76
188 INT65153 Binding of HLA-DPB1 5 0.34 3.29 1.4 99.76
189 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 99.76
190 INT25222 Positive_regulation of Gene_expression of Ifng 32 0.50 24.18 19.58 99.76
191 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 99.76
192 INT264641 Binding of AES 25 0.42 18.56 6.98 99.76
193 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 99.76
194 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89 99.76
195 INT222233 Gene_expression of Cxcl12 42 0.69 32.64 10.13 99.76
196 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 99.76
197 INT109558 Binding of Eae1 9 0.25 10.36 3.16 99.76
198 INT95136 Binding of FASLG 6 0.33 8.01 2.41 99.76
199 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 99.76
200 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63 99.76
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